Corynebacterium glutamicum genes encoding novel proteins

ABSTRACT

Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from  Corynebacterium glutamicum  are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCP proteins, mutated MCP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from  C. glutamicum  based on genetic engineering of MCP genes in this organism.

RELATED APPLICATIONS

This application is a divisional of U.S. application Ser. No.11/092,052, filed Mar. 28, 2005, which is a continuation of U.S.application Ser. No. 09/605,703, filed Jun. 27, 2000, now U.S. Pat. No.6,962,989, issued Nov. 8, 2005, which, in turn, claims priority to priorfiled U.S. Provisional Patent Application Ser. No. 60/142,764, filedJul. 8, 1999, and U.S. Provisional Patent Application Ser. No.60/152,318, filed Sep. 3, 1999. The entire contents of both of theaforementioned applications are hereby expressly incorporated herein byreference.

BACKGROUND OF THE INVENTION

Certain products and by-products of naturally-occurring metabolicprocesses in cells have utility in a wide array of industries, includingthe food, feed, cosmetics, and pharmaceutical industries. Thesemolecules, collectively termed ‘fine chemicals’, include organic acids,both proteinogenic and non-proteinogenic amino acids, nucleotides andnucleosides, lipids and fatty acids, diols, carbohydrates, aromaticcompounds, vitamins and cofactors, and enzymes. Their production is mostconveniently performed through the large-scale culture of bacteriadeveloped to produce and secrete large quantities of one or more desiredmolecules. One particularly useful organism for this purpose isCorynebacterium glutamicum, a gram positive, nonpathogenic bacterium.Through strain selection, a number of mutant strains have been developedwhich produce an array of desirable compounds. However, selection ofstrains improved for the production of a particular molecule is atime-consuming and difficult process.

INCORPORATION OF MATERIAL SUBMITTED ON COMPACT DISCS

This application incorporates herein by reference the material containedon the compact discs submitted herewith as part of this application.Specifically, the file “seqlistcorrected” (8.19 MB) contained on each ofCopy 1, Copy 2 and the CRF copy of the Sequence Listing is herebyincorporated herein by reference. This file was created on Jul. 31,2006. In addition, the files “Appendix A” (1.33 MB) and “Appendix B”(478 KB) contained on each of the compact disks entitled “AppendicesCopy I” and “Appendices Copy 2” are hereby incorporated herein byreference. Each of these files were created on Jul. 31, 2006.

SUMMARY OF THE INVENTION

The invention provides novel bacterial nucleic acid molecules which havea variety of uses. These uses include the identification ofmicroorganisms which can be used to produce fine chemicals, themodulation of fine chemical production in C. glutamicum or relatedbacteria, the typing or identification of C. glutamicum or relatedbacteria, as reference points for mapping the C. glutamicum genome, andas markers for transformation. These novel nucleic acid molecules encodeproteins, referred to herein as marker and fine chemical production(MCP) proteins.

C. glutamicum is a gram positive, aerobic bacterium which is commonlyused in industry for the large-scale production of a variety of finechemicals, and also for the degradation of hydrocarbons (such as inpetroleum spills) and for the oxidation of terpenoids. The MCP nucleicacid molecules of the invention, therefore, can be used to identifymicroorganisms which can be used to produce fine chemicals, e.g., byfermentation processes. Modulation of the expression of the MCP nucleicacids of the invention, or modification of the sequence of the MCPnucleic acid molecules of the invention, can be used to modulate theproduction of one or more fine chemicals from a microorganism (e.g., toimprove the yield or production of one or more fine chemicals from aCorynebacterium or Brevibacterium species).

The MCP nucleic acids of the invention may also be used to identify anorganism as being Corynebacterium glutamicum or a close relativethereof, or to identify the presence of C. glutamicum or a relativethereof in a mixed population of microorganisms. The invention providesthe nucleic acid sequences of a number of C. glutamicum genes; byprobing the extracted genomic DNA of a culture of a unique or mixedpopulation of microorganisms under stringent conditions with a probespanning a region of a C. glutamicum gene which is unique to thisorganism, one can ascertain whether this organism is present. AlthoughCorynebacterium glutamicum itself is nonpathogenic, it is related tospecies pathogenic in humans, such as Corynebacterium diphtheriae (thecausative agent of diphtheria); the detection of such organisms is ofsignificant clinical relevance.

The MCP nucleic acid molecules of the invention may also serve asreference points for mapping of the C. glutamicum genome, or of genomesof related organisms. Similarly, these molecules, or variants orportions thereof, may serve as markers for genetically engineeredCorynebacterium or Brevibacterium species.

The MCP proteins encoded by the novel nucleic acid molecules of theinvention may be involved, for example, in the direct or indirectproduction of one or more fine chemicals from C. glutamicum. The MCPproteins of the invention may also participate in the degradation ofhydrocarbons or the oxidation of terpenoids. These proteins may also beutilized for the identification of Corynebacterium glutamicum ororganisms related to C. glutamicum; the presence of an MCP proteinspecific to C. glutamicum and related species in a mixture of proteinsmay indicate the presence of one of these bacteria in the sample.Further, these MCP proteins may have homologues in plants or animalswhich are involved in a disease state or condition; these proteins thusmay serve as useful pharmaceutical targets for drug screening and thedevelopment of therapeutic compounds.

Given the availability of cloning vectors for use in Corynebacteriumglutamicum, such as those disclosed in Sinskey et al., U.S. Pat. No.4,649,119, and techniques for genetic manipulation of C. glutamicum andthe related Brevibacterium species (e.g., lactofermentum) (Yoshihama etal, J. Bacteriol. 162: 591-597 (1985); Katsumata et al., J. Bacteriol.159: 306-311 (1984); and Santamaria et al., J. Gen. Microbiol. 130:2237-2246 (1984)), the nucleic acid molecules of the invention may beutilized in the genetic engineering of this organism to modulate theproduction of one or more fine chemicals. This modulation may be due toa direct effect of manipulation of a gene of the invention, or it may bedue to an indirect effect of such manipulation. For example, bymodifying the activity of a protein involved in the biosynthesis ordegradation of a fine chemical (i.e., through mutagenesis of thecorresponding gene), one may directly modulate the ability of the cellto synthesize or to degrade this compound, thereby modulating the yieldand/or efficiency of production of the fine chemical. Similarly, bymodulating the activity of a protein which regulates a fine chemicalmetabolic pathway, one may directly influence whether the production ofthe desired compound is up- or down-regulated, either of which willmodulate the yield or efficiency of production of the fine chemical fromthe cell.

Indirect modulation of fine chemical production may also result bymodifying the activity of a protein of the invention (i.e., bymutagenesis of the corresponding gene) such that the overall ability ofthe cell to grow and divide or to remain viable and productive isincreased. The production of fine chemicals from C. glutamicum isgenerally accomplished by the large-scale fermentative culture of thesemicroorganisms, conditions which are frequently suboptimal for growthand cell division. By engineering a protein of the invention (e.g., astress response protein, a cell wall protein, or proteins involved inthe metabolism of compounds necessary for cell growth and division tooccur, such as nucleotides and amino acids) such that it is better ableto survive, grow, and multiply in such conditions, it may be possible toincrease the number and productivity of such engineered C. glutamicumcells in large-scale culture, which in turn should result in increasedyields and/or efficiency of production of one or more desired finechemicals. Further, the metabolic pathways of any cell are necessarilyinterrelated and coregulated. By altering the activity or regulation ofany one metabolic pathway in C. glutamicum (i.e., by altering theactivity of one of the proteins of the invention which participates insuch a pathway), it is possible to concomitantly alter the activity orregulation of other metabolic pathways in this microorganism, which maybe directly involved in the synthesis or degradation of a fine chemical.

The invention provides novel nucleic acid molecules which encodeproteins, referred to herein as MCP proteins, which are capable of, forexample, modulating the production or efficiency of production of one ormore fine chemicals from C. glutamicum, or of serving as identifyingmarkers for C. glutamicum or related organisms. Nucleic acid moleculesencoding an MCP protein are referred to herein as MCP nucleic acidmolecules. In a preferred embodiment, the MCP protein is capable ofmodulating the production or efficiency of production of one or morefine chemicals from C. glutamicum, or of serving as identifying markersfor C. glutamicum or related organisms. Examples of such proteinsinclude those encoded by the genes set forth in Table 1.

Accordingly, one aspect of the invention pertains to isolated nucleicacid molecules (e.g., cDNAs, DNAs, or RNAs) comprising a nucleotidesequence encoding an MCP protein or biologically active portionsthereof, as well as nucleic acid fragments suitable as primers orhybridization probes for the detection or amplification of MCP-encodingnucleic acid (e.g., DNA or mRNA). In particularly preferred embodiments,the isolated nucleic acid molecule comprises one of the nucleotidesequences set forth in Appendix A or the coding region or a complementthereof of one of these nucleotide sequences. In other particularlypreferred embodiments, the isolated nucleic acid molecule of theinvention comprises a nucleotide sequence which hybridizes to or is atleast about 50%, preferably at least about 60%, more preferably at leastabout 70%, 80% or 90%, and even more preferably at least about 95%, 96%,97%, 98%, 99% or more homologous to a nucleotide sequence set forth inAppendix A, or a portion thereof. In other preferred embodiments, theisolated nucleic acid molecule encodes one of the amino acid sequencesset forth in Appendix B. The preferred MCP proteins of the presentinvention also preferably possess at least one of the MCP activitiesdescribed herein.

In another embodiment, the isolated nucleic acid molecule encodes aprotein or portion thereof wherein the protein or portion thereofincludes an amino acid sequence which is sufficiently homologous to anamino acid sequence of Appendix B, e.g., sufficiently homologous to anamino acid sequence of Appendix B such that the protein or portionthereof maintains an MCP activity. Preferably, the protein or portionthereof encoded by the nucleic acid molecule maintains the ability tomodulate the production or efficiency of production of one or more finechemicals from C. glutamicum, or of serving as an identifying marker forC. glutamicum or related organisms. In one embodiment, the proteinencoded by the nucleic acid molecule is at least about 50%, preferablyat least about 60%, and more preferably at least about 70%, 80%, or 90%and most preferably at least about 95%, 96%, 97%, 98%, or 99% or morehomologous to an amino acid sequence of Appendix B (e.g., an entireamino acid sequence selected from those sequences set forth in AppendixB). In another preferred embodiment, the protein is a full length C.glutamicum protein which is substantially homologous to an entire aminoacid sequence of Appendix B (encoded by an open reading frame shown inAppendix A).

In another preferred embodiment, the isolated nucleic acid molecule isderived from C. glutamicum and encodes a protein (e.g., an MCP fusionprotein) which includes a biologically active domain which is at leastabout 50% or more homologous to one of the amino acid sequences ofAppendix B and is able to modulate the yield, production, and/orefficiency of production of one or more fine chemicals from C.glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve asa target for drug development, or to serve as an identifying marker forC. glutamicum or related organisms, and which also includes heterologousnucleic acid sequences encoding a heterologous polypeptide or regulatoryregions.

In another embodiment, the isolated nucleic acid molecule is at least 15nucleotides in length and hybridizes under stringent conditions to anucleic acid molecule comprising a nucleotide sequence of Appendix A.Preferably, the isolated nucleic acid molecule corresponds to anaturally-occurring nucleic acid molecule. More preferably, the isolatednucleic acid encodes a naturally-occurring C. glutamicum MCP protein, ora biologically active portion thereof.

Another aspect of the invention pertains to vectors, e.g., recombinantexpression vectors, containing the nucleic acid molecules of theinvention, and host cells into which such vectors have been introduced.In one embodiment, such a host cell is used to produce an MCP protein byculturing the host cell in a suitable medium. The MCP protein can thenbe isolated from the medium or the host cell.

Yet another aspect of the invention pertains to a genetically alteredmicroorganism in which an MCP gene has been introduced or altered. Inone embodiment, the genome of the microorganism has been altered byintroduction of a nucleic acid molecule of the invention encodingwild-type or mutated MCP sequence as a transgene. In another embodiment,an endogenous MCP gene within the genome of the microorganism has beenaltered, e.g., functionally disrupted, by homologous recombination withan altered MCP gene. In another embodiment, an endogenous or introducedMCP gene in a microorganism has been altered by one or more pointmutations, deletions, or inversions, but still encodes a functional MCPprotein. In still another embodiment, one or more of the regulatoryregions (e.g., a promoter, repressor, or inducer) of an MCP gene in amicroorganism has been altered (e.g., by deletion, truncation,inversion, or point mutation) such that the expression of the MCP geneis modulated. In a preferred embodiment, the microorganism belongs tothe genus Corynebacterium or Brevibacterium, with Corynebacteriumglutamicum being particularly preferred. In a preferred embodiment, themicroorganism is also utilized for the production of a desired compound,such as an amino acid, with lysine being particularly preferred.

In another aspect, the invention provides a method of identifying thepresence or activity of Cornyebacterium diphtheriae in a subject. Thismethod includes detection of one or more of the nucleic acid or aminoacid sequences of the invention (e.g., the sequences set forth inAppendix A or Appendix B) in a subject, thereby detecting the presenceor activity of Corynebacterium diphtheriae in the subject.

Still another aspect of the invention pertains to an isolated MCPprotein or a portion, e.g., a biologically active portion, thereof. In apreferred embodiment, the isolated MCP protein or portion thereof iscapable of modulating the production or efficiency of production of oneor more fine chemicals from C. glutamicum, or of serving as anidentifying marker for C. glutamicum or related organisms. In anotherpreferred embodiment, the isolated MCP protein or portion thereof issufficiently homologous to an amino acid sequence of Appendix B suchthat the protein or portion thereof maintains the ability to, forexample, modulate the production or efficiency of production of one ormore fine chemicals from C. glutamicum, or to serve as identifyingmarkers for C. glutamicum or related organisms.

The invention also provides an isolated preparation of an MCP protein.In preferred embodiments, the MCP protein comprises an amino acidsequence of Appendix B. In another preferred embodiment, the inventionpertains to an isolated full length protein which is substantiallyhomologous to an entire amino acid sequence of Appendix B (encoded by anopen reading frame set forth in Appendix A). In yet another embodiment,the protein is at least about 50%, preferably at least about 60%, andmore preferably at least about 70%, 80%, or 90%, and most preferably atleast about 95%, 96%, 97%, 98%, or 99% or more homologous to an entireamino acid sequence of Appendix B. In other embodiments, the isolatedMCP protein comprises an amino acid sequence which is at least about 50%or more homologous to one of the amino acid sequences of Appendix B andis able to modulate the yield, production, and/or efficiency ofproduction of one or more fine chemicals from C. glutamicum, to degradehydrocarbons, to oxidize terpenoids, to serve as a target for drugdevelopment, or to serve as an identifying marker for C. glutamicum orrelated organisms.

Alternatively, the isolated MCP protein can comprise an amino acidsequence which is encoded by a nucleotide sequence which hybridizes,e.g., hybridizes under stringent conditions, or is at least about 50%,preferably at least about 60%, more preferably at least about 70%, 80%,or 90%, and even more preferably at least about 95%, 96%, 97%, 98,%, or99% or more homologous, to a nucleotide sequence of Appendix B. It isalso preferred that the preferred forms of MCP proteins also have one ormore of the MCP bioactivities described herein.

The MCP polypeptide, or a biologically active portion thereof, can beoperatively linked to a non-MCP polypeptide to form a fusion protein. Inpreferred embodiments, this fusion protein has an activity which differsfrom that of the MCP protein alone. In other preferred embodiments, thisfusion protein is capable of modulating the yield, production and/orefficiency of production of one or more fine chemicals from C.glutamicum, or of serving as an identifying marker for C. glutamicum orrelated organisms. In particularly preferred embodiments, integration ofthis fusion protein into a host cell modulates production of a desiredcompound from the cell.

In another aspect, the invention provides methods for screeningmolecules which modulate the activity of an MCP protein, either byinteracting with the protein itself or a substrate or binding partner ofthe MCP protein, or by modulating the transcription or translation of anMCP nucleic acid molecule of the invention.

Another aspect of the invention pertains to a method for producing afine chemical. This method involves the culturing of a cell containing avector directing the expression of an MCP nucleic acid molecule of theinvention, such that a fine chemical is produced. In a preferredembodiment, this method further includes the step of obtaining a cellcontaining such a vector, in which a cell is transfected with a vectordirecting the expression of an MCP nucleic acid. In another preferredembodiment, this method further includes the step of recovering the finechemical from the culture. In a particularly preferred embodiment, thecell is from the genus Corynebacterium or Brevibacterium, or is selectedfrom those strains set forth in Table 3.

Another aspect of the invention pertains to methods for modulatingproduction of a molecule from a microorganism. Such methods includecontacting the cell with an agent which modulates MCP protein activityor MCP nucleic acid expression such that a cell associated activity isaltered relative to this same activity in the absence of the agent. In apreferred embodiment, the cell is modulated for one or more C.glutamicum MCP protein activities, such that the yield, production,and/or efficiency of production of a desired fine chemical by thismicroorganism is improved. The agent which modulates MCP proteinactivity can be an agent which stimulates MCP protein activity or MCPnucleic acid expression. Examples of agents which stimulate MCP proteinactivity or MCP nucleic acid expression include small molecules, activeMCP proteins, and nucleic acids encoding MCP proteins that have beenintroduced into the cell. Examples of agents which inhibit MCP activityor expression include small molecules and antisense MCP nucleic acidmolecules.

Another aspect of the invention pertains to methods for modulatingyields, production, and/or efficiency of production of a desiredcompound from a cell, involving the introduction of a wild-type ormutant MCP gene into a cell, either maintained on a separate plasmid orintegrated into the genome of the host cell. If integrated into thegenome, such integration can be random, or it can take place byhomologous recombination such that the native gene is replaced by theintroduced copy, causing the production of the desired compound from thecell to be modulated. In a preferred embodiment, said yields areincreased. In another preferred embodiment, said chemical is a finechemical. In a particularly preferred embodiment, said fine chemical isan amino acid. In especially preferred embodiments, said amino acid isL-lysine.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides MCP nucleic acid and protein molecules.These MCP nucleic acid molecules may be utilized in the identificationof Corynebacterium glutamicum or related organisms, in the mapping ofthe C. glutamicum genome (or a genome of a closely related organism), orin the identification of microorganisms which may be used to producefine chemicals, e.g., by fermentation processes. The proteins encoded bythese nucleic acids may be utilized in the direct or indirect modulationof the production or efficiency of production of one or more finechemicals from C. glutamicum, as identifying markers for C. glutamicumor related organisms, in the oxidation of terpenoids or the degradationof hydrocarbons, or as targets for the development of therapeuticpharmaceutical compounds. Aspects of the invention are furtherexplicated below.

I. Fine Chemicals

The term ‘fine chemical’ is art-recognized and includes moleculesproduced by an organism which have applications in various industries,such as, but not limited to, the pharmaceutical, agriculture, andcosmetics industries. Such compounds include organic acids, such astartaric acid, itaconic acid, and diaminopimelic acid, bothproteinogenic and non-proteinogenic amino acids, purine and pyrimidinebases, nucleosides, and nucleotides (as described e.g. in Kuninaka, A.(1996) Nucleotides and related compounds, p. 561-612, in Biotechnologyvol. 6, Rehm et al., eds. VCH: Weinheim, and references containedtherein), lipids, both saturated and unsaturated fatty acids (e.g.,arachidonic acid), diols (e.g., propane diol, and butane diol),carbohydrates (e.g., hyaluronic acid and trehalose), aromatic compounds(e.g., aromatic amines, vanillin, and indigo), vitamins and cofactors(as described in Ullmann's Encyclopedia of Industrial Chemistry, vol.A27, “Vitamins”, p. 443-613 (1996) VCH: Weinheim and references therein;and Ong, A. S., Niki, E. & Packer, L. (1995) “Nutrition, Lipids, Health,and Disease” Proceedings of the UNESCO/Confederation of Scientific andTechnological Associations in Malaysia, and the Society for Free RadicalResearch—Asia, held Sep. 1-3, 1994 at Penang, Malaysia, AOCS Press,(1995)), enzymes, polyketides (Cane et al. (1998) Science 282: 63-68),and all other chemicals described in Gutcho (1983) Chemicals byFermentation, Noyes Data Corporation, ISBN: 0818805086 and referencestherein. The metabolism and uses of certain of these fine chemicals arefurther explicated below.

A. Amino Acid Metabolism and Uses

Amino acids comprise the basic structural units of all proteins, and assuch are essential for normal cellular functioning in all organisms. Theterm “amino acid” is art-recognized. The proteinogenic amino acids, ofwhich there are 20 species, serve as structural units for proteins, inwhich they are linked by peptide bonds, while the nonproteinogenic aminoacids (hundreds of which are known) are not normally found in proteins(see Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97VCH: Weinheim (1985)). Amino acids may be in the D- or L-opticalconfiguration, though L-amino acids are generally the only type found innaturally-occurring proteins. Biosynthetic and degradative pathways ofeach of the 20 proteinogenic amino acids have been well characterized inboth prokaryotic and eukaryotic cells (see, for example, Stryer, L.Biochemistry, 3^(rd) edition, pages 578-590 (1988)). The ‘essential’amino acids (histidine, isoleucine, leucine, lysine, methionine,phenylalanine, threonine, tryptophan, and valine), so named because theyare generally a nutritional requirement due to the complexity of theirbiosyntheses, are readily converted by simple biosynthetic pathways tothe remaining 11 ‘nonessential’ amino acids (alanine, arginine,asparagine, aspartate, cysteine, glutamate, glutamine, glycine, proline,serine, and tyrosine). Higher animals do retain the ability tosynthesize some of these amino acids, but the essential amino acids mustbe supplied from the diet in order for normal protein synthesis tooccur.

Aside from their function in protein biosynthesis, these amino acids areinteresting chemicals in their own right, and many have been found tohave various applications in the food, feed, chemical, cosmetics,agriculture, and pharmaceutical industries. Lysine is an important aminoacid in the nutrition not only of humans, but also of monogastricanimals such as poultry and swine. Glutamate is most commonly used as aflavor additive (mono-sodium glutamate, MSG) and is widely usedthroughout the food industry, as are aspartate, phenylalanine, glycine,and cysteine. Glycine, L-methionine and tryptophan are all utilized inthe pharmaceutical industry. Glutamine, valine, leucine, isoleucine,histidine, arginine, proline, serine and alanine are of use in both thepharmaceutical and cosmetics industries. Threonine, tryptophan, andD/L-methionine are common feed additives. (Leuchtenberger, W. (1996)Amino aids—technical production and use, p. 466-502 in Rehm et al.(eds.) Biotechnology vol. 6, chapter 14a, VCH: Weinheim). Additionally,these amino acids have been found to be useful as precursors for thesynthesis of synthetic amino acids and proteins, such asN-acetylcysteine, S-carboxymethyl-L-cysteine, (S)-5-hydroxytryptophan,and others described in Ulmann's Encyclopedia of Industrial Chemistry,vol. A2, p. 57-97, VCH: Weinheim, 1985.

The biosynthesis of these natural amino acids in organisms capable ofproducing them, such as bacteria, has been well characterized (forreview of bacterial amino acid biosynthesis and regulation thereof, seeUmbarger, H. E. (1978) Ann. Rev. Biochem. 47: 533-606). Glutamate issynthesized by the reductive amination of α-ketoglutarate, anintermediate in the citric acid cycle. Glutamine, proline, and arginineare each subsequently produced from glutamate. The biosynthesis ofserine is a three-step process beginning with 3-phosphoglycerate (anintermediate in glycolysis), and resulting in this amino acid afteroxidation, transamination, and hydrolysis steps. Both cysteine andglycine are produced from serine; the former by the condensation ofhomocysteine with serine, and the latter by the transferal of theside-chain β-carbon atom to tetrahydrofolate, in a reaction catalyzed byserine transhydroxymethylase. Phenylalanine, and tyrosine aresynthesized from the glycolytic and pentose phosphate pathway precursorserythrose 4-phosphate and phosphoenolpyruvate in a 9-step biosyntheticpathway that differ only at the final two steps after synthesis ofprephenate. Tryptophan is also produced from these two initialmolecules, but its synthesis is an 11-step pathway. Tyrosine may also besynthesized from phenylalanine, in a reaction catalyzed by phenylalaninehydroxylase. Alanine, valine, and leucine are all biosynthetic productsof pyruvate, the final product of glycolysis. Aspartate is formed fromoxaloacetate, an intermediate of the citric acid cycle. Asparagine,methionine, threonine, and lysine are each produced by the conversion ofaspartate. Isoleucine is formed from threonine. A complex 9-step pathwayresults in the production of histidine from5-phosphoribosyl-1-pyrophosphate, an activated sugar.

Amino acids in excess of the protein synthesis needs of the cell cannotbe stored, and are instead degraded to provide intermediates for themajor metabolic pathways of the cell (for review see Stryer, L.Biochemistry 3^(rd) ed. Ch. 21 “Amino Acid Degradation and the UreaCycle” p. 495-516 (1988)). Although the cell is able to convert unwantedamino acids into useful metabolic intermediates, amino acid productionis costly in terms of energy, precursor molecules, and the enzymesnecessary to synthesize them. Thus it is not surprising that amino acidbiosynthesis is regulated by feedback inhibition, in which the presenceof a particular amino acid serves to slow or entirely stop its ownproduction (for overview of feedback mechanisms in amino acidbiosynthetic pathways, see Stryer, L. Biochemistry, 3^(rd) ed. Ch. 24:“Biosynthesis of Amino Acids and Heme” p. 575-600 (1988)). Thus, theoutput of any particular amino acid is limited by the amount of thatamino acid present in the cell.

B. Vitamin, Cofactor, and Nutraceutical Metabolism and Uses

Vitamins, cofactors, and nutraceuticals comprise another group ofmolecules which the higher animals have lost the ability to synthesizeand so must ingest, although they are readily synthesized by otherorganisms such as bacteria. These molecules are either bioactivesubstances themselves, or are precursors of biologically activesubstances which may serve as electron carriers or intermediates in avariety of metabolic pathways. Aside from their nutritive value, thesecompounds also have significant industrial value as coloring agents,antioxidants, and catalysts or other processing aids. (For an overviewof the structure, activity, and industrial applications of thesecompounds, see, for example, Ullman's Encyclopedia of IndustrialChemistry, “Vitamins” vol. A27, p. 443-613, VCH: Weinheim, 1996.) Theterm “vitamin” is art-recognized, and includes nutrients which arerequired by an organism for normal functioning, but which that organismcannot synthesize by itself. The group of vitamins may encompasscofactors and nutraceutical compounds. The language “cofactor” includesnonproteinaceous compounds required for a normal enzymatic activity tooccur. Such compounds may be organic or inorganic; the cofactormolecules of the invention are preferably organic. The term“nutraceutical” includes dietary supplements having health benefits inplants and animals, particularly humans. Examples of such molecules arevitamins, antioxidants, and also certain lipids (e.g., polyunsaturatedfatty acids).

The biosynthesis of these molecules in organisms capable of producingthem, such as bacteria, has been largely characterized (Ullman'sEncyclopedia of Industrial Chemistry, “Vitamins” vol. A27, p. 443-613,VCH: Weinheim, 1996; Michal, G. (1999) Biochemical Pathways: An Atlas ofBiochemistry and Molecular Biology, John Wiley & Sons; Ong, A. S., Niki,E. & Packer, L. (1995) “Nutrition, Lipids, Health, and Disease”Proceedings of the UNESCO/Confederation of Scientific and TechnologicalAssociations in Malaysia, and the Society for Free RadicalResearch—Asia, held Sep. 1-3, 1994 at Penang, Malaysia, AOCS Press:Champaign, Ill. X, 374 S).

Thiamin (vitamin B₁) is produced by the chemical coupling of pyrimidineand thiazole moieties. Riboflavin (vitamin B₂) is synthesized fromguanosine-5′-triphosphate (GTP) and ribose-5′-phosphate. Riboflavin, inturn, is utilized for the synthesis of flavin mononucleotide (FMN) andflavin adenine dinucleotide (FAD). The family of compounds collectivelytermed ‘vitamin B₆’ (e.g., pyridoxine, pyridoxamine,pyridoxa-5′-phosphate, and the commercially used pyridoxinhydrochloride) are all derivatives of the common structural unit,5-hydroxy-6-methylpyridine. Pantothenate (pantothenic acid,(R)-(+)-N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine) can beproduced either by chemical synthesis or by fermentation. The finalsteps in pantothenate biosynthesis consist of the ATP-drivencondensation of β-alanine and pantoic acid. The enzymes responsible forthe biosynthesis steps for the conversion to pantoic acid, to β-alanineand for the condensation to panthotenic acid are known. Themetabolically active form of pantothenate is Coenzyme A, for which thebiosynthesis proceeds in 5 enzymatic steps. Pantothenate,pyridoxal-5′-phosphate, cysteine and ATP are the precursors of CoenzymeA. These enzymes not only catalyze the formation of panthothante, butalso the production of (R)-pantoic acid, (R)-pantolacton, (R)-panthenol(provitamin B₅), pantetheine (and its derivatives) and coenzyme A.

Biotin biosynthesis from the precursor molecule pimeloyl-CoA inmicroorganisms has been studied in detail and several of the genesinvolved have been identified. Many of the corresponding proteins havebeen found to also be involved in Fe-cluster synthesis and are membersof the nifS class of proteins. Lipoic acid is derived from octanoicacid, and serves as a coenzyme in energy metabolism, where it becomespart of the pyruvate dehydrogenase complex and the α-ketoglutaratedehydrogenase complex. The folates are a group of substances which areall derivatives of folic acid, which is turn is derived from L-glutamicacid, p-amino-benzoic acid and 6-methylpterin. The biosynthesis of folicacid and its derivatives, starting from the metabolism intermediatesguanosine-5′-triphosphate (GTP), L-glutamic acid and p-amino-benzoicacid has been studied in detail in certain microorganisms.

Corrinoids (such as the cobalamines and particularly vitamin B₁₂) andporphyrines belong to a group of chemicals characterized by atetrapyrole ring system. The biosynthesis of vitamin B₁₂ is sufficientlycomplex that it has not yet been completely characterized, but many ofthe enzymes and substrates involved are now known. Nicotinic acid(nicotinate), and nicotinamide are pyridine derivatives which are alsotermed ‘niacin’. Niacin is the precursor of the important coenzymes NAD(nicotinamide adenine dinucleotide) and NADP (nicotinamide adeninedinucleotide phosphate) and their reduced forms.

The large-scale production of these compounds has largely relied oncell-free chemical syntheses, though some of these chemicals have alsobeen produced by large-scale culture of microorganisms, such asriboflavin, Vitamin B₆, pantothenate, and biotin. Only Vitamin B₁₂ isproduced solely by fermentation, due to the complexity of its synthesis.In vitro methodologies require significant inputs of materials and time,often at great cost.

C. Purine, Pyrimidine, Nucleoside and Nucleotide Metabolism and Uses

Purine and pyrimidine metabolism genes and their corresponding proteinsare important targets for the therapy of tumor diseases and viralinfections. The language “purine” or “pyrimidine” includes thenitrogenous bases which are constituents of nucleic acids, co-enzymes,and nucleotides. The term “nucleotide” includes the basic structuralunits of nucleic acid molecules, which are comprised of a nitrogenousbase, a pentose sugar (in the case of RNA, the sugar is ribose; in thecase of DNA, the sugar is D-deoxyribose), and phosphoric acid. Thelanguage “nucleoside” includes molecules which serve as precursors tonucleotides, but which are lacking the phosphoric acid moiety thatnucleotides possess. By inhibiting the biosynthesis of these molecules,or their mobilization to form nucleic acid molecules, it is possible toinhibit RNA and DNA synthesis; by inhibiting this activity in a fashiontargeted to cancerous cells, the ability of tumor cells to divide andreplicate may be inhibited. Additionally, there are nucleotides whichmay serve as energy stores (e.g., ADP, ATP) or as coenzymes (i.e., FADand NAD).

Several publications have described the use of these chemicals for thesemedical indications, by influencing purine and/or pyrimidine metabolism(e.g. Christopherson, R. I. and Lyons, S. D. (1990) “Potent inhibitorsof de novo pyrimidine and purine biosynthesis as chemotherapeuticagents.” Med. Res. Reviews 10: 505-548). Studies of enzymes involved inpurine and pyrimidine metabolism have been focused on the development ofnew drugs which can be used, for example, as immunosuppressants oranti-proliferants (Smith, J. L., (1995) “Enzymes in nucleotidesynthesis.” Curr. Opin. Struct. Biol. 5: 752-757; (1995) Biochem Soc.Transact. 23: 877-902). However, purine and pyrimidine bases,nucleosides and nucleotides have other utilities: as intermediates inthe biosynthesis of several fine chemicals (e.g., thiamine,S-adenosyl-methionine, folates, or riboflavin), as energy carriers forthe cell (e.g., ATP or GTP), and for chemicals themselves, commonly usedas flavor enhancers (e.g., IMP or GMP) or for several medicinalapplications (see, for example, Kuninaka, A. (1996) Nucleotides andRelated Compounds in Biotechnology vol. 6, Rehm et al., eds. VCH:Weinheim, p. 561-612). Also, enzymes involved in purine, pyrimidine,nucleoside, or nucleotide metabolism are increasingly serving as targetsagainst which chemicals for crop protection, including fungicides,herbicides and insecticides, are developed.

The metabolism of these compounds in bacteria has been characterized(for reviews see, for example, Zalkin, H. and Dixon, J. E. (1992) “denovo purine nucleotide biosynthesis”, in: Progress in Nucleic AcidResearch and Molecular Biology, vol. 42, Academic Press:, p. 259-287;and Michal, G. (1999) “Nucleotides and Nucleosides”, Chapter 8 in:Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology,Wiley: New York). Purine metabolism has been the subject of intensiveresearch, and is essential to the normal functioning of the cell.Impaired purine metabolism in higher animals can cause severe disease,such as gout. Purine nucleotides are synthesized fromribose-5-phosphate, in a series of steps through the intermediatecompound inosine-5′-phosphate (IMP), resulting in the production ofguanosine-5′-monophosphate (GMP) or adenosine-5′-monophosphate (AMP),from which the triphosphate forms utilized as nucleotides are readilyformed. These compounds are also utilized as energy stores, so theirdegradation provides energy for many different biochemical processes inthe cell. Pyrimidine biosynthesis proceeds by the formation ofuridine-5′-monophosphate (UMP) from ribose-5-phosphate. UMP, in turn, isconverted to cytidine-5′-triphosphate (CTP). The deoxy-forms of all ofthese nucleotides are produced in a one step reduction reaction from thediphosphate ribose form of the nucleotide to the diphosphate deoxyriboseform of the nucleotide. Upon phosphorylation, these molecules are ableto participate in DNA synthesis.

D. Trehalose Metabolism and Uses

Trehalose consists of two glucose molecules, bound in α, α-1,1 linkage.It is commonly used in the food industry as a sweetener, an additive fordried or frozen foods, and in beverages. However, it also hasapplications in the pharmaceutical, cosmetics and biotechnologyindustries (see, for example, Nishimoto et al., (1998) U.S. Pat. No.5,759,610; Singer, M. A. and Lindquist, S. (1998) Trends Biotech. 16:460-467; Paiva, C. L. A. and Panek, A. D. (1996) Biotech. Ann. Rev. 2:293-314; and Shiosaka, M. (1997) J. Japan 172: 97-102). Trehalose isproduced by enzymes from many microorganisms and is naturally releasedinto the surrounding medium, from which it can be collected usingmethods known in the art.

II. Elements and Methods of the Invention

The present invention is based, at least in part, on the discovery ofnovel molecules, referred to herein as MCP nucleic acid molecules. TheseMCP nucleic acid molecules are useful not only for the identification ofC. glutamicum or related bacterial species, but also as markers for themapping of the C. glutamicum genome and in the identification ofbacteria useful for the production of fine chemicals by, e.g.,fermentative processes. The present invention is also based, at least inpart, on the MCP protein molecules encoded by these MCP nucleic acidmolecules. These MCP proteins are capable of modulating the yield,production, and/or efficiency of production of one or more finechemicals from C. glutamicum, of serving as identifying markers for C.glutamicum or related organisms, of degrading hydrocarbons, and ofserving as targets for the development of therapeutic pharmaceuticalcompounds. In one embodiment, the MCP molecules of the inventiondirectly or indirectly participate in one or more fine chemicalmetabolic pathways in C. glutamicum. In a preferred embodiment, theactivity of the MCP molecules of the invention to indirectly or directlyparticipate in such metabolic pathways has an impact on the productionof a desired fine chemical by this microorganism. In a particularlypreferred embodiment, the MCP molecules of the invention are modulatedin activity, such that the C. glutamicum metabolic pathways in which theMCP proteins of the invention participate are modulated in efficiency oroutput, which either directly or indirectly modulates the production orefficiency of production of a desired fine chemical by C. glutamicum.

The language, “MCP protein” or “MCP polypeptide” includes proteins whichare able to modulate the yield, production, and/or efficiency ofproduction of one or more fine chemicals from C. glutamicum, to degradehydrocarbons, to oxidize terpenoids, to serve as a target protein fordrug screening or design, or to serve as identifying markers for C.glutamicum or related organisms. Examples of MCP proteins include thoseencoded by the MCP genes set forth in Table 1 and Appendix A. The terms“MCP gene” or “MCP nucleic acid sequence” include nucleic acid sequencesencoding an MCP protein, which consist of a coding region and alsocorresponding untranslated 5′ and 3′ sequence regions. Examples of MCPgenes include those set forth in Table 1. The terms “production” or“productivity” are art-recognized and include the concentration of thefermentation product (for example, the desired fine chemical) formedwithin a given time and a given fermentation volume (e.g., kg productper hour per liter). The term “efficiency of production” includes thetime required for a particular level of production to be achieved (forexample, how long it takes for the cell to attain a particular rate ofoutput of a fine chemical). The term “yield” or “product/carbon yield”is art-recognized and includes the efficiency of the conversion of thecarbon source into the product (i.e., fine chemical). This is generallywritten as, for example, kg product per kg carbon source. By increasingthe yield or production of the compound, the quantity of recoveredmolecules, or of useful recovered molecules of that compound in a givenamount of culture over a given amount of time is increased. The terms“biosynthesis” or a “biosynthetic pathway” are art-recognized andinclude the synthesis of a compound, preferably an organic compound, bya cell from intermediate compounds in what may be a multistep and highlyregulated process. The terms “degradation” or a “degradation pathway”are art-recognized and include the breakdown of a compound, preferablyan organic compound, by a cell to degradation products (generallyspeaking, smaller or less complex molecules) in what may be a multistepand highly regulated process. The language “metabolism” isart-recognized and includes the totality of the biochemical reactionsthat take place in an organism. The metabolism of a particular compound,then, (e.g., the metabolism of an amino acid such as glycine) comprisesthe overall biosynthetic, modification, and degradation pathways in thecell related to this compound.

In another embodiment, the MCP molecules of the invention are capable ofmodulating the production of a desired molecule, such as a finechemical, in a microorganism such as C. glutamicum, either directly orindirectly. Using recombinant genetic techniques, one or more of the MCPproteins of the invention may be manipulated such that its function ismodulated. Such modulation of function may result in the modulation ofthe yield, production, and/or efficiency of production of one or morefine chemicals from C. glutamicum.

For example, by modifying the activity of a protein involved in thebiosynthesis or degradation of a fine chemical (i.e., throughmutagenesis of the corresponding gene), one may directly modulate theability of the cell to synthesize or to degrade this compound, therebymodulating the yield and/or efficiency of production of the finechemical. Similarly, by modulating the activity of a protein whichregulates a fine chemical metabolic pathway, one may directly influencewhether the production of the desired compound is up- or down-regulated,either of which will modulate the yield or efficiency of production ofthe fine chemical from the cell.

Indirect modulation of fine chemical production may also result bymodifying the activity of a protein of the invention (i.e., bymutagenesis of the corresponding gene) such that the overall ability ofthe cell to grow and divide or to remain viable and productive isincreased. The production of fine chemicals from C. glutamicum isgenerally accomplished by the large-scale fermentative culture of thesemicroorganisms, conditions which are frequently suboptimal for growthand cell division. By engineering a protein of the invention (e.g., astress response protein, a cell wall protein, or proteins involved inthe metabolism of compounds necessary for cell growth and division tooccur, such as nucleotides and amino acids) such that it is better ableto survive, grow, and multiply in such conditions, it may be possible toincrease the number and productivity of such engineered C. glutamicumcells in large-scale culture, which in turn should result in increasedyields and/or efficiency of production of one or more desired finechemicals. Further, the metabolic pathways of any cell are necessarilyinterrelated and coregulated. By altering the activity or regulation ofany one metabolic pathway in C. glutamicum (i.e., by altering theactivity of one of the proteins of the invention which participates insuch a pathway), it is possible to concomitantly alter the activity orregulation of other metabolic pathways in this microorganism, which maybe directly involved in the synthesis or degradation of a fine chemical.

The isolated nucleic acid sequences of the invention are containedwithin the genome of a Corynebacterium glutamicum strain availablethrough the American Type Culture Collection, given designation ATCC13032. The nucleotide sequences of the isolated C. glutamicum MCPnucleic acid molecules and the predicted amino acid sequences of the C.glutamicum MCP proteins are shown in Appendices A and B, respectively.Computational analyses were performed which classified and/or identifiedmany of these nucleotide sequences as sequences having homology to E.coli or Bacillus subtilis genes.

The present invention also pertains to proteins which have an amino acidsequence which is substantially homologous to an amino acid sequence ofAppendix B. As used herein, a protein which has an amino acid sequencewhich is substantially homologous to a selected amino acid sequence isleast about 50% homologous to the selected amino acid sequence, e.g.,the entire selected amino acid sequence. A protein which has an aminoacid sequence which is substantially homologous to a selected amino acidsequence can also be least about 50-60%, preferably at least about60-70%, and more preferably at least about 70-80%, 80-90%, or 90-95%,and most preferably at least about 96%, 97%, 98%, 99% or more homologousto the selected amino acid sequence.

The MCP protein or a biologically active portion or fragment thereof ofthe invention is able to modulate the yield, production, and/orefficiency of production of one or more fine chemicals from C.glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve asa target for drug development, or to serve as an identifying marker forC. glutamicum or related organisms.

Various aspects of the invention are described in further detail in thefollowing subsections:

A. Isolated Nucleic Acid Molecules

One aspect of the invention pertains to isolated nucleic acid moleculesthat encode MCP polypeptides or biologically active portions thereof, aswell as nucleic acid fragments sufficient for use as hybridizationprobes or primers for the identification or amplification ofMCP-encoding nucleic acid (e.g., MCP DNA). These nucleic acid moleculesmay be used to identify C. glutamicum or related organisms, to map thegenome of C. glutamicum or closely related bacteria, or to identifymicroorganisms useful for the production of fine chemicals, e.g., byfermentative processes. As used herein, the term “nucleic acid molecule”is intended to include DNA molecules (e.g., cDNA or genomic DNA) and RNAmolecules (e.g., mRNA) and analogs of the DNA or RNA generated usingnucleotide analogs. This term also encompasses untranslated sequencelocated at both the 3′ and 5′ ends of the coding region of the gene: atleast about 100 nucleotides of sequence upstream from the 5′ end of thecoding region and at least about 20 nucleotides of sequence downstreamfrom the 3′end of the coding region of the gene. The nucleic acidmolecule can be single-stranded or double-stranded, but preferably isdouble-stranded DNA. An “isolated” nucleic acid molecule is one which isseparated from other nucleic acid molecules which are present in thenatural source of the nucleic acid. Preferably, an “isolated” nucleicacid is free of sequences which naturally flank the nucleic acid (i.e.,sequences located at the 5′ and 3′ ends of the nucleic acid) in thegenomic DNA of the organism from which the nucleic acid is derived. Forexample, in various embodiments, the isolated MCP nucleic acid moleculecan contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1kb of nucleotide sequences which naturally flank the nucleic acidmolecule in genomic DNA of the cell from which the nucleic acid isderived (e.g., a C. glutamicum cell). Moreover, an “isolated” nucleicacid molecule, such as a DNA molecule, can be substantially free ofother cellular material, or culture medium when produced by recombinanttechniques, or chemical precursors or other chemicals when chemicallysynthesized.

A nucleic acid molecule of the present invention, e.g., a nucleic acidmolecule having a nucleotide sequence of Appendix A, or a portionthereof, can be isolated using standard molecular biology techniques andthe sequence information provided herein. For example, a C. glutamicumMCP DNA can be isolated from a C. glutamicum library using all orportion of one of the sequences of Appendix A as a hybridization probeand standard hybridization techniques (e.g., as described in Sambrook,J., Fritsh, E. F., and Maniatis, T. Molecular Cloning: A LaboratoryManual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring HarborLaboratory Press, Cold Spring Harbor, N.Y., 1989). Moreover, a nucleicacid molecule encompassing all or a portion of one of the sequences ofAppendix A can be isolated by the polymerase chain reaction usingoligonucleotide primers designed based upon this sequence (e.g., anucleic acid molecule encompassing all or a portion of one of thesequences of Appendix A can be isolated by the polymerase chain reactionusing oligonucleotide primers designed based upon this same sequence ofAppendix A). For example, mRNA can be isolated from normal endothelialcells (e.g., by the guanidinium-thiocyanate extraction procedure ofChirgwin et al. (1979) Biochemistry 18: 5294-5299) and DNA can beprepared using reverse transcriptase (e.g., Moloney MLV reversetranscriptase, available from Gibco/BRL, Bethesda, Md.; or AMV reversetranscriptase, available from Seikagaku America, Inc., St. Petersburg,Fla.) and random polynucleotide primers or oligonucleotide primers basedupon one of the nucleotide sequences shown in Appendix A. Syntheticoligonucleotide primers for polymerase chain reaction amplification canbe designed based upon one of the nucleotide sequences shown in AppendixA. A nucleic acid of the invention can be amplified using cDNA or,alternatively, genomic DNA, as a template and appropriateoligonucleotide primers according to standard PCR amplificationtechniques. The nucleic acid so amplified can be cloned into anappropriate vector and characterized by DNA sequence analysis.Furthermore, oligonucleotides corresponding to an MCP nucleotidesequence can be prepared by standard synthetic techniques, e.g., usingan automated DNA synthesizer.

In a preferred embodiment, an isolated nucleic acid molecule of theinvention comprises one of the nucleotide sequences shown in Appendix A.The sequences of Appendix A correspond to the Corynebacterium glutamicumMCP DNAs of the invention. This cDNA comprises sequences encoding MCPproteins (i.e., the “coding region”, indicated in each sequence inAppendix A), as well as 5′ untranslated sequences and 3′ untranslatedsequences, also indicated in Appendix A. Alternatively, the nucleic acidmolecule can comprise only the coding region of any of the sequences inAppendix A.

For the purposes of this application, it will be understood that each ofthe sequences set forth in Appendix A has an identifying RXA or RXNnumber having the designation “RXA” or “RXN” followed by 5 digits (i.e.,RXA00003 or RXN0022). Each of these sequences comprises up to threeparts: a 5′ upstream region, a coding region, and a downstream region.Each of these three regions is identified by the same RXA or RXNdesignation to eliminate confusion. The recitation “one of the sequencesin Appendix A”, then, refers to any of the sequences in Appendix A,which may be distinguished by their differing RXA or RXN designations.The coding region of each of these sequences is translated into acorresponding amino acid sequence, which is set forth in Appendix B. Thesequences of Appendix B are identified by the same RXA or RXNdesignations as Appendix A, such that they can be readily correlated.For example, the amino acid sequence in Appendix B designated RXA00003is a translation of the coding region of the nucleotide sequence ofnucleic acid molecule RXA00003 in Appendix A, and the amino acidsequence in Appendix B designated RXN00022 is a translation of thecoding region of the nucleotide sequence of nucleic acid moleculeRXN00022 in Appendix A. Each of the RXA and RXN nucleotide and aminoacid sequences of the invention has also been assigned a SEQ ID NO, asindicated in Table 1.

Several of the genes of the invention are “F-designated genes”. AnF-designated gene includes those genes set forth in Table 1 which havean ‘F’ in front of the RXA designation. For example, SEQ ID NO:3,designated, as indicated on Table 1, as “F RXA01638”, is an F-designatedgene, as are SEQ ID NOs: 5, 9, and 11 (designated on Table 1 as “FRXA01639”, “F RXA01590”, and “F RXA01542”, respectively).

In one embodiment, the nucleic acid molecules of the present inventionare not intended to include those compiled in Table 2.

In another preferred embodiment, an isolated nucleic acid molecule ofthe invention comprises a nucleic acid molecule which is a complement ofone of the nucleotide sequences shown in Appendix A, or a portionthereof. A nucleic acid molecule which is complementary to one of thenucleotide sequences shown in Appendix A is one which is sufficientlycomplementary to one of the nucleotide sequences shown in Appendix Asuch that it can hybridize to one of the nucleotide sequences shown inAppendix A, thereby forming a stable duplex.

In still another preferred embodiment, an isolated nucleic acid moleculeof the invention comprises a nucleotide sequence which is at least about50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably atleast about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, morepreferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%,or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%,92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%,98%, 99% or more homologous to a nucleotide sequence shown in AppendixA, or a portion thereof. Ranges and identity values intermediate to theabove-recited ranges, (e.g., 70-90% identical or 80-95% identical) arealso intended to be encompassed by the present invention. For example,ranges of identity values using a combination of any of the above valuesrecited as upper and/or lower limits are intended to be included. In anadditional preferred embodiment, an isolated nucleic acid molecule ofthe invention comprises a nucleotide sequence which hybridizes, e.g.,hybridizes under stringent conditions, to one of the nucleotidesequences shown in Appendix A, or a portion thereof.

Moreover, the nucleic acid molecule of the invention can comprise only aportion of the coding region of one of the sequences in Appendix A, forexample a fragment which can be used as a probe or primer or a fragmentencoding a biologically active portion of an MCP protein. The nucleotidesequences determined from the cloning of the MCP genes from C.glutamicum allows for the generation of probes and primers designed foruse in identifying and/or cloning MCP homologues in other cell types andorganisms, as well as MCP homologues from other Corynebacteria orrelated species. The probe/primer typically comprises substantiallypurified oligonucleotide. The oligonucleotide typically comprises aregion of nucleotide sequence that hybridizes under stringent conditionsto at least about 12, preferably about 25, more preferably about 40, 50or 75 consecutive nucleotides of a sense strand of one of the sequencesset forth in Appendix A, an anti-sense sequence of one of the sequencesset forth in Appendix A, or naturally occurring mutants thereof. Primersbased on a nucleotide sequence of Appendix A can be used in PCRreactions to clone MCP homologues. Probes based on the MCP nucleotidesequences can be used to detect transcripts or genomic sequencesencoding the same or homologous proteins. In preferred embodiments, theprobe further comprises a label group attached thereto, e.g. the labelgroup can be a radioisotope, a fluorescent compound, an enzyme, or anenzyme co-factor. Such probes can be used as a part of a diagnostic testkit for identifying cells which misexpress an MCP protein, such as bymeasuring a level of an MCP-encoding nucleic acid in a sample of cells,e.g., detecting MCP mRNA levels or determining whether a genomic MCPgene has been mutated or deleted.

In one embodiment, the nucleic acid molecule of the invention encodes aprotein or portion thereof which includes an amino acid sequence whichis sufficiently homologous to an amino acid sequence of Appendix B suchthat the protein or portion thereof maintains the ability to modulatethe yield, production, and/or efficiency of production of one or morefine chemicals from C. glutamicum, to degrade hydrocarbons, to oxidizeterpenoids, to serve as a target for drug development, or to serve as anidentifying marker for C. glutamicum or related organisms. As usedherein, the language “sufficiently homologous” refers to proteins orportions thereof which have amino acid sequences which include a minimumnumber of identical or equivalent (e.g., an amino acid residue which hasa similar side chain as an amino acid residue in one of the sequences ofAppendix B) amino acid residues to an amino acid sequence of Appendix Bsuch that the protein or portion thereof is able to modulate the yield,production, and/or efficiency of production of one or more finechemicals from C. glutamicum, to degrade hydrocarbons, to oxidizeterpenoids, to serve as a target for drug development, or to serve as anidentifying marker for C. glutamicum or related organisms. Examples ofsuch activities are also described herein. Thus, “the function of an MCPprotein” contributes to the overall regulation of one or more finechemical metabolic pathways, or to the degradation of a hydrocarbon, orto the oxidation of a terpenoid.

In another embodiment, the protein is at least about 50-60%, preferablyat least about 60-70%, and more preferably at least about 70-80%,80-90%, 90-95%, and most preferably at least about 96%, 97%, 98%, 99% ormore homologous to an entire amino acid sequence of Appendix B.

Portions of proteins encoded by the MCP nucleic acid molecules of theinvention are preferably biologically active portions of one of the MCPproteins. As used herein, the term “biologically active portion of anMCP protein” is intended to include a portion, e.g., a domain/motif, ofan MCP protein that modulates the yield, production, and/or efficiencyof production of one or more fine chemicals from C. glutamicum, thatdegrades hydrocarbons, that oxidizes terpenoids, that may serve as atarget for drug development, or that may serve as an identifying markerfor C. glutamicum or related organisms. To determine whether an MCPprotein or a biologically active portion thereof can modulate the yield,production, and/or efficiency of production of one or more finechemicals from C. glutamicum, can degrade hydrocarbons, or can oxidizeterpenoids, an assay of activity may be performed. Such assay methodsare well known to those of ordinary skill in the art, as detailed inExample 8 of the Exemplification.

Additional nucleic acid fragments encoding biologically active portionsof an MCP protein can be prepared by isolating a portion of one of thesequences in Appendix B, expressing the encoded portion of the MCPprotein or peptide (e.g., by recombinant expression in vitro) andassessing the activity of the encoded portion of the MCP protein orpeptide.

The invention further encompasses nucleic acid molecules that differfrom one of the nucleotide sequences shown in Appendix A (and portionsthereof) due to degeneracy of the genetic code and thus encode the sameMCP protein as that encoded by the nucleotide sequences shown inAppendix A. In another embodiment, an isolated nucleic acid molecule ofthe invention has a nucleotide sequence encoding a protein having anamino acid sequence shown in Appendix B. In a still further embodiment,the nucleic acid molecule of the invention encodes a full length C.glutamicum protein which is substantially homologous to an amino acidsequence of Appendix B (encoded by an open reading frame shown inAppendix A).

It will be understood by one of ordinary skill in the art that in oneembodiment the sequences of the invention are not meant to include thesequences of the prior art, such as those Genbank sequences set forth inTables 2 or 4 which were available prior to the present invention. Inone embodiment, the invention includes nucleotide and amino acidsequences having a percent identity to a nucleotide or amino acidsequence of the invention which is greater than that of a sequence ofthe prior art (e.g., a Genbank sequence (or the protein encoded by sucha sequence) set forth in Tables 2 or 4). For example, the inventionincludes a nucleotide sequence which is greater than and/or at least 39%identical to the nucleotide sequence designated RXA00008 (SEQ ID NO:1549), a nucleotide sequence which is greater than and/or at least 42%identical to the nucleotide sequence designated RXA00059 (SEQ IDNO:1571), and a nucleotide sequence which is greater than and/or atleast 39% identical to the nucleotide sequence designated RXA00096 (SEQID NO:93). One of ordinary skill in the art would be able to calculatethe lower threshold of percent identity for any given sequence of theinvention by examining the GAP-calculated percent identity scores setforth in Table 4 for each of the three top hits for the given sequence,and by subtracting the highest GAP-calculated percent identity from 100percent. One of ordinary skill in the art will also appreciate thatnucleic acid and amino acid sequences having percent identities greaterthan the lower threshold so calculated (e.g., at least 50%, 51%, 52%,53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably atleast about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%,82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%,and even more preferably at least about 95%, 96%, 97%, 98%, 99% or moreidentical) are also encompassed by the invention.

In addition to the C. glutamicum MCP nucleotide sequences shown inAppendix A, it will be appreciated by those of ordinary skill in the artthat DNA sequence polymorphisms that lead to changes in the amino acidsequences of MCP proteins may exist within a population (e.g., the C.glutamicum population). Such genetic polymorphism in the MCP gene mayexist among individuals within a population due to natural variation. Asused herein, the terms “gene” and “recombinant gene” refer to nucleicacid molecules comprising an open reading frame encoding an MCP protein,preferably a C. glutamicum MCP protein. Such natural variations cantypically result in 1-5% variance in the nucleotide sequence of the MCPgene. Any and all such nucleotide variations and resulting amino acidpolymorphisms in MCP that are the result of natural variation and thatdo not alter the functional activity of MCP proteins are intended to bewithin the scope of the invention.

Nucleic acid molecules corresponding to natural variants and non-C.glutamicum homologues of the C. glutamicum MCP DNA of the invention canbe isolated based on their homology to the C. glutamicum MCP nucleicacid disclosed herein using the C. glutamicum DNA, or a portion thereof,as a hybridization probe according to standard hybridization techniquesunder stringent hybridization conditions. Accordingly, in anotherembodiment, an isolated nucleic acid molecule of the invention is atleast 15 nucleotides in length and hybridizes under stringent conditionsto the nucleic acid molecule comprising a nucleotide sequence ofAppendix A. In other embodiments, the nucleic acid is at least 30, 50,100, 250 or more nucleotides in length. As used herein, the term“hybridizes under stringent conditions” is intended to describeconditions for hybridization and washing under which nucleotidesequences at least 60% homologous to each other typically remainhybridized to each other. Preferably, the conditions are such thatsequences at least about 65%, more preferably at least about 70%, andeven more preferably at least about 75% or more homologous to each othertypically remain hybridized to each other. Such stringent conditions areknown to those of ordinary skill in the art and can be found in CurrentProtocols in Molecular Biology, John Wiley & Sons, N.Y. (1989),6.3.1-6.3.6. A preferred, non-limiting example of stringenthybridization conditions are hybridization in 6× sodium chloride/sodiumcitrate (SSC) at about 45° C., followed by one or more washes in0.2×SSC, 0.1% SDS at 50-65° C. Preferably, an isolated nucleic acidmolecule of the invention that hybridizes under stringent conditions toa sequence of Appendix A corresponds to a naturally-occurring nucleicacid molecule. As used herein, a “naturally-occurring” nucleic acidmolecule refers to an RNA or DNA molecule having a nucleotide sequencethat occurs in nature (e.g., encodes a natural protein). In oneembodiment, the nucleic acid encodes a natural C. glutamicum MCPprotein.

In addition to naturally-occurring variants of the MCP sequence that mayexist in the population, one of ordinary skill in the art will furtherappreciate that changes can be introduced by mutation into a nucleotidesequence of Appendix A, thereby leading to changes in the amino acidsequence of the encoded MCP protein, without altering the functionalability of the MCP protein. For example, nucleotide substitutionsleading to amino acid substitutions at “non-essential” amino acidresidues can be made in a sequence of Appendix A. A “non-essential”amino acid residue is a residue that can be altered from the wild-typesequence of one of the MCP proteins (Appendix B) without altering theactivity of said MCP protein, whereas an “essential” amino acid residueis required for MCP protein activity. Other amino acid residues,however, (e.g., those that are not conserved or only semi-conserved inthe domain having MCP activity) may not be essential for activity andthus are likely to be amenable to alteration without altering MCPactivity.

Accordingly, another aspect of the invention pertains to nucleic acidmolecules encoding MCP proteins that contain changes in amino acidresidues that are not essential for MCP activity. Such MCP proteinsdiffer in amino acid sequence from a sequence contained in Appendix Byet retain at least one of the MCP activities described herein. In oneembodiment, the isolated nucleic acid molecule comprises a nucleotidesequence encoding a protein, wherein the protein comprises an amino acidsequence at least about 50% homologous to an amino acid sequence ofAppendix B and is able to modulate the yield, production, and/orefficiency of production of one or more fine chemicals from C.glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve asa target for drug development, or to serve as an identifying marker forC. glutamicum or related organisms. Preferably, the protein encoded bythe nucleic acid molecule is at least about 50-60% homologous to one ofthe sequences in Appendix B, more preferably at least about 60-70%homologous to one of the sequences in Appendix B, even more preferablyat least about 70-80%, 80-90%, 90-95% homologous to one of the sequencesin Appendix B, and most preferably at least about 96%, 97%, 98%, or 99%homologous to one of the sequences in Appendix B.

To determine the percent homology of two amino acid sequences (e.g., oneof the sequences of Appendix B and a mutant form thereof) or of twonucleic acids, the sequences are aligned for optimal comparison purposes(e.g., gaps can be introduced in the sequence of one protein or nucleicacid for optimal alignment with the other protein or nucleic acid). Theamino acid residues or nucleotides at corresponding amino acid positionsor nucleotide positions are then compared. When a position in onesequence (e.g., one of the sequences of Appendix B) is occupied by thesame amino acid residue or nucleotide as the corresponding position inthe other sequence (e.g., a mutant form of the sequence selected fromAppendix B), then the molecules are homologous at that position (i.e.,as used herein amino acid or nucleic acid “homology” is equivalent toamino acid or nucleic acid “identity”). The percent homology between thetwo sequences is a function of the number of identical positions sharedby the sequences (i.e., % homology=# of identical positions/total # ofpositions×100).

An isolated nucleic acid molecule encoding an MCP protein homologous toa protein sequence of Appendix B can be created by introducing one ormore nucleotide substitutions, additions or deletions into a nucleotidesequence of Appendix A such that one or more amino acid substitutions,additions or deletions are introduced into the encoded protein.Mutations can be introduced into one of the sequences of Appendix A bystandard techniques, such as site-directed mutagenesis and PCR-mediatedmutagenesis. Preferably, conservative amino acid substitutions are madeat one or more predicted non-essential amino acid residues. A“conservative amino acid substitution” is one in which the amino acidresidue is replaced with an amino acid residue having a similar sidechain. Families of amino acid residues having similar side chains havebeen defined in the art. These families include amino acids with basicside chains (e.g., lysine, arginine, histidine), acidic side chains(e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g.,glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine),nonpolar side chains (e.g., alanine, valine, leucine, isoleucine,proline, phenylalanine, methionine, tryptophan), beta-branched sidechains (e.g., threonine, valine, isoleucine) and aromatic side chains(e.g., tyrosine, phenylalanine, tryptophan, histidine). Thus, apredicted nonessential amino acid residue in an MCP protein ispreferably replaced with another amino acid residue from the same sidechain family. Alternatively, in another embodiment, mutations can beintroduced randomly along all or part of an MCP coding sequence, such asby saturation mutagenesis, and the resultant mutants can be screened foran MCP activity described herein to identify mutants that retain MCPactivity. Following mutagenesis of one of the sequences of Appendix A,the encoded protein can be expressed recombinantly and the activity ofthe protein can be determined using, for example, assays describedherein (see Example 8 of the Exemplification).

In addition to the nucleic acid molecules encoding MCP proteinsdescribed above, another aspect of the invention pertains to isolatednucleic acid molecules which are antisense thereto. An “antisense”nucleic acid comprises a nucleotide sequence which is complementary to a“sense” nucleic acid encoding a protein, e.g., complementary to thecoding strand of a double-stranded cDNA molecule or complementary to anmRNA sequence. Accordingly, an antisense nucleic acid can hydrogen bondto a sense nucleic acid. The antisense nucleic acid can be complementaryto an entire MCP coding strand, or to only a portion thereof. In oneembodiment, an antisense nucleic acid molecule is antisense to a “codingregion” of the coding strand of a nucleotide sequence encoding an MCPprotein. The term “coding region” refers to the region of the nucleotidesequence comprising codons which are translated into amino acid residues(e.g., the entire coding region of SEQ ID NO. 1 (RXN01638) comprisesnucleotides 1 to 900). In another embodiment, the antisense nucleic acidmolecule is antisense to a “noncoding region” of the coding strand of anucleotide sequence encoding MCP. The term “noncoding region” refers to5′ and 3′ sequences which flank the coding region that are nottranslated into amino acids (i.e., also referred to as 5′ and 3′untranslated regions).

Given the coding strand sequences encoding MCP disclosed herein (e.g.,the sequences set forth in Appendix A), antisense nucleic acids of theinvention can be designed according to the rules of Watson and Crickbase pairing. The antisense nucleic acid molecule can be complementaryto the entire coding region of MCP mRNA, but more preferably is anoligonucleotide which is antisense to only a portion of the coding ornoncoding region of MCP mRNA. For example, the antisense oligonucleotidecan be complementary to the region surrounding the translation startsite of MCP mRNA. An antisense oligonucleotide can be, for example,about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. Anantisense nucleic acid of the invention can be constructed by chemicalsynthesis and enzymatic ligation reactions using procedures known in theart. For example, an antisense nucleic acid (e.g., an antisenseoligonucleotide) can be chemically synthesized using naturally occurringnucleotides or variously modified nucleotides designed to increase thebiological stability of the molecules or to increase the physicalstability of the duplex formed between the antisense and sense nucleicacids, e.g., phosphorothioate derivatives and acridine substitutednucleotides can be used. Examples of modified nucleotides which can beused to generate the antisense nucleic acid include 5-fluorouracil,5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine,4-acetylcytosine, 5-(carboxyhydroxylmethyl)uracil,5-carboxymethylaminomethyl-2-thiouridine,5-carboxymethylaminomethyluracil, dihydrouracil,beta-D-galactosylqueosine, inosine, N6-isopentenyladenine,1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine,2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine,7-methylguanine, 5-methylaminomethyluracil,5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine,5′-methoxycarboxymethyluracil, 5-methoxyuracil,2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v),wybutoxosine, pseudouracil, queosine, 2-thiocytosine,5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil,uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v),5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl)uracil, (acp3)w,and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can beproduced biologically using an expression vector into which a nucleicacid has been subcloned in an antisense orientation (i.e., RNAtranscribed from the inserted nucleic acid will be of an antisenseorientation to a target nucleic acid of interest, described further inthe following subsection).

The antisense nucleic acid molecules of the invention are typicallyadministered to a cell or generated in situ such that they hybridizewith or bind to cellular mRNA and/or genomic DNA encoding an MCP proteinto thereby inhibit expression of the protein, e.g., by inhibitingtranscription and/or translation. The hybridization can be byconventional nucleotide complementarity to form a stable duplex, or, forexample, in the case of an antisense nucleic acid molecule which bindsto DNA duplexes, through specific interactions in the major groove ofthe double helix. The antisense molecule can be modified such that itspecifically binds to a receptor or an antigen expressed on a selectedcell surface, e.g., by linking the antisense nucleic acid molecule to apeptide or an antibody which binds to a cell surface receptor orantigen. The antisense nucleic acid molecule can also be delivered tocells using the vectors described herein. To achieve sufficientintracellular concentrations of the antisense molecules, vectorconstructs in which the antisense nucleic acid molecule is placed underthe control of a strong prokaryotic, viral, or eukaryotic promoter arepreferred.

In yet another embodiment, the antisense nucleic acid molecule of theinvention is an α-anomeric nucleic acid molecule. An α-anomeric nucleicacid molecule forms specific double-stranded hybrids with complementaryRNA in which, contrary to the usual β-units, the strands run parallel toeach other (Gaultier et al. (1987) Nucleic Acids. Res. 15:6625-6641).The antisense nucleic acid molecule can also comprise a2′-o-methylribonucleotide (Inoue et al. (1987) Nucleic Acids Res.15:6131-6148) or a chimeric RNA-DNA analogue (Inoue et al. (1987) FEBSLett. 215:327-330).

In still another embodiment, an antisense nucleic acid of the inventionis a ribozyme. Ribozymes are catalytic RNA molecules with ribonucleaseactivity which are capable of cleaving a single-stranded nucleic acid,such as an mRNA, to which they have a complementary region. Thus,ribozymes (e.g., hammerhead ribozymes (described in Haselhoff andGerlach (1988) Nature 334:585-591)) can be used to catalytically cleaveMCP mRNA transcripts to thereby inhibit translation of MCP mRNA. Aribozyme having specificity for an MCP-encoding nucleic acid can bedesigned based upon the nucleotide sequence of an MCP DNA disclosedherein (i.e., SEQ ID NO. 1 (RXN01368) in Appendix A). For example, aderivative of a Tetrahymena L-19 IVS RNA can be constructed in which thenucleotide sequence of the active site is complementary to thenucleotide sequence to be cleaved in an MCP-encoding mRNA. See, e.g.,Cech et al. U.S. Pat. No. 4,987,071 and Cech et al. U.S. Pat. No.5,116,742. Alternatively, MCP mRNA can be used to select a catalytic RNAhaving a specific ribonuclease activity from a pool of RNA molecules.See, e.g., Bartel, D. and Szostak, J. W. (1993) Science 261:1411-1418.

Alternatively, MCP gene expression can be inhibited by targetingnucleotide sequences complementary to the regulatory region of an MCPnucleotide sequence (e.g., an MCP promoter and/or enhancers) to formtriple helical structures that prevent transcription of an MCP gene intarget cells. See generally, Helene, C. (1991) Anticancer Drug Des.6(6):569-84; Helene, C. et al. (1992) Ann. N.Y. Acad. Sci. 660:27-36;and Maher, L. J. (1992) Bioassays 14(12):807-15.

B. Recombinant Expression Vectors and Host Cells

Another aspect of the invention pertains to vectors, preferablyexpression vectors, containing a nucleic acid encoding an MCP protein(or a portion thereof). As used herein, the term “vector” refers to anucleic acid molecule capable of transporting another nucleic acid towhich it has been linked. One type of vector is a “plasmid”, whichrefers to a circular double stranded DNA loop into which additional DNAsegments can be ligated. Another type of vector is a viral vector,wherein additional DNA segments can be ligated into the viral genome.Certain vectors are capable of autonomous replication in a host cellinto which they are introduced (e.g., bacterial vectors having abacterial origin of replication and episomal mammalian vectors). Othervectors (e.g., non-episomal mammalian vectors) are integrated into thegenome of a host cell upon introduction into the host cell, and therebyare replicated along with the host genome. Moreover, certain vectors arecapable of directing the expression of genes to which they areoperatively linked. Such vectors are referred to herein as “expressionvectors”. In general, expression vectors of utility in recombinant DNAtechniques are often in the form of plasmids. In the presentspecification, “plasmid” and “vector” can be used interchangeably as theplasmid is the most commonly used form of vector. However, the inventionis intended to include such other forms of expression vectors, such asviral vectors (e.g., replication defective retroviruses, adenovirusesand adeno-associated viruses), which serve equivalent functions.

The recombinant expression vectors of the invention comprise a nucleicacid of the invention in a form suitable for expression of the nucleicacid in a host cell, which means that the recombinant expression vectorsinclude one or more regulatory sequences, selected on the basis of thehost cells to be used for expression, which is operatively linked to thenucleic acid sequence to be expressed. Within a recombinant expressionvector, “operably linked” is intended to mean that the nucleotidesequence of interest is linked to the regulatory sequence(s) in a mannerwhich allows for expression of the nucleotide sequence (e.g., in an invitro transcription/translation system or in a host cell when the vectoris introduced into the host cell). The term “regulatory sequence” isintended to include promoters, repressor binding sites, activatorbinding sites, enhancer regions and other expression control elements(e.g., terminators, other elements of mRNA secondary structure, orpolyadenylation signals). Such regulatory sequences are described, forexample, in Goeddel; Gene Expression Technology: Methods in Enzymology185, Academic Press, San Diego, Calif. (1990). Regulatory sequencesinclude those which direct constitutive expression of a nucleotidesequence in many types of host cell and those which direct expression ofthe nucleotide sequence only in certain host cells. Preferred regulatorysequences are, for example, promoters such as cos-, tac-, trp-, tet-,trp-tet-, lpp-, lac-, lpp-lac-, lacI^(q)-, T7-, T5-, T3-, gal-, trc-,ara-, SP6-, arny, SPO2, λ-P_(R)- or λP_(L), which are used preferably inbacteria. Additional regulatory sequences are, for example, promotersfrom yeasts and fungi, such as ADC1, MFα, AC, P-60, CYC1, GAPDH, TEF,rp28, ADH, promoters from plants such as CaMV/35S, SSU, OCS, lib4, usp,STLS1, B33, nos or ubiquitin- or phaseolin-promoters. It is alsopossible to use artificial promoters. It will be appreciated by those ofordinary skill in the art that the design of the expression vector candepend on such factors as the choice of the host cell to be transformed,the level of expression of protein desired, etc. The expression vectorsof the invention can be introduced into host cells to thereby produceproteins or peptides, including fusion proteins or peptides, encoded bynucleic acids as described herein (e.g., MCP proteins, mutant forms ofMCP proteins, fusion proteins, etc.).

The recombinant expression vectors of the invention can be designed forexpression of MCP proteins in prokaryotic or eukaryotic cells. Forexample, MCP genes can be expressed in bacterial cells such as C.glutamicum, insect cells (using baculovirus expression vectors), yeastand other fungal cells (see Romanos, M. A. et al. (1992) “Foreign geneexpression in yeast: a review”, Yeast 8: 423-488; van den Hondel, C. A.M. J. J. et al. (1991) “Heterologous gene expression in filamentousfungi” in: More Gene Manipulations in Fungi, J. W. Bennet & L. L.Lasure, eds., p. 396-428: Academic Press: San Diego; and van den Hondel,C. A. M. J. J. & Punt, P. J. (1991) “Gene transfer systems and vectordevelopment for filamentous fungi, in: Applied Molecular Genetics ofFungi, Peberdy, J. F. et al., eds., p. 1-28, Cambridge University Press:Cambridge), algae and multicellular plant cells (see Schmidt, R. andWillmitzer, L. (1988) High efficiency Agrobacteriumtumefactiens-mediated transformation of Arabidopsis thaliana leaf andcotyledon explants” Plant Cell Rep.: 583-586), or mammalian cells.Suitable host cells are discussed further in Goeddel, Gene ExpressionTechnology: Methods in Enzymology 185, Academic Press, San Diego, Calif.(1990). Alternatively, the recombinant expression vector can betranscribed and translated in vitro, for example using T7 promoterregulatory sequences and T7 polymerase.

Expression of proteins in prokaryotes is most often carried out withvectors containing constitutive or inducible promoters directing theexpression of either fusion or non-fusion proteins. Fusion vectors add anumber of amino acids to a protein encoded therein, usually to the aminoterminus of the recombinant protein. Such fusion vectors typically servethree purposes: 1) to increase expression of recombinant protein; 2) toincrease the solubility of the recombinant protein; and 3) to aid in thepurification of the recombinant protein by acting as a ligand inaffinity purification. Often, in fusion expression vectors, aproteolytic cleavage site is introduced at the junction of the fusionmoiety and the recombinant protein to enable separation of therecombinant protein from the fusion moiety subsequent to purification ofthe fusion protein. Such enzymes, and their cognate recognitionsequences, include Factor Xa, thrombin and enterokinase.

Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc;Smith, D. B. and Johnson, K. S. (1988) Gene 67:31-40), pMAL (New EnglandBiolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) whichfuse glutathione S-transferase (GST), maltose E binding protein, orprotein A, respectively, to the target recombinant protein. In oneembodiment, the coding sequence of the MCP protein is cloned into a pGEXexpression vector to create a vector encoding a fusion proteincomprising, from the N-terminus to the C-terminus, GST-thrombin cleavagesite-X protein. The fusion protein can be purified by affinitychromatography using glutathione-agarose resin. Recombinant MCP proteinunfused to GST can be recovered by cleavage of the fusion protein withthrombin.

Examples of suitable inducible non-fusion E. coli expression vectorsinclude pTrc (Amann et al., (1988) Gene 69:301-315), pLG338, pACYC184,pBR322, pUC18, pUC19, pKC30, pRep4, pHS1, pHS2, pPLc236, pMBL24, pLG200,pUR290, pIN-III113-B1, λgt11, pBdCl, and pET 11d (Studier et al., GeneExpression Technology: Methods in Enzymology 185, Academic Press, SanDiego, Calif. (1990) 60-89; and Pouwels et al., eds. (1985) CloningVectors. Elsevier: New York IBSN 0 444 904018). Target gene expressionfrom the pTrc vector relies on host RNA polymerase transcription from ahybrid trp-lac fusion promoter. Target gene expression from the pET 11dvector relies on transcription from a T7 gn10-lac fusion promotermediated by a coexpressed viral RNA polymerase (T7 gn1). This viralpolymerase is supplied by host strains BL21 (DE3) or HMS174(DE3) from aresident λ prophage harboring a T7 gn1 gene under the transcriptionalcontrol of the lacUV 5 promoter. For transformation of other varietiesof bacteria, appropriate vectors may be selected. For example, theplasmids pIJ101, pIJ364, pIJ702 and pIJ361 are known to be useful intransforming Streptomyces, while plasmids pUB110, pC194, or pBD214 aresuited for transformation of Bacillus species. Several plasmids of usein the transfer of genetic information into Corynebacterium includepHM1519, pBL1, pSA77, or pAJ667 (Pouwels et al., eds. (1985) CloningVectors. Elsevier: New York IBSN 0 444 904018).

One strategy to maximize recombinant protein expression is to expressthe protein in a host bacteria with an impaired capacity toproteolytically cleave the recombinant protein (Gottesman, S., GeneExpression Technology: Methods in Enzymology 185, Academic Press, SanDiego, Calif. (1990) 119-128). Another strategy is to alter the nucleicacid sequence of the nucleic acid to be inserted into an expressionvector so that the individual codons for each amino acid are thosepreferentially utilized in the bacterium chosen for expression, such asC. glutamicum (Wada et al. (1992) Nucleic Acids Res. 20:2111-2118). Suchalteration of nucleic acid sequences of the invention can be carried outby standard DNA synthesis techniques.

In another embodiment, the MCP protein expression vector is a yeastexpression vector. Examples of vectors for expression in yeast S.cerevisiae include pYepSec1 (Baldari, et al., (1987) Embo J. 6:229-234),2μ, pAG-1, Yep6, Yep13, pEMBL Ye23, pMFa (Kurjan and Herskowitz, (1982)Cell 30:933-943), pJRY88 (Schultz et al., (1987) Gene 54:113-123), andpYES2 (Invitrogen Corporation, San Diego, Calif.). Vectors and methodsfor the construction of vectors appropriate for use in other fungi, suchas the filamentous fungi, include those detailed in: van den Hondel, C.A. M. J. J. & Punt, P. J. (1991) “Gene transfer systems and vectordevelopment for filamentous fungi, in: Applied Molecular Genetics ofFungi, J. F. Peberdy, et al., eds., p. 1-28, Cambridge University Press:Cambridge, and Pouwels et al., eds. (1985) Cloning Vectors. Elsevier:New York (IBSN 0 444 904018).

Alternatively, the MCP proteins of the invention can be expressed ininsect cells using baculovirus expression vectors. Baculovirus vectorsavailable for expression of proteins in cultured insect cells (e.g., Sf9 cells) include the pAc series (Smith et al. (1983) Mol. Cell Biol.3:2156-2165) and the pVL series (Lucklow and Summers (1989) Virology170:31-39).

In another embodiment, the MCP proteins of the invention may beexpressed in unicellular plant cells (such as algae) or in plant cellsfrom higher plants (e.g., the spermatophytes, such as crop plants).Examples of plant expression vectors include those detailed in: Becker,D., Kemper, E., Schell, J. and Masterson, R. (1992) “New plant binaryvectors with selectable markers located proximal to the left border”,Plant Mol. Biol. 20: 1195-1197; and Bevan, M. W. (1984) “BinaryAgrobacterium vectors for plant transformation”, Nuc. Acid. Res. 12:8711-8721, and include pLGV23, pGHlac+, pBIN19, pAK2004, and pDH51(Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0444 904018).

In yet another embodiment, a nucleic acid of the invention is expressedin mammalian cells using a mammalian expression vector. Examples ofmammalian expression vectors include pCDM8 (Seed, B. (1987) Nature329:840) and pMT2PC (Kaufman et al. (1987) EMBO J. 6:187-195). When usedin mammalian cells, the expression vector's control-functions are oftenprovided by viral regulatory elements. For example, commonly usedpromoters are derived from polyoma, Adenovirus 2, cytomegalovirus andSimian Virus 40. For other suitable expression systems for bothprokaryotic and eukaryotic cells see chapters 16 and 17 of Sambrook, J.,Fritsh, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual.2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor LaboratoryPress, Cold Spring Harbor, N.Y., 1989.

In another embodiment, the recombinant mammalian expression vector iscapable of directing expression of the nucleic acid preferentially in aparticular cell type (e.g., tissue-specific regulatory elements are usedto express the nucleic acid). Tissue-specific regulatory elements areknown in the art. Non-limiting examples of suitable tissue-specificpromoters include the albumin promoter (liver-specific; Pinkert et al.(1987) Genes Dev. 1:268-277), lymphoid-specific promoters (Calame andEaton (1988) Adv. Immunol. 43:235-275), in particular promoters of Tcell receptors (Winoto and Baltimore (1989) EMBO J. 8:729-733) andimmunoglobulins (Banerji et al. (1983) Cell 33:729-740; Queen andBaltimore (1983) Cell 33:741-748), neuron-specific promoters (e.g., theneurofilament promoter; Byrne and Ruddle (1989) PNAS 86:5473-5477),pancreas-specific promoters (Edlund et al. (1985) Science 230:912-916),and mammary gland-specific promoters (e.g., milk whey promoter; U.S.Pat. No. 4,873,316 and European Application Publication No. 264,166).Developmentally-regulated promoters are also encompassed, for examplethe murine hox promoters (Kessel and Gruss (1990) Science 249:374-379)and the α-fetoprotein promoter (Campes and Tilghman (1989) Genes Dev.3:537-546).

The invention further provides a recombinant expression vectorcomprising a DNA molecule of the invention cloned into the expressionvector in an antisense orientation. That is, the DNA molecule isoperatively linked to a regulatory sequence in a manner which allows forexpression (by transcription of the DNA molecule) of an RNA moleculewhich is antisense to MCP mRNA. Regulatory sequences operatively linkedto a nucleic acid cloned in the antisense orientation can be chosenwhich direct the continuous expression of the antisense RNA molecule ina variety of cell types, for instance viral promoters and/or enhancers,or regulatory sequences can be chosen which direct constitutive, tissuespecific or cell type specific expression of antisense RNA. Theantisense expression vector can be in the form of a recombinant plasmid,phagemid or attenuated virus in which antisense nucleic acids areproduced under the control of a high efficiency regulatory region, theactivity of which can be determined by the cell type into which thevector is introduced. For a discussion of the regulation of geneexpression using antisense genes see Weintraub, H. et al. (1986)“Antisense RNA as a molecular tool for genetic analysis”, Reviews—Trendsin Genetics, Vol. 1(1).

Another aspect of the invention pertains to host cells into which arecombinant expression vector of the invention has been introduced. Theterms “host cell” and “recombinant host cell” are used interchangeablyherein. It is understood that such terms refer not only to theparticular subject cell but to the progeny or potential progeny of sucha cell. Because certain modifications may occur in succeedinggenerations due to either mutation or environmental influences, suchprogeny may not, in fact, be identical to the parent cell, but are stillincluded within the scope of the term as used herein.

A host cell can be any prokaryotic or eukaryotic cell. For example, anMCP protein can be expressed in bacterial cells such as C. glutamicum,insect cells, yeast or mammalian cells (such as Chinese hamster ovarycells (CHO) or COS cells). Other suitable host cells are known to thoseof ordinary skill in the art. Microorganisms related to Corynebacteriumglutamicum which may be conveniently used as host cells for the nucleicacid and protein molecules of the invention are set forth in Table 3.

Vector DNA can be introduced into prokaryotic or eukaryotic cells viaconventional transformation or transfection techniques. As used herein,the terms “transformation”, “transfection”, “conjugation” and“transduction” are intended to refer to a variety of art-recognizedtechniques for introducing foreign nucleic acid (e.g., linear DNA or RNA(e.g., a linearized vector or a gene construct alone without a vector)or nucleic acid in the form of a vector (e.g., a plasmid, phage,phasmid, phagemid, transposon or other DNA) into a host cell, includingusing natural competence, chemical mediated transfer, calcium phosphateor calcium chloride co-precipitation, DEAE-dextran-mediatedtransfection, lipofection, or electroporation. Suitable methods fortransforming or transfecting host cells can be found in Sambrook, et al.(Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring HarborLaboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor,N.Y., 1989), and other laboratory manuals.

For stable transfection of mammalian cells, it is known that, dependingupon the expression vector and transfection technique used, only a smallfraction of cells may integrate the foreign DNA into their genome. Inorder to identify and select these integrants, a gene that encodes aselectable marker (e.g., resistance to antibiotics) is generallyintroduced into the host cells along with the gene of interest.Preferred selectable markers include those which confer resistance todrugs, such as G418, hygromycin and methotrexate. Nucleic acid encodinga selectable marker can be introduced into a host cell on the samevector as that encoding an MCP protein or can be introduced on aseparate vector. Cells stably transfected with the introduced nucleicacid can be identified by, for example, drug selection (e.g., cells thathave incorporated the selectable marker gene will survive, while theother cells die).

To create a homologous recombinant microorganism, a vector is preparedwhich contains at least a portion of an MCP gene into which a deletion,addition or substitution has been introduced to thereby alter, e.g.,functionally disrupt, the MCP gene. Preferably, this MCP gene is aCorynebacterium glutamicum MCP gene, but it can be a homologue from arelated bacterium or even from a mammalian, yeast, or insect source. Ina preferred embodiment, the vector is designed such that, uponhomologous recombination, the endogenous MCP gene is functionallydisrupted (i.e., no longer encodes a functional protein; also referredto as a “knock out” vector). Alternatively, the vector can be designedsuch that, upon homologous recombination, the endogenous MCP gene ismutated or otherwise altered but still encodes functional protein (e.g.,the upstream regulatory region can be altered to thereby alter theexpression of the endogenous MCP protein). In the homologousrecombination vector, the altered portion of the MCP gene is flanked atits 5′ and 3′ ends by additional nucleic acid of the MCP gene to allowfor homologous recombination to occur between the exogenous MCP genecarried by the vector and an endogenous MCP gene in a microorganism. Theadditional flanking MCP nucleic acid is of sufficient length forsuccessful homologous recombination with the endogenous gene. Typically,less than one kilobase of flanking DNA (both at the 5′ and 3′ ends) isincluded in the vector (see e.g., Thomas, K. R., and Capecchi, M. R.(1987) Cell 51: 503 for a description of homologous recombinationvectors). The vector is introduced into a microorganism (e.g., byelectroporation) and cells in which the introduced MCP gene hashomologously recombined with the endogenous MCP gene are selected, usingart-known techniques.

In another embodiment, recombinant microorganisms can be produced whichcontain selected systems which allow for regulated expression of theintroduced gene. For example, inclusion of an MCP gene on a vectorplacing it under control of the lac operon permits expression of the MCPgene in the presence of IPTG. Such regulatory systems are well known inthe art.

In another embodiment, an endogenous MCP gene in a host cell isdisrupted (e.g., by homologous recombination or other genetic meansknown in the art) such that expression of its protein product does notoccur. In another embodiment, an endogenous or introduced MCP gene in ahost cell has been altered by one or more point mutations, deletions, orinversions, but still encodes a functional MCP protein. In still anotherembodiment, one or more of the regulatory regions (e.g., a promoter,repressor, or inducer) of an MCP gene in a microorganism has beenaltered (e.g., by deletion, truncation, inversion, or point mutation)such that the expression of the MCP gene is modulated. One of ordinaryskill in the art will appreciate that host cells containing more thanone of the described MCP gene and protein modifications may be readilyproduced using the methods of the invention, and are meant to beincluded in the present invention.

A host cell of the invention, such as a prokaryotic or eukaryotic hostcell in culture, can be used to produce (i.e., express) an MCP protein.Accordingly, the invention further provides methods for producing MCPproteins using the host cells of the invention. In one embodiment, themethod comprises culturing the host cell of invention (into which arecombinant expression vector encoding an MCP protein has beenintroduced, or into which genome has been introduced a gene encoding awild-type or altered MCP protein) in a suitable medium until MCP proteinis produced. In another embodiment, the method further comprisesisolating MCP proteins from the medium or the host cell.

C. Isolated MCP Proteins

Another aspect of the invention pertains to isolated MCP proteins, andbiologically active portions thereof. An “isolated” or “purified”protein or biologically active portion thereof is substantially free ofcellular material when produced by recombinant DNA techniques, orchemical precursors or other chemicals when chemically synthesized. Thelanguage “substantially free of cellular material” includes preparationsof MCP protein in which the protein is separated from cellularcomponents of the cells in which it is naturally or recombinantlyproduced. In one embodiment, the language “substantially free ofcellular material” includes preparations of MCP protein having less thanabout 30% (by dry weight) of non-MCP protein (also referred to herein asa “contaminating protein”), more preferably less than about 20% ofnon-MCP protein, still more preferably less than about 10% of non-MCPprotein, and most preferably less than about 5% non-MCP protein. Whenthe MCP protein or biologically active portion thereof is recombinantlyproduced, it is also preferably substantially free of culture medium,i.e., culture medium represents less than about 20%, more preferablyless than about 10%, and most preferably less than about 5% of thevolume of the protein preparation. The language “substantially free ofchemical precursors or other chemicals” includes preparations of MCPprotein in which the protein is separated from chemical precursors orother chemicals which are involved in the synthesis of the protein. Inone embodiment, the language “substantially free of chemical precursorsor other chemicals” includes preparations of MCP protein having lessthan about 30% (by dry weight) of chemical precursors or non-MCPchemicals, more preferably less than about 20% chemical precursors ornon-MCP chemicals, still more preferably less than about 10% chemicalprecursors or non-MCP chemicals, and most preferably less than about 5%chemical precursors or non-MCP chemicals. In preferred embodiments,isolated proteins or biologically active portions thereof lackcontaminating proteins from the same organism from which the MCP proteinis derived. Typically, such proteins are produced by recombinantexpression of, for example, a C. glutamicum MCP protein in amicroorganism such as C. glutamicum.

An isolated MCP protein or a portion thereof of the invention is able tomodulate the yield, production, and/or efficiency of production of oneor more fine chemicals from C. glutamicum, to degrade hydrocarbons, tooxidize terpenoids, to serve as a target for drug development, or toserve as an identifying marker for C. glutamicum or related organisms.In preferred embodiments, the protein or portion thereof comprises anamino acid sequence which is sufficiently homologous to an amino acidsequence of Appendix B such that the protein or portion thereofmaintains the ability to modulate the yield, production, and/orefficiency of production of one or more fine chemicals from C.glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve asa target for drug development, or to serve as an identifying marker forC. glutamicum or related organisms. The portion of the protein ispreferably a biologically active portion as described herein. In anotherpreferred embodiment, an MCP protein of the invention has an amino acidsequence shown in Appendix B. In yet another preferred embodiment, theMCP protein has an amino acid sequence which is encoded by a nucleotidesequence which hybridizes, e.g., hybridizes under stringent conditions,to a nucleotide sequence of Appendix A. In still another preferredembodiment, the MCP protein has an amino acid sequence which is encodedby a nucleotide sequence that is at least about 50%, 51%, 52%, 53%, 54%,55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%,63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at leastabout 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%,83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, andeven more preferably at least about 95%, 96%, 97%, 98%, 99% or morehomologous to one of the nucleic acid sequences of Appendix A, or aportion thereof. Ranges and identity values intermediate to theabove-recited values, (e.g., 70-90% identical or 80-95% identical) arealso intended to be encompassed by the present invention. For example,ranges of identity values using a combination of any of the above valuesrecited as upper and/or lower limits are intended to be included. Thepreferred MCP proteins of the present invention also preferably possessat least one of the MCP activities described herein. For example, apreferred MCP protein of the present invention includes an amino acidsequence encoded by a nucleotide sequence which hybridizes, e.g.,hybridizes under stringent conditions, to a nucleotide sequence ofAppendix A, and which is able to modulate the yield, production, and/orefficiency of production of one or more fine chemicals from C.glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve asa target for drug development, or to serve as an identifying marker forC. glutamicum or related organisms.

In other embodiments, the MCP protein is substantially homologous to anamino acid sequence of Appendix B and retains the functional activity ofthe protein of one of the sequences of Appendix B yet differs in aminoacid sequence due to natural variation or mutagenesis, as described indetail in subsection I above. Accordingly, in another embodiment, theMCP protein is a protein which comprises an amino acid sequence which isat least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%,preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%,or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%,77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%,96%, 97%, 98%, 99% or more homologous to an entire amino acid sequenceof Appendix B and which has at least one of the MCP activities describedherein. Ranges and identity values intermediate to the above-recitedvalues, (e.g., 70-90% identical or 80-95% identical) are also intendedto be encompassed by the present invention. For example, ranges ofidentity values using a combination of any of the above values recitedas upper and/or lower limits are intended to be included. In anotherembodiment, the invention pertains to a full length C. glutamicumprotein which is substantially homologous to an entire amino acidsequence of Appendix B.

Biologically active portions of an MCP protein include peptidescomprising amino acid sequences derived from the amino acid sequence ofan MCP protein, e.g., an amino acid sequence shown in Appendix B or theamino acid sequence of a protein homologous to an MCP protein, whichinclude fewer amino acids than a full length MCP protein or the fulllength protein which is homologous to an MCP protein, and exhibit atleast one activity of an MCP protein. Typically, biologically activeportions (peptides, e.g., peptides which are, for example, 5, 10, 15,20, 30, 35, 36, 37, 38, 39, 40, 50, 100 or more amino acids in length)comprise a domain or motif with at least one activity of an MCP protein.Moreover, other biologically active portions, in which other regions ofthe protein are deleted, can be prepared by recombinant techniques andevaluated for one or more of the activities described herein.Preferably, the biologically active portions of an MCP protein includeone or more selected domains/motifs or portions thereof havingbiological activity.

MCP proteins are preferably produced by recombinant DNA techniques. Forexample, a nucleic acid molecule encoding the protein is cloned into anexpression vector (as described above), the expression vector isintroduced into a host cell (as described above) and the MCP protein isexpressed in the host cell. The MCP protein can then be isolated fromthe cells by an appropriate purification scheme using standard proteinpurification techniques. Alternative to recombinant expression, an MCPprotein, polypeptide, or peptide can be synthesized chemically usingstandard peptide synthesis techniques. Moreover, native MCP protein canbe isolated from cells (e.g., endothelial cells, bacterial cells, fungalcells or other cells), for example using an anti-MCP antibody, which canbe produced by standard techniques utilizing an MCP protein or fragmentthereof of this invention.

The invention also provides MCP chimeric or fusion proteins. As usedherein, an MCP “chimeric protein” or “fusion protein” comprises an MCPpolypeptide operatively linked to a non-MCP polypeptide. An “MCPpolypeptide” refers to a polypeptide having an amino acid sequencecorresponding to an MCP protein, whereas a “non-MCP polypeptide” refersto a polypeptide having an amino acid sequence corresponding to aprotein which is not substantially homologous to the MCP protein, e.g.,a protein which is different from the MCP protein and which is derivedfrom the same or a different organism. Within the fusion protein, theterm “operatively linked” is intended to indicate that the MCPpolypeptide and the non-MCP polypeptide are fused in-frame to eachother. The non-MCP polypeptide can be fused to the N-terminus orC-terminus of the MCP polypeptide. For example, in one embodiment thefusion protein is a GST-MCP fusion protein in which the MCP sequencesare fused to the C-terminus of the GST sequences. Such fusion proteinscan facilitate the purification of recombinant MCP proteins. In anotherembodiment, the fusion protein is an MCP protein containing aheterologous signal sequence at its N-terminus. In certain host cells(e.g., mammalian host cells, bacterial host cells, fungal host cells),expression and/or secretion of an MCP protein can be increased throughuse of a heterologous signal sequence.

Preferably, an MCP chimeric or fusion protein of the invention isproduced by standard recombinant DNA techniques. For example, DNAfragments coding for the different polypeptide sequences are ligatedtogether in-frame in accordance with conventional techniques, forexample by employing blunt-ended or stagger-ended termini for ligation,restriction enzyme digestion to provide for appropriate termini,filling-in of cohesive ends as appropriate, alkaline phosphatasetreatment to avoid undesirable joining, and enzymatic ligation. Inanother embodiment, the fusion gene can be synthesized by conventionaltechniques including automated DNA synthesizers. Alternatively, PCRamplification of gene fragments can be carried out using anchor primerswhich give rise to complementary overhangs between two consecutive genefragments which can subsequently be annealed and reamplified to generatea chimeric gene sequence (see, for example, Current Protocols inMolecular Biology, eds. Ausubel et al. John Wiley & Sons: 1992).Moreover, many expression vectors are commercially available thatalready encode a fusion moiety (e.g., a GST polypeptide). AnMCP-encoding nucleic acid can be cloned into such an expression vectorsuch that the fusion moiety is linked in-frame to the MCP protein.

Homologues of the MCP protein can be generated by mutagenesis, e.g.,discrete point mutation or truncation of the MCP protein. As usedherein, the term “homologue” refers to a variant form of the MCP proteinwhich acts as an agonist or antagonist of the activity of the MCPprotein. An agonist of the MCP protein can retain substantially thesame, or a subset, of the biological activities of the MCP protein. Anantagonist of the MCP protein can inhibit one or more of the activitiesof the naturally occurring form of the MCP protein, by, for example,competitively binding to a downstream or upstream member of abiochemical pathway which includes the MCP protein.

In an alternative embodiment, homologues of the MCP protein can beidentified by screening combinatorial libraries of mutants, e.g.,truncation mutants, of the MCP protein for MCP protein agonist orantagonist activity. In one embodiment, a variegated library of MCPvariants is generated by combinatorial mutagenesis at the nucleic acidlevel and is encoded by a variegated gene library. A variegated libraryof MCP variants can be produced by, for example, enzymatically ligatinga mixture of synthetic oligonucleotides into gene sequences such that adegenerate set of potential MCP sequences is expressible as individualpolypeptides, or alternatively, as a set of larger fusion proteins(e.g., for phage display) containing the set of MCP sequences therein.There are a variety of methods which can be used to produce libraries ofpotential MCP homologues from a degenerate oligonucleotide sequence.Chemical synthesis of a degenerate gene sequence can be performed in anautomatic DNA synthesizer, and the synthetic gene then ligated into anappropriate expression vector. Use of a degenerate set of genes allowsfor the provision, in one mixture, of all of the sequences encoding thedesired set of potential MCP sequences. Methods for synthesizingdegenerate oligonucleotides are known in the art (see, e.g., Narang, S.A. (1983) Tetrahedron 39:3; Itakura et al. (1984) Annu. Rev. Biochem.53:323; Itakura et al. (1984) Science 198:1056; Ike et al. (1983)Nucleic Acid Res. 11:477.

In addition, libraries of fragments of the MCP protein coding can beused to generate a variegated population of MCP fragments for screeningand subsequent selection of homologues of an MCP protein. In oneembodiment, a library of coding sequence fragments can be generated bytreating a double stranded PCR fragment of an MCP coding sequence with anuclease under conditions wherein nicking occurs only about once permolecule, denaturing the double stranded DNA, renaturing the DNA to formdouble stranded DNA which can include sense/antisense pairs fromdifferent nicked products, removing single stranded portions fromreformed duplexes by treatment with S1 nuclease, and ligating theresulting fragment library into an expression vector. By this method, anexpression library can be derived which encodes N-terminal, C-terminaland internal fragments of various sizes of the MCP protein.

Several techniques are known in the art for screening gene products ofcombinatorial libraries made by point mutations or truncation, and forscreening cDNA libraries for gene products having a selected property.Such techniques are adaptable for rapid screening of the gene librariesgenerated by the combinatorial mutagenesis of MCP homologues. The mostwidely used techniques, which are amenable to high through-put analysis,for screening large gene libraries typically include cloning the genelibrary into replicable expression vectors, transforming appropriatecells with the resulting library of vectors, and expressing thecombinatorial genes under conditions in which detection of a desiredactivity facilitates isolation of the vector encoding the gene whoseproduct was detected. Recrusive ensemble mutagenesis (REM), a newtechnique which enhances the frequency of functional mutants in thelibraries, can be used in combination with the screening assays toidentify MCP homologues (Arkin and Yourvan (1992) PNAS 89:7811-7815;Delgrave et al. (1993) Protein Engineering 6(3):327-331).

In another embodiment, cell based assays can be exploited to analyze avariegated MCP library, using methods well known in the art.

D. Uses and Methods of the Invention

The nucleic acid molecules, proteins, protein homologues, fusionproteins, primers, vectors, and host cells described herein can be usedin one or more of the following methods: identification of C. glutamicumand related organisms; mapping of genomes of organisms related to C.glutamicum; identification and localization of C. glutamicum sequencesof interest; evolutionary studies; determination of MCP protein regionsrequired for function; modulation of an MCP protein activity; modulationof the activity of one or more metabolic pathways; and modulation ofcellular production of a desired compound, such as a fine chemical.

The MCP nucleic acid molecules of the invention have a variety of uses.First, they may be used to identify an organism as being Corynebacteriumglutamicum or a close relative thereof. Also, they may be used toidentify the presence of C. glutamicum or a relative thereof in a mixedpopulation of microorganisms. The invention provides the nucleic acidsequences of a number of C. glutamicum genes, and probes based thereon;by probing the extracted genomic DNA of a culture of a unique or mixedpopulation of microorganisms under stringent conditions with a probespanning a region of a C. glutamicum gene which is unique to thisorganism, one can ascertain whether this organism is present. AlthoughCorynebacterium glutamicum itself is nonpathogenic, it is related topathogenic species, such as Corynebacterium diphtheriae. Corynebacteriumdiphtheriae is the causative agent of diphtheria, a rapidly developing,acute, febrile infection which involves both local and systemicpathology. In this disease, a local lesion develops in the upperrespiratory tract and involves necrotic injury to epithelial cells; thebacilli secrete toxin which is disseminated through this lesion todistal susceptible tissues of the body. Degenerative changes broughtabout by the inhibition of protein synthesis in these tissues, whichinclude heart, muscle, peripheral nerves, adrenals, kidneys, liver andspleen, result in the systemic pathology of the disease. Diphtheriacontinues to have high incidence in many parts of the world, includingAfrica, Asia, Eastern Europe and the independent states of the formerSoviet Union. An ongoing epidemic of diphtheria in the latter tworegions has resulted in at least 5,000 deaths since 1990.

In one embodiment, the invention provides a method of identifying thepresence or activity of Corynebacterium diphtheriae in a subject. Thismethod includes detection of one or more of the nucleic acid or aminoacid sequences of the invention (e.g., the sequences set forth inAppendix A or Appendix B) in a subject, thereby detecting the presenceor activity of Corynebacterium diphtheriae in the subject. C. glutamicumand C. diphtheriae are related bacteria, and many of the nucleic acidand protein molecules in C. glutamicum are homologous to C. diphtheriaenucleic acid and protein molecules, and can therefore be used to detectC. diphtheriae in a subject.

To detect the presence of C. glutamicum in a sample, techniques wellknown in the art may be employed. Specifically, the cells in the samplemay optionally first be cultured in a suitable liquid or on a suitablesolid culture medium to increase the number of cells in the sample.These cells are lysed, and the total DNA content extracted andoptionally purified to remove debris and protein material which mayinterfere with subsequent analysis. The polymerase chain reaction or asimilar technique known in the art is performed (for general referenceon methodologies commonly used for the amplification of nucleic acidsequences, see Mullis et al., U.S. Pat. No. 4,683,195, Mullis et al.,U.S. Pat. No. 4,965,188, and Innis, M. A., and Gelfand, D. H., (1989)PCR Protocols, A guide to Methods and Applications, Academic Press, p.3-12, and (1988) Biotechnology 6:1197, and International PatentApplication No. WO89/01050) in which primers specific to an MCP nucleicacid molecule of the invention are incubated with the nucleic acidsample such that, if present in the sample, that particular MCP nucleicacid sequence will be amplified. The particular MCP nucleic acid to beamplified is selected based on its uniqueness to the C. glutamicumgenome, or to the genomes of C. glutamicum and only a few closelyrelated bacteria. The presence of the desired amplified product is thusindicative of the presence of C. glutamicum, or an organism closelyrelated to C. glutamicum.

Further, the nucleic acid and protein molecules of the invention mayserve as markers for specific regions of the genome. It is possible,using techniques well known in the art, to ascertain the physicallocation on the C. glutamicum genome of the MCP nucleic acid moleculesof the invention, which in turn provides markers on the genome which canbe used to aid in the placement of other nucleic acid molecules andgenes on the genome map. Also, the nucleic acid molecules of theinvention may be sufficiently homologous to the sequences of relatedbacterial species that these nucleic acid molecules may similarly permitthe construction of a genomic map in such bacteria (e.g., Brevibacteriumlactofermentum).

The nucleic acid molecules of the invention have utility not only in themapping of the genome, but also for functional studies of C. glutamicumproteins. For example, to identify the region of the genome to which aparticular C. glutamicum DNA-binding protein binds, the C. glutamicumgenome could be digested, and the fragments incubated with theDNA-binding protein. Those which bind the protein may be additionallyprobed with the nucleic acid molecules of the invention, preferably withreadily detectable labels; binding of such a nucleic acid molecule tothe genome fragment enables the localization of the fragment to thegenome map of C. glutamicum, and, when performed multiple times withdifferent enzymes, facilitates a rapid determination of the nucleic acidsequence to which the protein binds.

The MCP nucleic acid molecules of the invention are also useful forevolutionary and protein structural studies. The metabolic processes inwhich the molecules of the invention participate are utilized by a widevariety of prokaryotic and eukaryotic cells; by comparing the sequencesof the nucleic acid molecules of the present invention to those encodingsimilar enzymes from other organisms, the evolutionary relatedness ofthe organisms can be assessed. Similarly, such a comparison permits anassessment of which regions of the sequence are conserved and which arenot, which may aid in determining those regions of the protein which areessential for the functioning of the enzyme. This type of determinationis of value for protein engineering studies and may give an indicationof what the protein can tolerate in terms of mutagenesis without losingfunction.

The MCP protein molecules of the invention may also be utilized asmarkers for the classification of an unknown bacterium as C. glutamicum,or for the identification of C. glutamicum or closely related bacteriain a sample. For example, using techniques well known in the art, cellsin a sample may optionally be amplified (e.g., by culturing in anappropriate medium) to increase the sample size, and then may be lysedto release proteins contained therein. This sample may optionally bepurified to remove debris and nucleic acid molecules which may interferewith subsequent analysis. Antibodies specific for a selected MCP proteinof the invention may be incubated with the protein sample in a typicalWestern assay format (see, e.g., Ausubel et al., (1988) CurrentProtocols in Molecular Biology, Wiley: New York) in which the antibodywill bind to its target protein if this protein is present in thesample. An MCP protein is selected for this type of assay if it isunique or nearly unique to C. glutamicum or C. glutamicum and bacteriavery closely related to C. glutamicum. Proteins in the sample are thenseparated by gel electrophoresis, and transferred to a suitable matrix,such as nitrocellulose. An appropriate secondary antibody having adetectable label (e.g., chemiluminescent or colorimetric) is incubatedwith this matrix, followed by stringent washing. The presence or absenceof the label is indicative of the presence or absence of the targetprotein in the sample. If the protein is present, then this isindicative of the presence of C. glutamicum. A similar process enablesthe classification of an unknown bacterium as C. glutamicum; if a panelof proteins specific to C. glutamicum are not detected in proteinsamples prepared from the unknown bacterium, then that bacterium is notlikely to be C. glutamicum.

The invention provides methods for screening molecules which modulatethe activity of an MCP protein, either by interacting with the proteinitself or a substrate or binding partner of the MCP protein, or bymodulating the transcription or translation of an MCP nucleic acidmolecule of the invention. In such methods, a microorganism expressingone or more MCP proteins of the invention is contacted with one or moretest compounds, and the effect of each test compound on the activity orlevel of expression of the MCP protein is assessed.

Genetic manipulation of the MCP nucleic acid molecules of the inventionmay result in the production of MCP proteins having functionaldifferences from the wild-type MCP proteins. These proteins may beimproved in efficiency or activity, may be present in greater numbers inthe cell than is usual, or may be decreased in efficiency or activity.

Such changes in activity may directly modulate the yield, production,and/or efficiency of production of one or more fine chemicals from C.glutamicum. For example, by modifying the activity of a protein involvedin the biosynthesis or degradation of a fine chemical (i.e., throughmutagenesis of the corresponding gene), one may directly modulate theability of the cell to synthesize or to degrade this compound, therebymodulating the yield and/or efficiency of production of the finechemical. Similarly, by modulating the activity of a protein whichregulates a fine chemical metabolic pathway, one may directly influencewhether the production of the desired compound is up- or down-regulated,either of which will modulate the yield or efficiency of production ofthe fine chemical from the cell.

Indirect modulation of fine chemical production may also result bymodifying the activity of a protein of the invention (i.e., bymutagenesis of the corresponding gene) such that the overall ability ofthe cell to grow and divide or to remain viable and productive isincreased. The production of fine chemicals from C. glutamicum isgenerally accomplished by the large-scale fermentative culture of thesemicroorganisms, conditions which are frequently suboptimal for growthand cell division. By engineering a protein of the invention (e.g., astress response protein, a cell wall protein, or proteins involved inthe metabolism of compounds necessary for cell growth and division tooccur, such as nucleotides and amino acids) such that it is better ableto survive, grow, and multiply in such conditions, it may be possible toincrease the number and productivity of such engineered C. glutamicumcells in large-scale culture, which in turn should result in increasedyields and/or efficiency of production of one or more desired finechemicals. Further, the metabolic pathways of any cell are necessarilyinterrelated and coregulated. By altering the activity or regulation ofany one metabolic pathway in C. glutamicum (i.e., by altering theactivity of one of the proteins of the invention which participates insuch a pathway), it is possible to concomitantly alter the activity orregulation of other metabolic pathways in this microorganism, which maybe directly involved in the synthesis or degradation of a fine chemical.

The aforementioned mutagenesis strategies for MCP proteins to result inincreased yields of a fine chemical from C. glutamicum are not meant tobe limiting; variations on these strategies will be readily apparent toone of ordinary skill in the art. Using such strategies, andincorporating the mechanisms disclosed herein, the nucleic acid andprotein molecules of the invention may be utilized to generate C.glutamicum or related strains of bacteria expressing mutated MCP nucleicacid and protein molecules such that the yield, production, and/orefficiency of production of a desired compound is improved. This desiredcompound may be any natural product of C. glutamicum, which includes thefinal products of biosynthesis pathways and intermediates ofnaturally-occurring metabolic pathways, as well as molecules which donot naturally occur in the metabolism of C. glutamicum, but which areproduced by a C. glutamicum strain of the invention.

This invention is further illustrated by the following examples whichshould not be construed as limiting. The contents of all references,patent applications, patents, published patent applications, Tables,Appendices, and the sequence listing cited throughout this applicationare hereby incorporated by reference.

EXEMPLIFICATION Example 1 Preparation of Total Genomic DNA ofCorynebacterium glutamicum ATCC 13032

A culture of Corynebacterium glutamicum (ATCC 13032) was grown overnightat 30° C. with vigorous shaking in BHI medium (Difco). The cells wereharvested by centrifugation, the supernatant was discarded and the cellswere resuspended in 5 ml buffer-I (5% of the original volume of theculture—all indicated volumes have been calculated for 100 ml of culturevolume). Composition of buffer-I: 140.34 g/l sucrose, 2.46 g/lMgSO₄×7H₂O, 10 ml/l KH₂PO₄ solution (100 g/l, adjusted to pH 6.7 withKOH), 50 ml/l M12 concentrate (10 g/l (NH₄)₂SO₄, 1 g/l NaCl, 2 g/lMgSO₄×7H₂O, 0.2 g/l CaCl₂, 0.5 g/l yeast extract (Difco), 10 ml/ltrace-elements-mix (200 mg/l FeSO₄×H₂O, 10 mg/l ZnSO₄×7H₂O, 3 mg/lMnCl₂×4H₂O, 30 mg/l H₃BO₃ 20 mg/l CoCl₂×6H₂O, 1 mg/l NiCl₂×6H₂O, 3 mg/lNa₂MoO₄×2H₂O, 500 mg/l complexing agent (EDTA or critic acid), 100 ml/lvitamins-mix (0.2 mg/l biotin, 0.2 mg/l folic acid, 20 mg/l p-aminobenzoic acid, 20 mg/l riboflavin, 40 mg/l ca-panthothenate, 140 mg/lnicotinic acid, 40 mg/l pyridoxole hydrochloride, 200 mg/lmyo-inositol). Lysozyme was added to the suspension to a finalconcentration of 2.5 mg/ml. After an approximately 4 h incubation at 37°C., the cell wall was degraded and the resulting protoplasts areharvested by centrifugation. The pellet was washed once with 5 mlbuffer-I and once with 5 ml TE-buffer (10 mM Tris-HCl, 1 mM EDTA, pH 8).The pellet was resuspended in 4 ml TE-buffer and 0.5 ml SDS solution(10%) and 0.5 ml NaCl solution (5 M) are added. After adding ofproteinase K to a final concentration of 200 μg/ml, the suspension isincubated for ca. 18 h at 37° C. The DNA was purified by extraction withphenol, phenol-chloroform-isoamylalcohol and chloroform-isoamylalcoholusing standard procedures. Then, the DNA was precipitated by adding 1/50volume of 3 M sodium acetate and 2 volumes of ethanol, followed by a 30min incubation at −20° C. and a 30 min centrifugation at 12,000 rpm in ahigh speed centrifuge using a SS34 rotor (Sorvall). The DNA wasdissolved in 1 ml TE-buffer containing 20 μg/ml RNaseA and dialysed at4° C. against 1000 ml TE-buffer for at least 3 hours. During this time,the buffer was exchanged 3 times. To aliquots of 0.4 ml of the dialysedDNA solution, 0.4 ml of 2 M LiCl and 0.8 ml of ethanol are added. Aftera 30 min incubation at −20° C., the DNA was collected by centrifugation(13,000 rpm, Biofuge Fresco, Heraeus, Hanau, Germany). The DNA pelletwas dissolved in TE-buffer. DNA prepared by this procedure could be usedfor all purposes, including southern blotting or construction of genomiclibraries.

Example 2 Construction of Genomic Libraries in Escherichia coli ofCorynebacterium glutamicum ATCC13032

Using DNA prepared as described in Example 1, cosmid and plasmidlibraries were constructed according to known and well establishedmethods (see e.g., Sambrook, J. et al. (1989) “Molecular Cloning: ALaboratory Manual”, Cold Spring Harbor Laboratory Press, or Ausubel, F.M. et al. (1994) “Current Protocols in Molecular Biology”, John Wiley &Sons.)

Any plasmid or cosmid could be used. Of particular use were the plasmidspBR322 (Sutcliffe, J. G. (1979) Proc. Natl. Acad. Sci. USA,75:3737-3741); pACYC177 (Change & Cohen (1978) J. Bacteriol134:1141-1156), plasmids of the pBS series (pBSSK+, pBSSK− and others;Stratagene, LaJolla, USA), or cosmids as SuperCos1 (Stratagene, LaJolla,USA) or Lorist6 (Gibson, T. J., Rosenthal A. and Waterson, R. H. (1987)Gene 53:283-286. Gene libraries specifically for use in C. glutamicummay be constructed using plasmid pSL109 (Lee, H.-S. and A. J. Sinskey(1994) J. Microbiol. Biotechnol. 4: 256-263).

Example 3 DNA Sequencing and Computational Functional Analysis

Genomic libraries as described in Example 2 were used for DNA sequencingaccording to standard methods, in particular by the chain terminationmethod using ABI377 sequencing machines (see e.g., Fleischman, R. D. etal. (1995) “Whole-genome Random Sequencing and Assembly of HaemophilusInfluenzae Rd., Science, 269:496-512). Sequencing primers with thefollowing nucleotide sequences were used: 5′-GGAAACAGTATGACCATG-3′ or5′-GTAAAACGACGGCCAGT-3′.

Example 4 In Vivo Mutagenesis

In vivo mutagenesis of Corynebacterium glutamicum can be performed bypassage of plasmid (or other vector) DNA through E. coli or othermicroorganisms (e.g. Bacillus spp. or yeasts such as Saccharomycescerevisiae) which are impaired in their capabilities to maintain theintegrity of their genetic information. Typical mutator strains havemutations in the genes for the DNA repair system (e.g., mutHLS, mutD,mutT, etc.; for reference, see Rupp, W. D. (1996) DNA repair mechanisms,in: Escherichia coli and Salmonella, p. 2277-2294, ASM: Washington.)Such strains are well known to those of ordinary skill in the art. Theuse of such strains is illustrated, for example, in Greener, A. andCallahan, M. (1994) Strategies 7: 32-34.

Example 5 DNA Transfer Between Escherichia Coli and Corynebacteriumglutamicum

Several Corynebacterium and Brevibacterium species contain endogenousplasmids (as e.g., pHM1519 or pBL1) which replicate autonomously (forreview see, e.g., Martin, J. F. et al. (1987) Biotechnology, 5:137-146).Shuttle vectors for Escherichia coli and Corynebacterium glutamicum canbe readily constructed by using standard vectors for E. coli (Sambrook,J. et al. (1989), “Molecular Cloning: A Laboratory Manual”, Cold SpringHarbor Laboratory Press or Ausubel, F. M. et al. (1994) “CurrentProtocols in Molecular Biology”, John Wiley & Sons) to which a origin orreplication for and a suitable marker from Corynebacterium glutamicum isadded. Such origins of replication are preferably taken from endogenousplasmids isolated from Corynebacterium and Brevibacterium species. Ofparticular use as transformation markers for these species are genes forkanamycin resistance (such as those derived from the Tn5 or Tn903transposons) or chloramphenicol (Winnacker, E. L. (1987) “From Genes toClones—Introduction to Gene Technology, VCH, Weinheim). There arenumerous examples in the literature of the construction of a widevariety of shuttle vectors which replicate in both E. coli and C.glutamicum, and which can be used for several purposes, including geneover-expression (for reference, see e.g., Yoshihama, M. et al. (1985) J.Bacteriol. 162:591-597, Martin J. F. et al. (1987) Biotechnology,5:137-146 and Eikmanns, B. J. et al. (1991) Gene, 102:93-98).

Using standard methods, it is possible to clone a gene of interest intoone of the shuttle vectors described above and to introduce such ahybrid vectors into strains of Corynebacterium glutamicum.Transformation of C. glutamicum can be achieved by protoplasttransformation (Kastsumata, R. et al. (1984) J. Bacteriol. 159306-311),electroporation (Liebl, E. et al. (1989) FEMS Microbiol. Letters,53:399-303) and in cases where special vectors are used, also byconjugation (as described e.g. in Schafer, A et al. (1990) J. Bacteriol.172:1663-1666). It is also possible to transfer the shuttle vectors forC. glutamicum to E. coli by preparing plasmid DNA from C. glutamicum(using standard methods well-known in the art) and transforming it intoE. coli. This transformation step can be performed using standardmethods, but it is advantageous to use an Mcr-deficient E. coli strain,such as NM522 (Gough & Murray (1983) J. Mol. Biol. 166:1-19).

Genes may be overexpressed in C. glutamicum strains using plasmids whichcomprise pCG1 (U.S. Pat. No. 4,617,267) or fragments thereof, andoptionally the gene for kanamycin resistance from TN903 (Grindley, N. D.and Joyce, C. M. (1980) Proc. Natl. Acad. Sci. USA 77(12): 7176-7180).In addition, genes may be overexpressed in C. glutamicum strains usingplasmid pSL109 (Lee, H.-S. and A. J. Sinskey (1994) J. Microbiol.Biotechnol. 4: 256-263).

Aside from the use of replicative plasmids, gene overexpression can alsobe achieved by integration into the genome. Genomic integration in C.glutamicum or other Corynebacterium or Brevibacterium species may beaccomplished by well-known methods, such as homologous recombinationwith genomic region(s), restriction endonuclease mediated integration(REMI) (see, e.g., DE Patent 19823834), or through the use oftransposons. It is also possible to modulate the activity of a gene ofinterest by modifying the regulatory regions (e.g., a promoter, arepressor, and/or an enhancer) by sequence modification, insertion, ordeletion using site-directed methods (such as homologous recombination)or methods based on random events (such as transposon mutagenesis orREMI). Nucleic acid sequences which function as transcriptionalterminators may also be inserted 3′ to the coding region of one or moregenes of the invention; such terminators are well-known in the art andare described, for example, in Winnacker, E. L. (1987) From Genes toClones—Introduction to Gene Technology. VCH: Weinheim.

Example 6 Assessment of the Expression of the Mutant Protein

Observations of the activity of a mutated protein in a transformed hostcell rely on the fact that the mutant protein is expressed in a similarfashion and in a similar quantity to that of the wild-type protein. Auseful method to ascertain the level of transcription of the mutant gene(an indicator of the amount of mRNA available for translation to thegene product) is to perform a Northern blot (for reference see, forexample, Ausubel et al. (1988) Current Protocols in Molecular Biology,Wiley: New York), in which a primer designed to bind to the gene ofinterest is labeled with a detectable tag (usually radioactive orchemiluminescent), such that when the total RNA of a culture of theorganism is extracted, run on gel, transferred to a stable matrix andincubated with this probe, the binding and quantity of binding of theprobe indicates the presence and also the quantity of mRNA for thisgene. This information is evidence of the degree of transcription of themutant gene. Total cellular RNA can be prepared from Corynebacteriumglutamicum by several methods, all well-known in the art, such as thatdescribed in Bormann, E. R. et al. (1992) Mol. Microbiol. 6: 317-326.

To assess the presence or relative quantity of protein translated fromthis mRNA, standard techniques, such as a Western blot, may be employed(see, for example, Ausubel et al. (1988) Current Protocols in MolecularBiology, Wiley: New York). In this process, total cellular proteins areextracted, separated by gel electrophoresis, transferred to a matrixsuch as nitrocellulose, and incubated with a probe, such as an antibody,which specifically binds to the desired protein. This probe is generallytagged with a chemiluminescent or colorimetric label which may bereadily detected. The presence and quantity of label observed indicatesthe presence and quantity of the desired mutant protein present in thecell.

Example 7 Growth of Genetically Modified Corynebacterium glutamicum—Media and Culture Conditions

Genetically modified Corynebacteria are cultured in synthetic or naturalgrowth media. A number of different growth media for Corynebacteria areboth well-known and readily available (Lieb et al. (1989) Appl.Microbiol. Biotechnol., 32:205-210; von der Osten et al. (1998)Biotechnology Letters, 11:11-16; Patent DE 4,120,867; Liebl (1992) “TheGenus Corynebacterium, in: The Procaryotes, Volume II, Balows, A. etal., eds. Springer-Verlag). These media consist of one or more carbonsources, nitrogen sources, inorganic salts, vitamins and trace elements.Preferred carbon sources are sugars, such as mono-, di-, orpolysaccharides. For example, glucose, fructose, mannose, galactose,ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starchor cellulose serve as very good carbon sources. It is also possible tosupply sugar to the media via complex compounds such as molasses orother by-products from sugar refinement. It can also be advantageous tosupply mixtures of different carbon sources. Other possible carbonsources are alcohols and organic acids, such as methanol, ethanol,acetic acid or lactic acid. Nitrogen sources are usually organic orinorganic nitrogen compounds, or materials which contain thesecompounds. Exemplary nitrogen sources include ammonia gas or ammoniasalts, such as NH₄Cl or (NH₄)₂SO₄, NH₄OH, nitrates, urea, amino acids orcomplex nitrogen sources like corn steep liquor, soy bean flour, soybean protein, yeast extract, meat extract and others.

Inorganic salt compounds which may be included in the media include thechloride-, phosphorous- or sulfate-salts of calcium, magnesium, sodium,cobalt, molybdenum, potassium, manganese, zinc, copper and iron.Chelating compounds can be added to the medium to keep the metal ions insolution. Particularly useful chelating compounds includedihydroxyphenols, like catechol or protocatechuate, or organic acids,such as citric acid. It is typical for the media to also contain othergrowth factors, such as vitamins or growth promoters, examples of whichinclude biotin, riboflavin, thiamin, folic acid, nicotinic acid,pantothenate and pyridoxin. Growth factors and salts frequentlyoriginate from complex media components such as yeast extract, molasses,corn steep liquor and others. The exact composition of the mediacompounds depends strongly on the immediate experiment and isindividually decided for each specific case. Information about mediaoptimization is available in the textbook “Applied Microbiol.Physiology, A Practical Approach (eds. P. M. Rhodes, P. F. Stanbury, IRLPress (1997) pp. 53-73, ISBN 0 19 963577 3). It is also possible toselect growth media from commercial suppliers, like standard 1 (Merck)or BHI (grain heart infusion, DIFCO) or others.

All medium components are sterilized, either by heat (20 minutes at 1.5bar and 121° C.) or by sterile filtration. The components can either besterilized together or, if necessary, separately. All media componentscan be present at the beginning of growth, or they can optionally beadded continuously or batchwise.

Culture conditions are defined separately for each experiment. Thetemperature should be in a range between 15° C. and 45° C. Thetemperature can be kept constant or can be altered during theexperiment. The pH of the medium should be in the range of 5 to 8.5,preferably around 7.0, and can be maintained by the addition of buffersto the media. An exemplary buffer for this purpose is a potassiumphosphate buffer. Synthetic buffers such as MOPS, HEPES, ACES and otherscan alternatively or simultaneously be used. It is also possible tomaintain a constant culture pH through the addition of NaOH or NH₄OHduring growth. If complex medium components such as yeast extract areutilized, the necessity for additional buffers may be reduced, due tothe fact that many complex compounds have high buffer capacities. If afermentor is utilized for culturing the microorganisms, the pH can alsobe controlled using gaseous ammonia.

The incubation time is usually in a range from several hours to severaldays. This time is selected in order to permit the maximal amount ofproduct to accumulate in the broth. The disclosed growth experiments canbe carried out in a variety of vessels, such as microtiter plates, glasstubes, glass flasks or glass or metal fermentors of different sizes. Forscreening a large number of clones, the microorganisms should becultured in microtiter plates, glass tubes or shake flasks, either withor without baffles. Preferably 100 ml shake flasks are used, filled with10% (by volume) of the required growth medium. The flasks should beshaken on a rotary shaker (amplitude 25 mm) using a speed-range of100-300 rpm. Evaporation losses can be diminished by the maintenance ofa humid atmosphere; alternatively, a mathematical correction forevaporation losses should be performed.

If genetically modified clones are tested, an unmodified control cloneor a control clone containing the basic plasmid without any insertshould also be tested. The medium is inoculated to an OD₆₀₀ of 0.5-1.5using cells grown on agar plates, such as CM-plates (10 g/l glucose, 2,5g/l NaCl, 2 g/l urea, 10 g/l polypeptone, 5 g/l yeast extract, 5 g/lmeat extract, 22 g/l NaCl, 2 g/l urea, 10 g/l polypeptone, 5 g/l yeastextract, 5 g/l meat extract, 22 g/l agar, pH 6.8 with 2M NaOH) that hadbeen incubated at 30° C. Inoculation of the media is accomplished byeither introduction of a saline suspension of C. glutamicum cells fromCM plates or addition of a liquid preculture of this bacterium.

Example 8 In vitro Analysis of the Function of Mutant Proteins

The determination of activities and kinetic parameters of enzymes iswell established in the art. Experiments to determine the activity ofany given altered enzyme must be tailored to the specific activity ofthe wild-type enzyme, which is well within the ability of one ofordinary skill in the art. Overviews about enzymes in general, as wellas specific details concerning structure, kinetics, principles, methods,applications and examples for the determination of many enzymeactivities may be found, for example, in the following references:Dixon, M., and Webb, E. C., (1979) Enzymes. Longmans: London; Fersht,(1985) Enzyme Structure and Mechanism. Freeman: New York; Walsh, (1979)Enzymatic Reaction Mechanisms. Freeman: San Francisco; Price, N.C.,Stevens, L. (1982) Fundamentals of Enzymology. Oxford Univ. Press:Oxford; Boyer, P. D., ed. (1983) The Enzymes, 3^(rd) ed. Academic Press:New York; Bisswanger, H., (1994) Enzymkinetik, 2^(nd) ed. VCH: Weinheim(ISBN 3527300325); Bergmeyer, H. U., Bergmeyer, J., Graβl, M., eds.(1983-1986) Methods of Enzymatic Analysis, 3^(rd) ed., vol. I-XII,Verlag Chemie: Weinheim; and Ullmann's Encyclopedia of IndustrialChemistry (1987) vol. A9, “Enzymes”. VCH: Weinheim, p. 352-363.

The activity of proteins which bind to DNA can be measured by severalwell-established methods, such as DNA band-shift assays (also called gelretardation assays). The effect of such proteins on the expression ofother molecules can be measured using reporter gene assays (such as thatdescribed in Kolmar, H. et al. (1995) EMBO J. 14: 3895-3904 andreferences cited therein). Reporter gene test systems are well known andestablished for applications in both pro- and eukaryotic cells, usingenzymes such as beta-galactosidase, green fluorescent protein, andseveral others.

The determination of activity of membrane-transport proteins can beperformed according to techniques such as those described in Gennis, R.B. (1989) “Pores, Channels and Transporters”, in Biomembranes, MolecularStructure and Function, Springer: Heidelberg, p. 85-137; 199-234; and270-322.

Example 9 Analysis of Impact of Mutant Protein on the Production of theDesired Product

The effect of the genetic modification in C. glutamicum on production ofa desired compound (such as an amino acid) can be assessed by growingthe modified microorganism under suitable conditions (such as thosedescribed above) and analyzing the medium and/or the cellular componentfor increased production of the desired product (i.e., an amino acid).Such analysis techniques are well known to one of ordinary skill in theart, and include spectroscopy, thin layer chromatography, stainingmethods of various kinds, enzymatic and microbiological methods, andanalytical chromatography such as high performance liquid chromatography(see, for example, Ullman, Encyclopedia of Industrial Chemistry, vol.A2, p. 89-90 and p. 443-613, VCH: Weinheim (1985); Fallon, A. et al.,(1987) “Applications of HPLC in Biochemistry” in: Laboratory Techniquesin Biochemistry and Molecular Biology, vol. 17; Rehm et al. (1993)Biotechnology, vol. 3, Chapter III: “Product recovery and purification”,page 469-714, VCH: Weinheim; Belter, P. A. et al. (1988) Bioseparations:downstream processing for biotechnology, John Wiley and Sons; Kennedy,J. F. and Cabral, J. M. S. (1992) Recovery processes for biologicalmaterials, John Wiley and Sons; Shaeiwitz, J. A. and Henry, J. D. (1988)Biochemical separations, in: Ulmann's Encyclopedia of IndustrialChemistry, vol. B3, Chapter 11, page 1-27, VCH: Weinheim; and Dechow, F.J. (1989) Separation and purification techniques in biotechnology, NoyesPublications.)

In addition to the measurement of the final product of fermentation, itis also possible to analyze other components of the metabolic pathwaysutilized for the production of the desired compound, such asintermediates and side-products, to determine the overall efficiency ofproduction of the compound. Analysis methods include measurements ofnutrient levels in the medium (e.g., sugars, hydrocarbons, nitrogensources, phosphate, and other ions), measurements of biomass compositionand growth, analysis of the production of common metabolites ofbiosynthetic pathways, and measurement of gasses produced duringfermentation. Standard methods for these measurements are outlined inApplied Microbial Physiology, A Practical Approach, P. M. Rhodes and P.F. Stanbury, eds., IRL Press, p. 103-129; 131-163; and 165-192 (ISBN:0199635773) and references cited therein.

Example 10 Purification of the Desired Product from C. glutamicumCulture

Recovery of the desired product from the C. glutamicum cells orsupernatant of the above-described culture can be performed by variousmethods well known in the art. If the desired product is not secretedfrom the cells, the cells can be harvested from the culture by low-speedcentrifugation, the cells can be lysed by standard techniques, such asmechanical force or sonication. The cellular debris is removed bycentrifugation, and the supernatant fraction containing the solubleproteins is retained for further purification of the desired compound.If the product is secreted from the C. glutamicum cells, then the cellsare removed from the culture by low-speed centrifugation, and thesupernate fraction is retained for further purification.

The supernatant fraction from either purification method is subjected tochromatography with a suitable resin, in which the desired molecule iseither retained on a chromatography resin while many of the impuritiesin the sample are not, or where the impurities are retained by the resinwhile the sample is not. Such chromatography steps may be repeated asnecessary, using the same or different chromatography resins. One ofordinary skill in the art would be well-versed in the selection ofappropriate chromatography resins and in their most efficaciousapplication for a particular molecule to be purified. The purifiedproduct may be concentrated by filtration or ultrafiltration, and storedat a temperature at which the stability of the product is maximized.

There are a wide array of purification methods known to the art and thepreceding method of purification is not meant to be limiting. Suchpurification techniques are described, for example, in Bailey, J. E. &Ollis, D. F. Biochemical Engineering Fundamentals, McGraw-Hill: New York(1986).

The identity and purity of the isolated compounds may be assessed bytechniques standard in the art. These include high-performance liquidchromatography (HPLC), spectroscopic methods, staining methods, thinlayer chromatography, NIRS, enzymatic assay, or microbiologically. Suchanalysis methods are reviewed in: Patek et al. (1994) Appl. Environ.Microbiol. 60: 133-140; Malakhova et al. (1996) Biotekhnologiya 11:27-32; and Schmidt et al. (1998) Bioprocess Engineer. 19: 67-70.Ulmann's Encyclopedia of Industrial Chemistry, (1996) vol. A27, VCH:Weinheim, p. 89-90, p. 521-540, p. 540-547, p. 559-566, 575-581 and p.581-587; Michal, G. (1999) Biochemical Pathways: An Atlas ofBiochemistry and Molecular Biology, John Wiley and Sons; Fallon, A. etal. (1987) Applications of HPLC in Biochemistry in: LaboratoryTechniques in Biochemistry and Molecular Biology, vol. 17.

Example 11 Analysis of the Gene Sequences of the Invention

The comparison of sequences and determination of percent homologybetween two sequences are art-known techniques, and can be accomplishedusing a mathematical algorithm, such as the algorithm of Karlin andAltschul (1990) Proc. Natl. Acad Sci. USA 87:2264-68, modified as inKarlin and Altschul (1993) Proc. Natl. Acad. Sci. USA 90:5873-77. Suchan algorithm is incorporated into the NBLAST and XBLAST programs(version 2.0) of Altschul, et al. (1990) J. Mol. Biol. 215:403-10. BLASTnucleotide searches can be performed with the NBLAST program, score=100,wordlength=12 to obtain nucleotide sequences homologous to MCP nucleicacid molecules of the invention. BLAST protein searches can be performedwith the XBLAST program, score=50, wordlength=3 to obtain amino acidsequences homologous to MCP protein molecules of the invention. Toobtain gapped alignments for comparison purposes, Gapped BLAST can beutilized as described in Altschul et al., (1997) Nucleic Acids Res.25(17):3389-3402. When utilizing BLAST and Gapped BLAST programs, one ofordinary skill in the art will know how to optimize the parameters ofthe program (e.g., XBLAST and NBLAST) for the specific sequence beinganalyzed.

Another example of a mathematical algorithm utilized for the comparisonof sequences is the algorithm of Meyers and Miller ((1988) Comput. Appl.Biosci. 4: 11-17). Such an algorithm is incorporated into the ALIGNprogram (version 2.0) which is part of the GCG sequence alignmentsoftware package. When utilizing the ALIGN program for comparing aminoacid sequences, a PAM120 weight residue table, a gap length penalty of12, and a gap penalty of 4 can be used. Additional algorithms forsequence analysis are known in the art, and include ADVANCE and ADAM.described in Torelli and Robotti (1994) Comput. Appl. Biosci. 10:3-5;and FASTA, described in Pearson and Lipman (1988) P.N.A.S. 85:2444-8.

The percent homology between two amino acid sequences can also beaccomplished using the GAP program in the GCG software package(available at http://www.gcg.com), using either a Blosum 62 matrix or aPAM250 matrix, and a gap weight of 12, 10, 8, 6, or 4 and a lengthweight of 2, 3, or 4. The percent homology between two nucleic acidsequences can be accomplished using the GAP program in the GCG softwarepackage, using standard parameters, such as a gap weight of 50 and alength weight of 3.

A comparative analysis of the gene sequences of the invention with thosepresent in Genbank has been performed using techniques known in the art(see, e.g., Bexevanis and Ouellette, eds. (1998) Bioinformatics: APractical Guide to the Analysis of Genes and Proteins. John Wiley andSons: New York). The gene sequences of the invention were compared togenes present in Genbank in a three-step process. In a first step, aBLASTN analysis (e.g., a local alignment analysis) was performed foreach of the sequences of the invention against the nucleotide sequencespresent in Genbank, and the top 500 hits were retained for furtheranalysis. A subsequent FASTA search (e.g., a combined local and globalalignment analysis, in which limited regions of the sequences arealigned) was performed on these 500 hits. Each gene sequence of theinvention was subsequently globally aligned to each of the top threeFASTA hits, using the GAP program in the GCG software package (usingstandard parameters). In order to obtain correct results, the length ofthe sequences extracted from Genbank were adjusted to the length of thequery sequences by methods well-known in the art. The results of thisanalysis are set forth in Table 4. The resulting data is identical tothat which would have been obtained had a GAP (global) analysis alonebeen performed on each of the genes of the invention in comparison witheach of the references in Genbank, but required significantly reducedcomputational time as compared to such a database-wide GAP (global)analysis. Sequences of the invention for which no alignments above thecutoff values were obtained are indicated on Table 4 by the absence ofalignment information. It will further be understood by one of ordinaryskill in the art that the GAP alignment homology percentages set forthin Table 4 under the heading “% homology (GAP)” are listed in theEuropean numerical format, wherein a ‘,’ represents a decimal point. Forexample, a value of “40,345” in this column represents “40.345%”.

Example 12 Construction and Operation of DNA Microarrays

The sequences of the invention may additionally be used in theconstruction and application of DNA microarrays (the design,methodology, and uses of DNA arrays are well known in the art, and aredescribed, for example, in Schena, M. et al. (1995) Science 270:467-470; Wodicka, L. et al. (1997) Nature Biotechnology 15: 1359-1367;DeSaizieu, A. et al. (1998) Nature Biotechnology 16: 45-48; and DeRisi,J. L. et al. (1997) Science 278: 680-686).

DNA microarrays are solid or flexible supports consisting ofnitrocellulose, nylon, glass, silicone, or other materials. Nucleic acidmolecules may be attached to the surface in an ordered manner. Afterappropriate labeling, other nucleic acids or nucleic acid mixtures canbe hybridized to the immobilized nucleic acid molecules, and the labelmay be used to monitor and measure the individual signal intensities ofthe hybridized molecules at defined regions. This methodology allows thesimultaneous quantification of the relative or absolute amount of all orselected nucleic acids in the applied nucleic acid sample or mixture.DNA microarrays, therefore, permit an analysis of the expression ofmultiple (as many as 6800 or more) nucleic acids in parallel (see, e.g.,Schena, M. (1996) BioEssays 18(5): 427-431).

The sequences of the invention may be used to design oligonucleotideprimers which are able to amplify defined regions of one or more C.glutamicum genes by a nucleic acid amplification reaction such as thepolymerase chain reaction. The choice and design of the 5′ or 3′oligonucleotide primers or of appropriate linkers allows the covalentattachment of the resulting PCR products to the surface of a supportmedium described above (and also described, for example, Schena, M. etal. (1995) Science 270: 467-470).

Nucleic acid microarrays may also be constructed by in situoligonucleotide, synthesis as described by Wodicka, L. et al. (1997)Nature Biotechnology 15: 1359-1367. By photolithographic methods,precisely defined regions of the matrix are exposed to light. Protectivegroups which are photolabile are thereby activated and undergonucleotide addition, whereas regions that are masked from light do notundergo any modification. Subsequent cycles of protection and lightactivation permit the synthesis of different oligonucleotides at definedpositions. Small, defined regions of the genes of the invention may besynthesized on microarrays by solid phase oligonucleotide synthesis.

The nucleic acid molecules of the invention present in a sample ormixture of nucleotides may be hybridized to the microarrays. Thesenucleic acid molecules can be labeled according to standard methods. Inbrief, nucleic acid molecules (e.g., mRNA molecules or DNA molecules)are labeled by the incorporation of isotopically or fluorescentlylabeled nucleotides, e.g., during reverse transcription or DNAsynthesis. Hybridization of labeled nucleic acids to microarrays isdescribed (e.g., in Schena, M. et al. (1995) supra; Wodicka, L. et al.(1997), supra; and DeSaizieu A. et al. (1998), supra). The detection andquantification of the hybridized molecule are tailored to the specificincorporated label. Radioactive labels can be detected, for example, asdescribed in Schena, M. et al. (1995) supra) and fluorescent labels maybe detected, for example, by the method of Shalon et al. (1996) GenomeResearch 6: 639-645).

The application of the sequences of the invention to DNA microarraytechnology, as described above, permits comparative analyses ofdifferent strains of C. glutamicum or other Corynebacteria. For example,studies of inter-strain variations based on individual transcriptprofiles and the identification of genes that are important for specificand/or desired strain properties such as pathogenicity, productivity andstress tolerance are facilitated by nucleic acid array methodologies.Also, comparisons of the profile of expression of genes of the inventionduring the course of a fermentation reaction are possible using nucleicacid array technology.

Example 13 Analysis of the Dynamics of Cellular Protein Populations(Proteomics)

The genes, compositions, and methods of the invention may be applied tostudy the interactions and dynamics of populations of proteins, termed‘proteomics’. Protein populations of interest include, but are notlimited to, the total protein population of C. glutamicum (e.g., incomparison with the protein populations of other organisms), thoseproteins which are active under specific environmental or metabolicconditions (e.g., during fermentation, at high or low temperature, or athigh or low pH), or those proteins which are active during specificphases of growth and development.

Protein populations can be analyzed by various well-known techniques,such as gel electrophoresis. Cellular proteins may be obtained, forexample, by lysis or extraction, and may be separated from one anotherusing a variety of electrophoretic techniques. Sodium dodecyl sulfatepolyacrylamide gel electrophoresis (SDS-PAGE) separates proteins largelyon the basis of their molecular weight. Isoelectric focusingpolyacrylamide gel electrophoresis (IEF-PAGE) separates proteins bytheir isoelectric point (which reflects not only the amino acid sequencebut also posttranslational modifications of the protein). Another, morepreferred method of protein analysis is the consecutive combination ofboth IEF-PAGE and SDS-PAGE, known as 2-D-gel electrophoresis (described,for example, in Hermann et al. (1998) Electrophoresis 19: 3217-3221;Fountoulakis et al. (1998) Electrophoresis 19: 1193-1202; Langen et al.(1997) Electrophoresis 18: 1184-1192; Antelmann et al. (1997)Electrophoresis 18: 1451-1463). Other separation techniques may also beutilized for protein separation, such as capillary gel electrophoresis;such techniques are well known in the art.

Proteins separated by these methodologies can be visualized by standardtechniques, such as by staining or labeling. Suitable stains are knownin the art, and include Coomassie Brilliant Blue, silver stain, orfluorescent dyes such as Sypro Ruby (Molecular Probes). The inclusion ofradioactively labeled amino acids or other protein precursors (e.g.,³⁵S-methionine, ³⁵S-cysteine, ¹⁴C-labelled amino acids, ¹⁵N-amino acids,¹⁵NO₃ or ¹⁵NH₄+ or ¹³C-labelled amino acids) in the medium of C.glutamicum permits the labeling of proteins from these cells prior totheir separation. Similarly, fluorescent labels may be employed. Theselabeled proteins can be extracted, isolated and separated according tothe previously described techniques.

Proteins visualized by these techniques can be further analyzed bymeasuring the amount of dye or label used. The amount of a given proteincan be determined quantitatively using, for example, optical methods andcan be compared to the amount of other proteins in the same gel or inother gels. Comparisons of proteins on gels can be made, for example, byoptical comparison, by spectroscopy, by image scanning and analysis ofgels, or through the use of photographic films and screens. Suchtechniques are well-known in the art.

To determine the identity of any given protein, direct sequencing orother standard techniques may be employed. For example, N- and/orC-terminal amino acid sequencing (such as Edman degradation) may beused, as may mass spectrometry (in particular MALDI or ESI techniques(see, e.g., Langen et al. (1997) Electrophoresis 18: 1184-1192)). Theprotein sequences provided herein can be used for the identification ofC. glutamicum proteins by these techniques.

The information obtained by these methods can be used to comparepatterns of protein presence, activity, or modification betweendifferent samples from various biological conditions (e.g., differentorganisms, time points of fermentation, media conditions, or differentbiotopes, among others). Data obtained from such experiments alone, orin combination with other techniques, can be used for variousapplications, such as to compare the behavior of various organisms in agiven (e.g., metabolic) situation, to increase the productivity ofstrains which produce fine chemicals or to increase the efficiency ofthe production of fine chemicals.

Equivalents

Those of ordinary skill in the art will recognize, or will be able toascertain using no more than routine experimentation, many equivalentsto the specific embodiments of the invention described herein. Suchequivalents are intended to be encompassed by the following claims.TABLE 4 ALIGNMENT RESULTS % homo- length logy ID # (NT) Genbank HitLength Accession Name of Genbank Hit Source of Genbank Hit (GAP) Date ofDeposit rxa00003 864 GB_BA2: MPAE000013 10328 AE000013 Mycoplasmapneumoniae section 13 of 63 of the complete genome. Mycoplasmapneumoniae 37,409 18-Nov-98 GB_BA2: MPAE000013 10328 AE000013 Mycoplasmapneumoniae section 13 of 63 of the complete genome. Mycoplasmapneumoniae 36,768 18-Nov-98 rxa00008 615 GB_HTG2: AC007356 185382AC007356 Drosophila melanogaster chromosome 2 clone BACR24H09 (D595)Drosophila melanogaster 39,203 2-Aug-99 RPCI-98 24.H.9 map 49A-49Bstrain y: cn bw sp. *** SEQUENCING IN PROGRESS ***, 13 unordered pieces.GB_HTG2: AC007356 185382 AC007356 Drosophila melanogaster chromosome 2clone BACR24H09 (D595) Drosophila melanogaster 39,203 2-Aug-99 RPCI-9824.H.9 map 49A-49B strain y; cn bw sp. *** SEQUENCING IN PROGRESS***, 13unordered pieces. GB_EST36: AV194293 380 AV194293 AV194293 Yuji Koharaunpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis elegans38,947 22-Jul-99 Caenorhabditis elegans cDNA clone yk627f12 5′, mRNAsequence. rxa00015 432 GB_GSS4: AQ684785 671 AQ684785HS_5481_B2_H06_SP6E RPCI-11 Human Male BAC Library Homo sapiens 41,38828-Jun-99 Homo sapiens genomic clone Plate = 1057 Col = 12 Row = P.genomic survey sequence. GB_PR2: HS217O16 87552 AL031771 Human DNAsequence from clone 217O16 on chromosome 6q24 Homo sapiens 37,47123-Nov-99 Contains GSS, complete sequence. GB_EST15: AA528550 335AA528550 nf01f01.s1 NCI_CGAP_Kid1 Homo sapiens cDNA clone Homo sapiens40,789 19-Aug-97 IMAGE: 912505, mRNA sequence. rxa00018 1422 GB_VI:HS5MCP 4320 M25411 Human cytomegalovirus major capsid protein (MCP)gene, complete cds. human herpesvirus 5 38,231 30-OCT-1994 GB_BA2:AE001270 12448 AE001270 Treponema pallidum section 86 of 87 of thecomplete genome. Treponema pallidum 37,13 16-Jul-98 GB_IN1: LMFL238522004 AL034389 Leishmania major Friedlin cosmid L2385, completesequence. Leishmania major 37,518 15-MAR-1999 rxa00020 903 GB_PR4:AC006960 179757 AC006960 Homo sapiens clone UWGC: djs58 from 7p14-15,complete sequence. Homo sapiens 36,618 05-MAR-1999 GB_HTG3: AC008266178972 AC008266 Homo sapiens clone DJ1145A24, *** SEQUENCING IN PROGRESS***, Homo sapiens 35,419 21-Aug-99 3 unordered pieces. GB_HTG3: AC008266178972 AC008266 Homo sapiens clone DJ1145A24, *** SEQUENCING IN PROGRESS***, Homo sapiens 35,419 21-Aug-99 3 unordered pieces. rxa00021 1896GB_EST15: AA496164 429 AA496164 zu67e09.r1 Soares_testis_NHT Homosapiens cDNA Homo sapiens 35,526 11-Aug-97 clone IMAGE: 743080 5′, mRNAsequence. GB_EST30: AI660039 443 AI660039 we65d06.x1 Soares_thymus_NHFThHomo sapiens Homo sapiens 42,574 10-MAY-1999 cDNA clone IMAGE: 23459633′, mRNA sequence. GB_EST37: AI953059 522 AI953059 wq49g08.x1NCI_CGAP_GC6 Homo sapiens cDNA clone Homo sapiens 39,198 6-Sep-99 IMAGE:2474650 3′, mRNA sequence. rxa00022 1824 GB_EST15: AA496164 429 AA496164zu67e09.r1 Soares_testis_NHT Homo sapiens cDNA clone Homo sapiens 41,14111-Aug-97 IMAGE: 743080 5′, mRNA sequence. GB_PR3: AF022141 43473AF022141 Homo sapiens chromosome 21q22.2 cosmid Q13F10. completesequence. Homo sapiens 37,262 21-Jan-98 GB_EST18: AA678649 538 AA678649ah07c05.s1 Gessler Witms tumor Homo sapiens cDNA clone Homo sapiens38,104 02-DEC-1997 IMAGE: 1155944 3′ similar to gb: X16869 ELONGATIONFACTOR 1-ALPHA 1 (HUMAN);, mRNA sequence. rxa00025 1560 GB_PL2: AC00997897554 AC009978 Genomic sequence for Arabidopsis thaliana BAC T23E18 fromArabidopsis thaliana 34,173 15-Nov-99 chromosome I, complete sequence.GB_HTG2: AC005958 216706 AC005958 Homo sapiens, *** SEQUENCING INPROGRESS ***, 40 unordered pieces. Homo sapiens 35,374 11-Nov-98GB_HTG2: AC005958 216706 AC005958 Homo sapiens, *** SEQUENCING INPROGRESS ***, 40 unordered pieces. Homo sapiens 35,374 11-Nov-98rxa00027 489 GB_PR3: HSDJ247C2 98358 AL049713 Human DNA sequence fromclone 247C2 on chromosome 11p13, complete sequence. Homo sapiens 33,05623-Nov-99 GB_PR3: HSDJ247C2 98358 AL049713 Human DNA sequence from clone247C2 on chromosome 11p13, complete sequence. Homo sapiens 37,98823-Nov-99 rxa00028 rxa00031 525 GB_PL1: SPBC725 37949 AL034352 S. pombechromosome II cosmid c725. Schizosaccharomyces 36,084 29-MAR-1999 pombeGB_EST5: N22565 435 N22565 yw30f05.s1 Morton Fetal Cochlea Homo sapienscDNA clone IMAGE: Homo sapiens 41,57 20-DEC-1995 253761 3′, mRNAsequence. GB_EST21: AA993042 464 AA993042 ot92f07.s1Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone IMAGE: Homo sapiens41,499 27-Aug-98 1624261 3′, mRNA sequence. rxa00049 810 GB_HTG2:HSJ749H19 253387 AL117380 Homo sapiens chromosome 20 clone RP4-749H19map q13.11-13.33, Homo sapiens 37,132 03-DEC-1999 *** SEQUENCING INPROGRESS ***, in unordered pieces. GB_HTG2: HSJ749H19 253387 AL117380Homo sapiens chromosome 20 clone RP4-749H19 map q13.11-13.33, Homosapiens 37,132 03-DEC-1999 *** SEQUENCING IN PROGRESS ***, in unorderedpieces. GB_HTG4: AC010137 155817 AC010137 Homo sapiens clone NH0169D01,*** SEQUENCING Homo sapiens 40,052 17-OCT-1999 IN PROGRESS ***, 4unordered pieces. rxa00052 834 GB_EST37: AI962012 382 AI962012wt41e06.x1 NCI_CGAP_Pan1 Homo sapiens cDNA clone IMAGE: Homo sapiens40,486 20-Aug-99 2510050 3′ similar to SW: ALC2_HUMAN P01877 IG ALPHA-2CHAIN C REGION.;, mRNA sequence. GB_GSS13: AQ454792 450 AQ454792HS_5195_B2_H04_SP6E RPCI-11 Human Male BAC Library Homo sapiens 40,99121-Apr-99 Homo sapiens genomic clone Plate = 771 Col = 8 Row = P,genomic survey sequence. GB_GSS13: AQ454792 450 AQ454792HS_5195_B2_H04_SP6E RPCI-11 Human Male BAC Library Homo sapiens 40,27821-Apr-99 Homo sapiens genomic clone Plate = 771 Col = 8 Row = P,genomic survey sequence. rxa00054 3036 GB_GSS5: AQ773786 459 AQ773786HS_2222_A1_E07_MR CIT Approved Human Genomic Sperm Library D Homosapiens 40,087 29-Jul-99 Homo sapiens genomic clone Plate = 2222 Col =13 Row = 1, genomic survey sequence. GB_GSS5: AQ773786 459 AQ773786HS_2222_A1_E07_MR CIT Approved Human Genomic Sperm Library D Homosapiens 40,087 29-Jul-99 Homo sapiens genomic clone Plate = 2222 Col =13 Row = 1, genomic survey sequence. rxa00056 873 GB_IN1: CEF56H9 28291Z74473 Caenorhabditis elegans cosmid F56H9, complete sequence.Caenorhabditis elegans 35,301 23-Nov-98 GB_IN1: CEF56H9 28291 Z74473Caenorhabditis elegans cosmid F56H9, complele sequence. Caenorhabditiselegans 38,941 23-Nov-98 rxa00058 687 GB_HTG6: AC011647 141830 AC011647Homo sapiens clone RP11-15D18, *** SEQUENCING IN PROGRESS ***, Homosapiens 39,939 04-DEC-1999 29 unordered pieces. GB_HTG6: AC011647 141830AC011647 Homo sapiens clone RP11-15D18, *** SEQUENCING IN Homo sapiens37,537 04-DEC-1999 PROGRESS ***, 29 unordered pieces. rxa00059 405GB_GSS6: AQ825754 463 AQ825754 HS_5441_A2_G02_SP6E RPCI-11 Human MaleBAC Library Homo sapiens 34,444 27-Aug-99 Homo sapiens genomic clonePlate = 1017 Col = 4 Row = M, genomic survey sequence. GB_PAT: I3293930001 I32939 Sequence 1 from patent U.S. Pat. No. 5589385. Unknown.42,049 6-Feb-97 GB_PAT: AR031772 30001 AR031772 Sequence 1 from patentU.S. Pat. No. 5866410. Unknown. 42,049 29-Sep-99 rxa00065 396 GB_PAT:E16763 2517 E16763 gDNA encoding aspartate transferase (AAT).Corynebacterium 98,765 28-Jul-99 glutamicum GB_EST32: AU050556 813AU050556 AU050556 Paralichthys olivaceus library (Aoki T) Paralichthysolivaceus Paralichthys olivaceus 35,638 8-Jun-99 cDNA clone WF7-19, mRNAsequence. GB_EST32: AU050215 733 AU050215 AU050215 Paralichthysolivaceus library (Aoki T) Paralichthys olivaceus Paralichthys olivaceus35,638 8-Jun-99 cDNA clone WB1-12, mRNA sequence. rxa00067 609 GB_HTG3:AC008289 115120 AC008289 Drosophila melanogaster chromosome 2 cloneBACR04E05 (D1055) Drosophila melanogaster 30,397 17-Aug-99 RPCI-9804.E.5 map 57B-57B strain y; cn bw sp. *** SEQUENCING IN PROGRESS ***,100 unordered pieces. GB_IN2: AC004433 85862 AC004433 Drosophilamelanogaster, chromosome 2R, region 57B1-57B6, Drosophila melanogaster35,501 01-DEC-1998 P1 clone DS03659, complete sequence. GB_HTG3:AC008289 115120 AC008289 Drosophila melanogaster chromosome 2 cloneBACR04E05 (D1055) Drosophila melanogaster 30,397 17-Aug-99 RPCI-9804.E.5 map 57B-57B strain y; cn bw sp *** SEQUENCING IN PROGRESS ***,100 unordered pieces. rxa00068 705 GB_PL2: ATAC006201 87947 AC006201Arabidopsis thaliana chromosome I| BAC T27K22 genomic Arabidopsisthaliana 39,099 12-MAR-1999 sequence, complete sequence. GB_HTG5:AC010146 271437 AC010146 Homo sapiens clone NH0355|13, WORKING DRAFTHomo sapiens 34,237 12-Nov-99 SEQUENCE, 1 unordered pieces. GB_GSS3:B85079 307 B85079 RPCI11-29O9.TP RPCI-11 Homo sapiens genomic clone Homosapiens 39,56 9-Apr-99 RPCI-11-29O9, genomic survey sequence. rxa000771485 GB_PR4: AC007157 152937 AC007157 Homo sapiens, clone hRPK.78_A_1,complete sequence. Homo sapiens 37,661 27-Apr-99 GB_HTG1: CEY43C5 149571AL021449 Caenorhabditis elegans chromosome IV clone Y43C5, ***SEQUENCING IN Caenorhabditis elegans 25,242 23-Jan-98 PROGRESS ***, inunordered pieces. GB_HTG1: CEY43C5 149571 AL021449 Caenorhabditiselegans chromosome IV clone Y43C5, *** SEQUENCING IN Caenorhabditiselegans 38,258 23-Jan-98 PROGRESS ***, in unordered pieces. rxa00079 345GB_IN1: CTAJ2763 1097 AJ002763 Chironomus tentans mRNA for P23 protein(23 kDa). Chironomus tentans 36,176 26-Jan-98 GB_IN1: CTHRP23 752AJ003820 Chironomus tentans mRNA for hnRNP protein, hrp23. Chironomustentans 36,176 02-DEC-1998 GB_EST17: AA650674 540 AA650674 30788Lambda-PRL2 Arabidopsis thaliana cDNA clone 277G7T7, mRNA sequence.Arabidopsis thaliana 36,965 31-OCT-1997 rxa00080 1653 GB_EST38: AW039986564 AW039986 EST282477 tomato mixed elicitor. BTI Lycopersiconesculentum cDNA Lycopersicon esculentum 38,078 18-OCT-1999 clonecLET19F23, mRNA sequence. GB_EST33: AI778332 378 AI778332 EST259211tomato susceptible, Cornell Lycopersicon esculentum cDNA Lycopersiconesculentum 38,298 29-Jun-99 clone cLES5A13, mRNA sequence. GB_EST38:AW039988 564 AW039988 EST282479 tomato mixed elicitor, BTI Lycopersiconesculentum Lycopersicon esculentum 38,078 18-OCT-1999 cDNA clonecLET19F23, mRNA sequence. rxa00082 687 GB_PR1: HSS171 333303 AJ011930Homo sapiens chromosome 21q22.3, PAC clones 314N7, 225L15, Homo sapiens36,111 10-Nov-98 BAC clone 7B7, complete sequence bases 1..333303.GB_PR1: HSS171 333303 AJ011930 Homo sapiens chromosome 21q22.3, PACclones 314N7, Homo sapiens 35,432 10-Nov-98 225L15, BAC clone 7B7,complete sequence bases 1..333303. GB_PR3: AC004000 128117 AC004000Human PAC clone DJ404F18 from Xq23, complete sequence. Homo sapiens38,75 15-Jan-98 rxa00083 423 GB_HTG1: CNS018OY 168868 AL109769 Homosapiens chromosome 14 clone R-501E21, *** SEQUENCING IN Homo sapiens33,806 15-OCT-1999 PROGRESS ***, in ordered pieces. GB_HTG1: CNS018OY168868 AL109769 Homo sapiens chromosome 14 clone R-501E21, ***SEQUENCING IN Homo sapiens 33,806 15-OCT-1999 PROGRESS ***, in orderedpieces. GB_PR3: HS516C23 116685 Z93021 Human DNA sequence from clone516C23 on chromosome 6q12 Homo sapiens 38,582 23-Nov-99 Contains CArepeat (D6S402) and GSSs, complete sequence. rxa00087 651 GB_BA1:PSEBPHABC 6780 M83673 P. pseudoalcaligenes dioxygenase (bphABC) genecluster, complete cds. Pseudomonas 39,564 26-Apr-93 pseudoalcaligenesGB_BA1: PSEBPHA 5700 M86348 Pseudomonas sp. LB400 biphenyl dioxygenase(bphA), biphenyl Burkholderia sp. LB400 39,564 18-Jul-97 dioxygenase(bphE), biphenyl dioxygenase (bphF) and biphenyl dioxygenase (bphG)s,complete cds, and dihydrodiol dehydrogenase (bphB), partial cds. GB_PAT:E04215 4721 E04215 Benzene dioxygenase gene. Pseudomonas aeruginosa45,814 29-Sep-97 rxa00093 2346 GB_HTG2: AC007361 36465 AC007361 Homosapiens clone NH0144P23, *** SEQUENCING IN Homo sapiens 37,179 23-Apr-99PROGRESS ***, 1 unordered pieces. GB_PR4: AC006043 189036 AC006043 Homosapiens BAC clone NH0538D15 from 7q11.23-q21.1, complete sequence. Homosapiens 37,06 20-Feb-99 GB_HTG2: AC007361 36465 AC007361 Homo sapiensclone NH0144P23, *** SEQUENCING Homo sapiens 37,179 23-Apr-99 INPROGRESS ***, 1 unordered pieces. rxa00096 426 GB_EST15: AA533064 534AA533064 nj60d06.s1 NCI_CGAP_Pr9 Homo sapiens cDNA clone Homo sapiens39,024 21-Aug-97 IMAGE: 996875, mRNA sequence. GB_IN1: CELF01G12 34671U53342 Caenorhabditis elegans cosmid F01G12. Caenorhabditis elegans38,06 5-Apr-98 GB_PR3: AC004511 45005 AC004511 Homo sapiens chromosome5, P1 clone 792C12 (LBNL H22), complete sequence. Homo sapiens 39,16331-MAR-1998 rxa00097 1299 GB_OM: CFU60590 6726 U60590 Canis familiarisTTX-resistant sodium channel mRNA, complete cds. Canis familiaris 39,5288-Jan-98 GB_GSS15: AQ664394 485 AQ664394 HS_5480_B1_B02_SP6E RPCI-11Human Male BAC Library Homo sapiens 39,666 23-Jun-99 Homo sapiensgenomic clone Plate = 1056 Col = 3 Row = D, genomic survey sequence.GB_BA2: RSAF000233 5984 AF000233 Rhodobacter sphaeroides nitric oxidereductase operon: norC, Rhodobacter sphaeroides 37,5 6-Jun-97 norB,norQ, norD, nnrT and nnrU genes, complete cds. rxa00101 rxa00108 643GB_PR4: AC007115 180821 AC007115 Homo sapiens chromosome 12 clone 917O5,complete sequence. Homo sapiens 35,165 17-Aug-99 GB_PR3: AC004080 129354AC004080 Homo sapiens PAC clone DJ0170O19 from 7p15-p21, completesequence. Homo sapiens 38,56 29-Jan-98 GB_HTG1: HSAJ9613 45302 AJ009613Homo sapiens chromosome 17 clone cosmid 5L5 map p11, *** SEQUENCING Homosapiens 39,274 11-Nov-98 IN PROGRESS ***, in unordered pieces. rxa00110672 GB_PL1: MIATGENB 166924 Y08502 A thaliana mitochondrial genome, partB. Mitochondrion Arabidopsis 36,391 13-Nov-98 thaliana GB_PL2: AC01071887684 AC010718 Arabidopsis thaliana chromosome I BAC F28O16 Arabidopsisthaliana 36,622 30-OCT-1995 genomic sequence, complete sequence. GB_PL2:AC007729 106639 AC007729 Arabidopsis thaliana chromosome II BAC T18C6Arabidopsis thaliana 35,053 5-Jun-99 genomic sequence, completesequence. rxa00114 612 GB_OM: BTMICSD1 362 Z27071 B. taurus (cos1E3)microsatellite DNA (362 bp). Bos taurus 37,117 10-Aug-95 GB_OM: BTMICSD1362 Z27071 B. taurus (cos1E3) microsatellile DNA (362 bp). Bos taurus36,486 10-Aug-95 rxa00117 714 GB_PL2: AF080249 3194 AF080245 Arabidopsisthaliana kinesin-like heavy chain (KATD) mRNA, complete cds. Arabidopsisthaliana 37,846 14-Apr-99 GB_PL2: IG002P16 110946 AF007270 Arabidopsisthaliana BAC IG002P16. Arabidopsis thaliana 37,11 12-Jun-97 GB_PL2:AF080249 3194 AF080249 Arabidopsis thaliana kinesin-like heavy chain(KATD) mRNA. complete cds. Arabidopsis thaliana 36,506 14-Apr-59rxa00118 378 GB_HTG2: AC008043 124844 AC008043 Drosophila melanogasterchromosome 3 clone BACR05A08 Drosophila melanogaster 33,78 2-Aug-99(D750) RPCI-98 05.A.8 map 94A-94A strain y; cn bw sp, *** SEQUENCING INPROGRESS ***, 86 unordered pieces. GB_HTG2: AC008043 124844 AC008043Drosophila melanogaster chromosome 3 clone BACR05A08 Drosophilamelanogaster 33,78 2-Aug-99 (D750) RPCI-98 05.A.8 map 94A-94A strain y;cn bw sp. *** SEQUENCING IN PROGRESS***, 86 unordered pieces. GB_PR3:AC004827 129690 AC004827 Homo sapiens PAC clone DJ044L15 from Xq23,complete sequence. Homo sapiens 32,32 17-OCT-1998 rxa00119 882 GB_PR4:HSU34879 46610 U34879 Human 17-beta-hydroxysteroid dehydrogenase(EDH17B2) gene, complete cds. Homo sapiens 36,671 14-Jan-99 GB_PR4:HSU34879 46610 U34879 Human 17-beta-hydroxysteroid dehydrogenase(EDH17B2) gene, complete cds. Homo sapiens 38,345 14-Jan-99 GB_EST37:AW005997 702 AW005997 wz91c01.x1 NCI_CGAP_Brn25 Homo sapiens cDNA cloneIMAGE: Homo sapiens 40,774 10-Sep-99 2566176 3′ similar to TR: O08609O08609 TRANSCRIPTION FACTOR-LIKE PROTEIN 4.;, mRNA sequence. rxa00120963 GB_BA1: TRU80216 1936 U80216 Thermomicrobium roseum 70 kDa heatshock protein Hsp70 Thermomicrobium roseum 38 1-Feb-97 (DnaK) gene,complete cds. GB_HTG1: HS791K14 155318 AL035685 Homo sapiens chromosome20 clone RP4-791K14, *** SEQUENCING Homo sapiens 37,277 23-Nov-99 INPROGRESS ***, in unordered pieces. GB_HTG1: HS791K14 155318 AL035685Homo sapiens chromosome 20 clone RP4-791K14, *** SEQUENCING Homo sapiens37,277 23-Nov-99 unordered pieces. rxa00121 834 GB_HTG1: HSBA298O6198847 AL118525 Homo sapiens chromosome 20 clone RP11-298O6, ***SEQUENCING Homo sapiens 36,199 24-Nov-99 IN PROGRESS ***, in unorderedpieces. GB_HTG1: HS791K14 155318 AL035685 Homo sapiens chromosome 20clone RP4-791K14, *** SEQUENCING Homo sapiens 36,983 23-Nov-99 INPROGRESS ***, in unordered pieces. GB_HTG1: HS791K14 155318 AL035685Homo sapiens chromosome 20 clone RP4-791K14, *** SEQUENCING Homo sapiens36,983 23-Nov-99 IN PROGRESS ***, in unordered pieces. rxa00122 1746GB_PL1: MZECPN60A 6575 L21007 Corn nuclear-encoded mitochondrialchaperonin 60 (cpn60I) gene, complete cds. Zea mays 36,098 26-Jul-93GB_PL1: ZMCPNAGA 2247 Z12114 Z. mays CPNA gene encoding mitochondrialchaperonin-60. Zea mays 37,702 01-OCT-1992 GB_PL1: ZMCHHSP60 2138 Z11546Z. mays mRNA for mitochondrial chaperonin hsp60. Zea mays 37,72111-Jun-92 rxa00127 588 GB_PR4: AC005193 108400 AC005193 Homo sapiensclone DJ0655N24, complete sequence. Homo sapiens 37,5 1-Jul-99 GB_PR4:AC005193 108400 AC005193 Homo sapiens clone DJ0655N24, completesequence. Homo sapiens 36,796 1-Jul-99 rxa00128 1827 GB_GSS11: AQ299024449 AQ299024 HS_3178_B1_B06_T7 CIT Approved Human Genomic Homo sapiens40,757 15-DEC-1998 Sperm Library D Homo sapiens genomic clone Plate =3178 Col = 11 Row = D, genomic survey sequence. GB_GSS11: AQ299024 449AQ299024 HS_3178_B1_B06_T7 CIT Approved Human Genomic Homo sapiens40,443 15-DEC-1998 Sperm Library D Homo sapiens genomic clone Plate =3178 Col = 11 Row = D, genomic survey sequence. rxa00134 693 GB_GSS10:AQ177172 393 AQ177172 HS_3225_A2_E10_MR CIT Approved Human Genomic Homosapiens 50 17-OCT-1998 Sperm Library D Homo sapiens genomic clone Plate= 3225 Col = 20 Row = I, genomic survey sequence. GB_PR3: AC005726185215 AC005726 Homo sapiens chromosome 17, clone hRPK.192_H_23,complete sequence. Homo sapiens 37,778 30-OCT-1998 GB_PR3: AC005726185215 AC005726 Homo sapiens chromosome 17, clone hRPK.192_H_23,complete sequence. Homo sapiens 38,71 30-OCT-1998 rxa00140 309 GB_VI:OPU75930 131993 U75930 Orgyia pseudotsugata nuclear polyhedrosis viruscomplete genome. Orgyia pseudotsugata 39,007 06-MAR-1998 nuclearpolyhedrosis virus GB_HTG2: AC006319 156299 AC006319 Homo sapiens cloneDJ0837C09, *** SEQUENCING IN Homo sapiens 31,773 23-Apr-99 PROGRESS ***,1 unordered pieces. GB_HTG2: AC006319 156299 AC006319 Homo sapiens cloneDJ0837C09, *** SEQUENCING IN Homo sapiens 31,773 23-Apr-99 PROGRESS ***,1 unordered pieces. rxa00141 585 GB_VI: OPU75930 131993 U75930 Orgyiapseudotsugata nuclear polyhedrosis virus complete genome. Orgyiapseudotsugata 38,079 06-MAR-1998 nuclear polyhedrosis virus GB_PR4:AC004526 297898 AC004526 Homo sapiens chromosome 17, Neurofibromatosis 1locus, complete sequence. Homo sapiens 37,336 25-Feb-99 GB_PR2:HUMNEUROF 100849 L05367 Human oligodendrocyte myelin glycoprotein (OMG)exons 1-2; neurofibromatosis 1 Homo sapiens 37,336 20-Sep-95 (NF1) exons28-49; ecotropic viral integration site 2B (EVI2B) exons 1-2; ecotropicviral integration site 2A (EVI2A) exons 1-2; adenylate kinase (AK3)exons 1-2. rxa00142 600 GB_PR4: HUAC002331 139480 AC002331 Homo sapiensChromosome 16 BAC clone CIT987SK-A-A-218C7, Homo sapiens 38,89823-Nov-99 complete sequence. GB_PR3: AF064861 133965 AF064861 Homosapiens PAC 128M19 derived from chromosome 21q22.3, containing Homosapiens 37,182 2-Jun-98 the HMG-14 and CHD5 genes, complete cds,complete sequence. GB_HTG3: AC009451 165302 AC009451 Homo sapienschromosome 17 clone 2286_H_12 map 17, *** SEQUENCING Homo sapiens 33,16722-Aug-99 IN PROGRESS ***, 26 unordered pieces. rxa00150 897 GB_PR4:AF130343 292721 AF130343 Homo sapiens chromosome 8 clone PAC 87.2 map8q24.1, complete sequence. Homo sapiens 36,032 9-Jul-99 GB_HTG4:AC008578 98891 AC008578 Homo sapiens chromosome 5 clone CIT-HSPC_558D4,*** SEQUENCING Homo sapiens 38,129 31-OCT-1999 IN PROGRESS ***, 143unordered pieces. GB_HTG4: AC008578 98891 AC008578 Homo sapienschromosome 5 clone CIT-HSPC_558D4, *** SEQUENCING Homo sapiens 38,12931-OCT-1999 IN PROGRESS ***, 143 unordered pieces. rxa00151 720 GB_PL2:AF058914 111767 AF058914 Arabidopsis thaliana BAC F21E10. Arabidopsisthaliana 36,068 15-Apr-98 GB_PR1: AB019440 200000 AB019440 Homo sapiensDNA for immunoglobulin heavy-chain variable Homo sapiens 36,51724-Feb-99 region, complete sequence, 4 of 5. GB_PR2: AP000098 100000AP000098 Homo sapiens genomic DNA of 21q22.1, GART and AML related, Homosapiens 39,224 25-Sep-99 Q78C10-149C3 region, segment 1/20, completesequence. rxa00153 549 GB_PR4: AC006265 177707 AC006265 Homo sapienschromosome 17, clone hRPK.566_B_16, complete sequence. Homo sapiens34,862 28-Jan-99 GB_HTG2: AC007389 207188 AC007389 Homo sapiens cloneNH0418H16, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,044 5-Jun-996 unordered pieces. GB_HTG2: AC007389 207188 AC007389 Homo sapiens cloneNH0418H16, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,044 5-Jun-996 unordered pieces. rxa00154 rxa00155 906 GB_BA2: AE001707 19518AE001707 Thermotoga maritima section 19 of 136 of the complete genome.Thermotoga maritima 36,854 2-Jun-99 GB_PR2: HS1126I14 19544 AL078589Human DNA sequence from clone 1126I14 on chromosome Homo sapiens 36,72323-Nov-99 6q16.1-16.3. Contains an STS and GSSs, complete sequence.GB_BA1: MTCY01B2 35938 Z95554 Mycobacterium tuberculosis H37Rv completegenome; segment 72/162. Mycobacterium 40,435 17-Jun-98 tuberculosisrxa00159 1305 GB_EST38: AW048718 475 AW048718 UI-M-BH1-amy-d-01-0-UI.s1NIH_BMAP_M_S2 Mus musculus Mus musculus 39,789 18-Sep-99 cDNA cloneUI-M-BH1-amy-d-01-0-UI 3′, mRNA sequence. GB_EST21: AA993450 381AA993450 ot32h09.s1 Soares_testis_NHT Homo sapiens cDNA clone Homosapiens 38,684 27-Aug-98 IMAGE: 1618529 3′, mRNA sequence. GB_BA1:AB007009 363 AB007009 Cytophaga sp. 16S rRNA gene, partial sequence.Cytophaga sp. 39,039 13-OCT-1997 rxa00161 585 GB_HTG3: AC009708 25123AC009708 Homo sapiens chromosome 8 clone 318_G_5 map 8, Homo sapiens37,108 28-Aug-99 LOW-PASS SEQUENCE SAMPLING. GB_HTG3: AC009708 25123AC009708 Homo sapiens chromosome 8 clone 318_G_5 map 8, Homo sapiens37,108 28-Aug-99 LOW-PASS SEQUENCE SAMPLING. GB_PR3: HSN104C4 40203Z83855 Human DNA sequence from clone N104C4 on chromosome 22 ContainsHomo sapiens 37,634 23-Nov-99 GSSs, complete sequence. rxa00162 477GB_HTG1: CEY94A7 41009 Z99294 Caenorhabditis elegans chromosome V cloneY94A7, *** SEQUENCING Caenorhabditis elegans 41,502 18-Sep-97 INPROGRESS ***, in unordered pieces. GB_HTG1: CEY94A7 41009 Z99294Caenorhabditis elegans chromosome V clone Y94A7, *** SEQUENCINGCaenorhabditis elegans 41,502 18-Sep-97 IN PROGRESS ***, in unorderedpieces. GB_BA2: AE001182 11228 AE001182 Borrelia burgdorferi (section 68of 70) of the complete genome. Borrelia burgdorferi 39,655 15-DEC-1997rxa00167 621 GB_HTG7: AC007937 206265 AC007937 Mus musculus chromosome10 clone RP21-536F4 map 10, *** SEQUENCING Mus musculus 37,09209-DEC-1999 IN PROGRESS ***, 6 unordered pieces. GB_RO: MMU6590 6429AJ006590 Mus musculus mRNA for GANP protein. Mus musculus 38,6782-Jun-99 GB_HTG3: AC008852 116219 AC008852 Homo sapiens chromosome 5clone CITB-H1_2176I21, *** SEQUENCING Homo sapiens 35,691 3-Aug-99 INPROGRESS ***, 13 unordered pieces. rxa00169 2196 GB_GSS3: B11032 896B11032 T17F10-T7 TAMU Arabidopsis thaliana genomic clone T17F10,Arabidopsis thaliana 42,024 14-MAY-1997 genomic survey sequence.GB_GSS3: B10120 909 B10120 T27N10-Sp6.1 TAMU Arabidopsis thalianagenomic clone T27N10, Arabidopsis thaliana 41,581 14-MAY-1997 genomicsurvey sequence. GB_GSS3: B09409 916 B09409 T27M2-Sp6 TAMU Arabidopsisthaliana genomic clone T27M2, Arabidopsis thaliana 41,356 14-MAY-1997genomic survey sequence. rxa00170 1977 GB_GSS8: AQ027582 456 AQ027582CIT-HSP-2325M20.TR CIT-HSP Homo sapiens genomic Homo sapiens 40,74930-Jun-98 clone 2325M20, genomic survey sequence. GB_GSS6: AQ833529 484AQ833529 HS_5304_B2_C02_T7A RPCI-11 Human Male BAC Library Homo sapiensHomo sapiens 38,017 27-Aug-99 genomic clone Plate = 880 Col = 4 Row = F,genomic survey sequence. GB_PR2: HSM800174 2326 AL049389 Homo sapiensmRNA; cDNA DKFZp586O0118 (from clone DKFZp586O0118). Homo sapiens 37,55621-MAY-1999 rxa00171 281 GB_EST38: AL118463 279 AL118463 w9112a43Beddington mouse dissected endoderm Mus musculus cDNA Mus musculus 5023-Sep-99 clone 528_12E22 5′, mRNA sequence. GB_EST15: AA499834 419AA499834 vg05e06.r1 Soares mouse NbMH Mus musculus cDNA clone Musmusculus 39,801 1-Jul-97 IMAGE: 860482 5′, mRNA sequence. GB_EST24:AI211527 431 AI211527 p0h01a1.r1 Aspergillus nidulans 24 hr asexualdevelopmental Emericella nidulans 41,584 19-OCT-1998 and vegetative cDNAlambda zap library Emericella nidulans cDNA clone p0h01a1 5′, mRNAsequence. rxa00173 456 GB_PR3: AC004400 33367 AC004400 Homo sapienschromosome 19, cosmid F24069, complete sequence. Homo sapiens 38,90212-MAR-1998 GB_PL1: VFU14956 1474 U14956 Vicia faba ferredoxin NADP+reductase precursor (fnr) mRNA, complete cds. Vicia faba 38,75328-Sep-84 GB_PR3: AC004400 33367 AC004400 Homo sapiens chromosome 19,cosmid F24069, complete sequence. Homo sapiens 40,515 12-MAR-1998rxa00174 408 GB_PL2: AF075293 4332 AF075293 Candida albicans strain 1161agglutinin-like protein 6 (ALS6) gene, complete cds. Candida albicans41,235 2-Jul-99 GB_PL2: JSPCHS1 1525 X94995 Juglans nigra x Juglansregia mRNA for chalcone synthase (CHS1). Juglans nigra x Juglans 39,55819-Nov-99 regia GB_PL2: JSPCHS2 1534 X94706 Juglans nigra x Juglansregia mRNA for chalcone synthase (CHS2). Juglans nigra x Juglans 38,82119-Nov-99 regia rxa00175 rxa00179 582 GB_BA1: CGPUTP 3791 Y09163 C.glutamicum putP gene. Corynebacterium 100 8-Sep-97 glutamicum GB_IN2:L76038 2421 L76038 Anopheles gambiae prophenoloxidase mRNA, completecds. Anopheles gambiae 35,751 23-Jul-98 GB_IN2: AF031626 8486 AF031626Anopheles gambiae prophenoloxidase (AgProPO) gene, complete cds.Anopheles gambiae 36,395 5-Jan-99 rxa00180 663 GB_BA1: CGPUTP 3791Y09163 C. glutamicum putP gene. Corynebacterium 100 8-Sep-97 glutamicumGB_HTG1: HS120G22 57021 AL031847 Homo sapiens chromosome 1 cloneRP1-120G22, *** SEQUENCING Homo sapiens 35,976 23-Nov-99 IN PROGRESS***, in unordered pieces. GB_HTG1: HS120G22 57021 AL031847 Homo sapienschromosome 1 clone RP1-120G22, *** SEQUENCING Homo sapiens 35,97623-Nov-99 IN PROGRESS ***, in unordered pieces. rxa00183 975 GB_IN2:AF049132 16005 AF049132 Florometra serratissima mitochondrion, completegenome. Mitochondrion Florometra 33,71 15-Jan-99 serratissima GB_IN1:MTCE 13794 X54252 C. elegans complete mitochondrial genome.Mitochondrion 35,036 30-Nov-97 Caenorhabditis elegans GB_IN2: AF04913216005 AF049132 Florometra serratissima mitochondrion, complete genome.Mitochondrion Florometra 36,021 15-Jan-99 serratissima rxa00185 2751GB_EST31: AI693167 500 AI693167 wd66c11.x1 NCI_CGAP_Lu24 Homo sapienscDNA clone IMAGE: Homo sapiens 37,8 2-Jun-99 2336756 3′ similar to SW:HIOM_BOVIN P10950 HYDROXYINDOLE O-METHYLTRANSFERASE;, mRNA sequence.GB_GSS1: CNS010IZ 1000 AL099029 Drosophila melanogaster genome surveysequence Drosophila melanogaster 35,158 26-Jul-99 SP6 end of BACBACN04K17 of DrosBAC library from Drosophila melanogaster (fruit fly),genomic survey sequence. GB_EST31: AI693167 500 AI693167 wd68c11.x1NCI_CGAP_Lu24 Homo sapiens cDNA clone Homo sapiens 39,052 2-Jun-99 SW:HIOM_BOVIN P10950 HYDROXYINDOLE IMAGE: 2336756 3′ similar toO-METHYLTRANSFERASE;, mRNA sequence. rxa00194 564 GB_GSS10: AQ192671 396AQ192671 HS_2251_B2_A04_MF CIT Approved Human Genomic Sperm Library DHomo sapiens 44,24 4-Nov-98 Homo sapiens genomic clone Plate = 2251 Col= 8 Row = B, genomic survey sequence. GB_GSS8: AQ044307 644 AQ044307CIT-HSP-2331N9.TR CIT-HSP Homo sapiens genomic clone 2331N9, Homosapiens 36,15 14-Jul-98 genomic survey sequence. GB_EST36: AI925874 564AI925874 wo20d11.x1 NCI_CGAP_Pan1 Homo sapiens cDNA clone IMAGE: Homosapiens 45,588 2-Sep-99 2455893 3′ similar to TR: O67849 O67849GTP-BINDING PROTEIN.;, mRNA sequence. rxa00197 1335 GB_GSS12: AQ399208436 AQ399208 mgxb0001M23f CUGI Rice Blast BAC Library Magnaporthe griseaMagnaporthe grisea 63,529 06-MAR-1999 genomic clone mgxb0001M23f,genomic survey sequence. GB_GSS12: AQ398449 472 AQ398449 mgxb0001P11fCUGI Rice Blast BAC Library Magnaporthe grisea Magnaporthe grisea 49,5806-MAR-1999 genomic clone mgxb0001P11f, genomic survey sequence. GB_OM:BTMMP9 2350 X78324 B. taurus bmmp9 mRNA for matrix metalloproteinase.Bos taurus 40,44 30-MAR-1995 rxa00199 1542 GB_BA1: AB024708 8734AB024708 Corynebacterium glutamicum gltB and gltD genes for glutamine 2-Corynebacterium 36,237 13-MAR-1999 oxoglutarate aminotransferase largeand small subunits, complete cds. glutamicum GB_HTG2: AC007837 103949AC007837 Drosophila melanogaster chromosome 2 clone BACR04I07 Drosophilamelanogaster 36,045 2-Aug-99 (D644) RPCI-98 04.I.7 map 57B2-B3 strain y;cn bw sp, *** SEQUENCING IN PROGRESS***, 49 unordered pieces. GB_HTG2:AC007837 103949 AC007837 Drosophila melanogaster chromosome 2 cloneBACR04I07 Drosophila melanogaster 36,045 2-Aug-99 (D644) RPCI-98 04.I.7map 57B2-B3 strain y: cn bw sp. *** SEQUENCING IN PROGRESS***, 49unordered pieces. rxa00200 3561 GB_BA2: MSU46844 16951 U46844Mycobacterium smegmatis catalase-peroxidase (katG), putative arabinosylMycobacterium smegmatis 53,937 12-MAY-1997 transferase (embC, embA,embB), genes complete cds and putative propionyl-coA carboxylase betachain (pccB) genes, partial cds. GB_BA2: MAU66560 7853 U66560Mycobacterium avium EmbR (embR), EmbA (embA) and EmbB Mycobacteriumavium 52,241 8-Nov-96 (embB) genes, complete cds. GB_BA1: MTY13D12 37085Z80343 Mycobacterium tuberculosis H37Rv complete genome; segment156/162. Mycobacterium 52,812 17-Jun-98 tuberculosis rxa00207 441GB_PR3: HTCRBCHR9 216293 AF029308 Homo sapiens chromosome 9 duplicationof the T cell receptor beta Homo sapiens 39,286 13-Apr-98 locus andtrypsinogen gene families. GB_PR3: HTCRBCHR9 216293 AF029308 Homosapiens chromosome 9 duplication of the T cell receptor beta Homosapiens 37,116 13-Apr-98 locus and trypsinogen gene families. rxa00211786 GB_PR2: HSU81831 38674 U81831 Human cosmid LL12NCO1-67C6, ETV6 gene,intron 1A, partial sequence. Homo sapiens 35,509 3-Jan-97 GB_RO:MUSKROX2S2 2868 M28845 Mus musculus zinc finger protein (Krox-24) gene,exon 2. Mus musculus 40,566 21-MAY-1996 GB_HTG2: AC007440 120642AC007440 Drosophila melanogaster chromosome 2 clone BACR37I09 (D593)Drosophila melanogaster 36,753 2-Aug-99 RPCI-98 37.I.9 map 49A-49Bstrain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 103 unorderedpieces. rxa00218 rxa00220 627 GB_BA1: ASU04436 4668 U04436 Anabaena sp.PCC 7120 putative polyketide synthase gene, complete cds. Anabaena sp.33,766 21-DEC-1993 GB_RO: AF068199 3490 AF068199 Mus musculusD-dopachrome tautomerase gene, complete cds. Mus musculus 38,83326-Aug-98 GB_RO: AF068199 3490 AF068199 Mus musculus D-dopachrometautomerase gene, complete cds. Mus musculus 34,776 26-Aug-98 rxa002221269 GB_PL1: AB011477 78181 AB011477 Arabidopsis thaliana genomic DNA,chromosome 5, Arabidopsis thaliana 36,766 20-Nov-99 P1 clone: MHK7,complete sequence. GB_EST17: AA615900 427 AA615900 vo91b05.r1 Barsteadmouse irradiated colon MPLRB7 Mus musculus 39,782 07-OCT-1997 Musmusculus cDNA clone IMAGE: 1066449 5′ similar to SW: MUCL_RAT P98089INTESTINAL MUCIN-LIKE GB_EST38: AW039188 486 AW039188 EST281423 tomatomixed elicitor, BTI Lycopersicon esculentum Lycopersicon esculentum41,286 18-OCT-1999 PROTEIN;, mRNA sequence. cDNA clone cLET9F17, mRNAsequence. rxa00230 843 GB_PR3: AC005255 94343 AC005255 Homo sapienschromosome 19, CIT-HSP-146e8, complete sequence. Homo sapiens 35,996-Jul-98 GB_PR3: AC005255 94343 AC005255 Homo sapiens chromosome 19,CIT-HSP-146e8, complete sequence. Homo sapiens 38,175 6-Jul-98 rxa00232633 GB_HTG2: AC007118 200000 AC007118 Homo sapiens chromosome 4, ***SEQUENCING IN Homo sapiens 36,772 19-MAR-1999 PROGRESS ***, 45 unorderedpieces. GB_HTG2: AC007118 200000 AC007118 Homo sapiens chromosome 4, ***SEQUENCING IN Homo sapiens 36,772 19-MAR-1999 PROGRESS ***, 45 unorderedpieces. GB_GSS1: CNS004WZ 978 AL055537 Drosophila melanogaster genomesurvey sequence TET3 end of BAC # Drosophila melanogaster 34,5183-Jun-99 BACR11G02 of RPCI-98 library from Drosophila melanogaster(fruit fly), genomic survey sequence. rxa00233 517 GB_BA1: AB006206 7443AB006206 Streptomyces griseus AmfR, AmfA and AmfB genes and 4 ORFs,complete cds. Streptomyces griseus 38,69 5-Feb-99 GB_PR4: AC006999112878 AC006999 Homo sapiens clone NH0462A19, complete sequence. Homosapiens 40,244 17-Jul-99 GB_HTG2: AC007042 132400 AC007042 Homo sapiensclone NH0399H17, *** SEQUENCING IN Homo sapiens 40,244 06-MAR-1999PROGRESS ***, 5 unordered pieces. rxa00234 663 GB_PAT: E13059 3480E13059 gDNA encoding cytochrome b5. unidentified 40,091 24-Jun-98GB_PL1: AB022444 2104 AB022444 Mortierella alpina gene for cytochromeb5, complete cds. Mortierella alpina 42,314 14-Jul-99 GB_GSS9: AQ112619443 AQ112619 CIT-HSP-2371D11.TR CIT-HSP Homo sapiens genomic clone2371D11, Homo sapiens 39,623 29-Aug-98 genomic survey sequence. rxa00236849 GB_BA1: CGPROMF34 60 X90361 C. glutamicum DNA for promoter fragmentF34. Corynebacterium 98,333 4-Nov-96 glutamicum GB_IN1: CEF56G4 38062Z81552 Caenorhabditis elegans cosmid F56G4, complete sequence.Caenorhabditis elegans 36,19 08-OCT-1999 GB_EST16: C51159 370 C51159C51159 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryoCaenorhabditis elegans 41,096 18-OCT-1999 Caenorhabditis elegans cDNAclone yk491h3 5′, mRNA sequence. rxa00237 501 GB_GSS9: AQ148605 511AQ148605 HS_3137_B2_A11_T7 CIT Approved Human Genomic Sperm Homo sapiens37,959 08-OCT-1988 Library D Homo sapiens genomic clone Plate = 3137 Col= 22 Row = B, genomic survey sequence. GB_GSS11: AQ274889 622 AQ274889RPCI-5-1111N8T7 RPCI-5 Homo sapiens genomic clone Homo sapiens 44,62810-Nov-98 RPCI-5-1111N8T7, genomic survey sequence. GB_GSS11: AQ274889622 AQ274889 RPCI-5-1111N8T7 RPCI-5 Homo sapiens genomic clone Homosapiens 37,321 10-Nov-98 RPCI-5-1111N8T7, genomic survey sequence.rxa00238 492 GB_PL2: PBU91560 2605 U91560 Paracoccidioides brasiliensisheat shock protein 70 (Hsp70) gene, complete cds. Paracoccidioides37,137 12-MAR-1999 brasiliensis GB_HTG6: AC007957 212658 AC007957 Homosapiens, *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. Homo sapiens38,285 26-Nov-99 GB_PR4: AC009288 140876 AC009288 Homo sapiens, completesequence. Homo sapiens 36,575 19-Nov-99 rxa00239 708 GB_PL2: PBU915602605 U91560 Paracoccidioides brasiliensis heat shock protein 70 (Hsp70)gene, complete cds. Paracoccidioides 45,545 12-MAR-1999 brasiliensisGB_BA2: CJU96452 1450 U96452 Campylobacter jejuni major outer membraneporin gene, complete cds. Campylobacter jejuni 37,197 02-DEC-1998 GB_RO:RATPF4 1675 M15254 Rat platelet factor 4 (PF4) gene. Rattus norvegicus35,014 27-Apr-93 rxa00240 333 GB_BA1: CGLYSI 4232 X60312 C. glutamicumlysI gene for L-lysine permease. Corynebacterium 46,207 30-Jan-92glutamicum GB_PR3: AC005358 184886 AC005358 Homo sapiens chromosome 17,clone hRPK.746_E_8, complete sequence. Homo sapiens 35,843 29-Aug-98GB_BA1: CGLYSI 4232 X60312 C. glutamicum lysI gene for L-lysinepermease. Corynebacterium 42,025 30-Jan-92 glutamicum rxa00242 1401GB_BA1: CGLYSI 4232 X60312 C. glutamicum lysI gene for L-lysinepermease. Corynebacterium 100 30-Jan-92 glutamicum GB_PR3: HSJ514B11100494 AL049554 Human DNA sequence from clone 514B11 on chromosome6q16.1-21 Homo sapiens 37,01 23-Nov-99 Contains an EST, STSs and GSSs,complete sequence. GB_HTG3: AC009393 137353 AC009393 Drosophilamelanogaster chromosome 3 clone BACR17F05 (D977) Drosophila melanogaster39,6 27-Aug-99 RPCI-98 17.F.5 map 87D-87D strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 111 unordered pieces. rxa00244 759 GB_HTG4:AC011290 148409 AC011290 Homo sapiens clone NH0064I02, *** SEQUENCING INPROGRESS ***, Homo sapiens 38,102 15-OCT-1999 3 unordered pieces.GB_HTG4: AC011290 148409 AC011290 Homo sapiens clone NH0064I02, ***SEQUENCING IN PROGRESS ***, Homo sapiens 38,102 15-OCT-1999 3 unorderedpieces. GB_EST23: AI077162 527 AI077162 TENU338.4 T. cruzi epimastigotenormalized cDNA Library Trypanosoma cruzi 38,847 10-Aug-98 Trypanosomacruzi cDNA clone 28o6 5′ similar to TRANSPLANTATION ANTIGEN P35Bsp|P23591|TUM3_MOUSE, mRNA sequence. rxa00245 1608 GB_HTG2: AC007644141048 AC007644 Homo sapiens chromosome 17 clone hRPK.19_F_16 map Homosapiens 36,929 23-MAY-1999 17, *** SEQUENCING IN PROGRESS ***, 17unordered pieces. GB_HTG2: AC007644 141048 AC007644 Homo sapienschromosome 17 clone hRPK.19_F_16 map 17, *** SEQUENCING Homo sapiens36,929 23-MAY-1999 IN PROGRESS ***, 17 unordered pieces. GB_HTG2:AC007644 141048 AC007644 Homo sapiens chromosome 17 clone hRPK.19_F_16map 17, *** SEQUENCING Homo sapiens 34,025 23-MAY-1999 IN PROGRESS ***17, unordered pieces. rxa00247 1050 GB_PR2: AP000119 100000 AP000119Homo sapiens genomic DNA of 21q22.1, GART and AML related, SLC5A3-f4A4Homo sapiens 36,187 25-Sep-99 region, segment 2/8, complete sequence.GB_PR2: AP000051 100000 AP000051 Homo sapiens genomic DNA, chromosome21q22.1, Homo sapiens 36,187 20-Nov-99 segment 22/28, complete sequence.GB_PR2: AP000166 100000 AP000166 Homo sapiens genomic DNA, chromosome21q22.1, D21S226-AML region, Homo sapiens 37,942 20-Nov-99 cloneB2344F14-f50E8, segment 2/9, complete sequence. rxa00248 846 GB_PR4:AC006464 99908 AC006484 Homo sapiens BAC clone NH0436C12 from 2,complete sequence. Homo sapiens 36,797 22-OCT-1999 GB_PR4: AC006238211945 AC006238 Homo sapiens chromosome 18, clone hRPK.474_N_24,complete sequence. Homo sapiens 32,896 31-Jan-99 GB_PR4: AC006238 211945AC006238 Homo sapiens chromosome 18, clone hRPK.474_N_24, completesequence. Homo sapiens 34,438 31-Jan-99 rxa00250 870 GB_GSS10: AQ244736469 AQ244736 HS_2056_B1_F03_T7 CIT Approved Human Genomic Sperm Homosapiens 36,31 03-OCT-1998 Library D Homo sapiens genomic clone Plate =2056 Col = 5 Row = L, genomic survey sequence. GB_PAT: I07323 340 I07323Sequence 5 from Patent EP 0331961. Unknown. 38,125 02-DEC-1994 GB_PR1:HS11Q13RP 10777 Y12377 H. sapiens FGF/Int-2 gene upstream flankingregion. Homo sapiens 36,155 17-Apr-97 rxa00252 366 GB_BA1: MTCY20G937218 Z77162 Mycobacterium tuberculosis H37Rv complete genome; segment25/162. Mycobacterium 39,554 17-Jun-98 tuberculosis GB_BA1: MTV004 69350AL009198 Mycobacterium tuberculosis H37Rv complete genome; segment144/162. Mycobacterium 40,443 18-Jun-98 tuberculosis GB_BA1: MTV00469350 AL009198 Mycobacterium tuberculosis H37Rv complete genome; segment144/162. Mycobacterium 41,803 18-Jun-98 tuberculosis rxa00256 894GB_PR4: AC005343 137213 AC005343 Homo sapiens Chromosome 12p13.3 BACRPCI11-21K20 (Roswell Park Homo sapiens 36,436 2-Apr-99 Cancer InstituteHuman BAC Library) complete sequence. GB_PR3: AC003005 45084 AC003005Human DNA from chromosome 19-specific cosmid F25419 containing ZNF Homosapiens 36,395 22-OCT-1997 gene family members, genomic sequence,complete sequence. GB_HTG3: AC007930 67668 AC007930 Drosophilamelanogaster chromosome 2 clone BACR49A06 (D772) Drosophila melanogaster32,503 20-Sep-99 RPCI-98 49.A.6 map 43B-43B strain y; cn bw sp, ***SEQUENCING IN PROGRESS***, 40 unordered pieces. rxa00257 579 GB_PR4:AC005343 137213 AC005343 Homo sapiens Chromosome 12p13.3 BACRPCI11-21K20 (Roswell Park Cancer Homo sapiens 37,063 2-Apr-99 InstituteHuman BAC Library) complete sequence. GB_HTG1: HS1096J16 194423 AL121721Homo sapiens chromosome 20 clone RP5-1096J16, *** SEQUENCING IN Homosapiens 37,217 23-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1:HS1096J16 194423 AL121721 Homo sapiens chromosome 20 clone RP5-1096J16,*** SEQUENCING IN Homo sapiens 37,217 23-Nov-99 PROGRESS ***, inunordered pieces. rxa00258 795 GB_PR3: HSJ747H23 114201 AL049699 HumanDNA sequence from clone 747H23 on chromosome 6q13-15, Contains the 3′Homo sapiens 36,469 23-Nov-99 part of the ME1 gene for malic enzyme 1,soluble (NADP-dependent malic enzyme, malate oxidoreductase, EC1.1.1.40), a novel gene and the 5′ part of the gene forN-acetylglucosamine-phosphate mutase. Contains ESTs, STSs, GSSs and twoputative CpG islands, complete sequence. GB_HTG2: H5J202D23 175496AL121716 Homo sapiens chromosome 6 clone RP1-202D23 map q14.1-15, ***SEQUENCING Homo sapiens 36,469 03-DEC-1999 IN PROGRESS ***, in unorderedpieces. GB_HTG2: HSJ202D23 175496 AL121716 Homo sapiens chromosome 6clone RP1-202D23 map q14.1-15, *** SEQUENCING Homo sapiens 36,46903-DEC-1999 IN PROGRESS ***, in unordered pieces. rxa00260 1299 GB_PR3:HS360B4 23388 AL031716 Human DNA sequence from clone 360B4 on chromosome16. Contains part of Homo sapiens 36,145 23-Nov-99 a gene for a PUTATIVEnovel protein similar to predicted bacterial and worm proteins and ESTs,complete sequence. GB_EST19: AA741904 423 AA741904 LmLv39p3/71ALeishmania major promastigote full length cDNA library from earlyLeishmania major 39,192 10-DEC-1998 logarithmic stage (day 3) Leishmaniamajor cDNA clone 71A 5′, mRNA sequence. GB_PR3: HS360B4 23388 AL031716Human DNA sequence from clone 360B4 on chromosome 16. Contains part ofHomo sapiens 39,494 23-Nov-99 a gene for a PUTATIVE novel proteinsimilar to predicted bacterial and worm proteins and ESTs, completesequence. rxa00264 rxa00267 441 GB_GSS10: AQ258013 761 AQ258013nbxb0019H05f CUGI Rice BAC Library Oryza sativa genomic clonenbxb0019H05f, Oryza sativa 52,033 23-OCT-1998 genomic survey sequence.GB_EST10: AA167894 552 AA167894 CpEST 021 uniZAPCpIOWAsporoLib1Cryptosporidium parvum cDNA 5′ similar Cryptosporidium parvum 40,46219-DEC-1996 to lactate dehydrogenase, mRNA sequence. GB_HTG3: AC011591129431 AC011591 Homo sapiens chromosome 17 clone 118_B_18 map 17, ***SEQUENCING IN Homo sapiens 35,469 07-OCT-1999 PROGRESS ***, 25 unorderedpieces. rxa00271 1113 GB_PL1: CHTRP1 3480 X70035 C. heterostrophus genefor trifunctional tryptophan synthase. Cochliobolus 41,636 31-OCT-1996heterostrophus GB_VI: FLU47643 1492 U47643 Feline leukemia virus Notch2gene, clone FeLV/Notch2-AP (subgenomic), partial cds. Feline leukemiavirus 37,869 25-OCT-1996 GB_VI: FLU47644 1641 U47644 Feline leukemiavirus Notch2 gene, clone FeLV/Notch2-B, partial cds. Feline leukemiavirus 36,441 25-OCT-1996 rxa00272 495 GB_GSS8: AQ041841 373 AQ041841CIT-HSP-2335L1.TR CIT-HSP Homo sapiens genomic clone 2335L1, genomicHomo sapiens 45,455 14-Jul-98 survey sequence. GB_GSS13: AQ429301 591AQ429301 CITBI-E1-2562H16.TR CITBI-E1 Homo sapiens genomic clone2562H16, Homo sapiens 63,636 24-MAR-1999 genomic survey sequence.GB_GSS10: AQ237541 667 AQ237541 RPCI11-61O21.TJB.1 RPCI-11 Homo sapiensgenomic clone RPCI-11-61O21, Homo sapiens 62,222 21-Apr-99 genomicsurvey sequence. rxa00273 1236 GB_BA1: CGBETPGEN 2339 X93514 C.glutamicum betP gene. Corynebacterium 44,056 8-Sep-97 glutamicum GB_PR2:HS142F18 141672 AL031073 Human DNA sequence from clone 142F18 onchromosome Xq26.3-27.2 Contains Homo sapiens 44,643 23-Nov-99 part of agene similar to melanoma-associated antigen, EST, GSS and an invertedrepeat, complete sequence. GB_IN2: AC007177 101320 AC007177 Drosophilamelanogaster, chromosome 2R, region 59C1-59C5, P1 clones DS06821Drosophila melanogaster 36,721 27-MAR-1999 and DS02186, completesequence. rxa00274 2733 GB_HTG3: AC011675 98026 AC011675 Homo sapiensclone 10_J_17, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 35,40510-OCT-1999 GB_HTG3: AC011675 98026 AC011675 Homo sapiens clone 10_J_17,LOW-PASS SEQUENCE SAMPLING. Homo sapiens 35,405 10-OCT-1999 GB_HTG3:AC010598 174019 AC010598 Homo sapiens chromosome 5 clone CIT-HSPC_560O9,*** SEQUENCING IN Homo sapiens 36,908 16-Sep-99 PROGRESS ***, 50unordered pieces. rxa00275 582 GB_GSS14: AQ574926 666 AQ574926nbxb0086K14f CUGI Rice BAC Library Oryza sativa genomic clonenbxb0086K14f, Oryza sativa 33,83 2-Jun-99 genomic survey sequence.GB_HTG2: AC004396 43686 AC004396 Homo sapiens, *** SEQUENCING INPROGRESS ***, 2 unordered pieces. Homo sapiens 38,298 19-Jul-99 GB_HTG2:AC004396 43686 AC004396 Homo sapiens, *** SEQUENCING IN PROGRESS ***, 2unordered pieces. Homo sapiens 38,298 19-Jul-99 rxa00276 465 GB_PL1:SC9952X 29286 Z49212 S. cerevisiae chromosome XIII cosmid 9952.Saccharomyces cerevisiae 37,118 11-Aug-97 GB_PL1: S45357 4017 S45357PSE-1 = protein secretion enhancer [Saccharomyces cerevisise, Genomic,4017 nt]. Saccharomyces cerevisiae 41,394 08-MAY-1993 GB_PL1: SCPSE1G4017 Z11538 S. cerevisiae PSE-1 gene. Saccharomyces cerevisiae 41,39413-Aug-96 rxa00279 1509 GB_HTG3: AC009911 99707 AC009911 Drosophilamelanogaster chromosome 2 clone BACR01N17 (D1036) RPCI-98 Drosophilamelanogaster 33,023 05-OCT-1999 01.N.17 map 38A- 38A strain y; cn bw sp,*** SEQUENCING IN PROGRESS ***, 69 unordered pieces. GB_HTG3: AC00991199707 AC009911 Drosophila melanogaster chromosome 2 clone BACR01N17(D1036) RPCI-98 Drosophila melanogaster 33,023 05-OCT-1999 01.N.17 map38A- 38A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 69unordered pieces. GB_HTG4: AC008397 230451 AC008397 Homo sapienschromosome 19 clone CIT-HSPC_251H24, ***, SEQUENCING IN Homo sapiens37,432 31-OCT-1999 PROGRESS ***, 81 unordered pieces. rxa00282 889GB_PR3: HSB11B7 37290 Z82171 Human DNA sequence from cosmid B11B7 onchromosome 22 contains ESTs. Homo sapiens 35,845 23-Nov-99 GB_PR3:HSB11B7 37290 Z82171 Human DNA sequence from cosmid B11B7 on chromosome22 contains ESTs. Homo sapiens 37,126 23-Nov-99 GB_RO: RATMTA 4197L39264 Rattus norvegicus beta-2 adrenergic receptor gene, complete cdsand promoter region. Rattus norvegicus 41,259 23-Feb-96 rxa00283 1155GB_GSS8: AQ030327 411 AQ030327 HS_2177_B1_H06_MF CIT Approved HumanGenomic Sperm Library D Homo Homo sapiens 37,656 1-Jul-98 sapiensgenomic clone Plate = 2177 Col = 11 Row = P, genomic survey sequence.GB_PR3: HSL118GB 27858 Z68883 Human DNA sequence from cosmid L118G10,Huntington's Disease Region, Homo sapiens 37,412 23-Nov-99 chromosome4p16.3. GB_PR3: HSJ513G18 110770 AL109760 Human DNA sequence from clone513G18 on chromosome 4, complete sequence. Homo sapiens 37,412 23-Nov-99rxa00286 687 GB_EST10: AA157040 414 AA157040 zo51c05.r1 Stratageneendothelial cell 937223 Homo sapiens cDNA clone IMAGE: Homo sapiens37,136 11-DEC-1996 590408 5′ similar to gb: M84711 40S RIBOSOMAL PROTEINS3A (HUMAN);, mRNA sequence. GB_EST11: AA213935 629 AA213935 zn57a04.r1Stratagene muscle 937209 Homo sapiens cDNA clone IMAGE: Homo sapiens34,219 1-Aug-97 562254 5′ similar to gb: M84711 40S RIBOSOMAL PROTEINS3A (HUMAN);, mRNA sequence. GB_STS: BLYBG 459 L43987 Hordeum vulgare(clone ABG380) chromosome 4H, 6H, 7H STS mRNA, Hordeum vulgare 37,78627-Jul-95 sequence tagged site. rxa00294 552 GB_PR2: HSAC000121 93163AC000121 Human BAC clone RG249A12 from 7q22, complete sequence. Homosapiens 36,735 31-Jan-97 GB_BA2: CGU31281 1614 U31281 Corynebacteriumglutamicum biotin synthase (bioB) gene, complete cds. Corynebacterium100 21-Nov-96 glutamicum GB_PR2: HSAC000121 93163 AC000121 Human BACclone RG249A12 from 7q22, complete sequence. Homo sapiens 37,66231-Jan-97 rxa00297 1035 GB_HTG2: AC006938 82665 AC006938 Drosophilamelanogaster chromosome 2 clone DS01630 (D506) map 60C7-60C8 Drosophilamelanogaster 37,241 2-Aug-99 strain y; cn bw sp, *** SEQUENCING INPROGRESS ***, 9 unordered pieces. GB_HTG2: AC007116 25478 AC007116Drosophila melanogaster chromosome 2 clone DS04467 (D447) map 60C6-60C8Drosophila melanogaster 38,63 30-Jul-99 strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 5 unordered pieces. GB_HTG2: AC006938 82665AC006938 Drosophila melanogaster chromosome 2 clone DS01630 (D506) map60C7-60C8 Drosophila melanogaster 37,241 2-Aug-99 strain y; cn bw sp,*** SEQUENCING IN PROGRESS ***, 9 unordered pieces. rxa00320 303GB_GSS14: AQ585202 564 AQ585202 RPCI-11-451L11.TJ RPCI-11 Homo sapiensgenomic clone RPCI-11-451L11, Homo sapiens 37,319 7-Jun-99 genomicsurvey sequence. GB_BA1: NGPILC1 3144 Y13022 N. gonorrhoeae pilC1 gene,strain 640. Neisseria gonorrhoeae 38,667 07-OCT-1997 GB_BA1: NGPILC13144 Y13022 N. gonorrhoeae pilC1 gene, strain 640. Neisseria gonorrhoeae36 07-OCT-1997 rxa00321 rxa00322 1227 GB_HTG2: AC007533 153053 AC007533Homo sapiens chromosome 16 clone 474B12, *** SEQUENCING IN Homo sapiens39,469 12-MAY-1999 PROGRESS ***, 5 ordered pieces. GB_HTG2: AC007533153053 AC007533 Homo sapiens chromosome 16 clone 474B12, *** SEQUENCINGIN Homo sapiens 39,469 12-MAY-1999 PROGRESS ***, 5 ordered pieces.GB_PR2: HUM133K23 82512 AC000061 Human BAC clone 133K23 from 7q31.2,complete sequence. Homo sapiens 38,95 14-Nov-96 rxa00325 768 GB_BA2:CDU73860 1273 U73860 Corynebacterium diphtheriae heme oxygenase homolog(hmuO) gene, complete cds. Corynebacterium 52,604 7-Feb-97 diphtheriaeGB_BA1: AB019621 652 AB019621 Corynebacterium diphtheriae mRNA for Hemeoxygenase, complete cds. Corynebacterium 55,675 31-Jul-99 diphtheriaeGB_EST23: AI096171 554 AI096171 28 EcoRI Rice Etiolated Leaf cDNALibrary Oryza sativa cDNA clone RZ513, Oryza sativa 38,536 19-Aug-98mRNA sequence. rxa00326 603 GB_PH: MYP4CG 11624 X51522 Bacteriophage P4complete DNA genome. Bacteriophage P4 40,577 17-Feb-97 GB_PH: MYP4ALPH3063 X05623 Bacteriophage P4 alpha gene and cis replication region crr.Bacteriophage P4 38,64 12-Sep-93 GB_IN1: CEF22B3 30480 Z68336Caenorhabditis elegans cosmid F22B3, complete sequence. Caenorhabditiselegans 39,012 2-Sep-99 rxa00334 459 GB_BA1: CGGLNA 3686 Y13221Corynebacterium glutamicum glnA gene. Corynebacterium 37,64 28-Aug-97glutamicum GB_GSS10: AQ248516 259 AQ248516 T5J22-Sp6 TAMU Arabidopsisthaliana genomic clone T5J22, genomic Arabidopsis thaliana 38,52506-OCT-1998 survey sequence. GB_BA1: CGGLNA 3686 Y13221 Corynebacteriumglutamicum glnA gene. Corynebacterium 40,487 28-Aug-97 glutamicumrxa00336 594 GB_BA1: CGGLNA 3686 Y13221 Corynebacterium glutamicum glnAgene. Corynebacterium 34,797 28-Aug-97 glutamicum GB_OV: XLFIMB1GN 7026X95549 X. laevis FIM-B.1 gene. Xenopus laevis 33,217 13-Feb-97 GB_BA1:CGGLNA 3686 Y13221 Corynebacterium glutamicum glnA gene. Corynebacterium37,371 28-Aug-97 glutamicum rxa00337 1173 GB_BA1: CGU43536 3464 U43536Corynebacterium glutamicum heat shock, ATP-binding protein (clpB) gene,Corynebacterium 36,406 13-MAR-1997 complete cds. glutamicum GB_BA1:CGAJ4934 1160 AJ004934 Corynebacterium glutamicum dapD gene, completeCDS. Corynebacterium 39,734 17-Jun-98 glutamicum GB_EST37: AI944838 396AI944838 bs06a08.y1 Drosophila melanogaster adult testis libraryDrosophila melanogaster Drosophila melanogaster 37,626 17-Aug-99 cDNAclone bs06a08 5′, mRNA sequence. rxa00338 1263 GB_BA1: BLTRP 7725 X04960Brevibacterium lactofermentum tryptophan operon. Corynebacterium 39,7910-Feb-99 glutamicum GB_PAT: E01688 7725 E01688 Genomic DNA of trpoperon of prepibacterium latophelmentamn. unidentified 39,871 29-Sep-97GB_PAT: E01375 7726 E01375 DNA sequence of tryptophan operon.Corynebacterium 39,871 29-Sep-97 glutamicum rxa00339 840 GB_VI: OPU75930131993 U75930 Orgyia pseudotsugata nuclear polyhedrosis virus completegenome. Orgyia pseudotsugata 38,264 06-MAR-1998 nuclear polyhedrosisvirus GB_VI: OPU75930 131993 U75930 Orgyia pseudotsugata nuclearpolyhedrosis virus complete genome. Orgyia pseudotsugata 38,6206-MAR-1998 nuclear polyhedrosis virus GB_HTG3: AC008340 126593 AC008340Drosophila melanogaster chromosome 2 clone BACR07J20 (D918) RPCI-9807.J.20 Drosophila melanogaster 38,193 6-Aug-99 map 42D-42E strain y; cnbw Sp, *** SEQUENCING IN PROGRESS ***, 92 unordered pieces. rxa00342 552GB_EST34: AI794353 636 AI794353 fc43d12.y1 Zebrafish WashU MPIMG ESTDanio rerio cDNA 5′ similar to Danio rerio 40,283 2-Jul-99 TR: Q62868Q62868 ROK-ALPHA.;, mRNA sequence. GB_PR2: U73635 33676 U73635 HumanChromosome 11 Cosmid cSRL156b6, complete sequence. Homo sapiens 39,36625-Jul-97 GB_PR2: U73635 33676 U73635 Human Chromosome 11 CosmidcSRL156b6, complete sequence. Homo sapiens 37,97 25-Jul-97 rxa00344 1002GB_HTG2: HS312E8 33595 AL032819 Homo sapiens chromosome 16 cloneLA16-312E8, *** SEQUENCING IN Homo sapiens 40,415 03-DEC-1999 PROGRESS***, in unordered pieces. GB_HTG2: HS312E8 33595 AL032819 Homo sapienschromosome 16 clone LA16-312E8, *** SEQUENCING IN Homo sapiens 40,41503-DEC-1999 PROGRESS ***, in unordered pieces. GB_OM: BOVINOPHOS 1573M55916 Bovine inositol polyphosphate 1-phosphatase (inositolpolyphosphate 1-phosphatase Bos taurus 38,42 27-Apr-93 gene) mRNA,complete cds. rxa00349 1590 GB_PR3: HS353E16 189765 AL031591 Human DNAsequence from clone 353E16 on chromosome 22q11.22-12.3, Homo sapiens34,766 23-Nov-99 complete sequence. GB_HTG2: AC005059 170128 AC005059Homo sapiens clone RG074A24, *** SEQUENCING IN PROGRESS ***, 25 Homosapiens 37,011 13-MAR-1999 unordered pieces. GB_HTG2: AC005059 170128AC005059 Homo sapiens clone RG074A24, *** SEQUENCING IN PROGRESS ***, 25Homo sapiens 37,011 13-MAR-1999 unordered pieces. rxa00353 816 GB_BA1:D87976 2352 D87976 Brevibacterium lactofermentum DNA forD-2-hydroxyisocaproate dehydrogenase Corynebacterium 39,29 7-Feb-99(ddh), complete cds. glutamicum GB_BA1: CGDDH 1829 Y00151Corynebacterium glutamicum ddh gene for meso-diaminopimelateD-dehydrogenase Corynebacterium 39,342 12-Sep-93 (EC 1.4.1.16).glutamicum GB_BA1: CGDDH 1829 Y00151 Corynebacterium glutamicum ddh genefor meso-diaminopimelate D-dehydrogenase Corynebacterium 38,62412-Sep-93 (EC 1.4.1.16). glutamicum rxa00355 1143 GB_BA1: CGDDH 1829Y00151 Corynebacterium glutamicum ddh gene for meso-diaminopimelateD-dehydrogenase Corynebacterium 100 12-Sep-93 (EC 1.4.1.16). glutamicumGB_BA1: D87976 2352 D87976 Brevibacterium lactofermentum DNA forD-2-hydroxyisocaproate dehydrogenase Corynebacterium 98,411 7-Feb-99(ddh), complete cds. glutamicum GB_PAT: E14511 1034 E14511 DNA encodingBrevibacterium diaminopimelic acid dehydrogenase. Corynebacterium 10028-Jul-99 glutamicum rxa00362 1470 GB_HTG4: AC009043 170748 AC009043Homo sapiens chromosome 16 clone RPCI-11_184F14, *** SEQUENCING IN Homosapiens 37,337 31-OCT-1999 PROGRESS ***, 122 unordered pieces. GB_HTG4:AC009043 170748 AC009043 Homo sapiens chromosome 16 cloneRPCI-11_184F14, *** SEQUENCING IN Homo sapiens 37,337 31-OCT-1999PROGRESS ***, 122 unordered pieces. GB_PR4: HSZO2TJP09 811 AF177521 Homosapiens tight junction protein ZO-2 (TJP2) gene, exons 8 and 9. Homosapiens 40,758 28-Sep-99 rxa00373 439 GB_PAT: AR004983 2277 AR004983Sequence 5 from patent U.S. Pat. No. 5747317. Unknown. 41,63804-DEC-1998 GB_EST37: AI967505 380 AI967505 Ljirnpest03-215-c10 LjirnpLambda HybriZap two-hybrid library Lotus japonicus Lotus japonicus45,882 24-Aug-99 cDNA clone LP215-0.3-c10 5′ similar to 60S ribosomalprotein L39, mRNA sequence. GB_EST27: AI399460 670 AI399460 NCSP4F6T7Subtracted Perithecial Neurospora crassa cDNA clone SP4F6 3′, Neurosporacrassa 38,571 8-Feb-99 mRNA sequence. rxa00375 624 GB_IN2: AC00444561852 AC004445 Drosophila melanogaster DNA sequence (P1 DS00445 (D93)),complete sequence. Drosophila melanogaster 37,236 01-MAY-1998 GB_HTG6:AC011694 160557 AC011694 Homo sapiens clone RP11-19D19, *** SEQUENCINGIN PROGRESS ***, 33 Homo sapiens 34,087 03-DEC-1999 unordered pieces.GB_HTG6: AC011694 160557 AC011694 Homo sapiens clone RP11-19D19, ***SEQUENCING IN PROGRESS ***, 33 Homo sapiens 40,523 03-DEC-1999 unorderedpieces. rxa00380 744 GB_BA1: COXHSPAB 2302 M20482 C. burnetii heat shockoperon encoding two heat shock proteins (htpA and htpB), Coxiellaburnetii 37,788 26-Apr-93 complete cds. GB_RO: CBGPIMR 1735 Z37977 C.barabensis (griseus) mRNA for glucose phosphate isomerase. Cricetulusgriseus 37,823 14-Sep-95 GB_GSS10: AQ172617 505 AQ172617HS_3197_A2_G09_T7 CIT Approved Human Genomic Sperm Library D Homo Homosapiens 37,58 17-OCT-1998 sapiens genomic clone Plate = 3197 Col = 18Row = M, genomic survey sequence. rxa00387 978 GB_BA1: MTY25D10 40838Z95558 Mycobacterium tuberculosis H37Rv complete genome; segment 28/162.Mycobacterium 60,477 17-Jun-98 tuberculosis GB_BA1: MSGY224 40051AD000004 Mycobacterium tuberculosis sequence from clone y224.Mycobacterium 60,27 03-DEC-1998 tuberculosis GB_BA1: U00018 42991 U00018Mycobacterium leprae cosmid B2168. Mycobacterium leprae 37,91301-MAR-1994 rxa00390 528 GB_IN1: DMU29153 8230 U29153 Drosophilamelanogaster nudel (ndl) mRNA, complete cds. Drosophila melanogaster36,19 08-DEC-1995 GB_IN1: DMU29153 8230 U29153 Drosophila melanogasternudel (ndl) mRNA, complete cds. Drosophila melanogaster 37,20208-DEC-1995 rxa00392 987 GB_IN2: AE001274 268984 AE001274 Leishmaniamajor chromosome 1, complete sequence. Leishmania major 37,88524-MAR-1999 GB_EST11: AA270543 516 AA270543 va68h06.r1 Soares mouse3NME12 5 Mus musculus cDNA clone IMAGE: 736571 Mus musculus 40,54626-MAR-1997 5′, mRNA sequence. GB_IN2: AE001274 268984 AE001274Leishmania major chromosome 1, complete sequence. Leishmania major36,103 24-MAR-1999 rxa00394 456 GB_GSS9: AQ158990 728 AQ158990nbxb0012L11r CUGI Rice BAC Library Oryza sativa genomic clonenbxb0012L11r, Oryza sativa 41,463 12-Sep-98 genomic survey sequence.GB_GSS12: AQ342952 761 AQ342952 RPCI11-122O15.TV RPCI-11 Homo sapiensgenomic clone RPCI-11-122O15, Homo sapiens 37,556 07-MAY-1999 genomicsurvey sequence. GB_GSS9: AQ158990 728 AQ158990 nbxb0012L11r CUGI RiceBAC Library Oryza sativa genomic clone nbxb0012L11r, Oryza sativa 37,92312-Sep-98 genomic survey sequence. rxa00395 423 GB_PR2: HS1052M9 134245AL022718 Human DNA sequence from clone 1052M9 on chromosome Xq25.Contains the Homo sapiens 43,564 23-Nov-99 SH2D1A gene for SH2 domainprotein 1A, Duncan's disease (lymphoproliferative syndrome) (DSHP), partof a 60S Acidic Ribosomal protein 1 (RPLP1) LIKE gene and part of amouse DOC4 LIKE gene. Contains ESTs and GSSs, complete sequence. GB_BA2:RCPHSYNG 45959 Z11165 R. capsulatus complete photosynthesis genecluster. Rhadobacter capsulatus 36,930 2-Sep-99 GB_PR2: HS1052M9 134245AL022718 Human DNA sequence from clone 1052M9 on chromosome Xq25.Contains the Homo sapiens 33,981 23-Nov-99 SH2D1A gene for SH2 domainprotein 1A, Duncan's disease (lymphoproliferative syndrome) (DSHP), partof a 60S Acidic Ribosomal protein 1 (RPLP1) LIKE gene and part of amouse DOC4 LIKE gene. Contains ESTs and GSSs, complete sequence.rxa00396 594 GB_PL2: AC002311 85855 AC002311 Arabidopsis thalianachromosome I BAC T26J12 genomic sequence, complete Arabidopsia thaliana38,957 4-Feb-98 sequence. GB_PL2: AC002311 85855 AC002311 Arabidopsisthaliana chromosome I BAC T26J12 genomic sequence, complete Arabidopsisthaliana 36,3 4-Feb-98 sequence. rxa00397 924 GB_PL1: HASMT 27694 D31785Hansenula wingei mitochondrial DNA, complete sequence. MitochondrionPichia 33,985 10-Jun-99 canadensis GB_PL1: HASMT 27694 D31785 Hansenulawingel mitochondrial DNA. complete sequence. Mitochondrion Pichia 33,77510-Jun-99 canadensis rxa00398 873 GB_HTG1: CNS01DRT 222150 AL118557 Homosapiens chromosome 14 clone R-1033H12, *** SEQUENCING IN Homo sapiens35,417 25-Sep-99 PROGRESS ***, in ordered pieces. GB_HTG1: CNS01DRT222150 AL118557 Homo sapiens chromosome 14 clone R-1033H12, ***SEQUENCING IN Homo sapiens 35,417 25-Sep-99 PROGRESS ***, in orderedpieces. GB_HTG1: CNS01DRT 222150 AL118557 Homo sapiens chromosome 14clone R-1033H12, *** SEQUENCING IN Homo sapiens 38,005 25-Sep-99PROGRESS ***, in ordered pieces. rxa00399 438 GB_IN1: CELC32B5 42545U80843 Caenorhabditis elegans cosmid C32B5. Caenorhabditis elegans36,468 05-DEC-1996 GB_IN1: CELC32B5 42545 U80843 Caenorhabditis eleganscosmid C32B5. Caenorhabditis elegans 40 05-DEC-1996 rxa00408 570 GB_PR4:AC005940 158414 AC005940 Homo sapiens chromosome 17, clone hRPK.167_N_20, complete sequence. Homo sapiens 35,219 18-MAR-1999 GB_PR1:HSSERCA11 3050 Y15726 Homo sapiens SERCA3 gene, exons 11-14. Homosapiens 35,036 30-Jun-98 GB_PR4: AC005940 158414 AC005940 Homo sapienschromosome 17, clone hRPK. 167_N_20, complete sequence. Homo sapiens36,926 18-MAR-1999 rxa00409 1536 GB_PR1: HSSERCA11 3050 Y15726 Homosapiens SERCA3 gene, exons 11-14. Homo sapiens 38,555 30-Jun-98 GB_PR4:AC005940 158414 AC005940 Homo sapiens chromosome 17, clone hRPK.167_N_20, complete sequence. Homo sapiens 36,37 18-MAR-1999 GB_PR3:HS591B8 142552 AL035410 Human DNA sequence from clone 591B8 onchromosome 1p13.1. complete sequence. Homo sapiens 35,891 23-Nov-99rxa00411 798 GB_BA1: AP000003 233000 AP000003 Pyrococcus horikoshii OT3genomic DNA, 544001-777000 nt. position (3/7). Pyrococcus horikoshii36,849 8-Feb-99 GB_PL2: F25A4 115721 AC008263 Arabidopsis thalianachromosome 1 BAC F25A4 sequence, complete sequence. Arabidopsis thaliana37,628 15-Sep-99 GB_PR3: HS413H6 142599 AL022724 Human DNA sequence fromclone 413H6 on chromosome 6p22.3-24.3. Contains Homo sapiens 36,75523-Nov-99 a hamster Androgen-dependent Expressed Protein like proteingene, ESTs and GSSs, complete sequence. rxa00416 1673 GB_EST8: C10137360 C10137 C10137 Yuji Kohara unpublished cDNA: Strain N2 hermaphroditeembryo Caenorhabditis elegans 35,574 18-OCT-1999 Caenorhabditis eleganscDNA clone yk188a1 5′, mRNA sequence. GB_EST36: AV186952 376 AV186952AV186952 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryoCaenorhabditis elegans 36,702 22-Jul-99 Caenorhabditis elegans cDNAclone yk506a5 5′, mRNA sequence. GB_EST16: C48235 383 C48235 C48235 YujiKohara unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabdiliselegans 42,44 18-OCT-1999 Caenorhabditis elegans cDNA clone yk459h10 5′,mRNA sequence. rxa00422 1017 GB_BA1: MTCY227 35946 Z77724 Mycobacteriumtuberculosis H37RV complete genome; segment 114/162. Mycobacterium39,822 17-Jun-98 tuberculosis GB_BA1: MTV023 47852 AL022022Mycobacterium tuberculosis H37Rv complete genome; segment 148/162.Mycobacterium 39,841 17-Jun-98 tuberculosis GB_PR3: AC003091 137817AC003091 Human BAC clone RG326G04 from 7p21, complete sequence. Homosapiens 36,653 6-Nov-97 rxa00423 576 GB_BA1: AP000063 185300 AP000063Aeropyrum pernix genomic DNA, section 6/7. Aeropyrum pernix 38,90822-Jun-99 GB_IN1: LDHSP100 7726 Z94053 L. donovani hsp 100 gene.Leishmania donovani 39,646 28-Apr-97 GB_GSS11: AQ274393 572 AQ274393nbxb0035G12r CUGI Rice BAC Library Oryza sativa genomic clonenbxb0035G12r, Oryza sativa 35,714 3-Nov-98 genomic survey sequence.rxa00424 594 GB_BA1: AP000063 185300 AP000063 Aeropyrum pernix genomicDNA, section 6/7. Aeropyrum pernix 38,225 22-Jun-99 GB_BA1: AP000063185300 AP000063 Aeropyrum pernix genomic DNA, section 6/7. Aeropyrumpernix 36,735 22-Jun-99 GB_IN1: LDHSP100 7726 Z94053 L. donovani hsp100gene. Leishmania donovani 35,125 28-Apr-97 rxa00425 348 GB_EST30:AV021214 281 AV021214 AV021214 Mus musculus 18-day embryo C57BL/6J Musmusculus cDNA clone Mus musculus 35,849 28-Aug-99 1190021P08, mRNAsequence. GB_HTG3: AC009278 164119 AC009278 Homo sapiens clone 44_J_4,*** SEQUENCING IN PROGRESS ***, Homo sapiens 36,705 12-Aug-99 14unordered pieces. GB_HTG3: AC009278 164119 AC009278 Homo sapiens clone44_J_4, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,705 12-Aug-99 14unordered pieces. rxa00428 756 GB_BA2: AF127082 10847 AF127082Myxococcus xanthus ATP-dependent protease proteolytic subunit ClpP(clpP), Myxococcus xanthus 40,995 18-MAY-1999 ATP-dependent proteaseATPase subunit ClpX (clpX), prolyl endopeptidase precursor Pep (pep),ATP-dependent protease LonV(lonV), oligopeptide permease homolog OppA(oppA), oligopeptide permease homolog OppB (oppB), and oligopeptidepermease homolog OppC (oppC) genes, complete cds. GB_PL1: AB017080 653AB017080 Porphyra sp. DNA, internal transcribed spacer 1 (ITS1).Porphyra sp. 38,491 10-Sep-99 GB_EST27: AI442425 541 AI442425 sa26g05.y1Gm-c1004 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Glycine max 4001-DEC-1999 Gm-c1004-465 5′ similar to SW: NDC1_RABIT Q28615 RENALSODIUM/DICARBOXYLATE COTRANSPORTER;, mRNA sequence. rxa00429 525GB_EST3: R33129 440 R33129 yh81c08.s1 Soares placenta Nb2HP Homo sapienscDNA clone IMAGE: 136142 Homo sapiens 37,216 28-Apr-95 3′ similar to gb:X53742_rna1 FIBULIN 1, ISOFORM B PRECURSOR (HUMAN);, mRNA sequence.GB_PH: AF115103 40739 AF115103 Streptococcus thermophilus bacteriophageSfi21, complete genome. Streptococcus 36,069 18-Jul-99 thermophilusbacteriophage Sfi21 GB_PH: AF115102 37370 AF115102 Streptococcusthermophilus bacteriophage Sfi19, complete genome. Streptococcus 36,2618-Jul-99 thermophilus bacteriophage Sfi19 rxa00430 534 GB_BA1: MSGY12637164 AD000012 Mycobacterium tuberculosis uence from clone y126.Mycobacterium 55,491 10-DEC-1996 tuberculosis GB_BA1: MTY13D12 37085Z80343 Mycobacterium tuberculosis Rv complete genome; segment 156/162.Mycobacterium 55,491 17-Jun-98 tuberculosis GB_BA1: MSGB971CS 37566L78821 Mycobacterium leprae mid B971 DNA sequence. Mycobacterium leprae36,905 15-Jun-96 rxa00433 648 GB_PR2: AP000073 100000 AP000073 Homosapiens genomic DNA, chromosome 8p11.2, senescence gene region, sectionHomo sapiens 38,043 20-Nov-99 9/19, complete sequence. GB_IN1: CELF29G942751 AF016440 Caenorhabditis elegans cosmid F29G9. Caenorhabditiselegans 35,474 7-Aug-97 GB_BA1: MSGY414A 40121 AD000007 Mycobacteriumtuberculosis uence from clone y414a. Mycobacterium 36,809 03-DEC-1996tuberculosis rxa00447 rxa00451 615 GB_EST26: AI389267 643 AI389267GH20396.5prime GH Drosophila melanogaster head pOT2 DrosophilaDrosophila melanogaster 41,085 28-Jan-99 melanogaster cDNA clone GH203965prime, mRNA sequence. GB_EST37: AI945493 574 AI945493 bs13e05.y1Drosophila melanogaster adult testis library Drosophila Drosophilamelanogaster 44,04 17-Aug-99 melanogaster cDNA clone bs13e05 5′, mRNAsequence. GB_GSS11: AQ288118 630 AQ288118 nbxb0032l18r CUGI Rice BACLibrary Oryza sativa genomic clone nbxb0032l18r, Oryza sativa 37,88503-DEC-1998 genomic survey sequence. rxa00455 873 GB_IN1: DMOVO 6655X59772 D. melanogaster ovo gene required for female germ linedevelopment. Drosophila melanogaster 35,104 24-Feb-99 GB_EST14: AA390588513 AA390588 LD09657.5prime LD Drosophila melanogaster embryo BlueScriptDrosophila Drosophila melanogaster 39,759 28-Nov-98 melanogaster cDNAclone LD09657 5prime, mRNA sequence. GB_EST19: AA801874 621 AA801874GM03519.5prime GM Drosophila melanogaster ovary BlueScript DrosophilaDrosophila melanogaster 35,437 25-Nov-98 melanogaster cDNA clone GM035195prime similar to U11383: ovo FBgn0003028 PID: g520527 SWISS-PROT:P51521, mRNA sequence. rxa00457 1203 GB_GSS8: AQ000125 398 AQ000125CIT-HSP-2282P3.TF CIT-HSP Homo sapiens genomic clone 2282P3, Homosapiens 41,73 26-Jun-98 genomic survey sequence. GB_IN1: DROADDLIKE 4209L14330 Drosophila melanogaster adducin-like protein, complete cds.Drosophila melanogaster 37,795 11-Jun-93 GB_IN1: DROHTSC 3922 L05016Drosophila melanogaster hu-li tal shao (hts) mRNA, complete cds.Drosophila melanogaster 37,081 26-Apr-93 rxa00462 1503 GB_HTG3: AC009210103814 AC009210 Drosophila melanogaster chromosome 2 clone BACR01I06(D1054) RPCI-98 01.I.6 Drosophila melanogaster 33,356 20-Aug-99 map55D-55D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 86 unorderedpieces. GB_HTG3: AC009210 103814 AC009210 Drosophila melanogasterchromosome 2 clone BACR01I06 (D1054) RPCI-98 01.I.6 Drosophilamelanogaster 33,356 20-Aug-99 map 55D-55D strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 86 unordered pieces. GB_BA1: SCE9 37730AL049841 Streptomyces coelicolor mid E9. Streptomyces coelicolor 37,30819-MAY-1999 rxa00463 945 GB_BA2: AF052652 2096 AF052652 Corynebacteriumglutamicum oserine O-acetyltransferase (metA) gene, Corynebacterium99,481 19-MAR-1998 complete cds. glutamicum GB_GSS12: AQ407770 500AQ407770 HS_5069_B1_F03_T7A RPCI-11 Human Male BAC Library Homo sapiensHomo sapiens 40,081 17-MAR-1999 genomic clone Plate = 645 Col = 5 Row =L, genomic survey sequence. GB_GSS15: AQ596209 358 AQ596209HS_5482_A2_H10_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 40 8-Jun-99 genomic clone Plate = 1058 Col = 20 Row = O, genomicsurvey sequence. rxa00468 942 GB_EST32: AI763195 341 AI763196 wi65h04.x1NCI_CGAP_Kid12 Homo sapiens cDNA clone IMAGE: 2398231 3′, Homo sapiens38,824 24-Jun-99 mRNA sequence. GB_EST17: AA652964 329 AA652964ns62e02.s1 NCI_CGAP_Pr22 Homo sapiens cDNA clone IMAGE: 1188218 3′, Homosapiens 41,104 13-Nov-97 mRNA sequence. GB_EST20: AA864303 411 AA864303oh54d02.s1 NCI_CGAP_GC4 Homo sapiens cDNA clone IMAGE: 1470435 3′, Homosapiens 41,422 13-MAY-1998 mRNA sequence. rxa00469 1299 GB_PR4: AC005988173126 AC005988 Homo sapiens chromosome 17, clone hRPK.299_G_24,complete sequence. Homo sapiens 34,699 15-Jan-99 GB_PR4: AC005988 173126AC005988 Homo sapiens chromosome 17, clone hRPK.299_G_24, completesequence. Homo sapiens 35,725 15-Jan-99 GB_HTG3: AC009116 186292AC009116 Homo sapiens chromosome 18 clone RPCI-11_47703, *** SEQUENCINGIN Homo sapiens 36,222 3-Aug-99 PROGRESS ***, 47. unordered pieces.rxa00472 942 GB_HTG3: AC007882 214882 AC007882 Homo sapiens cloneNH0499D05, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,245 8-Sep-992 unordered pieces. GB_HTG3: AC007882 214882 AC007882 Homo sapiens cloneNH0499D05, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,245 8-Sep-992 unordered pieces. GB_PR2: HUAC002038 161973 AC002038 Homo sapienschromosome 2 clone 101B6 map 2p11, complete sequence. Homo sapiens37,961 30-Jun-97 rxa00473 912 GB_HTG3: AC011445 144370 AC011445 Homosapiens chromosome 19 clone CIT-HSPC_246B18, *** SEQUENCING IN Homosapiens 38,47 07-OCT-1999 PROGRESS ***, 31 unordered pieces. GB_HTG3:AC011445 144370 AC011445 Homo sapiens chromosome 19 cloneCIT-HSPC_246B18, *** SEQUENCING IN Homo sapiens 38,47 07-OCT-1999PROGRESS ***, 31 unordered pieces. GB_RO: AB026437 2097 AB026437 Musmusculus DNA, 5′ flanking region of interleukin 12 receptor beta 1. Musmusculus 40 02-OCT-1999 rxa00474 1701 GB_GSS10: AQ223838 543 AQ223838HS_2218_A1_H03_MR CIT Approved Human Genomic Sperm Library D Homo Homosapiens 40,189 20-Sep-98 sapiens genomic clone Plate = 2218 Col = 5 Row= O, genomic survey sequence. GB_GSS10: AQ223838 543 AQ223838HS_2218_A1_H03_MR CIT Approved Human Genomic Sperm Library D Homo Homosapiens 37,944 20-Sep-98 sapiens genomic clone Plate = 2218 Col = 5 Row= O, genomic survey sequence. rxa00475 783 GB_PL2: GMAKHSDH2 10535AF049708 Glycine max aspartokinase-homoserine dehydrogenase (AK-HSDH)gene, partial cds. Glycine max 36,446 7-Jul-99 GB_EST14: AA386651 351AA386651 vb54b04.r1 Ko mouse embryo 11 5dpc Mus musculus cDNA cloneIMAGE: 760783 Mus musculus 41,311 23-Apr-97 5′, mRNA sequence. GB_EST14:AA386603 498 AA386603 vb53c02.r1 Ko mouse embryo 11 5dpc Mus musculuscDNA clone IMAGE: 760706 Mus musculus 40,644 23-Apr-97 5′ similar to TR:G56689 G56689 DIMETHYLGLYCINE DEHYDROGENASE.;, mRNA sequence. rxa00476984 GB_GSS5: AQ770769 554 AQ770769 HS_5357_B2_H01_T7A RPCI-11 Human MaleBAC Library Homo sapiens Homo sapiens 35,56 28-Jul-99 genomic clonePlate = 933 Col = 2 Row = P, genomic survey sequence. GB_IN1: CEM16239977 Z82278 Caenorhabditis elegans cosmid M162, complete sequence.Caenorhabditis elegans 34,224 19-Nov-99 GB_IN1: CEM162 39977 Z82278Caenorhabditis elegans cosmid M162, complete sequence. Caenorhabditiselegans 33,777 19-Nov-99 rxa00481 708 GB_PR4: AC005013 195910 AC005013Homo sapiens BAC clone GS165L15 from 7p15, complete sequence. Homosapiens 35,755 28-Nov-98 GB_HTG1: PFMAL4P4 224448 AL035477 Plasmodiumfalciparum chromosome 4 strain 3D7, *** SEQUENCING IN Plasmodiumfalciparum 37,213 11-Aug-99 PROGRESS ***, in unordered pieces. GB_HTG1:PFMAL4P4 224448 AL035477 Plasmodium falciparum chromosome 4 strain 3D7,*** SEQUENCING IN Plasmodium falciparum 37,213 11-Aug-99 PROGRESS ***,in unordered pieces. rxa00485 2418 GB_EST30: AV017239 238 AV017239AV017239 Mus musculus 18-day embryo C57BL/6J Mus musculus cDNA Musmusculus 39,916 28-Aug-99 clone 1110069G23, mRNA sequence. GB_EST33:AV093875 254 AV093875 AV093875 Mus musculus C57BL/6J ES Cell Musmusculus cDNA clone Mus musculus 38,189 22-Nov-99 2400006D21, mRNAsequence. GB_EST33: AV084536 287 AV084536 AV084536 Mus musculus tongueC57BL/6J adult Mus musculus cDNA clone Mus musculus 37,282 25-Jun-992310007K01, mRNA sequence. rxa00486 1032 GB_RO: MUSP3VPR2 1089 AF098867Mus sp. 129SV V3/V1b vasopressin receptor gene, exon 2 and complete cds.Mus musculus 38,163 28-Apr-99 GB_GSS9: AQ166448 407 AQ166448HS_3137_B2_A06_MR CIT Approved Human Genomic Sperm Library D Homo Homosapiens 40,25 16-OCT-1998 sapiens genomic clone Plate = 3137 Col = 12Row = B, genomic survey sequence. GB_GSS15: AQ614261 505 AQ614261HS_5123_B1_F11_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 37,905 15-Jun-99 genomic clone Plate = 699 Col = 21 Row = L,genomic survey sequence. rxa00490 1026 GB_EST15: AA463205 282 AA463205zx71c06.s1 Soares_total_fetus_Nb2HF8_9w_Homo sapiens cDNA clone IMAGE:Homo sapiens 39,502 10-Jun-97 796906 3′, mRNA sequence. GB_BA1: SLLINC36270 X79146 S. lincolnensis (78-11) Lincomycin production genes.Streptomyces lincolnensis 37,278 15-MAY-1996 GB_GSS3: B10984 646 B10984F22I8-Sp6 IGF Arabidopsis thaliana genomic clone F22I8, genomic surveysequence. Arabidopsis thaliana 39,205 14-MAY-1997 rxa00491 543 GB_HTG1:CEY87G2 330612 AL022597 Caenorhabditis elegans chromosome I clone Y87G2,*** SEQUENCING IN Caenorhabditis elegans 37,405 26-OCT-1999 PROGRESS***, in unordered pieces. GB_HTG1: CEY87G2 330612 AL022597Caenorhabditis elegans chromosome I clone Y87G2, *** SEQUENCING INCaenorhabditis elegans 37,405 26-OCT-1999 PROGRESS ***, in unorderedpieces. GB_HTG1: CEY6B3 253516 Z92865 Caenorhabditis elegans chromosomeI clone Y6B3, *** SEQUENCING IN Caenorhabditis elegans 38,213 30-Jul-98PROGRESS ***, in unordered pieces. rxa00493 1737 GB_BA1: SC6G4 41055AL031317 Streptomyces coelicolor cosmid 6G4. Streptomyces coelicolor61,649 20-Aug-98 GB_BA2: U00015 42325 U00015 Mycobacterium leprae cosmidB1620. Mycobacterium leprae 38,567 01-MAR-1994 GB_BA1: U00020 36947U00020 Mycobacterium leprae cosmid B229. Mycobacterium leprae 38,56701-MAR-1994 rxa00496 1149 GB_VI: TVRNAP 6404 X68414 Toscana Virusgenomic RNA for RNA-dependent RNA polymerase. Toscana virus 35,42827-OCT-1992 GB_IN2: DMU09808 9239 U09808 Drosophila melanogaster twistedgastrulation (tsg) and serine protease (gd) genes, Drosophilamelanogaster 36,837 25-Jun-98 complete cds. GB_IN2: DMU09808 9239 U09808Drosophila melanogaster twisted gastrulation (tsg) and serine protease(gd) genes, Drosophila melanogaster 37,782 25-Jun-98 complete cds.rxa00504 543 GB_BA1: MTCY159 33818 Z83863 Mycobacterium tuberculosisH37Rv complete genome; segment 111/162. Mycobacterium 36,961 17-Jun-98tuberculosis GB_PR1: HUMHM145 2214 D10925 Human mRNA for HM145. Homesapiens 38,066 3-Feb-99 GB_EST14: AA415083 332 AA415083 Mg0017 RCWLambda Zap Express Library Pyricularia grisea cDNA clone Pyriculariagrisea 40,181 09-DEC-1999 RCW17 5′, mRNA sequence. rxa00505 618 GB_PAT:I92047 551 I92047 Sequence 14 from patent U.S. Pat. No. 5726299.Unknown. 46,25 01-DEC-1998 GB_PAT: I78759 549 I78759 Sequence 15 frompatent U.S. Pat. No. 5693781. Unknown. 44,813 3-Apr-98 GB_PAT: I92048549 I92048 Sequence 15 from patent U.S. Pat. No. 5726299. Unknown.44,813 01-DEC-1998 rxa00507 978 GB_PR2: HS1063B2 114596 AL035683 HumanDNA sequence from clone 1063B2 on chromosome 20q13.1-13.2. Contains Homosapiens 36,449 23-Nov-99 the 3′ part of the gene forBeta-1,4-galactosyltransferase, ESTs, STSs and GSSs, complete sequence.GB_HTG2: AC007225 218892 AC007225 Homo sapiens chromosome 16 clone480G7, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,646 6-Apr-99 38unordered pieces. GB_HTG2: AC007225 218892 AC007225 Homo sapienschromosome 16 clone 480G7, *** SEQUENCING IN PROGRESS ***, Homo sapiens36,646 6-Apr-99 38 unordered pieces. rxa00510 1632 GB_GSS4: AQ707590 499AQ707590 HS_5560_B1_H02_SP6E RPCI-11 Human Male BAC Library Homo sapiensHomo sapiens 37,275 7-Jul-99 genomic clone Plate = 1136 Col = 3 Row = P,genomic survey sequence. GB_GSS4: AQ707590 499 AQ707590HS_5560_B1_H02_SP6E RPCI-11 Human Male BAC Library Home sapiens Homosapiens 37,275 7-Jul-99 genomic clone Plate = 1136 Col = 3 Row = P,genomic survey sequence. rxa00515 825 GB_BA1: CGICD 3595 X71489 C.glutamicum icd gene for monomeric isocitrate dehydrogenase.Corynebacterium 100 17-Feb-95 glutamicum GB_BA1: CGICD 3595 X71489 C.glutamicum icd gene for monomeric isocitrate dehydrogenase.Corynebacterium 38,15 17-Feb-95 glutamicum GB_GSS13: AQ451896 509AQ451896 HS_5184_B1_C03_SP6E RPCI-11 Human Male BAC Library Homo sapiensHomo sapiens 36,638 21-Apr-99 genomic clone Plate = 760 Col = 5 Row = F,genomic survey sequence. rxa00519 2337 GB_BA1: CGICD 3595 X71489 C.glutamicum icd gene for monomeric isocitrate dehydrogenase.Corynebacterium 100 17-Feb-95 glutamicum GB_BA2: AF127018 2560 AF127018Streptomyces coelicolor isocitrate dehydrogenase (idh) gene, idh-Ballele, complete Streptomyces coelicolor 66,667 1-Jun-99 cds. GB_BA1:AVIICD 3550 D73443 Azotobacter vinelandil icd gene for isocitratedehydrogenase, complete cds. Azotobacter vinelandil 63,652 4-Feb-99rxa00527 1887 GB_PAT: I92049 2248 I92049 Sequence 16 from patent U.S.Pat. No. 5726299. Unknown. 39,25 01-DEC-1998 GB_PAT: I92053 2213 I92053Sequence 20 from patent U.S. Pat. No. 5726299. Unknown. 70,63501-DEC-1998 GB_BA1: MTCY98 31225 Z83860 Mycobacterium tuberculosis H37Rvcomplete genome; segment 103/162. Mycobacterium 37,741 17-Jun-98tuberculosis rxa00528 1212 GB_BA1: MSGY219 38721 AD000013 Mycobacteriumtuberculosis sequence from clone y219. Mycobacterium 68,672 10-DEC-1996tuberculosis GB_BA1: MTCY21D4 20760 Z80775 Mycobacterium tuberculosisH37Rv complete genome; segment 3/262. Mycobacterium 39,762 24-Jun-99tuberculosis GB_BA1: SCH24 41625 AL049826 Streptomyces coelicolor cosmidH24. Streptomyces coelicolor 40,411 11-MAY-1999 rxa00529 666 GB_PR2:HSAC000109 41122 AC000109 Human Cosmid g0771a222 from 7q31.3, completesequence. Homo sapiens 37,462 11-Sep-97 GB_PR2: HSAC000110 45508AC000110 Human Cosmid g0771a233, complete sequence. Homo sapiens 37,46230-Jan-97 GB_PR2: HSAC000109 41122 AC000109 Human Cosmid g0771a222 from7q31.3, complete sequence. Homo sapiens 39,724 11-Sep-97 rxa00530 1404GB_PR3: HS435C23 151798 Z92844 Human DNA sequence from PAC 435C23 onchromosome X. Contains ESTs. Homo sapiens 36,482 23-Nov-99 GB_PR3:HS435C23 151798 Z92844 Human DNA sequence from PAC 435C23 on chromosomeX. Contains ESTs. Homo sapiens 37,918 23-Nov-99 GB_PL1: YSCADE3 4883M12878 Saccharomyces cerevisiae C-1-tetrahydrofolate synthase (ADE3)gene, complete cds. Saccharomyces cerevisiae 37,034 11-MAY-1995 rxa00535840 GB_BA1: CGLEUA 3492 X70959 C. glutamicum gene leuA forisopropylmalate synthase. Corynebacterium 100 10-Feb-99 glutamicumGB_BA1: CORASKD 2957 L16848 Corynebacterium flavum aspartokinase (ask),and aspartate-semialdehyde Corynebacterium 43,75 11-Jun-93 dehydrogenase(asd) genes, complete cds. flavescens GB_GSS10: AQ193141 515 AQ193141HS_3060_B1_F11_MF CIT Approved Human Genomic Sperm Library D Homosapiens 44,773 4-Nov-98 Homo sapiens genomic clone Plate = 3060 Col = 21Row = L, genomic survey sequence. rxa00540 366 GB_PAT: I92052 2115I92052 Sequence 19 from patent U.S. Pat. No. 5726299. Unknown. 74,79501-DEC-1998 GB_HTG2: AC008095 126322 AC008095 Drosophila melanogasterchromosome 2 clone BACR11H16 (D932) RPCI-98 11.H.16 Drosophilamelanogaster 41,899 2-Aug-99 map 52A-52A strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 95 unordered pieces. GB_HTG2: AC008095126322 AC008095 Drosophila melanogaster chromosome 2 clone BACR11H16(D932) RPCI-98 11.H.16 Drosophila melanogaster 41,899 2-Aug-99 map52A-52A strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 95 unorderedpieces. rxa00547 1521 GB_BA1: MSGY219 38721 AD000013 Mycobacteriumtuberculosis sequence from clone y219. Mycobacterium 36,91 10-DEC-1996tuberculosis GB_BA1: MTCY21D4 20760 Z80775 Mycobacterium tuberculosisH37Rv complete genome; segment 3/262. Mycobacterium 51,125 24-Jun-99tuberculosis GB_EST27: AI415174 292 AI415174 mc05c02.x1 Soares mousep3NMF19.5 Mus musculus cDNA clone IMAGE: Mus musculus 39,384 9-Feb-99338018 3′, mRNA sequence. rxa00549 1797 GB_PL2: ATAC007135 27313AC007135 Arabidopsis thaliana chromosome II BAC F9C22 genomic sequence,Arabidopsis thaliana 35,584 26-MAY-1999 complete sequence. GB_PL2:ATAC006921 76042 AC006921 Arabidopsis thaliana chromosome II BAC F2H17genomic sequence, Arabidopsis thaliana 36,581 23-MAR-1999 completesequence. GB_PL2: ATAC007135 27313 AC007135 Arabidopsis thalianachromosome II BAC F9C22 genomic sequence, Arabidopsis thaliana 35,82726-MAY-1999 complete sequence. rxa00550 rxa00552 1059 GB_BA1: D9074219201 D90742 Escherichia coli genomic DNA. (23.8-24.2 min). Escherichiacoli 46,072 7-Feb-99 GB_BA1: ECHTRB 3129 X61000 E. coli K12 HtrB gene.Escherichia coli 39,164 30-Jun-93 GB_BA2: AE000207 11148 AE000207Escherichia coli K-12 MG1655 section 97 of 400 of the complete genome.Escherichia coli 46,072 12-Nov-98 rxa00553 444 GB_EST18: AB009093 479AB009093 AB009093 Chlamydomonas W80 lambda ZAP II Chlamydomonas sp. cDNAsimilar Chlamydomonas sp. 41,808 05-DEC-1997 to photosystem II 10 kDaprotein, mRNA sequence. GB_EST30: AI640954 641 AI640954 AEMTAP02 Aedesaegypti MT pSPORT Library Aedes aegypti cDNA clone Aedes aegypti 38,99128-Apr-99 AP02 5′, mRNA sequence. GB_GSS13: AQ467517 206 AQ467517HS_5219_A2_F02_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 45,255 23-Apr-99 genomic clone Plate = 795 Col = 4 Row = K,genomic survey sequence. rxa00554 594 GB_EST6: W04418 364 W04418za43c06.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA cloneIMAGE: Homo sapiens 39,688 22-Apr-96 295306 5′, mRNA sequence. GB_EST35:AL041829 564 AL041829 DKFZp434C0318_s1 434 (synonym: htes3) Homo sapienscDNA clone Homo sapiens 40,433 29-Sep-99 DKFZp434C0318 3′, mRNAsequence. GB_EST35: AL041828 386 AL041828 DKFZp434C0318_r1 434 (synonym:htes3) Homo sapiens cDNA clone Homo sapiens 39,688 29-Sep-99DKFZp434C0318 5′, mRNA sequence. rxa00555 rxa00560 498 GB_BA1: MTCY7H7A10451 Z95618 Mycobacterium tuberculosis H37Rv complete genome; segment39/162. Mycobacterium 52,727 17-Jun-98 tuberculosis GB_BA1: BAPURF 1885X91252 B. ammoniagenes purF gene. Corynebacterium 61,092 5-Jun-97ammoniagenes GB_PL1: YSCMET10A 3650 L26504 Saccharomyces carlsbergensisassimilatory sulfite reductase (MET10) gene, Saccharomyces 41,2737-Feb-95 complete cds. pastorianus rxa00563 2762 GB_BA1: BAFASAA 10549X64795 B. ammoniagenes FAS gene. Corynebacterium 66,91 14-OCT-1997ammoniagenes GB_BA1: MTCY159 33818 Z83863 Mycobacterium tuberculosisH37Rv complete genome; segment 111/162. Mycobacterium 40,086 17-Jun-98tuberculosis GB_BA1: MBU36763 8391 U36763 Mycobacterium bovis fatty acidsynthase gene, complete cds. Mycobacterium bovis 61,178 15-Jul-96rxa00564 528 GB_PR3: HS833B7 86574 AL008637 Human DNA sequence fromclone 833B7 on chromosome 22q12.3-13.2 Contains Homo sapiens 39,01523-Nov-99 genes for NCF4 (P40PHOX) protein, cytokine receptor commonbeta chain precursor CSF2RB (partial), ESTs, CA repeat, STS, GSS,complete sequence. GB_HTG3: AC008543 278334 AC008543 Homo sapienschromosome 19 clone CIT-HSPC_499B15, *** SEQUENCING Homo sapiens 36,3282-Sep-99 IN PROGRESS ***, 134 unordered pieces. GB_HTG3: AC008543 278334AC008543 Homo sapiens chromosome 19 clone CIT-HSPC_499B15, ***SEQUENCING Homo sapiens 36,328 2-Sep-99 IN PROGRESS ***, 134 unorderedpieces. rxa00573 rxa00574 1002 GB_GSS11: AQ301816 481 AQ301816HS_3174_A1_B04_T7 CIT Approved Human Genomic Sperm Library D Homosapiens 43,137 16-DEC-1998 Homo sapiens genomic clone Plate = 3174 Col =7 Row = C, genomic survey sequence. GB_PR3: AC004537 88872 AC004537 Homosapiens PAC clone DJ0872F07 from 7q31, complete sequence. Homo sapiens34,712 9-Apr-98 GB_EST29: AI563059 339 AI563059 EST00183 watermelonlambda zap library Citrullus lanatus cDNA clone WMLS355 5′ Citrulluslanatus 37,758 26-MAR-1999 similar to unknown protein, mRNA sequence.rxa00576 795 GB_EST37: AI947508 533 AI947508 603022E09.x1 603 - stressedroot cDNA library from Wang/Bohnert lab Zea mays Zea mays 38,72819-Aug-99 cDNA, mRNA sequence. GB_GSS11: AQ296770 347 AQ296770HS_3087_A2_B12_MF CIT Approved Human Genomic Sperm Library D Homosapiens 40,058 15-DEC-1998 Homo sapiens genomic clone Plate = 3087 Col =24 Row = C, genomic survey sequence. GB_GSS13: AQ503769 589 AQ503769RPCI-11-282O13.TV RPCI-11 Homo sapiens genomic clone RPCI-11-282O13,Homo sapiens 37,993 29-Apr-99 genomic survey sequence. rxa00577 471GB_GSS14: AQ533027 638 AQ533027 RPCI-11-351M24.TJ RPCI-11 Homo sapiensgenomic clone RPCI-11-351M24, Homo sapiens 34,944 18-MAY-1999 genomicsurvey sequence. GB_PR3: HS440B3 28047 AL022331 Homo sapiens DNAsequence from clone 440B3 on chromosome 22q12.1-3 Contains Homo sapiens33,626 23-Nov-99 a pseudogene similar to 60S Ribosomal protein L17.Contains ESTs and an STS (genomic marker D22S1176), complete sequence.GB_PL2: ZEU19267 1230 U19267 Zinnia elegans cysteine proteinase mRNA,complete cds. Zinnia elegans 35,456 26-Aug-96 rxa00578 rxa00582 642GB_BA1: CORAHPS 2570 L07603 Corynebacterium glutamicum3-deoxy-D-arabinoheptulosonate-7-phosphate Corynebacterium 98,90126-Apr-93 synthase gene, complete cds. glutamicum GB_PR3: AC005389120359 AC005389 Homo sapiens chromosome 17, clone hRPK.601_N_13,complete sequence. Homo sapiens 38,315 14-Aug-98 GB_HTG6: AC008002126629 AC008002 Drosophila melanogaster chromosome 2 clone BACR48E08(D843) RPCI-98 Drosophila melanogaster 32,437 07-DEC-1999 48.E.8 map21D-21E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 85 unorderedpieces. rxa00585 441 GB_BA1: CORAHPS 2570 L07603 Corynebacteriumglutamicum 3-deoxy-D-arabinoheptulosonate-7-phosphate Corynebacterium98,039 26-Apr-93 synthase gene, complete cds. glutamicum GB_PR4:AC004970 149951 AC004970 Homo sapiens BAC clone DJ1122F04 from7q11.23-q21.2, complete sequence. Homo sapiens 39,9 27-Aug-99 GB_PR2:HS102G20 99207 Z99127 Human DNA sequence from PAC 102G20 on chromosome1q24-q25. Contains ESTS, Homo sapiens 41,509 23-Nov-99 STSs and apredicted CpG island. rxa00586 1005 GB_BA1: MTV017 67200 AL021897Mycobacterium tuberculosis H37Rv complete genome; segment 48/162.Mycobacterium 56,219 24-Jun-99 tuberculosis GB_BA1: MLU15183 36800U15183 Mycobacterium leprae cosmid B1740. Mycobacterium leprae 55,62209-MAR-1995 GB_BA1: MTV017 67200 AL021897 Mycobacterium tuberculosisH37Rv complete genome; segment 48/162. Mycobacterium 37,838 24-Jun-99tuberculosis rxa00587 459 GB_EST37: AI993539 514 AI993539 701496589 A.thaliana, Ohio State clone set Arabidopsis thaliana cDNA cloneArabidopsis thaliana 40,153 8-Sep-99 701496589, mRNA sequence. GB_GSS10:AQ224941 511 AQ224941 HS_2009_B1_B06_T7 CIT Approved Human Genomic SpermLibrary D Homo sapiens 43,75 20-Sep-98 Homo sapiens genomic clone Plate= 2009 Col = 11 Row = D, genomic survey sequence. GB_EST23: AI099719 475AI099719 33872 Lambda-PRL2 Arabidopsis thaliana cDNA clone 120M10XP 3′,Arabidopsis thaliana 36,752 21-Aug-98 mRNA sequence. rxa00589 573GB_PL2: ATAC003673 70575 AC003673 Arabidopsis thaliana chromosome II BACF19F24 genomic sequence, Arabidopsis thaliana 39,785 1-Apr-98 completesequence. GB_PR3: HS427A4 149466 Z98049 Human DNA sequence from PAC427A4 on chromosome 6q26-q27. Homo sapiens 35,145 23-Nov-99 Containsribosomal protein S6 kinase, RSK3, ESTs, CpG island. rxa00595 GB_PL2:ATAC005724 86671 AC005724 Arabidopsis thaliana chromosome II P1 MSF3genomic sequence, complete sequence. Arabidopsis thaliana 39,78524-Jan-99 rxa00595 rxa00597 393 GB_PR3: AC004659 129577 AC004659 Homosapiens chromosome 19, CIT-HSP-87m17 BAC clone, complete sequence. Homosapiens 39,459 02-MAY-1998 GB_GSS14: AQ575039 927 AQ575039 nbxb0086L01rCUGI Rice BAC Library Oryza sativa genomic clone nbxb0086L01r, Oryzasativa 37,786 2-Jun-99 genomic survey sequence. GB_BA1: NMRRNA 5209X72495 N. magadii rRNA operon. Natrialba magadii 39,788 10-Feb-95rxa00598 rxa00601 414 GB_BA2: AF175719 1368 AF175719 Porphyromonagingivalis strain W50 immunoreactive 51 kD antigen PG52 gene,Porphyromonas gingivalis 35,331 23-Aug-99 complete cds. GB_GSS9:AQ140775 464 AQ140775 HS_3128_A1_B11_MR CIT Approved Human Genomic SpermLibrary D Homo sapiens 40,431 24-Sep-98 Homo sapiens genomic clone Plate= 3128 Col = 21 Row = C, genomic survey sequence. GB_EST8: AA018824 542AA018824 ze57e09.s1 Soares retina N2b4HR Homo sapiens cDNA clone IMAGE:363112 3′, Homo sapiens 40,59 30-Jan-97 mRNA sequence. rxa00602 876GB_EST30: AI642687 479 AI642687 vw02h03.x1 Soares mouse mammary glandNbMMG Mus musculus cDNA clone Mus musculus 40,042 29-Apr-99 IMAGE:1230773 3′, mRNA sequence. GB_EST20: AA879989 412 AA879989 vw03a05.r1Soares mouse mammary gland NbMMG Mus musculus cDNA clone Mus musculus39,948 26-MAR-1998 IMAGE: 1230800 5′, mRNA sequence. GB_EST28: AI481047438 AI481047 vf91a05.x1 Soares mouse mammary gland NbMMG Mus musculuscDNA clone Mus musculus 38,128 09-MAR-1999 IMAGE: 851120 3′, mRNAsequence. rxa00604 414 GB_HTG2: AC008205 131658 AC008205 Drosophilamelanogaster chromosome 3 clone BACR33F18 (D764) RPCI-98 33.F.18Drosophila melanogaster 33,907 2-Aug-99 map 96A-96B strain y; cn bw sp,*** SEQUENCING IN PROGRESS ***, 118 unordered pieces. GB_HTG2: AC008205131658 AC008205 Drosophila melanogaster chromosome 3 clone BACR33F18(D764) RPCI-98 33.F.18 Drosophila melanogaster 33,907 2-Aug-99 map96A-96B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 118unordered pieces. GB_IN1: DMBR7C10 56820 AL121804 Drosophilamelanogaster clone BACR7C10. Drosophila melanogaster 44,267 10-OCT-1999rxa00610 987 GB_BA1: SME242575 1403 AJ242575 Sinorhizobium melilotipartial oxi1 and dehydrogenase genes, isolate lpu119. Sinorhizobiummeliloti 41,76 26-MAY-1999 GB_PR3: AC004655 134929 AC004655 Homo sapiensXp22-140-141 BAC GSHB-128G5 (Genome Systems Human SAC Homo sapiens38,422 17-Sep-98 library) complete sequence. GB_PR3: HS598F2 99886AL021579 Human DNA sequence from clone 598F2 on chromosome 1q23.1-24.3Contains Homo sapiens 38,351 23-Nov-99 ESTs, STS and GSS, completesequence. rxa00611 1599 GB_HTG2: AC007108 190000 AC007108 Homo sapienschromosome 4, *** SEQUENCING IN PROGRESS***, Homo sapiens 17,45117-MAR-1999 24 unordered pieces. GB_HTG2: AC007108 190000 AC007108 Homosapiens chromosome 4, *** SEQUENCING IN PROGRESS ***, Homo sapiens17,451 17-MAR-1999 24 unordered pieces. GB_HTG4: AC010893 176178AC010893 Homo sapiens chromosome unknown clone NH0480A20, WORKING DRAFTHomo sapiens 35,819 29-OCT-1999 SEQUENCE, in unordered pieces. rxa00613576 GB_IN2: AC004361 87747 AC004361 Drosophila melanogaster DNA sequence(P1 DS07851 (D49)), complete sequence. Drosophila melanogaster 35,08129-MAY-1998 GB_PL2: AC006268 105420 AC006268 Arabidopsis thaliana BACT24G23 from chromosome IV near 21 cM, Arabidopsis thaliana 43,6821-Jan-99 complete sequence. GB_BA1: MLCB596 38426 AL035472 Mycobacteriumleprae cosmid B596. Mycobacterium leprae 35,026 27-Aug-99 rxa00614 1038GB_BA1: MTV025 121125 AL022121 Mycobacterium tuberculosis H37Rv completegenome; segment 155/162. Mycobacterium 53,061 24-Jun-99 tuberculosisGB_BA1: SCH66 9153 AL049731 Streptomyces coelicolor cosmid H66.Streptomyces coelicolor 52,817 29-Apr-99 GB_EST14: AA446728 411 AA446728zw84f03.r1 Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone Homosapiens 36,548 3-Jun-97 IMAGE: 783677 5′, mRNA sequence. rxa00616rxa00617 351 GB_PL1: AB009030 2589 AB009030 Panax ginseng OSCPNY1 mRNAfor beta-Amyrin Synthase, complete cds. Panax ginseng 39,048 03-OCT-1998GB_PR3: HS905G11 122469 AL035045 Human DNA sequence from clone 905G11 onchromosome 20p11.2-12.1. Homo sapiens 39,255 23-Nov-99 Contains STSs,GSSs and genomic marker D20S182, complete sequence. GB_RO: MMT1CPS 8147X15147 Mouse Tla region T1c pseudogene for class I antigen major Musmusculus 36,311 19-Feb-90 histocompatibility complex. rxa00628 531GB_HTG5: AC010674 220575 AC010674 Homo sapiens chromosome 15 cloneRP11-430B1 map 15q21, *** SEQUENCING Homo sapiens 37,714 5-Nov-99 INPROGRESS ***, 46 ordered pieces. GB_HTG5: AC010674 220575 AC010674 Homosapiens chromosome 15 clone RP11-430B1 map 15q21, *** SEQUENCING Homosapiens 39,293 5-Nov-99 IN PROGRESS ***, 46 ordered pieces. rxa006311578 GB_BA1: BRLBIOAD 2272 D14083 Brevibacterium flavum genes for7,8-diaminopelargonic acid aminotransferase Corynebacterium 47,3683-Feb-99 and dethiobiotin synthetase, complete cds. glutamicum GB_PAT:E04041 675 E04041 DNA sequence coding for desthiobiotinsynthetase.Corynebacterium 46,552 29-Sep-97 glutamicum GB_EST20: AA820386 453AA820386 LD23968.5prime LD Drosophila melanogaster embryo pOT2Drosophila Drosophila melanogaster 45,679 25-Feb-99 melanogaster cDNAclone LD23968 5prime, mRNA sequence. rxa00637 876 GB_HTG2: AC007589134659 AC007589 Drosophila melanogaster chromosome 3 clone BACR20D10(D667) RPCI-98 20.D.10 Drosophila melanogaster 32,102 2-Aug-99 map82D-82E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 73 unorderedpieces. GB_HTG2: AC007589 134659 AC007589 Drosophila melanogasterchromosome 3 clone BACR20D10 (D667) RPCI-98 20.D.10 Drosophilamelanogaster 32,102 2-Aug-99 map 82D-82E strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 73 unordered pieces. GB_HTG3: AC009212125452 AC009212 Drosophila melanogaster chromosome 3 clone BACR01A18(D669) RPCI-98 01.A.18 Drosophila melanogaster 37,126 23-Aug-99 map82E-82F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 119unordered pieces. rxa00646 541 GB_HTG1: AP000488 123363 AP000488 Homosapiens chromosome 11 clone B759H8 map 11q23, *** SEQUENCING Homosapiens 38,264 13-Sep-99 IN PROGRESS ***, in unordered pieces. GB_HTG1:AP000488 123363 AP000488 Homo sapiens chromosome 11 clone B759H8 map11q23,*** SEQUENCING Homo sapiens 38,264 13-Sep-99 IN PROGRESS ***, inunordered pieces. GB_HTG1: AP000488 123363 AP000488 Homo sapienschromosome 11 clone B759H8 map 11q23, *** SEQUENCING Homo sapiens 36,48413-Sep-99 IN PROGRESS ***, in unordered pieces. rxa00647 756 GB_GSS13:AQ431426 536 AQ431426 HS_5140_A2_E01_T7A RPCI-11 Human Male BAC LibraryHomo sapiens 35,635 31-MAR-1999 Homo sapiens genomic clone Plate = 716Col = 2 Row = I, genomic survey sequence. GB_OV: CHKP4HA 3149 M26217Chicken prolyl 4-hydroxylase alpha subunit gene, 3′ end. Gallus gallus40,655 28-Apr-93 GB_HTG2: AC008271 168302 AC008271 Homo sapiens cloneNH0123E16, *** SEQUENCING IN PROGRESS ***, Homo sapiens 37,417 31-Jul-992 unordered pieces. rxa00649 579 GB_PR2: AC002563 136436 AC002563 HumanPAC clone 127H14 from 12q, complete sequence. Homo sapiens 37,93726-Sep-97 GB_HTG3: AC011466 165953 AC011466 Home sapiens chromosome 19clone CIT-HSPC_453G23, *** SEQUENCING Homo sapiens 38,179 07-OCT-1999 INPROGRESS ***, 74 unordered pieces. GB_HTG3: AC011466 165953 AC011466Homo sapiens chromosome 19 clone CIT-HSPC_453G23, *** SEQUENCING Homosapiens 38,179 07-OCT-1999 IN PROGRESS ***, 74 unordered pieces.rxa00652 rxa00653 rxa00654 1389 GB_EST1: Z34080 271 Z34080 ATTS3128Grenoble-B Arabidopsis thaliana cDNA clone GBGe328 5′, Arabidopsisthaliana 40,37 6-Jun-94 mRNA sequence. GB_PR3: AC004460 113803 AC004460Homo sapiens PAC clone DJ1086D14, complete sequence. Homo sapiens 36,1524-MAR-1998 GB_GSS6: AQ835185 571 AQ835185 HS_4832_A1_E02_T7A CITApproved Human Genomic Sperm Library D Homo sapiens 39,429 27-Aug-99Homo sapiens genomic clone Plate = 4832 Col = 3 Row = I, genomic surveysequence. rxa00656 384 GB_HTG3: AC009948 172463 AC009948 Homo sapiensclone NH0065L03, *** SEQUENCING IN PROGRESS ***, Homo sapiens 43,16425-Sep-99 2 unordered pieces. GB_HTG3: AC009948 172463 AC009948 Homosapiens clone NH0065L03, *** SEQUENCING IN PROGRESS ***, Homo sapiens43,164 25-Sep-99 2 unordered pieces. GB_GSS13: AQ462899 522 AQ462899HS_5212_A1_C09_T7A RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 42,529 23-Apr-99 genomic clone Plate = 788 Col = 17 Row = E,genomic survey sequence. rxa00657 1026 GB_BA2: AF064700 3481 AF064700Rhodococcus sp. NO1-1 CprS and CprR genes, complete cds. Rhodococcus sp.NO1-1 40,558 15-Jul-98 GB_PR3: AC005346 38849 AC005346 Homo sapienschromosome 16, cosmid clone 2H2 (LANL), complete sequence. Homo sapiens35,553 31-Jul-98 GB_HTG3: AC008905 129915 AC008905 Homo sapienschromosome 5 clone CITB-H1_2259114, *** SEQUENCING Homo sapiens 37,1793-Aug-99 IN PROGRESS ***, 40 unordered pieces. rxa00661 813 GB_PL2:AC006193 118335 AC006193 Arabidopsis thaliana chromosome I BAC F13O11genomic sequence, Arabidopsis thaliana 35,513 11-Jun-99 completesequence. GB_RO: MMFABPE 6593 AJ223066 Mus musculus Fabpe gene. Musmusculus 37,5 27-Jul-98 GB_PL2: AC006193 118335 AC006193 Arabidopsisthaliana chromosome I BAC F13O11 genomic sequence, Arabidopsis thaliana33,552 11-Jun-99 complete sequence. rxa00662 1392 GB_EST29: AI551960 718AI551960 vi48d09.y1 Beddington mouse embryonic region Mus musculus cDNAMus musculus 39,972 23-MAR-1999 clone IMAGE: 907025 5′ similar to gb:D10576 Mouse mRNA for ubiqultin activating enzyme E1 (MOUSE);, mRNAsequence. GB_BA2: AE000633 19734 AE000633 Helicobacter pylori 26695section 111 of 134 of the complete genome. Helicobacter pylori 2669536,606 6-Apr-99 GB_GSS10: AQ216730 529 AQ216730 HS_2262_A1_G06_MR CITApproved Human Genomic Sperm Library D Homo sapiens 32,703 19-Sep-98Homo sapiens genomic clone Plate = 2262 Col = 11 Row = M, genomic surveysequence. rxa00666 1038 GB_HTG3: AC009205 113482 AC009205 Drosophilamelanogaster chromosome 2 clone BACR04C20 (D1035) Drosophilamelanogaster 36,713 17-Sep-99 RPCI-98 04.C.20 map 36E-37C strain y; cnbw sp, *** SEQUENCING IN PROGRESS ***, 101 unordered pieces. GB_EST25:AI259480 626 AI259480 LP02903.5prime LP Drosophila melanogastertarval-early pupal pOT2 Drosophila melanogaster 37,173 17-Nov-98Drosophila melanogaster cDNA clone LP02903 5prime, mRNA sequence.GB_HTG3: AC009205 113482 AC009205 Drosophila melanogaster chromosome 2clone BACR04C20 Drosophila melanogaster 36,713 17-Sep-99 (D1035) RPCI-9804.C.20 map 36E-37C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***,101 unordered pieces. rxa00667 1137 GB_PAT: AR048317 2627 AR048317Sequence 3 from patent U.S. Pat. No. 5821090. Unknown. 39,805 29-Sep-99GB_PAT: A46560 2627 A46560 Sequence 3 from Patent WO9526406.Eremothecium gossypll 39,805 07-MAR-1997 GB_VI: HEHCMVCG 229354 X17403Human cytomegalovirus strain AD169 complete genome. human herpesvirus 539,854 10-Feb-99 rxa00676 870 GB_HTG1: CEY38F1 178443 Z98861Caenorhabditis elegans chromosome II clone Y38F1, *** SEQUENCINGCaenorhabditis elegans 35,88 03-DEC-1998 IN PROGRESS ***, in unorderedpieces. GB_HTG1: CEY38F1 178443 Z98861 Caenorhabditis elegans chromosomeII clone Y38F1, *** SEQUENCING Caenorhabditis elegans 35,88 03-DEC-1998IN PROGRESS ***, in unordered pieces. GB_PR3: HS934G17 107603 AL021155Homo sapiens DNA sequence from PAC 934G17 on chromosome 1p36.21. Homosapiens 38,489 23-Nov-99 Contains the alternatively spliced CLCN6 genefor chloride chanel proteins CLC-6A (KIAA0046) -B, -C and -D, thealternatively spliced NPPA gene coding for Atrial Natriuretic Factor ANFprecursor (Atrial Natriuretic peptide ANP, Prepronatriodilatin), theNPPB gene for Brain Natriuretic Protein BNP, and a pseudogene similar toSBF1 (and other Myotubularin-related protein genes). Contains ESTs, STSsand the genomic marker D1S2740, complete sequence. rxa00678 858 GB_PR2:CNS00004 205573 AL049778 Human chromosome 14 DNA sequence *** INPROGRESS *** BAC R-643C12 Homo sapiens 33,138 17-Jun-99 of RPCt-11library from chromosome 14 of Homo sapiens (Human), complete sequence.GB_GSS1: AG000894 723 AG000894 Homo sapiens genomic DNA, 21q region,clone: 64E11X19, Homo sapiens 37,391 6-Feb-99 genomic survey sequence.GB_IN1: TSMIEXRNA 481 X90847 Trypanosoma simiae mini-exon DNA.Trypanosoma simiae 35,135 15-Feb-99 rxa00691 1053 GB_EST26: AA899042 505AA899042 UI-R-E0-bz-a-06-0-UI.s2 UI-R-E0 Rattus norvegicus cDNA cloneRattus norvegicus 41,4 4-Jul-99 UI-R-E0-bz-a-06-0-UI 3′ similar togi|485266|gb|U09256|RNU09256 Rattus norvegicus Sprague-Dawleytransketolase mRNA, complete cds, mRNA sequence. GB_RO: RNU09256 2098U09256 Rattus norvegicus Sprague-Dawley transketolase mRNA, completecds. Rattus norvegicus 39,652 11-MAY-1994 GB_EST29: AI599628 510AI599628 EST251331 Normalized rat embryo, Bento Soares Rattus sp. cDNAclone REMEH65 Rattus sp. 39,096 21-Apr-99 3′ end, mRNA sequence.rxa00692 1257 GB_PL2: SPU66305 8226 U66305 Schizosaccharomyces pombe ABCtransporter (mam1) gene, complete cds. Schizosaccharomyces 36,84230-Jul-97 pombe GB_PL1: SPBC25B2 26016 AL031853 S. pombe chromosome IIcosmid c25B2. Schizosaccharomyces 36,803 09-OCT-1998 pombe GB_PL1:SPBC2G5 23645 AL033385 S. pombe chromosome II cosmid c2G5.Schizosaccharomyces 36,803 04-DEC-1998 pombe rxa00693 606 GB_BA2:RRU65510 16259 U65510 Rhodospirillum rubrum CO-induced hydrogenaseoperon (cooM, cooK, cooL, Rhodospirillum rubrum 41,97 9-Apr-97 cooX,cooU. cooH) genes, iron sulfur protein (cooF) gene, carbon monoxidedehydrogenase (cooS) gene, carbon monoxide dehydrogenase accessoryproteins (cooC, cooT, cooJ) genes, putative transcriptional activator(cooA) gene, nicotinate-nucleotide pyrophosphorylase (nadC) gene,complete cds, L- aspartate oxidase (nadB) gene, and alkyl hydroperoxidereductase (ahpC) gene, partial cds. GB_PL1: LETHM27 1152 X95296 L.esculentum mRNA for THM27 protein. Lycopersicon esculentum 38,91910-Jun-96 GB_EST38: AW033855 646 AW033855 EST277426 tomato callus, TAMULycopersicon esculentum cDNA clone cLEC29F6 Lycopersicon esculentum35,945 15-Sep-99 similar to transcription factor, myb-related, mRNAsequence. rxa00701 498 GB_EST34: AI785570 454 AI785570 uj44d03.x1 Suganomouse liver mlia Mus musculus cDNA clone IMAGE: 1922789 Mus musculus37,565 2-Jul-99 3′ similar to gb: Z28407 60S RIBOSOMAL PROTEIN L8(HUMAN);, mRNA sequence. GB_EST25: AI256147 684 AI256147 ui95e12.x1Sugano mouse liver mlia Mus musculus cDNA clone IMAGE: 1890190 Musmusculus 41,232 12-Nov-98 3′ similar to gb: Z28407 60S RIBOSOMAL PROTEINL8 (HUMAN);, mRNA sequence. GB_BA1: CARCG12 2079 X14979 C. aurantiacusreaction center genes 1 and 2. Chloroflexus aurantiacus 36,943 23-Apr-91rxa00704 750 GB_EST15: AA497266 456 AA497266 fa04f08.s1 ZebrafishICRFzfls Danio rerio cDNA clone 3A13 3′, mRNA sequence. Danio rerio38,631 30-Jun-97 GB_EST36: AI884217 515 AI884217 fc75e10.x1 ZebrafishWashU MPIMG EST Danio rerio cDNA 3′, mRNA sequence. Danio rerio 36,01226-Jul-99 GB_HTG1: CEY43F8_1 110000 Z95393 Caenorhabditis eleganschromosome V clone Y43F8, *** SEQUENCING Caenorhabditis elegans 37,889Z95393 IN PROGRESS ***, in unordered pieces. rxa00707 906 GB_GSS8:AQ013755 715 AQ013755 RPCI11-23F24.TKBF RPCI-11 Homo sapiens genomicclone RPCI-11-23F24, Homo sapiens 41,724 14-Apr-99 genomic surveysequence. GB_GSS3: B86449 434 B86449 RPCI11-23F24.TV RPCI-11 Homosapiens genomic clone RPCI-11-23F24, Homo sapiens 42,936 9-Apr-99genomic survey sequence. GB_GSS5: AQ797072 449 AQ797072 nbxb0071D10fCUGI Rice BAC Library Oryza sativa genomic clone nbxb0071D10f, Oryzasativa 39,101 4-Aug-99 genomic survey sequence. rxa00712 819 GB_BA2:AF011544 7527 AF011544 Bacillus subtilisphosphoribosylaminoimidazote-carboxamide Bacillus subtilis 36,92706-OCT-1997 formyltransferase (purH-J) gene, partial cds,phosphoribosylglycinamide synthetase (purD), YecA (yecA), putativeadenine deaminase (yecB), YecC (yecC), and YecD (yecD) genes, completecds, and putative glutamate synthase (yecE) gene, partial cds. GB_BA2:AF011544 7527 AF011544 Bacillus subtilisphosphoribosylaminoimidazole-carboxam;de formyltransferase Bacillussubtilis 39,752 06-OCT-1997 (purH-J) gene, partial cds,phosphoribosylglycinamide synthetase (purD), YecA (yecA), putativeadenine deaminase (yecB), YecC (yecC), and YecD (yecD) genes, completecds, and putative glutamate synthase (yecE) gene, partial cds. rxa007131056 GB_PAT: I92037 241 I92037 Sequence 4 from patent U.S. Pat. No.5726299. Unknown. 99,048 01-DEC-1998 GB_PAT: I78748 241 I78748 Sequence4 from patent U.S. Pat. No. 5693781. Unknown. 99,048 3-Apr-98 GB_HTG3:AC009281 221178 AC009281 Homo sapiens chromosome 15 clone 8_C_22 map 15,*** SEQUENCING Homo sapiens 36,255 12-Aug-99 IN PROGRESS ***, 49unordered pieces. rxa00714 684 GB_PL1: CCR5839 871 AJ005839 Cyclotellacryptica mRNA for fucoxanthin chlorophyll a/c binding protein, fcp12.Cyclotella cryptica 36,364 30-Jul-98 GB_PR2: HS1002M8 111768 AL035454Human DNA sequence from clone 1002M8 on chromosome 20p11.21-11.23, Homosapiens 36,444 23-Nov-99 complete sequence. GB_PR2: HS1002M8 111768AL035454 Human DNA sequence from clone 1002M8 on chromosome20p11.21-11.23. Homo sapiens 34,894 23-Nov-99 complete sequence.rxa00716 636 GB_PAT: I78753 1187 I78753 Sequence 9 from patent U.S. Pat.No. 5693781. Unknown. 36,022 3-Apr-98 GB_PAT: I92042 1187 I92042Sequence 9 from patent U.S. Pat. No. 5726299. Unknown. 36,02201-DEC-1998 GB_HTG3: AC005769 200000 AC005769 Homo sapiens chromosome 4,*** SEQUENCING IN PROGRESS ***, Homo sapiens 36,745 21-Aug-99 5unordered pieces. rxa00719 1752 GB_BA2: U32687 11847 U32687 Haemophilusinfluenzae Rd section 2 of 163 of the complete genome. Haemophilusinfluenzae Rd 36,937 29-MAY-1998 GB_EST13: AA333802 357 AA333602EST37710 Embryo, 8 week | Homo sapiens cDNA 5′ end similar to guanineHomo sapiens 45,938 21-Apr-97 nucleotide-binding protein rap2,ras-oncogene related, mRNA sequence. GB_BA2: U32687 11847 U32687Haemophilus influenzae Rd section 2 of 163 of the complete genome.Haemophilus influenzae Rd 36,39 29-MAY-1998 rxa00720 789 GB_EST1: M61974437 M61974 EST00024 Fetal brain, Stratagene (cat#936206) Homo sapienscDNA Homo sapiens 40,138 26-MAY-1992 clone HFBA87, mRNA sequence.GB_EST3: R73776 389 R73776 yi55h07.r1 Soares placenta Nb2HP Homo sapienscDNA clone IMAGE: 143197 5′, Homo sapiens 41,818 5-Jun-93 mRNA sequence.GB_EST35: AL043192 793 AL043192 DKFZp434G0723_r1 434 (synonym: htes3)Homo sapiens cDNA clone Homo sapiens 38,571 29-Sep-99 DKFZp434G0723 5′,mRNA sequence. rxa00722 1088 GB_HTG3: AC008573 205755 AC008573 Homosapiens chromosome 5 clone CIT-HSPC_551|11, *** SEQUENCING Homo sapiens38,506 3-Aug-99 IN PROGRESS ***, 95 unordered pieces. GB_HTG3: AC008573205755 AC008573 Homo sapiens chromosome 5 clone CIT-HSPC_551|11, ***SEQUENCING Homo sapiens 38,506 3-Aug-99 IN PROGRESS ***, 95 unorderedpieces. GB_BA1: MTV014 58280 AL021646 Mycobacterium tuberculosis H37Rvcomplete genome; segment 137/162. Mycobacterium 41,392 18-Jun-98tuberculosis rxa00724 2100 GB_BA1: SC7A1 32039 AL034447 Streptomycescoelicolor cosmid 7A1. Streptomyces coelicolor 54,858 15-DEC-1998GB_BA1: BSY13937 27779 Y13937 Bacillus subtilis genomic DNA from thespoVM region. Bacillus subtilis 47,01 30-MAR-1998 GB_BA2: L78127 1225L78127 Enterococcus faecium genomic DNA fragment. Enterococcus faecium36,88 18-Aug-99 rxa00726 614 GB_BA1: BACJH642 282700 D84432 Bacillussubtilis DNA, 283 Kb region containing skin element. Bacillus subtilis56,694 6-Feb-99 GB_BA1: BSUB0013 218470 Z99116 Bacillus subtiliscomplete genome (section 13 of 21): from 2395261 to 2613730. Bacillussubtilis 36,513 26-Nov-97 GB_BA1: SC4H8 15560 AL020958 Streptomycescoelicolor cosmid 4H8. Streptomyces coelicolor 35,073 10-DEC-1997rxa00729 rxa00730 930 GB_HTG3: AC010758 145821 AC010758 Homo sapiensclone 1_B_18, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,73822-Sep-99 20 unordered pieces. GB_HTG3: AC010758 145821 AC010758 Homosapiens clone 1_B_18, *** SEQUENCING IN PROGRESS ***, Homo sapiens35,738 22-Sep-99 20 unordered pieces. GB_GSS13: AQ469090 414 AQ469090CITBI-E1-2596D12.TF CITBI-E1 Homo sapiens genomic clone 2596D12, Homosapiens 36,842 23-Apr-99 genomic survey sequence. rxa00731 2619 GB_BA1:CGLYSI 4232 X60312 C. glutamicum lysi gene for L-lysine permease.Corynebacterium 100 30-Jan-92 glutamicum GB_BA1: CGLYSI 4232 X60312 C.glutamicum lysi gene for L-lysine permease. Corynebacterium 37,64530-Jan-92 glutamicum rxa00738 386 GB_BA1: MTCY10G2 38970 Z92539Mycobacterium tuberculosis H37Rv complete genome: segment 47/162.Mycobacterium 54,427 17-Jun-98 tuberculosis GB_HTG1: HSJ564F22 106277AL080249 Homo sapiens chromosome 20 clone RP4-564F22, *** SEQUENCINGHomo sapiens 44 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1:HSJ564F22 106277 AL080249 Homo sapiens chromosome 20 clone RP4-564F22,*** SEQUENCING Homo sapiens 44 23-Nov-99 IN PROGRESS ***, in unorderedpieces. rxa00740 702 GB_PL2: AF100167 1557 AF100167 Glycine max unknownmRNA. Glycine max 35,823 4-Nov-98 GB_EST28: AI465702 268 AI465702vw83g01.y1 Stratagene mouse skin (#937313) Mus musculus cDNA cloneIMAGE: Mus musculus 43,226 09-MAR-1999 1261584 5′, mRNA sequence.GB_EST20: AA856157 359 AA856157 vw83g01.r1 Stratagene mouse skin(#937313) Mus musculus cDNA clone IMAGE: Mus musculus 43,226 06-MAR-19981261584 5′, mRNA sequence. rxa00741 1056 GB_HTG2: AC007185 199340AC007185 Drosophila melanogaster chromosome 2 clone BACR44N04 (D545)RPCI-98 Drosophila melanogaster 39,583 2-Aug-99 44.N.4 map 36A-36Astrain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 50 unordered pieces.GB_HTG2: AC007185 199340 AC007185 Drosophila melanogaster chromosome 2clone BACR44N04 (D545) RPCI-98 Drosophila melanogaster 39,583 2-Aug-9944.N.4 map 36A-36A strain y: cn bw sp. *** SEQUENCING IN PROGRESS ***,50 unordered pieces. GB_PL2: F17123 134784 AF160182 Arabidopsis thalianaBAC F17I23. Arabidopsis thaliana 37,788 20-Jun-99 rxa00742 1773 GB_IN1:CEC05C10 26263 Z48178 Caenorhabditis elegans cosmid C05C10, completesequence. Caenorhabditis elegans 39,243 2-Sep-99 GB_IN1: CEC05C10 26263Z48178 Caenorhabditis elegans cosmid C05C10, complete sequence.Caenorhabditis elegans 38,041 2-Sep-99 rxa00743 546 GB_GSS9: AQ093649320 AQ093649 HS_3022_A1_E06_MR CIT Approved Human Genomic Sperm LibraryD Homo sapiens 34,277 27-Aug-98 Homo sapiens genomic clone Plate = 3022Col = 11 Row = I, genomic survey sequence. GB_GSS9: AQ093649 320AQ093649 HS_3022_A1_E06_MR CIT Approved Human Genomic Sperm Library DHomo sapiens 34,277 27-Aug-98 Homo sapiens genomic clone Plate = 3022Col = 11 Row = I, genomic survey sequence. rxa00745 657 GB_HTG2:AC008195 130309 AC008195 Drosophila melanogaster chromosome 3 cloneBACR42I20 (D748) RPCI-98 42.I.20 Drosophila melanogaster 38,095 2-Aug-99map 93F-93F strain y; cn bw sp. *** SEQUENCING IN PROGRESS ***, 77unordered pieces. GB_IN2: DMU53190 3477 U53190 Drosophila melanogasterCamguk (cmg) mRNA, complete cds. Drosophila melanogaster 39,62330-Nov-98 GB_HTG2: AC008195 130309 AC008195 Drosophila melanogasterchromosome 3 clone BACR42I20 (D748) RPCI-98 42.I.20 Drosophilamelanogaster 38,095 2-Aug-99 map 93F-93F strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 77 unordered pieces. rxa00746 1314 GB_HTG3:AC010076 148614 AC010076 Homo sapiens chromosome 15 clone BAC 64K10 map14q25, Homo sapiens 36,336 11-Sep-99 LOW-PASS SEQUENCE SAMPLING.GB_HTG3: AC010076 148614 AC010076 Homo sapiens chromosome 15 clone BAC64K10 map 14q25, Homo sapiens 36,336 11-Sep-99 LOW-PASS SEQUENCESAMPLING. GB_PR3: MS402G11 177241 AL022328 Human DNA sequence from clone402G11 on chromosome 22q13.31-13.33 Homo sapiens 38,752 23-Nov-99Contains genes for SAPK3 (stress-activated protein kinase 3), PRKM11(protein kinase mitogen-activated 11), KIAA0315, ESTs, GSSs and CpGislands, complete sequence. rxa00747 711 GB_HTG4: AC010081 176777AC010081 Homo sapiens clone NH0065E07, *** SEQUENCING IN PROGRESS ***,Homo sapiens 37,016 29-OCT-1999 1 unordered pieces. GB_HTG4: AC010081176777 AC010081 Homo sapiens clone NH0065E07, *** SEQUENCING IN PROGRESS***, Homo sapiens 37,016 29-OCT-1999 1 unordered pieces. GB_HTG3:AC011194 196098 AC011194 Mus musculus chromosome 11 clone 196_F_5 map11, *** SEQUENCING Mus musculus 38,735 01-OCT-1999 IN PROGRESS ***, 32unordered pieces. rxa00748 567 GB_GSS13: AQ457887 478 AQ457887HS_5189_B2_B06_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 37,844 23-Apr-99 genomic clone Plate = 765 Col = 12 Row = D,genomic survey sequence. GB_IN1: EHEXRIDRI 170 X58630 E. histolyticaextrachromosomal ribosomal DNA for DRA I repeat unit. Entamoebahistolytica 42,353 13-Aug-91 GB_IN1: EHEXRDNA 3699 X61182 E. histolyticaextrachromosomal ribasomal DNA downstream of rRNA genes. Entamoebahistolytica 38,905 2-Sep-96 rxa00749 822 GB_BA1: BSUB0003 209100 Z99106Bacillus subtilis complete genome (section 3 of 21): from 402751 to611850. Bacillus subtilis 37,238 26-Nov-97 GB_BA1: AB001488 148068AB001488 Bacillus subtilis genome sequence, 148 kb sequence of theregion Bacillus subtilis 37,238 13-Feb-99 between 35 and 47 degree.rxa00750 GB_HTG3: AC008060 161486 AC008060 Homo sapiens clone DJ0912I13,*** SEQUENCING IN PROGRESS ***, Homo sapiens 39,474 13-Aug-99 4unordered pieces. rxa00751 951 GB_PR4: AC006449 286758 AC006449 Homosapiens chromosome 17, clone hCIT.58_E_17, complete sequence. Homosapiens 38,223 23-OCT-1999 GB_HTG2: AC002118 170891 AC002118 Homosapiens chromosome 17 clone 303_E_14, *** SEQUENCING Homo sapiens 37,11213-Feb-98 IN PROGRESS ***, 20 unordered pieces. GB_HTG2: AC002118 170891AC002118 Homo sapiens chromosome 17 clone 303_E_14, *** SEQUENCING Homosapiens 37,112 13-Feb-98 IN PROGRESS ***, 20 unordered pieces. rxa00752552 GB_PL2: F5K24 109786 AF128395 Arabidopsis thaliana BAC F5K24.Arabidopsis thaliana 38,899 03-MAR-1999 GB_BA1: MBHRDED 6300 Y09870 M.barkeri hdrE & hdrD genes, ORF1, ORF2, ORF3 & ORF4. Methanosarcinabarkeri 40,609 04-DEC-1998 GB_PL1: SC9920 23498 Z48639 S. cerevisiaechromosome XIII cosmid 9920. Saccharomyces cerevisiae 35,754 11-Aug-97rxa00757 1377 GB_PAT: E13655 2260 E13655 gDNA encodingglucose-6-phosphate dehydrogenase. Corynebacterium 46,045 24-Jun-98glutamicum GB_GSS9: AQ103710 369 AQ103710 HS_3092_B1_C01_MF CIT ApprovedHuman Genomic Sperm Library D Homo sapiens 36,339 27-Aug-98 Homo sapiensgenomic clone Plate = 3092 Col = 1 Row = F, genomic survey sequence.GB_HTG3: AC009305 167705 AC009305 Homo sapiens clone NH0153B21, ***SEQUENCING IN PROGRESS ***, Homo sapiens 36,691 13-Aug-99 3 unorderedpieces. rxa00763 906 GB_BA1: SC7B7 13800 AL009199 Streptomycescoelicolor cosmid 7B7. Streptomyces coelicolor 39,013 02-DEC-1997GB_HTG2: HSJ473J16 203460 AL109942 Homo sapiens chromosome 6 cloneRP3-473J16 map q25.3-26, *** SEQUENCING Homo sapiens 38,192 03-DEC-1999IN PROGRESS ***, in unordered pieces. GB_HTG2: HSJ473J16 203460 AL109942Homo sapiens chromosome 6 clone RP3-473J16 map q25.3-26, *** SEQUENCINGHomo sapiens 38,192 03-DEC-1999 IN PROGRESS ***, in unordered pieces.rxa00765 810 GB_BA1: MTV043 68848 AL022004 Mycobacterium tuberculosisH37Rv complete genome; segment 40/162. Mycobacterium 38,568 24-Jun-99tuberculosis GB_BA2: PAU93274 8008 U93274 Pseudomonas aeruginosa YafE(yafE), LeuB (leuB), Asd (asd), Pseudomonas aeruginosa 37,656 23-Jun-98FimV (fimV), and HisT (hisT) genes, complete cds; TrpF (trpF) gene,partial cds: and unknown gene. GB_BA1: MTCY31 37630 Z73101 Mycobacteriumtuberculosis H37Rv complete genome; segment 41/162. Mycobacterium 38,20917-Jun-98 tuberculosis rxa00768 1242 GB_HTG5: AC008194 194555 AC008194Drosophila melanogaster chromosome X clone BACR49A05 (D745) RPCI-9849.A.5 Drosophila melanogaster 34,078 15-Nov-99 map 18A-18 Astrain y; cnbw sp, *** SEQUENCING IN PROGRESS ***, 90 unordered pieces. GB_HTG5:AC008194 194555 AC008194 Drosophila melanogaster chromosome X cloneBACR49A05 (D745) RPCI-98 49.A.5 Drosophila melanogaster 31,194 15-Nov-99map 18A-18A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 90unordered pieces. GB_BA2: AF044495 9599 AF044495 Agrobacteriumtumefaciens chemotaxis operon, complete Agrobacterium tumefaciens 40,1652-Jul-98 sequence. rxa00769 336 GB_PR3: AC003068 42184 AC003068 HumanCosmid g5129z059 from 7q31.3. complete sequence. Homo sapiens 35,1526-Nov-97 GB_PR2: HSAC000374 41585 AC000374 Human cosmid g1980a170,complete sequence. Homo sapiens 35,152 12-MAR-1997 GB_PR3: AC00306842184 AC003068 Human Cosmid g5129z059 from 7q31.3, complete sequence.Homo sapiens 37,309 6-Nov-97 rxa00771 942 GB_PR2: HS172K2 131234 Z84814Human DNA sequence from PAC 172K2 on chromosome 6 Homo sapiens 34,71923-Nov-99 contains HLA CLASS II DRA pseudogene, DRB3*01012 genes, DRB9pseudogene butyrophilin precursor and ESTs. GB_HTG1: HSA555E18 1177AL121780 Homo sapiens chromosome 20 clone RP11-555E18, Homo sapiens41,45 23-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces.GB_HTG1: HSA555E18 1177 AL121780 Homo sapiens chromosome 20 cloneRP11-555E18, Homo sapiens 41,45 23-Nov-99 *** SEQUENCING IN PROGRESS***, in unordered pieces. rxa00781 411 GB_PR3: HS48A11 129294 AL031132Human DNA sequence from clone 48A11 on chromosome Homo sapiens 37,28423-Nov-99 20p12 Contains EST, STS, GSS, complete sequence. GB_IN1:CELC03B1 42297 U40952 Caenorhabditis elegans cosmid C03B1.Caenorhabditis elegans 38,177 25-Nov-95 GB_PR3: HS48A11 129294 AL031132Human DNA sequence from clone 48A11 on chromosome 20p12 Homo sapiens35,162 23-Nov-99 Contains EST, STS, GSS, complete sequence. rxa00785 680GB_EST11: AA223451 349 AA223451 zr06d01.r1 Stratagene NT2 neuronalprecursor 937230 Homo sapiens cDNA clone Homo sapiens 38,682 19-Feb-97IMAGE: 6506895', mRNA sequence. GB_EST9: AA081255 446 AA081255zn33d08.r1 Stratagene endothelial cell 937223 Homo sapiens cDNA cloneHomo sapiens 40,271 21-OCT-1996 IMAGE: 549231 5', mRNA sequence.GB_EST9: C16722 314 C16722 C16722 Clontech human aorta polyA+ mRNA(#6572) Homo sapiens cDNA clone Homo sapiens 44,013 30-Sep-96 GEN-522C025', mRNA sequence. rxa00788 348 GB_PL2: UMU62738 13812 U62738 Ustilagomaydis ferrichrome siderophore peptide synthetase (sid2) gene, completecds. Ustilago maydis 31,792 30-DEC-1997 GB_PR1: AB012723 40850 AB012723Homo sapiens gene for kinesin-like protein, complete cds. Homo sapiens35,398 8-Jan-99 GB_HTG3: AC008625 16830 AC008625 Homo sapienschromosomes 5 clone CIT978SKB_157D17, *** SEQUENCING Homo sapiens 42,563-Aug-99 IN PROGRESS***, 19 unordered pieces. rxa00795 651 GB_IN2:AC003120 59991 AC003120 Drosophila melanogaster DNA sequence (P1 DS01523(D34)), complete sequence. Drosophila melanogaster 39,252 17-Jul-98GB_EST19: AA802212 574 AA802212 GM04027.5prime GM Drosophilamelanogaster ovary BlueScript Drosophila Drosophila melanogaster 37,82625-Nov-98 melanogaster cDNA clone GM04027 5prime, mRNA sequence. GB_IN2:AF168467 4652 AF168467 Drosophila melanogaster dual specificity kinaseDYRK2 mRNA,complete cds. Drosophila melanogaster 36,933 5-Aug-99rxa00804 567 GB_GSS12: AQ356039 499 AQ356039 CITBI-E1-2535P11.TRCITBI-E1 Homo sapiens genomic clone 2535P11, Homo sapiens 40,56924-Jan-99 genomic survey sequence. GB_PR4: AC005037 190508 AC005037 Homosapiens clone NH0469M07, complete sequence. Homo sapiens 41,20914-MAY-1999 GB_HTG5: AC007272 175463 AC007272 Homo sapiens cloneNH0013J08, *** SEQUENCING IN PROGRESS ***, Homo sapiens 41,209 2-Nov-995 unordered pieces. rxa00805 1005 GB_GSS1: CNS00U61 320 AL090583Arabidopsis thaliana genome survey sequence SP6 end of BAC T6D17 of TAMUArabidopsis thaliana 36,364 28-Jun-99 library from strain Columbia ofArabidopsis thaliana, genomic survey sequence. GB_PL1: AB026639 63921AB026639 Arabidopsis thaliana genomic DNA, chromosome 5, TAC clone:K21L13, complete Arabidopsis thaliana 38,485 07-MAY-1999 sequence.GB_PL1: AB026639 63921 AB026639 Arabidopsis thaliana genomic DNA,chromosome 5, TAC clone: K21L13, complete Arabidopsis thaliana 35,45107-MAY-1999 sequence. rxa00808 1581 GB_BA1: MLCB2548 38916 AL023093Mycobacterium leprae cosmid B2548. Mycobacterium leprae 50,854 27-Aug-99GB_BA1: MLCL373 37304 AL035500 Mycobacterium leprae cosmid L373.Mycobacterium leprae 40,295 27-Aug-99 GB_PL2: SCE9781 68302 U18916Saccharomyces cerevisiae chromosome V cosmids 9781, 8198, 9115, 9981,and Saccharomyces cerevislae 37,677 1-Aug-97 lambda clones 3955 and6052. rxa00812 1182 GB_HTG2: AC006003 114949 AC006003 Homo sapiens cloneDJ0782K24, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,284 22-Nov-9816 unordered pieces. GB_HTG2: AC006003 114949 AC006003 Homo sapiensclone DJ0782K24, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,28422-Nov-98 16 unordered pieces. GB_GSS9: AQ090529 323 AQ090529HS_3007_B1_E09_MR CIT Approved Human Genomic Sperm Library D Homosapiens 41,176 26-Aug-98 Homo sapiens genomic clone Plate = 3007 Col =17 Row = J, genomic survey sequence. rxa00814 897 GB_VI: EHVU20824184427 U20824 Equine herpesvirus 2, complete genome. Equine herpesvirus2 35,274 2-Feb-96 GB_VI: EHVU20824 184427 U20824 Equine herpesvirus 2,complete genome. Equine herpesvirus 2 38,808 2-Feb-96 GB_PR3: HS466N179528 Z97630 Human DNA sequence from clone 466N1 on chromosome Homosapiens 38,496 23-Nov-99 22q12-13 Contains H1F0(H1 histone family,member 0) gene, 2-amino-3-ketobutyrate-CoA ligase(nuclear gene encodingmitochondrial protein), GALR3 (galanin receptor) gene, ESTs, GSSs andCpG islands, complete sequence. rxa00815 696 GB_PR3: CNS01DRL 174928AL117355 Human chromosome 14 DNA sequence *** IN PROGRESS *** BACR-354E14 of Homo sapiens 36,578 26-Nov-99 RPCI-11 library fromchromosome 14 of Homo sapiens (Human), complete sequence. GB_PR4:AC007283 127361 AC007283 Homo sapiens clone NH0536I18, completesequence. Homo sapiens 37,609 28-Sep-99 GB_EST14: AA406984 477 AA406984MBAFCZ7H08T3 Brugia malayi adult female cDNA (SAW96MLW-BmAF) Brugiamalayi 41,919 01-MAY-1997 Brugia malayi cDNA clone AFCZ7H08 5′, mRNAsequence. rxa00816 420 GB_EST27: AI414036 467 AI414036 ma03e08.x1 Soaresmouse p3NMF19.5 Mus musculus cDNA clone IMAGE: Mus musculus 40,1769-Feb-99 303494 3′ similar to TR: Q85299 Q85299 HOMOLOGUE OF RETROVIRALPSEUDOPROTEASE.;, mRNA sequence. GB_GSS15: AQ642295 501 AQ642295RPCI93-Dpnll-28G21.TV RPCI93-Dpnll Trypanosoma brucel genomic cloneTrypanosoma brucel 37,54 8-Jul-99 RPCI93-Dpnll-28G21, genomic surveysequence. GB_PL2: ZMU82481 2750 U82481 Zea mays KI domain interactingkinase 1 (KIK1) mRNA, complete cds. Zea mays 41,783 1-Jan-98 rax00826654 GB_PR4: AC008179 181745 AC008179 Homo sapiens clone NH0576F01,complete sequence. Homo sapiens 35,736 28-Sep-99 GB_HTG1: AC002413 63369AC002413 Homo sapiens chromosome X clone bWXD111, *** SEQUENCING IN Homosapiens 37,6 12-Aug-97 PROGRESS ***, 2 unordered pieces. GB_HTG1:AC002413 63369 AC002413 Homo sapiens chromosome X clone bWXD111, ***SEQUENCING IN Homo sapiens 37,6 12-Aug-97 PROGRESS ***, 2 unorderedpieces. rxa00830 846 GB_GSS6: AQ823465 535 AQ823465 HS_3217_A1_D08_T7CCIT Approved Human Genomic Sperm Library D Homo sapiens 40,417 26-Aug-99Homo sapiens genomic clone Plate = 3217 Col = 15 Row = G, genomic surveysequence. GB_GSS6: AQ825402 381 AQ825402 HS_5498_A1_G01_SP6E RPCI-11Human Male BAC Library Homo sapiens 43,068 26-Aug-99 Homo sapiensgenomic clone Plate = 1074 Col = 1 Row = M, genomic survey sequence.GB_HTG1: HSU242F8 92944 AL022167 Homo sapiens chromosome X cloneLL0XNC01-242F8, *** SEQUENCING IN Homo sapiens 38,321 23-Nov-99 PROGRESS***, in unordered pieces. rxa00831 rxa00835 1077 GB_EST35: AI864917 468AI864917 wj66f11.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE: Homosapiens 37,607 30-Aug-99 2407821 3′ similar to WP: F01F1.9 CE01235VACUOLAR AMINOPEPTIDASE;, mRNA sequence. GB_EST35: AI864917 468 AI864917wj66f11.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE: Homo sapiens38,444 30-Aug-99 2407821 3′ similar to WP: F01F1.9 CE01235 VACUOLARAMINOPEPTIDASE;, mRNA sequence. rxa00836 1816 GB_EST11: AA212728 424AA212728 mw81g02.r1 Soares mouse NML Mus musculus cDNA clone IMAGE: Musmusculus 40,284 18-Feb-97 677138 5′, mRNA sequence. GB_EST26: AI390258557 AI390258 mw81g02.y1 Soares mouse NML Mus musculus cDNA clone IMAGE:677138 5′, Mus musculus 41,261 2-Feb-99 mRNA sequence. GB_PR3: AC003669159446 AC003669 Homo sapiens Xp22 BAC GS-594A7 (Genome Systems Human BAClibrary) Homo sapiens 34,914 24-MAR-1998 contains Bmx gene, completesequence. rxa00840 rxa00841 rxa00846 993 GB_BA1: U00017 42157 U00017Mycobacterium leprae cosmid B2126. Mycobacterium leprae 35,63501-MAR-1994 GB_BA1: MLCB2533 40245 AL035310 Mycobacterium leprae cosmidB2533. Mycobacterium leprae 38,28 27-Aug-99 GB_RO: AB022047S7 18721AB022053 Mus musculus gene for prolyl oligopeptidase, exon 11, 12, 13,14, 15 and Mus musculus 36,633 20-Aug-99 complete cds. rxa00853 726GB_PR3: HS531H16 155116 AL031664 Human DNA sequence *** SEQUENCING INPROGRESS *** from clone Homo sapiens 41,11 23-Nov-99 531H16, completesequence. GB_PR3: HS531H16 155116 AL031664 Human DNA sequence ***SEQUENCING IN PROGRESS *** from Homo sapiens 37,343 23-Nov-99 clone531H16, complete sequence. GB_HTG3: AC010264 81671 AC010264 Homo sapienschromosome 5 clone CIT-HSPC_468K18, *** SEQUENCING IN Homo sapiens38,776 15-Sep-99 PROGRESS ***, 66 unordered pieces. rxa00854 336 GB_IN1:CELM04G7 41778 AF036700 Caenorhabditis elegans cosmid M04G7.Caenorhabditis elegans 37,349 05-DEC-1997 GB_EST20: AA850405 451AA850405 EST193172 Normalized rat ovary, Bento Soares Rattus sp. cDNAclone Rattus sp. 40,789 30-Apr-98 ROVAF27 3′ end, mRNA sequence.GB_HTG2: AF165144 110891 AF165144 Homo sapiens chromosome 8 clone BAC393A07 map 8q, *** SEQUENCING IN Homo sapiens 34,234 16-Jul-99 PROGRESS***, inordered pieces. rxa00855 408 GB_HTG2: AC007173 140775 AC007173Drosophila melanogaster chromosome 2 clone BACR01A03 (D538) Drosophilamelanogaster 36,341 2-Aug-99 RPCI-98 01.A.3 map 36E-36E strain y; cn bwsp, *** SEQUENCING IN PROGRESS ***, 36 unordered pieces. GB_NTG2:AC007173 140775 AC007173 Drosophila melanogaster chromosome 2 cloneBACR01A03 (D538) Drosophila melanogaster 36,341 2-Aug-99 RPCI-98 01.A.3map 36E-36E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 36unordered pieces. GB_PL2: YSCH8179 44113 U00062 Saccharomyces cerevisiaechromosome VIII cosmid 8179. Saccharomyces cerevisiae 38,56 4-Sep-97rxa00861 426 GB_BA1: CGORF4GEN 2398 X95649 C. glutamicum ORF4 gene.Corynebacterium 100 10-MAR-1998 glutamicum GB_BA1: SC9A10 9000 AL031260Streptomyces coelicolor cosmid 9A10. Streptomyces coelicolor 63,8311-Aug-98 GB_BA2: AF039028 2475 AF039028 Streptomyces toyocaensisD-ala-D-ala dipeptidase (vanXst) gene, Streptomyces toyocaensis 61,9395-Jan-99 complete cds; and unknown gene. rxa00862 682 GB_PAT: E145202001 E14520 DNA encoding Brevibacterium dihydrodipicolinic acidsynthase. Corynebacterium 36,154 28-Jul-99 glutamicum GB_PAT: E127732001 E12773 DNA encoding Brevibacterium dihydrodipicolinic acidreductase. Corynebacterium 36,154 24-Jun-98 glutamicum GB_PAT: E167492001 E16749 gDNA encoding dihydrodipicolinate synthase (DDPS).Corynebacterium 36,154 28-Jul-99 glutamicum rxa00869 1044 GB_EST24:AI166579 645 AI166579 xylem.est.398 Poplar xylem Lambda ZAPII libraryPopulus balsamifera subsp. Populus balsamifera 39,854 03-DEC-1998trichocarpa cDNA 5′, mRNA sequence. subsp. trichocarpa GB_BA1: MTCY06H1138000 Z85982 Mycobacterium tuberculosis H37Rv complete genome; segment73/162. Mycobacterium 42,801 17-Jun-98 tuberculosis GB_EST34: AV153098283 AV153098 AV153098 Mus musculus hippocampus C57BL/6J adult Musmusculus cDNA Mus musculus 39,576 7-Jul-99 clone 2900052L10, mRNAsequence. rxa00874 1212 GB_HTG2: AC007885 108561 AC007885 Drosophilamelanogaster chromosome 2 clone BACR02G15 (D643) RPCI-98 02.G.15Drosophila melanogaster 38,276 2-Aug-99 map 60F-60F strain y; cn bw sp,*** SEQUENCING IN PROGRESS ***, 65 unordered pieces. GB_NTG2: AC007582127205 AC007582 Drosophila melanogaster chromosome 2 clone BACR17E16(D642) RPCI-98 17.E.16 Drosophila melanogaster 36,246 2-Aug-99 map60F-60F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 81 unorderedpieces. GB_HTG2: AC007885 108561 AC007885 Drosophila melanogasterchromosome 2 clone BACR02G15 (D643) RPCI-98 02.G.15 Drosophilamelanogaster 38,276 2-Aug-99 map 60F-60F strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 65 unordered pieces. rxa00876 1878 GB_EST10:AA144736 479 AA144736 mr72d08.r1 Stratagene mouse testis (#937308) Musmusculus cDNA clone IMAGE: Mus musculus 41,474 11-Feb-97 602991 5′, mRNAsequence. GB_EST32: AU069076 316 AU069076 AU069076 Rice callus Oryzasativa cDNA clone C51993_1A, mRNA sequence. Oryza sativa 46,33 7-Jun-99GB_EST10: AA144736 479 AA144736 mr72d08.r1 Stratagene mouse testis(#937308) Mus musculus cDNA clone IMAGE: Mus musculus 43,243 11-Feb-97602991 5′, mRNA sequence. rxa00881 501 GB_HTG4: AC010103 192320 AC010103Homo sapiens chromosome unknown clone NH0508N21, WORKING DRAFT Homosapiens 36,62 29-OCT-1999 SEQUENCE, in unordered pieces. GB_HTG4:AC010103 192320 AC010103 Homo sapiens chromosome unknown cloneNH0508H21, WORKING DRAFT Homo sapiens 36,62 29-OCT-1999 SEQUENCE, inunordered pieces. GB_HTG4: AC010103 192320 AC010103 Homo sapienschromosome unknown clone NH0508H21, WORKING DRAFT Homo sapiens 34,2829-OCT-1999 SEQUENCE, in unordered pieces. rxa00882 801 GB_BA1: MTCY4835377 Z74020 Mycobacterium tuberculosis H37Rv complete genome; segment69/162. Mycobacterium 37,927 17-Jun-98 tuberculosis GB_PAT: AR0052113453 AR005211 Sequence 1 from patent US 5747651. Unknown. 39,6204-DEC-1998 GB_PAT: I40600 3453 I40600 Sequence 1 from patent US5621090. Unknown. 39,62 13-MAY-1997 rxa00883 642 GB_PR2: HS217O16 87552AL031771 Human DNA sequence from clone 217O16 on chromosome 6q24Contains GSS, Homo sapiens 33,866 23-Nov-99 complete sequence. GB_PR2:HS217O16 87552 AL031771 Human DNA sequence from clone 217O16 onchromosome 6q24 Contains GSS, Homo sapiens 35,479 23-Nov-99 completesequence. rxa00887 rxa00889 711 GB_BA1: MTCY27 27548 Z95208Mycobacterium tuberculosis H37Rv complete genome; segment 104/162.Mycobacterium 36,978 17-Jun-98 tuberculosis GB_BA1: U00016 42931 U00016Mycobacterium leprae cosmid B1937. Mycobacterium leprae 55,65101-MAR-1994 GB_PR4: AC007326 102898 AC007326 Homo sapiens, completesequence. Homo sapiens 40,205 2-Nov-99 rxa00893 720 GB_PL1: HVCPMII 6225Y09602 H. vulgare gene encoding serine carboxypeptidase II, CP-MII.Hordeum vulgare 35,704 10-MAR-1997 GB_EST35: AI814621 441 AI814621wj75d04.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE: Homo sapiens37,788 24-Aug-99 2408647 3′ similar to TR: O00578 O00578 KIAA0167. [1];,mRNA sequence. GB_EST3: R51723 376 R51723 yg77h06.r1 Soares infant brain1NIB Homo sapiens cDNA clone IMAGE: Homo sapiens 41,489 18-MAY-199539671 5′ similar to gb: M77016 TROPOMODULIN (HUMAN);, mRNA sequence.rxa00895 714 GB_HTG3: AC009414 188673 AC009414 Homo sapiens cloneNH0490M08, *** SEQUENCING IN Homo sapiens 36,775 17-Sep-99 PROGRESS ***,5 unordered pieces. GB_HTG3: AC009414 188673 AC009414 Homo sapiens cloneNH0490M08, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,775 17-Sep-995 unordered pieces. GB_PR3: HSJ824F16 139330 AL050325 Human DNA sequencefrom clone 824F16 on chromosome 20, complete sequence. Homo sapiens37,286 23-Nov-99 rxa00904 815 GB_HTG5: AC006447 141662 AC006447 Musmusculus, *** SEQUENCING IN PROGRESS ***, 2 unordered pieces. Musmusculus 35,945 17-Nov-99 GB_HTG5: AC011064 233428 AC011064 Drosophilamelanogaster chromosome X clone BACN05G06 (D1107) Drosophilamelanogaster 37,783 16-Nov-99 RPCI-98 05.G.6 map 12F-13A strain y; cn bwsp, *** SEQUENCING IN PROGRESS ***, 220 unordered pieces. GB_HTG6:AC008334 154566 AC008334 Drosophila melanogaster chromosome X cloneBACR08K05 (D885) Drosophila melanogaster 37,783 02-DEC-1999 RPCI-9808.K.5 map 12F-12F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***,84 unordered pieces. rxa00908 681 GB_GSS12: AQ409791 561 AQ409791HS_5090_B2_B12_T7A RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 39,711 17-MAR-1999 genomic clone Plate = 666 Col = 24 Row = Dgenomic survey sequence. GB_GSS3: B83773 535 B83773 CpG0110A CpIOWAgDNA1Cryptosporidium parvum Cryptosporidium parvum 44,615 06-MAY-1999genomic, genomic survey sequence. GB_GSS12: AQ409791 561 AQ409791HS_5090_B2_B12_T7A RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 41,333 17-MAR-1999 genomic clone Plate = 666 Col = 24 Row = D,genomic survey sequence. rxa00915 753 GB_HTG2: HS1118M15 190466 AL109964Homo sapiens chromosome 20 clone RP5-1118M15, *** SEQUENCING IN Homosapiens 40,027 30-Nov-99 PROGRESS ***, inunordered pieces. GB_HTG2:HS1057B20 204291 AL109823 Homo sapiens chromosome 20 clone RP5-1057B20map q11.21-12, Homo sapiens 38,535 30-Nov-99 *** SEQUENCING IN PROGRESS***, in unordered pieces. GB_HTG2: HS1118M15 190466 AL109964 Homosapiens chromosome 20 clone RP5-1118M15, Homo sapiens 40,027 30-Nov-99*** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa00916 3714GB_EST28: AI543268 568 AI543268 SD09973.5prime SD Drosophilamelanogaster Schnelder L2 cell culture pOT2 Drosophila melanogaster40,426 22-MAR-1999 Drosophila melanogaster cDNA clone SD09973 5prime,mRNA sequence. GB_IN2: AC004301 68620 AC004301 Drosophila melanogasterDNA sequence (P1 DS07134 (D192)), complete sequence. Drosophilamelanogaster 37,696 29-MAY-1998 GB_EST37: AI994315 524 AI994315701502677 A. thaliana, Ohio State clone set Arabidopsis thaliana cDNAArabidopsis thaliana 40,076 8-Sep-99 clone 701502677, mRNA sequence.rxa00917 2802 GB_BA1: SYCSLRB 146271 D64000 Synechocystis sp. PCC6803complete genome, 19/27, 2392729-2538999. Synechocystis sp. 38,44713-Feb-99 GB_HTG1: CEY39E4_2 110000 Z94158 Caenorhabditis eleganschromosome III clone Y39E4. Caenorhabditis elegans 38,218 Z94158 ***SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY39E4_2110000 Z94158 Caenorhabditis elegans chromosome III clone Y39E4,Caenorhabditis elegans 38,218 Z94158 *** SEQUENCING IN PROGRESS ***, inunordered pieces. rxa00921 rxa00926 486 GB_OM: SSU75316 5996 U75316 Susscrofa beta-myosin heavy chain mRNA, complete cds. Sus scrofa 38,95803-DEC-1996 GB_EST21: AA970971 371 AA970971 op10b11.s1 NCI_CGAP_Kid6Homo sapiens cDNA clone IMAGE: 1575261 3′, Homo sapiens 40,841 13-Apr-99mRNA sequence. GB_OM: SSU75316 5996 U75316 Sus scrofa beta-myosin heavychain mRNA, complete cds. Sus scrofa 38,578 03-DEC-1996 rxa00930 876GB_BA1: MTCI270A 1670 Z98045 Mycobacterium tuberculosis H37Rv completegenome; segment 116/162. Mycobacterium 37,927 17-Jun-98 tuberculosisGB_BA1: U00011 40429 U00011 Mycobacterium leprae cosmid B1177.Mycobacterium leprae 38,623 01-MAR-1994 GB_RO: S58745 817 S58745thyrotroph embryonic factor = leucine zipper transcription factor [rats,Rattus sp. 41,483 07-MAY-1993 pituitary, mRNA, 817 nt]. rxa00932 597GB_PR4: AC009509 192690 AC009509 Homo sapiens 12p11-37.2-54.4 BACRP11-1060J15 (Roswell Park Cancer Homo sapiens 38,776 01-DEC-1999Institute Human BAC Library) complete sequence. GB_PR3: AC004072 170658AC004072 Human Chromosome X clone bWXD342, complete sequence. Homosapiens 35 08-MAR-1998 GB_PR4: AC004617 176552 AC004617 Homo sapienschromosome Y, clone 264, M, 20, complete sequence. Homo sapiens 35,70213-OCT-1999 rxa00933 585 GB PL1: MGNGAGPOLI 5638 L35053 Transposon MAGGYgag and pol gene homologues, partial cds's. Magnaporthe grisea 40,2834-Aug-94 GB PL1: MGNGAGPOLI 5638 L35053 Transposon MAGGY gag and polgene homologues, partial cds's. Magnaporthe grisea 37,739 4-Aug-94rxa00940 519 GB_PR2: HS179N16 172048 Z95152 Homo sapiens DNA sequencefrom PAC 179N16 on chromosome 6p21.1-21.33. Homo sapiens 38,26223-Nov-99 Contains the SAPK4 (MAPK p38delta) gene, and the alternativelyspliced SAPK2 gene coding for CSaids binding protein CSBP2 and a MAPKp38beta LIKE protein. Contains ESTs, STSs and two predicted CpG islands,complete sequence. GB_EST26: AU001018 304 AU001018 AU001018 Bombyx morip50(Daizo) Bombyx mori cDNA clone fbf0932f, Bombyx mori 45,745 15-Jan-99mRNA sequence. GB_EST26: AU001019 304 AU001019 AU001019 Bombyx morip50(Daizo) Bombyx mori cDNA clone fbf0934f, Bombyx mori 45,745 15-Jan-99mRNA sequence. rxa00943 1035 GB_BA2: AF079317 184457 AF079317Sphingomonas aromaticivorans plasmid pNL1, complete plasmid sequence.Sphingomonas 38,151 12-Jan-99 aromaticivorans GB_HTG3: AC008329 114408AC008329 Drosophila melanogaster chromosome 2 clone BACR31D05 (D861)RPCI-98 31.D.5 Drosophila melanogaster 34,317 17-Aug-99 map 28C-28Dstrain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 105 unorderedpieces. GB_HTG3: AC008329 114408 AC008329 Drosophila melanogasterchromosome 2 clone BACR31D05 (D861) RPCI-98 31.D.5 Drosophilamelanogaster 34,317 17-Aug-99 map 28C-28D strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 105 unordered pieces. rxa00946 897 GB_BA1:MTV008 63033 AL021246 Mycobacterium tuberculosis H37Rv complete genome;segment 108/162. Mycobacterium 36,045 17-Jun-98 tuberculosis GB_GSS14:AQ571765 526 AQ571765 HS_2094_A2_B09_MR CIT Approved Human Genomic SpermLibrary D Homo sapiens 38,021 1-Jun-99 Homo sapiens genomic clone Plate= 2094 Col = 18 Row = C, genomic survey sequence. GB_RO: RRFE65G 2464X60468 R. rattus FE65 gene for adaptor protein interacting with thebeta-amyloid precursor Rattus rattus 38,417 1-Feb-96 proteinintracellular domain. rxa00949 771 GB_VI: PPCCGAAA 5366 M26281 Hamsterpapovavirus complete genome. Hamster papovavirus 36,579 22-MAY-1995GB_VI: HAPVXX 5366 X02449 Hamster papovavirus (HapV) genome. Hamsterpapovavirus 36,579 22-OCT-1999 GB_BA2: AE000878 15432 AE000878Methanobacterium thermoautotrophicum from bases 976801 to 992232Methanobacterium 36,856 15-Nov-97 (section 84 of 148) of the completegenome. thermoautotrophicum rxa00959 579 GB_BA1: CGMTRAR 951 X75083 C.glutamicum mtrA gene locus with 5-methyltryptophan resistance.Corynebacterium 99,133 18-Aug-94 glutamicum GB_BA1: CGMTRA 587 X75084 C.glutamicum sequence corresponding to mtrA locus. Corynebacterium 99,21618-Aug-94 glutamicum GB_BA1: BLTRP 7725 X04960 Brevibacteriumlactofermentum tryptophan operon. Corynebacterium 96,8 10-Feb-99glutamicum rxa00963 960 GB_EST15: AA484511 504 AA484511 nf08f07.s1NCI_CGAP_LI1 Homo sapiens cDNA clone IMAGE: 913189 similar Homo sapiens43,75 18-Aug-97 to gb: Y00764 UBIQUINOL-CYTOCHROME C REDUCTASE 11 KDPROTEIN (HUMAN);, mRNA sequence. GB_EST20: AA894481 544 AA894481nw76b10.s1 NCI_CGAP_Pr12 Homo sapiens cDNA clone IMAGE: 1252507 Homosapiens 37,5 6-Apr-98 similar to gb: Y00764 UBIQUINOL-CYTOCHROME CREDUCTASE 11 KD PROTEIN (HUMAN);, mRNA sequence. GB_EST15: AA526497 582AA526497 ni96d07.s1 NCI_CGAP_Pr21 Homo sapiens cDNA clone IMAGE: 9846853′ similar Homo sapiens 38,554 5-Aug-97 to gb: Y00764UBIQUINOL-CYTOCHROME C REDUCTASE 11 KD PROTEIN (HUMAN);, mRNA sequence.rxa00969 1458 GB_BA1: CGHOMTHR 3685 Y00546 Corynebacterium glutamicumhom-thrB genes for homoserine dehydrogenase and Corynebacterium 99,58812-Sep-93 homoserine kinase. glutamicum GB_PAT: I09077 3685 I09077Sequence 1 from Patent WO 8809819. Unknown. 99,246 02-DEC-1994 GB_BA1:BLTHRA 1483 Y00476 B. lactofermentum thr A gene. Corynebacterium 99,37805-MAY-1993 glutamicum rxa00971 341 GB_BA1: CGHOMTHR 3685 Y00546Corynebacterium glutamicum hom-thrB genes for homoserine dehydrogenaseand Corynebacterium 35,435 12-Sep-93 homoserine kinase. glutamicumGB_PAT: I09077 3685 I09077 Sequence 1 from Patent WO 8809819. Unknown.35,435 02-DEC-1994 GB_BA1: BLTHRB 1139 Y00140 Brevibacteriumlactofermentum thrB gene for homoserine kinase. Corynebacterium 40,96412-Sep-93 glutamicum rxa00973 726 GB_BA1: CGHOMTHR 3685 Y00546Corynebacterium glutamicum hom-thrB genes for homoserine dehydrogenaseand Corynebacterium 41,797 12-Sep-93 homoserine kinase. glutamicumGB_PAT: I09077 3685 I09077 Sequence 1 from Patent WO 8809819. Unknown.41,797 02-DEC-1994 GB_IN2: AC006574 127035 AC006574 Drosophilamelanogaster, chromosome 2R, region 39A3-39B1, P1 clones Drosophilamelanogaster 37,355 16-Feb-99 DS02919 and DS05130, complete sequence.rxa00978 738 GB_PR2: HSAC000372 41730 AC000372 Human cosmid g1980a186,complete sequence. Homo sapiens 34,674 12-MAR-1997 GB_PR3: AC00550340998 AC005503 Homo sapiens clone UWGC: g5129s003 from 7q31, completesequence. Homo sapiens 34,674 20-Aug-98 GB_PR2: HSAC000372 41730AC000372 Human cosmid g1980a186, complete sequence. Homo sapiens 38,88112-MAR-1997 rxa00986 465 GB_GSS10: AQ258013 761 AQ258013 nbxb0019H05fCUGI Rice BAC Library Oryza sativa genomic clone nbxb0019h05f, Oryzasativa 31,533 23-OCT-1998 genomic survey sequence. GB_PR3: HS83L6 61187Z99130 Human DNA sequence from PAC 83L6 on chromosome Xp11.1-11.22.Contains Homo sapiens 38,395 23-Nov-99 ZXDA (ZFPA) zinc finger gene,ESTs and STSs, complete sequence. GB_PR3: HS598A24 96558 AL031115 HumanDNA sequence from clone 598A24 on chromosome Xp11.1-11.23 Contains Homosapiens 37,333 23-Nov-99 zinc finger X-linked proteins ZXDA, ZXDB, ESTsand STS, complete sequence. rxa00987 588 GB_HTG1: HS24A17 2000 AL035452Homo sapiens chromosome X clone RP6-24A17, *** SEQUENCING IN Homosapiens 38,821 23-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1:HS24A17 2000 AL035452 Homo sapiens chromosome X clone RP6-24A17, ***SEQUENCING IN Homo sapiens 38,821 23-Nov-99 PROGRESS ***, In unorderedpieces. GB_PR2: HS1156N12 146360 AL009047 Human DNA sequence from clone1156N12 on chromosome X. Contains an STS Homo sapiens 38,821 23-Nov-99and GSSs complete sequence. rxa00988 546 GB_IN1: CELZC328 30350 AF000194Caenorhabditis elegans cosmid ZC328. Caenorhabditis elegans 36,12223-Apr-97 GB_IN1: CELZC328 30350 AF000194 Caenorhabditis elegans cosmidZC328. Caenorhabditis elegans 37,959 23-Apr-97 rxa01005 969 GB_BA1:FVBPOAD2A 45519 D26094 Flavobacterium sp. plasmid pOAD2 DNA, wholesequence. Flavobacterium sp. 37,998 6-Feb-99 GB_GSS1: CNS00UGV 472AL090973 Arabidopsis thaliana genome survey sequence SP6 end of BAC T6P9of TAMU Arabidopsis thaliana 39,024 28-Jun-99 library from strainColumbia of Arabidopsis thaliana, genomic survey sequence. GB_GSS1:CNS00S69 512 AL087999 Arabidopsis thaliana genome survey sequence SP6end of BAC T1C4 of TAMU Arabidopsis thaliana 35,938 28-Jun-99 libraryfrom strain Columbia of Arabidopsis thaliana, genomic survey sequence.rxa01007 rxa01008 rxa01011 1356 GB_EST38: AW039107 598 AW039107EST281080 tomato mixed elicitor, BTI Lycopersicon esculentum cDNA cloneLycopersicon esculentum 39,724 18-OCT-1999 cLET12F19, mRNA sequence.GB_BA1: MTY13E12 43401 Z95390 Mycobacterium tuberculosis H37Rv completegenome; segment 147/162. Mycobacterium 38,618 17-Jun-98 tuberculosisGB_BA1: MBU15140 2136 U15140 Mycobacterium bovis ribosomal proteins IF-1(infA), L36 (rpmJ), S13 (rpsM) and Mycobacterium bovis 37,07 28-OCT-1996S11 (rpsK) genes, complete cds, and S4 (rpsD) gene, partial cds.rxa01016 771 GB_BA1: CGBPHI16 962 Y12472 C. glutamicum DNA, attachmentsite bacteriophage Phi-16. Corynebacterium 45,098 05-MAR-1999 glutamicumGB_BA1: CGBPHI16 962 Y12472 C. glutamicum DNA, attachment sitebacteriophage Phi-16. Corynebacterium 37,251 05-MAR-1999 glutamicumrxa01017 732 GB_BA1: CGBPHI16 962 Y12472 C. glutamicum DNA, attachmentsite bacteriophage Phi-16. Corynebacterium 39,245 05-MAR-1999 glutamicumGB_BA2: AF099014 2500 AF099014 Streptomyces coelicolor strain A3(2)transposase (tnpA) and Fe-containing Streptomyces coelicolor 38,0361-Jun-99 superoxide dismutase I (sodF1) genes, complete cds. GB_HTG3:AC009249 119461 AC009249 Drosophila melanogaster chromosome 3 cloneBACR02M06 (D1003) Drosophila melanogaster 37,853 27-Aug-99 RPCI-9802.M.6 map 98B-98B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***,97 unordered pieces. rxa01021 622 GB_BA2: U39718 8603 U39718 Mycoplasmagenitalium section 40 of 51 of the complete genome. Mycoplasmagenitalium 39,348 5-Nov-98 GB_GSS3: B46221 457 B46221HS-1063-A2-D06-MR.abi CIT Human Genomic Sperm Library C Homo sapiensHomo sapiens 39,933 21-OCT-1997 genomic clone Plate = CT 796 Col = 12Row = G. genomic survey sequence. GB_OV: AF035529 848 AF035529 Xenopuslaevis Smad6 mRNA, partial cds. Xenopus laevis 37,203 1-Jan-98 rxa010231101 GB_HTG2: HSJ435K13 151301 AL109941 Homo sapiens chromosome 6 cloneRP3-435K13 map q14.1-16.1, Homo sapiens 34,405 03-DEC-1999 ***SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: HSJ435K13151301 AL109941 Homo sapiens chromosome 6 clone RP3-435K13 mapq14.1-16.1, Homo sapiens 34,405 03-DEC-1999 *** SEQUENCING IN PROGRESS***, in unordered pieces. GB_BA1: RCU57682 86896 U57682 Rhodobactercapsulatus cosmids 143-147, complete sequence. Rhodobacter capsulatus39,022 7-Feb-97 rxa01028 2172 GB_IN1: CBU55260 2518 U55260Caenorhabditis briggsae beta tubulin (mec-7) gene, complete cds.Caenorhabditis briggasae 39,467 5-Jun-96 GB_HTG1: CEY1A5 196643 AL008872Caenorhabditis elegans chromosome III clone Y1A5, *** SEQUENCING INCaenorhabditis elegans 38,168 9-Nov-97 PROGRESS ***, in unorderedpieces. GB_HTG1: CEY1A5 196643 AL008872 Caenorhabditis eleganschromosome III clone Y1A5, *** SEQUENCING Caenorhabditis elegans 38,1689-Nov-97 IN PROGRESS ***, in unordered pieces. rxa01029 612 GB_PR3:HS466P17 149963 AL023806 Human DNA sequence from clone 466P17 onchromosome 6q24. Contains a putative Homo sapiens 38,33 23-Nov-99 novelgene, the 5′ part of the EPM2A (Laforin) gene, ESTs. STSs, GSSs, genomicmarker D6S1703 and D6S1443, a putative CpG island and a ca repeatpolymorphism, complete sequence. GB_PR3: HS466P17 149963 AL023806 HumanDNA sequence from clone 466P17 on chromosome 6q24. Contains a Homosapiens 39,262 23-Nov-99 putative novel gene, the 5′ part of the EPM2A(Laforin) gene, ESTs. STSs, GSSs, genomic marker D6S1703 and D6S1443, aputative CpG island and a ca repeat polymorphism, complete sequence.GB_RO: D78344 59641 D78344 Mouse DNA for Ig gamma-chains, partial cds.Mus musculus 35,472 5-Feb-99 rxa01031 789 GB_PR4: AC006948 168558AC006948 Homo sapiens chromosome 17, clone hRPK.334_M_10, completesequence. Homo sapiens 44,005 27-Apr-99 GB_PL2: AC011665 101845 AC011665Arabidopsis thaliana chromosome I BAC T6L1 genomic sequence, completeArabidopsis thaliana 38,17 11-Nov-99 sequence. GB_RO: MMU19724 5523U19724 Mus musculus MMTV integration locus. aromatase gene, 3′UTR. Musmusculus 35,256 17-Feb-96 rxa01032 498 GB_EST9: AA118349 576 AA118349ml56b06.r1 Stratagene mouse testis (#937308) Mus musculus cDNA cloneIMAGE: Mus musculus 43,056 19-Nov-96 515987 5′ similar to gb: L04852Mouse (MOUSE);, mRNA sequence. GB_EST9: AA118349 576 AA118349 ml56b06.r1Stratagene mouse testis (#937308) Mus musculus cDNA clone IMAGE: Musmusculus 42,273 19-Nov-96 515987 5′ similar to gb: L04852 Mouse(MOUSE);, mRNA sequence. rxa01033 459 GB_GSS13: AQ434868 520 AQ434868HS_5117_B1_D07_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 38,608 31-MAR-1999 genomic clone Plate = 693 Col = 13 Row = H,genomic survey sequence. GB_HTG2: HSDJ794I6 137124 AL109976 Homo sapienschromosome 20 clone RP4-794I6, *** SEQUENCING IN Homo sapiens 28,92927-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG2: HSDJ794I6 137124AL109976 Homo sapiens chromosome 20 clone RP4-794I6, *** SEQUENCING INHomo sapiens 28,929 27-Nov-99 PROGRESS ***, in unordered pieces.rxa01034 477 GB_PL2: ATT29H11 87011 AL049659 Arabidopsis thaliana DNAchromosome 3, BAC clone T29H11. Arabidopsis thaliana 32,495 9-Jun-99GB_PL2: ATT29H11 87011 AL049659 Arabidopsis thaliana DNA chromosome 3,BAC clone T29H11. Arabidopsis thaliana 40,042 9-Jun-99 GB_EST25:AU045739 436 AU045739 AU045739 Mouse sixteen-cell-embryo cDNA Musmusculus cDNA clone Mus musculus 35,435 09-DEC-1998 J0940F02 3′, mRNAsequence. rxa01035 729 GB_GSS1: CNS00QD8 526 AL085658 Arabidopsisthaliana genome survey sequence SP6 end of BAC F11C22 of IGF Arabidopsisthaliana 36,466 28-Jun-99 library from strain Columbia of Arabidopsisthaliana, genomic survey sequence. GB_GSS13: AQ447948 515 AQ447948mgxb0015A01r CUGI Rice Blast BAC Library Magnaporthe grisea genomicMagnaporthe grisea 45,833 8-Apr-99 clone mgxb0015A01r, genomic surveysequence. GB_GSS1: CNS00QD8 526 AL085658 Arabidopsis thaliana genomesurvey sequence SP6 end of BAC F11C22 of IGF library Arabidopsisthaliana 37,5 28-Jun-99 from strain Columbia of Arabidopsis thaliana,genomic survey sequence. rxa01036 576 GB_HTG2: AC004846 143577 AC004846Homo sapiens clone DJ0647C14, *** SEQUENCING IN PROGRESS ***, Homosapiens 38,137 12-Jun-98 21 unordered pieces. GB_EST19: AA804532 427AA804532 ns28c05.s1 NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE: Homosapiens 33,582 18-Feb-98 1184936 3′ similar to contains element MER40repetitive element;, mRNA sequence. GB_HTG2: AC006342 201618 AC006342Homo sapiens clone DJ0054D12, *** SEQUENCING IN PROGRESS ***, Homosapiens 38,137 11-Jan-99 3 unordered pieces. rxa01037 651 GB_PR4:AC004812 138532 AC004812 Homo sapiens PAC clone 267D11 from 12, completesequence. Homo sapiens 39,75 05-DEC-1998 GB_HTG2: AC006342 201618AC006342 Homo sapiens clone DJ0054D12, *** SEQUENCING IN PROGRESS ***,Homo sapiens 41,214 11-Jan-99 3 unordered pieces. GB_HTG2: AC004846143577 AC004846 Homo sapiens clone DJ0647C14, *** SEQUENCING IN PROGRESS***, Homo sapiens 41,214 12-Jun-98 21 unordered pieces. rxa01038rxa01039 699 GB_PR4: HUAC004682 189134 AC004682 Homo sapiens Chromosome16 BAC clone CIT987SK-A-259H10, complete sequence. Homo sapiens 36,19223-Nov-99 GB_HTG2: HS500L14 164856 AL023583 Homo sapiens chromosome 6clone RP3-500L14 map p23-24.3, Homo sapiens 34,632 30-Nov-99 ***SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: HS500L14164856 AL023583 Homo sapiens chromosome 6 clone RP3-500L14 map p23-24.3,Homo sapiens 34,632 30-Nov-99 *** SEQUENCING IN PROGRESS ***, inunordered pieces. rxa01040 1026 GB_EST24: AI193549 479 AI193549qe70e06.x1 Soares_fetal_lung_NbHL19W Homo sapiens cDNA clone IMAGE: Homosapiens 40,126 29-OCT-1998 1744354 3′, mRNA sequence. GB_PR2: HSU385453609 U38545 Human ARF-activated phosphatidytcholine-specificphospholipase D1a (hPLD1) Homo sapiens 38,652 10-MAR-1997 mRNA, completecds. GB_PR2: AC002481 28244 AC002481 Human cosmid clone LUCA12 from3p21.3, complete sequence, Homo sapiens 39,643 21-Aug-97 rxa01041 276GB_HTG6: AC007957 212658 AC007957 Homo sapiens, *** SEQUENCING INPROGRESS ***, 2 ordered pieces. Homo sapiens 40,809 26-Nov-99 GB_PR2:AP000552 157086 AP000552 Homo sapiens genomic DNA. chromosome 22q11.2,BCRL2 region, clone: Homo sapiens 40,809 01-OCT-1999 KB1183D5. GB_PR3:HS57A13 169693 Z83848 Human DNA sequence from PAC 57A13 between markersDXS6791 and Homo sapiens 37,647 23-Nov-99 DXS8038 on chromosome Xcontains glutamate receptor subunit GluRC, ESTs, STS and polymorphic CArepeat. rxa01042 1401 GB_BA1: MTCY10G2 38970 Z92539 Mycobacteriumtuberculosis H37Rv complete genome; segment 47/162. Mycobacterium 36,02317-Jun-98 tuberculosis GB_BA1: MTCY10G2 38970 Z92539 Mycobacteriumtuberculosis H37Rv complete genome; segment 47/162. Mycobacterium 37,0117-Jun-98 tuberculosis GB_EST29: AI551042 538 AI551042 vx33d11.x1Stratagene mouse lung 937302 Mus musculus cDNA clone IMAGE: Mus musculus38,806 23-MAR-1999 1277013 3′, mRNA sequence. rxa01043 696 GB_BA1:AF006658 2500 AF006658 Bacteroides fragilis beta-glucosidase gene,complete cds. Bacteroides fragilis 39,156 12-Jul-97 GB_BA1: MLB1790G37617 Z14314 M. leprae genes rplL, rpoB, rpoC, end, rpsL, rpsG, efg,tuf, rpsJ, rplC for ribosomal Mycobacterium leprae 39,97 11-Feb-93protein L7, RNA polymerase beta subunit, RNA polymerase beta' subunit,endonuclease. ribosomal protein S7, ribosomal protein S12, elongationfactor G, elongation factor Tu, ribosomal protein S10, ribosomal proteinL3 and mkl gene. GB_BA1: AF006658 2500 AF006658 Bacteroides fragilisbeta-glucosidase gene, complete cds. Bacteroides fragilis 36,47212-Jul-97 rxa01044 1380 GB_HTG6: AC010998 144338 AC010998 Homo sapiensclone RP11-95l16, *** SEQUENCING IN PROGRESS ***, Homo sapiens 37,6308-DEC-1999 17 unordered pieces. GB_HTG6: AC010998 144338 AC010998 Homosapiens clone RP11-95l16, *** SEQUENCING IN PROGRESS ***, Homo sapiens37,864 08-DEC-1999 17 unordered pieces. GB_BA2: AE000939 10599 AE000939Methanobacterium thermoautotrophicum from bases 1698671 to 1709269Methanobacterium 34,48 15-Nov-97 (section 145 of 148) of the completegenome. thermoautotrophicum rxa01045 1947 GB_VI: FCVF6A 8440 M18247Feline leukemia virus, subgroup A (FeLV-FAIDS), complete nucleotidesequence. Feline leukemia virus 37,617 29-MAR-1998 GB_OM: CATFLVPOL 3639L06140 Felis catus endogenous FeLV proviral polyprotein (protease (PRO),reverse Felis catus 41,966 21-Aug-95 transcriptase (RT),integrase/endonuclease (INT)) and pol pseudogene, 3′ end. GB_VI: CEAVCG9189 M33677 Caprine arthritis encephalitis virus, complete proviralgenome. Caprine arthritis- 36,297 04-MAR-1996 encephalitis virusrxa01046 1902 GB_HTG3: AC008423 177734 AC008423 Homo sapiens chromosome5 clone CIT-HSPC_298N6, *** SEQUENCING IN Homo sapiens 38,72 3-Aug-99PROGRESS ***, 56 unordered pieces. GB_HTG3: AC008423 177734 AC008423Homo sapiens chromosome 5 clone CIT-HSPC_298N6, *** SEQUENCING IN Homosapiens 38,72 3-Aug-99 PROGRESS ***, 56 unordered pieces. GB_HTG3:AC008423 177734 AC008423 Homo sapiens chromosome 5 clone CIT-HSPC_298N6,*** SEQUENCING IN Homo sapiens 35,882 3-Aug-99 PROGRESS ***, 56unordered pieces. rxa01047 597 GB_EST20: AA842685 510 AA842685MBAFCZ9C11T3 Brugia malayi adult female cDNA (SAW96MLW-BmAF) Brugiamalayl 37,965 02-MAR-1998 Brugia malayl cDNA clone AFCZ9C11 5′, mRNAsequence. GB_EST20: AA842685 510 AA842685 MBAFCZ9C11T3 Brugia malayiadult female cDNA (SAW96MLW-BmAF) Brugia malayi 41,697 02-MAR-1998Brugia malayi cDNA clone AFCZ9C11 5′. mRNA sequence. GB_EST20: AA842685510 AA842685 MBAFCZ9C11T3 Brugia malayi adult female cDNA(SAW96MLW-BmAF) Brugia malayi 41,697 02-MAR-1998 Brugia malayi cDNAclone AFCZ9C11 5′. mRNA sequence. rxa01058 444 GB_GSS9: AQ160800 745AQ160800 nbxb0006C07r CUGI Rice BAC Library Oryza sativa genomic cloneOryza sativa 38,242 12-Sep-98 nbxb0006C07r, genomic surveysequence.GB_GSS3: B10162 1102 B10162 F11B10-Sp6 IGF Arabidopsis thaliana genomicclone F11B10, Arabidopsis thaliana 42,263 14-MAY-1997 genomic surveysequence. GB_BA1: AB032799 9077 AB032799 Chromobacterium violaceumviolacein biosynthetic gene Chromobacterium 34,475 02-OCT-1999 cluster(vioA, vio B, vio C, vio D), complete cds. violaceum rxa01063 453GB_GSS4: AQ707752 510 AQ707752 HS_5560_A2_G07_T7A RPCI-11 Human MaleHomo sapiens 36,932 7-Jul-99 BAC Library Homo sapiens genomic clonePlate = 1136 Col = 14 Row = M, genomic survey sequence. GB_GSS4:AQ707752 510 AQ707752 HS_5560_A2_G07_T7A RPCI-11 Human Male BAC LibraryHomo sapiens 35,885 7-Jul-99 Homo sapiens genomic clone Plate = 1136 Col= 14 Row = M, genomic survey sequence. rxa01066 849 GB_BA2: U32709 10010U32709 Haemophilus influenzae Rd section 24 of 163 of the completegenome. Haemophilus influenzae Rd 36,158 29-MAY-1998 GB_RO: AB0096151515 AB009615 Mus musculus mRNA for type IIphosphatidylinositolphosphate kinase-alpha, Mus musculus 37,86113-Feb-99 complete cds. GB_RO: AB032899 1914 AB032899 Rattus norvegicusPIPK2 alpha mRNA for phosphatidylinositol 5-phosphate Rattus norvegicus38,48 07-OCT-1999 4-kinase alpha, complete cds. rxa01068 1194 GB_HTG4:AC006091 176878 AC006091 Drosophila melanogaster chromosome 3 cloneBACR48G05 (D475) Drosophila melanogaster 35,539 27-OCT-1999 RPCI-9848.G.5 map 91F1-91F13 strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 4 unordered pieces. GB_HTG4: AC006091 176878 AC006091 Drosophilamelanogaster chromosome 3 clone BACR48G05 (D475) RPCI-98 Drosophilamelanogaster 35,539 27-OCT-1999 48.G.5 map 91F1-91F13 strain y; cn bwsp, *** SEQUENCING IN PROGRESS ***, 4 unordered pieces. GB_HTG2:AC008141 100729 AC008141 Drosophila melanogaster chromosome 3 cloneBACR17F04 (D988) RPCI-98 Drosophila melanogaster 34,415 2-Aug-99 17.F.4map 91F-91F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 69unordered pieces. rxa01069 837 GB_EST15: AA531901 524 AA531901TgESTzz32g09.r1 TgME49 invivo Bradyzoite cDNA size selected Toxoplasmagondii 43,005 22-Jul-97 Toxoplasma gondii cDNA clone tgzz32g09.r1 5′,mRNA sequence. GB_EST15: AA520183 527 AA520183 TgESTzz39d01.s1 TgME49invivo Bradyzoite cDNA size selected Toxoplasma Toxoplasma gondii 40,66416-Jul-97 gondii cDNA clone tgzz39d01.s1 3′, mRNA sequence. GB_HTG6:AC010846 187611 AC010846 Drosophila melanogaster chromosome X cloneBACR13G13 (D894) RPCI-98 Drosophila melanogaster 36,679 03-DEC-199913.G.13 map 14B-14C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***,97 unordered pieces. rxa01071 2187 GB_EST20: AA880319 450 AA880319vx39h01.r1 Stratagene mouse lung 937302 Mus musculus cDNA Mus musculus40,724 26-MAR-1998 clone IMAGE: 1277617 5′, mRNA sequence. GB_GSS14:AQ558382 435 AQ558382 HS_2068_B1_F06_T7C CIT Approved Human Homo sapiens36,882 29-MAY-1999 Genomic Sperm Library D Homo sapiens genomic clonePlate = 2068 Col = 11 Row = L, genomic survey sequence. GB_GSS15:AQ600385 483 AQ600385 HS_5357_B2_C05_SP6E RPCI-11 Human Male Homosapiens 40,476 10-Jun-99 BAC Library Homo sapiens genomic clone Plate =933 Col = 10 Row = F, genomic survey sequence. rxa01074 828 GB_BA1:PSEHEDDH 3060 M74256 Pseudomonas aeruginosa Pseudomonas aeruginosa39,657 30-Nov-93 6-phosphogluconate dehydratase (edd) gene, andglyceraldehyde-3- phosphate dehydrogenase (gap) gene, complete cds.GB_BA1: CGL007732 4460 AJ007732 Corynebacterium glutamicum 3′ ppc gene,secG gene, amt gene, Corynebacterium 39,168 7-Jan-99 ocd gene and 5′soxA gene. glutamicum GB_EST9: AA066016 406 AA066016 ml52f12.r1Stratagene mouse testis (#937308) Mus musculus cDNA Mus musculus 43,3823-Feb-97 clone IMAGE: 515663 5′, mRNA sequence. rxa01075 534 GB_EST21:AA986543 445 AA986543 ue14f08.x1 Sugano mouse embryo mewa Mus musculuscDNA Mus musculus 31,236 28-MAY-1998 clone IMAGE: 1480359 3′, mRNAsequence. GB_EST22: AI035794 509 AI035794 ue17d01.y1 Sugano mouse embryomewa Mus musculus cDNA clone IMAGE: Mus musculus 42,264 26-Jun-981480609 5′, mRNA sequence. GB_EST22: AI006506 384 AI006506 ue14f08.y1Sugano mouse embryo mewa Mus musculus cDNA clone IMAGE: Mus musculus46,637 12-Jun-98 1480359 5′, mRNA sequence. rxa01076 1143 GB_HTG2:AC007741 162450 AC007741 Homo sapiens clone NH0340F16, *** SEQUENCING INHomo sapiens 38,209 5-Jun-99 PROGRESS ***, 3 unordered pieces. GB_HTG2:AC007741 162450 AC007741 Homo sapiens clone NH0340F16, *** SEQUENCING INPROGRESS ***, Homo sapiens 38,209 5-Jun-99 3 unordered pieces. GB_EST33:AV072325 317 AV072325 AV072325 Mus musculus stomach C57BL/6J adult Musmusculus Mus musculus 48,485 24-Jun-99 cDNA clone 2200003E03, mRNAsequence. rxa01078 957 GB_BA2: RCPHSYNG 45959 Z11165 R. capsulatuscomplete photosynthesis gene cluster. Rhodobacter capsulatus 36,6032-Sep-99 GB_BA2: RCPHSYNG 45959 Z11165 R. capsulatus completephotosynthesis gene cluster. Rhodobacter capsulatus 37,989 2-Sep-99GB_PR4: AF073931 7898 AF073931 Homo sapiens low-voltage activatedcalcium channel alpha 1H mRNA, complete cds. Homo sapiens 37,95304-MAR-1999 rxa01083 399 GB_BA2: AF112535 4363 AF112535 Corynebacteriumglutamicum putative glutaredoxin NrdH (nrdH), Nrdl Corynebacterium99,499 5-Aug-99 (nrdl), and ribonucleotide reductase alpha-chain (nrdE)genes, complete cds. glutamicum GB_PR3: HSH3D2 1789 AF053138 Homosapiens histone deacetylase 3 gene, exons 11, 12, 13 and partial cds.Homo sapiens 33,512 28-MAR-1998 GB_PR4: AF059650 16015 AF059650 Homosapiens histone deacetylase 3 (HDAC3) gene, complete cds. Homo sapiens38,814 03-MAR-1999 rxa01085 902 GB_EST4: H55032 951 H55032 HHU58aSorghum bicolor cv. TX430 Sorghum bicolor cDNA clone HHU58 Sorghumbicolor 41,111 27-Sep-99 5′ similar to transketolase, chloroplast(TKLC1), mRNA sequence. GB_HTG2: HSBA27F12 123489 AL109914 Homo sapienschromosome 6 clone RP11-27F12 map p22.3-24, Homo sapiens 35,15630-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2:HSBA27F12 123489 AL109914 Homo sapiens chromosome 6 clone RP11-27F12 mapp22.3-24, Homo sapiens 35,156 30-Nov-99 *** SEQUENCING IN PROGRESS ***,in unordered pieces. rxa01088 1305 GB_HTG5: AC010202 170004 AC010202Homo sapiens chromosome 12q seeders clone RP11-210L7, Homo sapiens37,313 6-Nov-99 *** SEQUENCING IN PROGRESS ***, 40 unordered pieces. INPROGRESS GB_HTG5: AC010202 170004 AC010202 Homo sapiens chromosome 12qseeders clone RP11-210L7, *** SEQUENCING Homo sapiens 37,422 6-Nov-99***, 40 unordered pieces. GB_PR1: HSIGFACI 7260 X57025 Human IGF-I mRNAfor insulin-like growth factor I. Homo sapiens 38,043 17-Feb-92 rxa01091664 GB_BA1: ECORELA 4034 J04039 E. coli relA gene encoding ATP: GTP3′-pyrophosphotransferase, complete cds. Escherichia coli 54,71116-Nov-93 GB_BA2: ECU29580 13234 U29580 Escherichia coli K-12 genome;approximately 62 minute region. Escherichia coli 37,327 5-Apr-99 GB_BA2:AE000362 12595 AE000362 Escherichia coli K-12 MG1655 section 252 of 400of the complete genome. Escherichia coli 37,327 12-Nov-98 rxa01096 547GB_PL1: PCX24CRY 357 Z34459 P. cryptogea X24 gene for cryptogein.Phytophthora cryptogea 43,31 19-Sep-96 GB_EST24: AI244520 414 AI244520qk14c08.x1 NCI_CGAP_Kid3 Homo sapiens cDNA clone IMAGE: 1868942 3′, Homosapiens 33,528 28-Jan-99 mRNA sequence. GB_RO: MM26SPROT 1479 Y13071 Musmusculus mRNA for 26S proteasome non-ATPase subunit. Mus musculus 37,94110-Sep-98 rxa01102 1368 GB_HTG3: AC009219 127519 AC009219 Drosophilamelanogaster chromosome 3 clone BACR32N16 (D973) RPCI-98 32.N.16Drosophila melanogaster 35,08 20-Aug-99 map 86C-86C strain y; cn bw sp,*** SEQUENCING IN PROGRESS***, 74 unordered pieces. GB_HTG3: AC009219127519 AC009219 Drosophila melanogaster chromosome 3 clone BACR32N16(D973) RPCI-98 32.N.16 Drosophila melanogaster 35,08 20-Aug-99 map86C-86C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 74 unorderedpieces. GB_PR4: AC006065 191134 AC006065 Homo sapiens 12q24.2 BACRPCI11-407A16 (Roswell Park Cancer Institute Homo sapiens 37,45327-Feb-99 Human BAC Library) complete sequence. rxa01103 348 GB_EST13:AA340958 338 AA340958 EST46332 Fetal kidney II Homo sapiens cDNA 5′ end,mRNA sequence. Homo sapiens 36,596 21-Apr-97 GB_RO: MUSBCL22 5806 L31532Mus musculus bcl-2 alpha gene, exon 2. Mus musculus 33,913 5-Apr-94GB_BA2: AE001165 13021 AE001165 Borrelia burgdorferi (section 51 of 70)of the complete genome. Borrelia burgdorferi 31,412 15-DEC-1997 rxa011071323 GB_HTG1: HS1030M6 173804 AL035089 Homo sapiens chromosome 20 cloneRP5-1030M6, *** SEQUENCING IN Homo sapiens 34,935 23-Nov-99 PROGRESS***, inunordered pieces. GB_HTG1: HS1030M6 173804 AL035089 Homo sapienschromosome 20 clone RP5-1030M6, *** SEQUENCING IN Homo sapiens 34,93523-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG2: AC005057 99370AC005057 Homo sapiens clone RG052H06, *** SEQUENCING IN PROGRESS ***, 11Homo sapiens 35,897 12-Jun-98 unordered pieces. rxa01108 774 GB_PR2:HSJ193N13 122961 AL078600 Human DNA sequence from clone RP1-193N13 onchromosome Homo sapiens 37,115 22-Nov-99 6q21-22.31, complete sequence.GB_EST34: AV139054 287 AV139054 AV139054 Mus musculus C57BL/6J 10-11 dayembryo Mus musculus cDNA Mus musculus 35,54 1-Jul-99 clone 2810048D09,mRNA sequence. GB_PL1: GTU21246 926 U21246 Gracilariopsis tenuifronsInternal transcribed spacer region of the Gracilariopsis tenuifrons 37,212-MAR-1995 ribosomal repeat, ITS1, 5.8S rRNA gene and ITS2, completesequence. rxa01109 765 GB_BA1: AB003332 1424 AB003332 Anabaenavariabilis rbpF gene for RNA binding protein, complete cds. Anabaenavariabilis 35,958 21-MAY-1999 GB_BA1: BPETOXOP 9342 L10720 Bordetellapertussis toxin liberation operon. Bordetella pertussis 40,107 9-Jul-93GB_PAT: I50844 951 I50844 Sequence 12 from patent U.S. Pat. No. 5643747.Unknown. 39,973 07-OCT-1997 rxa01119 1053 GB_GSS3: B36708 438 B36708HS-1041-B1-C05-MF.abi CIT Human Genomic Sperm Library C Homo Homosapiens 37,3 17-OCT-1997 sapiens genomic clone Plate = CT 823 Col = 9Row = F, genomic survey sequence. GB_PL2: F11A17 102077 AC007932Arabidopsis thaliana chromosome 1 BAC F11A17 sequence, completesequence. Arabidopsis thaliana 37,488 16-Aug-99 GB_EST22: AI043264 283AI043264 TENU0904 T. cruzi epimastigote normalized cDNA LibraryTrypanosoma Trypanosoma cruzi 40,989 1-Jul-98 cruzi cDNA clone 2i143′,mRNA sequence. rxa01121 1209 GB_PAT: I78756 737 I78756 Sequence 12from patent U.S. Pat. No. 5693781. Unknown. 40,975 3-Apr-98 GB_PAT:I92045 737 I92045 Sequence 12 from patent U.S. Pat. No. 5726299.Unknown. 40,975 01-DEC-1988 GB_PL1: MTPACG 100314 X55026 P. anserinacomplete mitochondrial genome. Mitochondrion Podospora 34,47708-DEC-1997 anserina rxa01122 645 GB_HTG4: AC010148 228794 AC010148 Homosapiens chromosome unknown Homo sapiens 42,13 29-OCT-1999 cloneNH0367B19, WORKING DRAFT SEQUENCE, inunordered pieces. GB_HTG4: AC010148228794 AC010148 Homo sapiens chromosome unknown clone Homo sapiens 42,1329-OCT-1999 NH0367B19, WORKING DRAFT SEQUENCE, inunordered pieces.GB_HTG4: AC010148 228794 AC010148 Homo sapiens chromosome unknown cloneHomo sapiens 37,559 29-OCT-1999 NH0367B19, WORKING DRAFT SEQUENCE,inunordered pieces. rxa01123 570 GB_EST33: AV090612 274 AV090612AV090612 Mus musculus tongue C57BL/6J adult Mus musculus 33,21228-Jun-99 Mus musculus cDNA clone 2310051C21, mRNA sequence. GB_EST33:AV090612 274 AV090612 AV090612 Mus musculus tongue C57BL/6J adult MusMus musculus 34,529 28-Jun-99 musculus cDNA clone 2310051C21, mRNAsequence. rxa01127 1143 GB_BA1: CGLEUB 2042 Y09578 C. glutamicum leuBgene. Corynebacterium 99,913 02-MAR-1999 glutamicum GB_BA1: MTV012 70287AL021287 Mycobacterium tuberculosis H37Rv complete genome; segment132/162. Mycobacterium 39,295 23-Jun-99 tuberculosis GB_BA1: SC1C2 42210AL031124 Streptomyces coelicolor cosmid 1C2. Streptomyces coelicolor62,456 15-Jan-99 rxa01128 1137 GB_BA1: CGLEUB 2042 Y09578 C. glutamicumleuB gene. Corynebacterium 38,515 02-MAR-1999 glutamicum GB_GSS8:AQ066341 241 AQ066341 HS_2243_B1_A02_MF CIT Homo sapiens 39,004 4-Aug-98Approved Human Genomic Sperm Library D Homo sapiens genomic clone Plate= 2243 Col = 3 Row = B, genomic survey sequence. GB_EST24: AI168493 459AI168493 ou64g08.s1 NCI_CGAP_Br2 Homo sapiens cDNA clone IMAGE: Homosapiens 42,117 23-OCT-1998 1632638 3′ similar to gb: D90209 DNA-BINDINGPROTEIN TAXREB67 (HUMAN);, mRNA sequence. rxa01129 1989 GB_BA1: MTCI2836300 Z97050 Mycobacterium tuberculosis H37Rv complete genome; segment10/162. Mycobacterium 38,159 23-Jun-98 tuberculosis GB_HTG1: LMFL685237286 AL034359 Leishmania major chromosome 4 clone L6852 strainFreidlin, *** SEQUENCING Leishmania major 38,485 29-Apr-99 IN PROGRESS***, in unordered pieces. GB_HTG1: LMFL6852 37286 AL034359 Leishmaniamajor chromosome 4 clone L6852 strain Freidlin, *** SEQUENCINGLeishmania major 38,485 29-Apr-99 IN PROGRESS ***, in unordered pieces.rxa01131 990 GB_BA1: CGLEUB 2042 Y09578 C. glutamicum leuB gene.Corynebacterium 99,313 02-MAR-1999 glutamicum GB_PR4: AC007253 225699AC007253 Homo sapiens BAC clone NH0454P05 from 2, complete sequence.Homo sapiens 35,421 22-OCT-1999 GB_HTG3: AC011305 171067 AC011305 Homosapiens clone NH0390E09, *** SEQUENCING Homo sapiens 35,955 05-OCT-1999IN PROGRESS ***, 1 unordered pieces. rxa01134 871 GB_HTG4: AC009375137069 AC009375 Drosophila melanogaster chromosome 3L/75A1 cloneDrosophila melanogaster 37,38 16-OCT-1999 RPCI98-44L18, *** SEQUENCINGIN PROGRESS ***, 59 unordered pieces. GB_HTG4: AC009375 137069 AC009375Drosophila melanogaster chromosome 3L/75A1 clone RPCI98-44L18,Drosophila melanogaster 37,38 16-OCT-1999 *** SEQUENCING IN PROGRESS***, 59 unordered pieces. GB_HTG4: AC009375 137069 AC009375 Drosophilamelanogaster chromosome 3L/75A1 clone RPCI98-44L18, Drosophilamelanogaster 38,489 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 59unordered pieces. rxa01137 483 GB_IN2: AC005421 69992 AC005421Drosophila melanogaster, chromosome 2L, region Drosophila melanogaster37,387 31-OCT-1998 22A1-22A1, P1 clone DS03601, complete sequence.GB_GSS1: CNS00KX9 1101 AL078350 Drosophila melanogaster genome surveysequence TET3 end Drosophila melanogaster 30,67 3-Jun-99 of BAC:BACR23A23 of RPCI-98 library from Drosophila melanogaster (fruit fly),genomic survey sequence. GB_IN2: AC005421 69992 AC005421 Drosophilamelanogaster, chromosome 2L, region 22A1-22A1, P1 Drosophilamelanogaster 33,333 31-OCT-1998 clone DS03601, complete sequence.rxa01140 1056 GB_PR4: AC007948 99904 AC007948 Genomic sequence of Homosapiens clone R417F14A from chromosome 18, Homo sapiens 36,249 6-Nov-99complete sequence. GB_HTG3: AC006278 140290 AC006278 Plasmodiumfalciparum chromosome 12 clone 3D7, *** SEQUENCING Plasmodium falciparum36,592 23-Sep-99 IN PROGRESS ***, 18 unordered pieces. GB_HTG3: AC006278140290 AC006278 Plasmodium falciparum chromosome 12 clone 3D7, ***SEQUENCING Plasmodium falciparum 36,592 23-Sep-99 IN PROGRESS ***, 18unordered pieces. rxa01148 723 GB_BA1: MTCY261 27322 Z97559Mycobacterium tuberculosis H37Rv complete genome; segment 95/162.Mycobacterium 50,139 17-Jun-98 tuberculosis GB_EST15: AA501229 548AA501229 vh62g12.r1 Knowles Solter mouse 11 5day limb bud Mus musculusMus musculus 36,25 1-Jul-97 cDNA clone IMAGE: 891622 5′ similar to TR:G762951 G762951 PRPL-2 PROTEIN;, mRNA sequence. GB_PR4: AF106062 1306AF106062 Homo sapiens Wiskott-Aldrich syndrome protein interacting Homosapiens 43,205 31-Jul-99 protein (WASPIP) mRNA, partial cds. rxa01153543 GB_BA1: MTCY261 27322 Z97559 Mycobacterium tuberculosis H37Rvcomplete genome; segment 95/162. Mycobacterium 40 17-Jun-98 tuberculosisGB_BA1: MLCB2533 40245 AL035310 Mycobacterium leprae cosmid B2533.Mycobacterium leprae 61,765 27-Aug-99 GB_BA1: U00017 42157 U00017Mycobacterium leprae cosmid B2126. Mycobacterium leprae 39,61501-MAR-1994 rxa01154 677 GB_BA1: MTCY49 39430 Z73966 Mycobacteriumtuberculosis H37Rv complete genome; segment 93/162. Mycobacterium 37,61524-Jun-99 tuberculosis GB_BA1: U00017 42157 U00017 Mycobacterium lepraecosmid B2126. Mycobacterium leprae 36,957 01-MAR-1994 GB_BA2: AF08683210612 AF086832 Streptomyces coelicolor putative Streptomyces coelicolor53,354 30-Jun-99 ferredoxin, ARC (arc), 20S proteasome beta-subunitprecursor (prcB), 20S proteasome alpha-subunit (prcA), putative LacIfamily repressor, and putative transporter genes, complete cds; andunknown genes. rxa01155 1570 GB_BA1: MTCY49 39430 Z73966 Mycobacteriumtuberculosis H37Rv complete genome; segment 93/162. Mycobacterium 37,02524-Jun-99 tuberculosis GB_BA1: REZ82005 3301 Z82005 R. erythropolis DNA,20S proteasome structural genes region (3301 bp). Rhodococcuserythropolis 54,128 8-Nov-97 GB_BA2: RSU26422 3554 U26422 Rhodococcuserythropolis ORF6(2), ORF7(2), proteasome beta-type subunit Rhodococcuserythropolis 45,951 08-OCT-1997 2 (prcB(2)), and proteasome alpha-typesubunit 2 (prcA(2))genes, complete cds. rxa01156 257 GB_BA2: RSU264223554 U26422 Rhodococcus erythropolis ORF6(2), ORF7(2), proteasomeRhodococcus erythropolis 54,724 08-OCT-1997 beta-type subunit 2(prcB(2)), and proteasome alpha-type subunit 2 (prcA(2)) genes, completecds. GB_HTG6: AC009218 126649 AC009218 Drosophila melanogasterchromosome 2 clone BACR33D17 (D945) Drosophila melanogaster 42,5702-DEC-1999 RPCI-98 33.D.17 map 57B-57B strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 76 unordered pieces. GB_OV: QULNFLW 7933D13223 Japanese quail genomic DNA for neurofilament-L (NF-L). Coturnixcoturnix 44,758 3-Feb-99 rxa01158 1065 GB_HTG3: AC011401 321277 AC011401Homo sapiens chromosome 5 Homo sapiens 35,048 06-OCT-1999 cloneCIT978SKB_35K5, *** SEQUENCING IN PROGRESS ***, 65 unordered pieces.GB_HTG3: AC011401 321277 AC011401 Homo sapiens chromosome 5 cloneCIT978SKB_35K5, Homo sapiens 35,048 06-OCT-1999 *** SEQUENCING INPROGRESS ***, 65 unordered pieces. GB_PR3: AC004386 172657 AC004386 Homosapiens Chromosome X clone bWXD691, complete sequence. Homo sapiens37,223 10-Apr-98 rxa01159 438 GB_PAT: I92035 413 I92035 Sequence 2 frompatent U.S. Pat. No. 5726299. Unknown. 78,169 01-DEC-1998 GB_PAT: I78746413 I78746 Sequence 2 from patent U.S. Pat. No. 5693781. Unknown. 78,1693-Apr-98 GB_HTG3: AC009209 108370 AC009209 Drosophila melanogasterchromosome 2 Drosophila melanogaster 43,59 20-Aug-99 clone BACR24G16(D1051) RPCI-98 24.G.16 map 47D- 47D strain y; cn bw sp, *** SEQUENCINGIN PROGRESS ***, 93 unordered pieces. rxa01160 998 GB_PAT: I78746 413I78746 Sequence 2 from patent U.S. Pat. No. 5693781. Unknown. 96,0323-Apr-98 GB_PAT: I92035 413 I92035 Sequence 2 from patent U.S. Pat. No.5726299. Unknown. 96,032 01-DEC-1998 GB_BA2: AF014804 6449 AF014804Neisseria meningitidis PglB (pglB), PglC Neisseria meningitidis 37,9773-Sep-99 (pglC), PglD (pglD), and AvtA (avtA) genes, complete cds.rxa01165 696 GB_HTG2: AC007851 128979 AC007851 Drosophila melanogasterDrosophila melanogaster 37,9 2-Aug-99 chromosome 2 clone BACR06M19(D615) RPCI-98 06.M.19 map 50C-50D strain y; cn bw sp, *** SEQUENCING INPROGRESS ***, 86 unordered pieces. GB_HTG2: AC007851 128979 AC007851Drosophila melanogaster chromosome Drosophila melanogaster 37,9 2-Aug-992 clone BACR06M19 (D615) RPCI-98 06.M.19 map 50C-50D strain y; cn bw sp,*** SEQUENCING IN PROGRESS ***, 86 unordered pieces. GB_HTG2: AC007851128979 AC007851 Drosophila melanogaster chromosome Drosophilamelanogaster 34,114 2-Aug-99 2 clone BACR06M19 (D615) RPCI-98 06.M.19map 50C-50D strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 86unordered pieces. rxa01166 1428 GB_BA1: LEUG6PD 1957 M64446 L.mesenteroides glucose-6-phosphate dehydrogenase gene, complete cds.Leuconostoc 41,259 26-Apr-93 mesenteroides GB_HTG3: AF188026 101456AF188026 Homo sapiens chromosome 8 Homo sapiens 35,535 08-OCT-1999 cloneBAC 2379L20 map 8q24, *** SEQUENCING IN PROGRESS ***, in ordered pieces.GB_HTG3: AF188026 101456 AF188026 Homo sapiens chromosome 8 Homo sapiens35,535 08-OCT-1999 clone BAC 2379L20 map 8q24, *** SEQUENCING INPROGRESS ***, in ordered pieces. rxa01167 519 GB_PR2: HS1026E2 100418AL022143 Human DNA sequence Homo sapiens 38,281 23-Nov-99 from clone1026E2 on chromosome 1q24.1-25.3 EST, CA repeat, STS, GSS, completesequence. GB_EST36: AI900015 496 AI900015 sb97f05.y1 Gm-c1012 Glycinemax Glycine max 42,045 06-DEC-1999 cDNA clone GENOME SYSTEMS CLONE ID:Gm-c1012-634 5′ similar to WP: T11G6.8 CE06432 RNA RECOGNITION MOTIF.;,mRNA sequence. GB_PR2: HS1026E2 100418 AL022143 Human DNA sequence fromclone Homo sapiens 40,99 23-Nov-99 1026E2 on chromosome 1q24.1-25.3 EST,CA repeat, STS, GSS, complete sequence. rxa01169 1119 GB_HTG2: AC00597892586 AC005978 Drosophila melanogaster chromosome 2 clone Drosophilamelanogaster 34,266 30-Jul-99 DS00678 (D449) map 59D3-59D4 strain y; cnbw sp, *** SEQUENCING IN PROGRESS ***, 6 unordered pieces. GB_HTG2:AC005978 92586 AC005978 Drosophila melanogaster chromosome 2 cloneDS00678 Drosophila melanogaster 34,266 30-Jul-99 (D449) map 59D3-59D4strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 6 unordered pieces.GB_HTG3: AC008304 91552 AC008304 Drosophila melanogaster chromosome 2clone BACR04G19 Drosophila melanogaster 31,278 20-Sep-99 (D646) RPCI-9804.G.19 map 59D2-59D3 strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 90 unordered pieces. rxa01170 606 GB_PR1: AB014524 6542 AB014524Homo sapiens mRNA for KIAA0624 protein, partial cds. Homo sapiens 43,4786-Feb-99 GB_EST38: AW016078 496 AW016078 UI-H-BI0p-abf-h-01-0-UI.s1NCI_CGAP_Sub2 Homo sapiens Homo sapiens 36,667 10-Sep-99 cDNA cloneIMAGE: 2711665 3′, mRNA sequence. GB_EST24: AI193238 323 AI193238qe56c06.x1 Soares_fetal_lung_NbHL19W Homo sapiens 37,427 29-OCT-1998Homo sapiens cDNA clone IMAGE: 1742986 3′, mRNA sequence. rxa01171 816GB_HTG2: AC007548 110249 AC007548 Drosophila melanogaster chromosome 2clone Drosophila melanogaster 35,634 2-Aug-99 BACR48M17 (D614) RPCI-9848.M.17 map 41C-41D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***,66 unordered pieces. GB_PR3: HS273F20 111253 AL034371 Human DNA sequencefrom clone 273F20 on chromosome 6q16.1-16.3 Homo sapiens 34,58223-Nov-99 Contains ESTs, STSs and GSSs, complete sequence. GB_HTG2:AC007548 110249 AC007548 Drosophila melanogaster chromosome 2 cloneBACR48M17 Drosophila melanogaster 35,634 2-Aug-99 (D614) RPCI-98 48.M.17map 41C-41D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 66unordered pieces. rxa01173 738 GB_GSS8: B93272 338 B93272CIT-HSP-2171E14.TF CIT-HSP Homo sapiens genomic Homo sapiens 42,01225-Jun-98 clone 2171E14, genomic survey sequence. GB_EST35: AV156265 282AV156265 AV156265 Mus musculus head C57BL/6J 12-day embryo Mus musculus41,35 7-Jul-99 Mus musculus cDNA clone 3000001I03, mRNA sequence. GB_RO:AF035777 2154 AF035777 Mus musculus somatostatin receptor subtype 5(sst5) gene, complete cds. Mus musculus 38,928 05-DEC-1997 rxa01174 873GB_HTG1: CEY51A2_3 110000 Z99275 Caenorhabditis elegans chromosome Vclone Y51A2, Caenorhabditis elegans 38,045 3-Dec-98 *** SEQUENCING INPROGRESS ***, in unordered pieces. GB_IN1: CEY51A2D 139259 AL021497Caenorhabditis elegans cosmid Y51A2D, complete sequence. Caenorhabditiselegans 38,045 2-Sep-99 GB_HTG1: CEY51A2_3 110000 Z99275 Caenorhabditiselegans chromosome V clone Y51A2, Caenorhabditis elegans 38,045 3-Dec-98*** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa01176 627GB_BA1: MTV021 23400 AL021957 Mycobacterium tuberculosis H37Rv completegenome; segment 97/162. Mycobacterium 39,159 18-Jun-98 tuberculosisGB_BA1: MSGB1551CS 36548 L78813 Mycobacterium leprae cosmid B1551 DNAsequence. Mycobacterium leprae 53,215 15-Jun-96 GB_BA1: MSGB1554CS 36548L78814 Mycobacterium leprae cosmid B1554 DNA sequence. Mycobacteriumleprae 53,215 15-Jun-96 rxa01177 rxa01178 573 GB_PR4: AC006126 46100AC006126 Homo sapiens chromosome 19, cosmid F18718, complete sequence.Homo sapiens 36,832 17-DEC-1998 GB_PR4: AC006126 46100 AC006126 Homosapiens chromosome 19, cosmid F18718, complete sequence. Homo sapiens40,463 17-DEC-1998 GB_EST23: AI128078 443 AI128078 qc47d10.x1Soares_pregnant_uterus_NbHPU Homo Homo sapiens 38,318 27-OCT-1998sapiens cDNA clone IMAGE: 1712755 3′ similar to SW: IF16_HUMAN Q16666GAMMA-INTERFERON-INDUCIBLE PROTEIN IFI-16;, mRNA sequence. rxa01184 1596GB_HTG2: HSG248A21 96783 AL118512 Homo sapiens chromosome 1 cloneGS1-248A21, *** SEQUENCING Homo sapiens 36,994 30-Nov-99 IN PROGRESS***, in unordered pieces. GB_HTG2: HSG248A21 96783 AL118512 Homo sapienschromosome 1 clone GS1-248A21, *** SEQUENCING Homo sapiens 38,99430-Nov-99 IN PROGRESS ***, in unordered pieces. GB_PR3: AC004237 38715AC004237 Homo sapiens chromosome 5, P1 clone 565a12 (LBNL N23). completesequence. Homo sapiens 36,514 27-Feb-98 rxa01186 1221 GB_BA1: MTCY27439991 Z74024 Mycobacterium tuberculosis N37Rv complete genome; segment126/162. Mycobacterium 34,758 19-Jun-98 tuberculosis GB_BA1: SC6A9 39461AL031035 Streptomyces coelicolor cosmid 6A9. Streptomyces coelicolor38,5 24-Jul-98 GB_BA2: AE000689 14698 AE000689 Aquifex aeolicus section21 of 109 of the complete genome. Aquifex aeolicus 45,379 25-MAR-1998rxa01187 573 GB_EST5: H60943 361 H60943 yr14g08.r1 Soares fetal liverspleen 1NFLS Homo sapiens cDNA clone IMAGE: Homo sapiens 39,20506-OCT-1995 205310 5′, mRNA sequence. GB_GSS1: AG018858 570 AG018858Homo sapiens genomic DNA, 21q region, clone: B125C11 SpN045(−21),genomic Homo sapiens 41,423 10-OCT-1999 survey sequence. GB_GSS13:AQ454839 505 AQ454839 HS_5218_A1_E03_T7A RPCI-11 Human Male Homo sapiens34,599 21-Apr-99 BAC Library Homo sapiens genomic clone Plate = 794 Col= 5 Row = I, genomic survey sequence. rxa01195 570 GB_PR3: AF022813 1358AF022813 Homo sapiens tetraspan (NAG-2) mRNA, complete cds. Homo sapiens40,614 18-Nov-97 GB_EST34: AI798721 765 AI798721 we91g10.x1Soares_NFL_T_GBC_S1 Homo sapiens 35,256 6-Jul-99 Homo sapiens cDNA cloneIMAGE: 2348514 3′ similar to SW: NAG2_HUMAN O14817 NOVEL ANTIGEN 2;,mRNA sequence. GB_EST34: AI808898 696 AI808898 wf66d02.x1Soares_NFL_T_GBC_S1 Homo sapiens 35,354 7-Jul-99 Homo sapiens cDNA cloneIMAGE: 2360547 3′ similar to SW: NAG2_HUMAN O14817 NOVEL ANTIGEN 2;,mRNA sequence. rxa01196 813 GB_BA1: MSGY151 37036 AD000018 Mycobacteriumtuberculosis sequence from clone y151. Mycobacterium 36,634 10-DEC-1996tuberculosis GB_BA1: MTCY130 32514 Z73902 Mycobacterium tuberculosisH37Rv complete genome; segment 59/162. Mycobacterium 59,596 17-Jun-98tuberculosis GB_BA1: MSGY151 37036 AD000018 Mycobacterium tuberculosissequence from clone y151. Mycobacterium 39,567 10-DEC-1996 tuberculosisrxa01197 576 GB_EST18: AA676822 524 AA676822 zj65c11.s1Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens 40,741 19-DEC-1997 Homosapiens cDNA clone IMAGE: 455156 3′, mRNA sequence. GB_EST18: AA676822524 AA676822 zj65c11.s1 Soares_fetal_liver_spleen_1NFLS_S1 Homo sapienscDNA Homo sapiens 40,331 19-DEC-1997 clone IMAGE: 455156 3′, mRNAsequence. rxa01198 426 GB_HTG4: AC010195 164935 AC010195 Homo sapienschromosome 10 clone RPCI11-587C2, *** SEQUENCING Homo sapiens 36,05821-OCT-1999 IN PROGRESS ***, 61 unordered pieces. GB_HTG4: AC010195164935 AC010195 Homo sapiens chromosome 10 clone RPCI11-587C2, ***SEQUENCING Homo sapiens 36,058 21-OCT-1999 IN PROGRESS ***, 61 unorderedpieces. GB_HTG1: CEY44A6 326074 Z98863 Caenorhabditls elegans chromosomeV clone Y44A6, *** Caenorhabditis elegans 39,151 03-DEC-1998 SEQUENCINGIN PROGRESS ***, in unordered pieces. rxa01206 400 GB_HTG1: CER08A551920 Z82281 Caenorhabditis elegans chromosome V clone R08A5,Caenorhabditis elegans 43,557 14-OCT-1998 *** SEQUENCING IN PROGRESS***, in unordered pieces. GB_HTG1: CER08A5 51920 Z82281 Caenorhabditiselegans chromosome V clone R08A5, Caenorhabditis elegans 43,55714-OCT-1998 *** SEQUENCING IN PROGRESS ***, in unordered pieces.GB_HTG1: CER08A5 51920 Z82281 Caenorhabditis elegans chromosome V cloneR08A5, Caenorhabditis elegans 34,987 14-OCT-1998 *** SEQUENCING INPROGRESS ***, in unordered pieces. rxa01207 771 GB_PL2: SPBC8D2 43757AL022072 S. pombe chromosome II cosmid c8D2. Schizosaccharomyces 36,56624-Nov-99 pombe GB_PL1: AB004538 38911 AB004538 Schizosaccharomycespombe 39 kb genomic DNA, clone c568. Schizosaccharomyces 36,14815-Jul-97 pombe GB_HTG6: AC009220 110000 AC009220 Homo sapienschromosome 7, *** SEQUENCING IN PROGRESS ***, Homo sapiens 33,9415-Sep-99 191 unordered pieces. rxa01210 954 GB_GSS4: AQ694235 530AQ694235 HS_5496_A1_D03_T7A RPCI-11 Human Male BAC Library Homo sapiens37,259 6-Jul-99 Homo sapiens genomic clone Plate = 1072 Col = 5 Row = G,genomic survey sequence. GB_GSS11: AQ322059 519 AQ322059RPCI11-100G10.TV RPCI-11 Homo sapiens genomic clone Homo sapiens 37,22906-MAY-1999 RPCI-11-100G10, genomic survey sequence. GB_BA1: SCH24 41625AL049826 Streptomyces coelicolor cosmid H24. Streptomyces coelicolor38,126 11-MAY-1999 rxa01213 1350 GB_PR3: HS356B7 20733 AL031714 HumanDNA sequence from clone 356B7 on chromosome 16. Homo sapiens 36,68423-Nov-99 Contains the UBE21 gene for ubiquitin-conjugating enzyme E21(homologous to yeast UBC9), and an RPS20 (40S Ribosomal protein S20)pseudogene. Contains ESTs, STSs. GSSs and a putative CpG island,complete sequence. GB_PR3: HS356B7 20733 AL031714 Human DNA sequencefrom clone 356B7 on chromosome 16. Homo sapiens 39,621 23-Nov-99Contains the UBE21 gene for ubiquitin-conjugating enzyme E21 (homologousto yeast UBC9), and an RPS20 (40S Ribosomal protein S20) pseudogene.Contains ESTs, STSs. GSSs and a putative CpG island, complete sequence.GB_PR1: HSEF1AL1 1815 X16870 Human DNA for elongation factor 1-alpha(clone lambda-1. Homo sapiens 37,462 12-Jun-90 rxa01218 552 GB_PR3:HS257I9 90695 AL031773 Human DNA sequence from clone 257I9 on chromosome6q25.1-26 Homo sapiens 35,897 23-Nov-99 Contains gene similar toCytochrome B, CA repeat, GSS, complete sequence. GB_PR3: HS287L14 112831Z95325 Human DNA sequence from clone 287L14 on chromosome Xq21.1-21.33Homo sapiens 37,778 23-Nov-99 Contains STSs and GSSs, complete sequence.GB_EST8: AA035251 493 AA035251 zk23d09.s1 Soares_pregnant_uterus_NbHPUHomo sapiens cDNA Homo sapiens 40,191 10-MAY-1997 clone IMAGE: 4713773′, mRNA sequence. rxa01229 1401 GB_PR4: HUAC002394 107910 AC002394Human Chromosome 16 BAC clone CIT987SK-A-211C6, complete sequence. Homosapiens 33,633 23-Nov-99 GB_OV: AF138905 1678 AF138905 Gallus gallus NKclass homeodomain transcription Gallus gallus 30,556 4-Sep-99 factorNKX3.2 mRNA, complete cds. GB_PAT: AR031772 30001 AR031772 Sequence 1from patent U.S. Pat. No. 5866410. Unknown. 34,304 29-Sep-99 rxa01231366 GB_EST25: AI295169 507 AI295169 LP08720.3prime LP Drosophilamelanogaster larval-early pupal Drosophila melanogaster 38,27901-DEC-1998 pOT2c Drosophila melanogaster cDNA clone LP08720 3prime,mRNA sequence. GB_EST25: AI297653 512 AI297653 LP12002.3prime LPDrosophila melanogaster larval-early pupal Drosophila melanogaster36,893 01-DEC-1998 pOT2 Drosophila melanogaster cDNA clone LP120023prime, mRNA sequence. GB_EST21: AA951454 677 AA951454 LD31920.5prime LDDrosophila melanogaster embryo Drosophila melanogaster 44,167 24-Nov-98pOT2 Drosophila melanogaster cDNA clone LD31920 5prime, mRNA sequence.rxa01234 507 GB_GSS12: AQ365352 431 AQ365352 nbxb0063L13f CUGI Rice BACLibraryOryza sativa genomic Oryza sativa 34,677 3-Feb-99 clonenbxb0063L13f, genomic survey sequence. GB_PR4: AC007544 119034 AC007544Homo sapiens Human 12p11-37.2-54.4 BAC RPCI11-12D15 (Roswell Park Homosapiens 34,35 29-OCT-1999 Cancer Institute Human BAC Library) completesequence. GB_PR4: AC007544 119034 AC007544 Homo sapiens Human12p11-37.2-54.4 BAC RPCI11-12D15 (Roswell Park Homo sapiens 37,98829-OCT-1999 Cancer Institute Human BAC Library) complete sequence.rxa01237 564 GB_GSS1: AG009269 706 AG009269 Homo sapiens genomic DNA,21q region, clone: 31C6X11, genomic survey sequence. Homo sapiens 36,32814-Apr-99 GB_GSS1: AG009269 706 AG009269 Homo sapiens genomic DNA, 21qregion, clone: 31C6X11, genomic survey sequence. Homo sapiens 37,39114-Apr-99 rxa01246 630 GB_HTG2: AC007646 180133 AC007646 Drosophilamelanogaster chromosome 3 clone BACR03J04 Drosophila melanogaster 38,1882-Aug-99 (D687) RPCI-98 03.J.4 map 87F-87F strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 10 unordered pieces. GB_HTG2: AC007646180133 AC007646 Drosophila melanogaster chromosome 3 clone BACR03J04(D687) RPCI-98 Drosophila melanogaster 38,188 2-Aug-99 03.J.4 map87F-87F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 10 unorderedpieces. GB_HTG4: AC009492 212394 AC009492 Homo sapiens clone NH0423F09,*** SEQUENCING Homo sapiens 38,762 29-OCT-1999 IN PROGRESS ***, 2unordered pieces. rxa01249 471 GB_EST7: W84105 361 W84105 T2969 MVAT4bloodstream form of serodeme WRATat1.1 Trypanosoma brucei 38,26112-Aug-96 Trypanosoma brucei rhodesiense cDNA 5′, mRNA sequence.rhodesiense GB_EST7: W84105 361 W84105 T2969 MVAT4 bloodstream form ofserodeme WRATat1.1 Trypanosoma brucei Trypanosoma brucei 33,89412-Aug-98 rhodesiense cDNA 5′, mRNA sequence. rhodesiense rxa01251 432GB_RO: AC005240 41830 AC005240 Mus musculus clone UWGC: magap from14D1-D2 (T-cell Receptor Mus musculus 41,463 8-Jul-98 Alpha Locus),complete sequence. GB_RO: AC004101 39491 AC004101 Mouse Cosmid ma53a016from 14D1-D2, complete sequence. Mus musculus 41,463 2-Feb-98 GB_HTG3:AC009837 162287 AC009837 Homo sapiens chromosome 17 clone 550_K_23 map17, *** SEQUENCING Homo sapiens 36,131 2-Sep-99 IN PROGRESS ***, 13unordered pieces. rxa01263 1035 GB_PR4: AC005919 156300 AC005919 Homosapiens chromosome 17, clone hRPK.142_H_19, complete sequence. Homosapiens 39,822 18-Nov-98 GB_PR4: AC005919 156300 AC005919 Homo sapienschromosome 17, clone hRPK.142_H_19, complete sequence. Homo sapiens38,319 18-Nov-98 GB_HTG1: CEY71A12_3 110000 AL021390 Caenorhabditiselegans chromosome I clone Y71A12, *** Caenorhabditis elegans 36,88415-Sep-99 SEQUENCING IN PROGRESS ***, in unordered pieces. rxa01266 1158GB_HTG4: AC010775 165565 AC010775 Homo sapiens clone 2_G_17, ***SEQUENCING IN PROGRESS ***, Homo sapiens 38,67 20-OCT-1999 14 unorderedpieces. GB_HTG4: AC010775 165565 AC010775 Homo sapiens clone 2_G_17, ***SEQUENCING IN PROGRESS ***, Homo sapiens 38,67 20-OCT-1999 14 unorderedpieces. GB_HTG4: AC010775 165565 AC010775 Homo sapiens clone 2_G_17, ***SEQUENCING IN PROGRESS ***, Homo sapiens 36,131 20-OCT-1999 14 unorderedpieces. rxa01267 1437 GB_PR3: AF070717 100793 AF070717 Homo sapiens BACclone 393I22 from 8q21, Complete sequence. Homo sapiens 38,826 2-Jul-98GB_BA2: MPU34931 2571 U34931 Mycoplasma pulmonis FtsZ (ftsZ) gene,complete cds, methionyl-tRNA synthetase Mycoplasma pulmonis 37,09230-MAY-1996 (metG) gene, partial cds. GB_EST25: AI322057 638 AI322057SWOv3MCAM09A04SK Onchocerca volvulus molting L3 larva cDNA Onchocercavolvulus 40,566 22-DEC-1998 (SL96MLW-OvmL3) Onchocerca volvulus cDNAclone SWOv3MCAM09A04 5′, mRNA sequence. rxa01268 963 GB_HTG3: AC010878288945 AC010878 Homo sapiens clone NH0230E20, *** SEQUENCING IN PROGRESS*** Homo sapiens 36,496 25-Sep-99 , 65 unordered pieces. GB_HTG3:AC010878 288945 AC010878 Homo sapiens clone NH0230E20, *** SEQUENCING INPROGRESS ***, 65 Homo sapiens 36,496 25-Sep-99 unordered pieces.GB_HTG3: AC010878 288945 AC010878 Homo sapiens clone NH0230E20, ***SEQUENCING IN PROGRESS ***, 65 Homo sapiens 36,354 25-Sep-99 unorderedpieces. rxa01271 1935 GB_BA2: U67549 14561 U67549 Methanococcusjannaschii section 91 of 150 of the complete genome. Methanococcusjannaschii 37,841 28-Jan-98 GB_PR2: HSJ836N17 111694 AL049539 Human DNAsequence from clone RP5-836N17 on chromosome Homo sapiens 34,87222-Nov-99 20q11.1-11.21, complete sequence. GB_OV: AF089743 30676AF089743 Morone saxatilis homeodomain protein Hox-A10 (Hoxa10),homeodomain protein Morone saxatilis 36,738 2-Aug-99 Hox-A9 (Hoxa9),homeodomain protein Hox-A7 (Hoxa7), homeodomain protein Hox-A5 (Hoxa5),and homeodomain protein Hox-A4 (Hoxa4) genes, complete cds. rxa012731557 GB_PR3: AC004070 110192 AC004070 Human Chromosome X, completesequence. Homo sapiens 37,679 29-Jan-98 GB_PR2: AC002410 96217 AC002410Human BAC clone RG264L19 from 7p15-p21, complete sequence. Homo sapiens38,587 11-Aug-97 GB_PR2: AC002410 96217 AC002410 Human BAC cloneRG264L19 from 7p15-p21, complete sequence. Homo sapiens 37,035 11-Aug-97rxa01275 1041 GB_EST8: C03322 357 C03322 C03322 Human heart cDNA(YNakamura) Homo sapiens cDNA clone Homo sapiens 35,393 30-Jul-963NHC1263, mRNA sequence. GB_EST4: R92079 410 R92079 yp96g02.r1 Soaresfetal liver spleen 1NFLS Homo sapiens cDNA clone IMAGE: Homo sapiens37,01 25-Aug-95 195314 5′, mRNA sequence. GB_EST4: H57724 461 H57724yr21a12.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA cloneIMAGE: Homo sapiens 37,281 05-OCT-1995 205918 5′, mRNA sequence.rxa01276 567 GB_OM: OCMYLC1 962 X54041 Rabbit mRNA for myosin lightchain 1. Oryctolagus cuniculus 40,503 26-Nov-90 GB_PR3: AC005383 123110AC005383 Homo sapiens chromosome 10 clone CIT987SK-1144G6 map 10q25.1,Homo sapiens 38,93 31-OCT-1998 complete sequence. GB_RO: RATPTPECA 2155D78610 Rat mRNA for protein tyrosine phosphatase epsilon C, partial cds.Rattus norvegicus 37,77 5-Feb-99 rxa01281 885 GB_HTG4: AC009366 199607AC009366 Drosophila melanogaster chromosome 3L/79D4 clone RPCI98-48E10,Drosophila melanogaster 34,025 16-OCT-1999 *** SEQUENCING IN PROGRESS***, 31 unordered pieces. GB_HTG4: AC009366 199607 AC009366 Drosophilamelanogaster chromosome 3L/79D4 clone RPCI98-48E10, Drosophilamelanogaster 34,025 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 31unordered pieces. GB_HTG4: AC009366 199607 AC009366 Drosophilamelanogaster chromosome 3L/79D4 clone RPCI98-48E10, Drosophilamelanogaster 34,386 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 31unordered pieces. rxa01282 903 GB_GSS11: AQ263970 363 AQ263970CITBI-E1-2503H24.TF CITBI-E1 Homo sapiens genomic clone 2503H24, Homosapiens 40,361 27-OCT-1998 genomic survey sequence. GB_GSS1: FR0025959603 AL018794 F. rubripes GSS sequence, clone 165E10aE1, genomic surveysequence. Fugu rubripes 34,824 10-DEC-1997 GB_GSS9: AQ102435 334AQ102435 HS_3038_B2_D09_MF CIT Approved Human Genomic Sperm Library DHomo sapiens 37,624 27-Aug-98 Homo sapiens genomic clone Plate = 3038Col = 18 Row = H, genomic survey sequence. rxa01294 789 GB_PL2: AC007258144422 AC007258 Arabidopsis thaliana chromosome I BAC F23H11 genomicsequence, Arabidopsis thaliana 39,453 16-Jun-99 complete sequence.GB_EST17: T04634 491 T04634 681 Lambda-PRL1 Arabidopsis thaliana cDNAclone SBD1T7P, mRNA sequence. Arabidopsis thaliana 38,693 6-Nov-97GB_PL2: AC007258 144422 AC007258 Arabidopsis thaliana chromosome I BACF23H11 genomic sequence, Arabidopsis thaliana 36,17 16-Jun-99 completesequence. rxa01295 1098 GB_HTG3: AC009803 235360 AC009803 Homo sapiensclone RPCI11-1028N23, *** SEQUENCING Homo sapiens 38,662 24-Sep-99 INPROGRESS ***, 47 unordered pieces. GB_HTG3: AC009803 235360 AC009803Homo sapiens clone RPCI11-1028N23, *** SEQUENCING IN Homo sapiens 38,66224-Sep-99 PROGRESS ***, 47 unordered pieces. GB_IN2: AC004333 63178AC004333 Drosophila melanogaster DNA sequence (P1 DS05969 (D229)),complete sequence. Drosophila melanogaster 39,252 20-Jun-98 rxa012961206 GB_PR4: AC004961 68130 AC004961 Homo sapiens clone DJ1098J04,complete sequence. Homo sapiens 39,409 5-Jun-99 GB_GSS14: AQ525299 447AQ525299 HS_5227_B2_H03_SP6E RPCI-11 Human Male BAC Library Homo sapiens37,33 11-MAY-1999 Homo sapiens genomic clone Plate = 803 Col = 6 Row =P, genomic survey sequence. GB_BA2: BFU78108 1900 U78108 Bacteroidesfragilis NAD(H) glutamate dehydrogenase (gdhB) gene, complete cds.Bacteroides fragilis 40,509 15-Jul-98 rxa01301 648 GB_PR4: AC007051167810 AC007051 Homo sapiens chromosome 3, clone hRPK.44_A_1, completesequence. Homo sapiens 38,498 11-Jun-99 GB_PR4: AC007919 184989 AC007919Homo sapiens 3q26.2-27 BAC RPCI11-408H1 (Roswell Park Cancer InstituteHomo sapiens 35,139 09-OCT-1999 Human BAC Library) complete sequence.GB_EST11: AA252547 454 AA252547 zp87g09.r1 Stratagene HeLa cell s3937216 Homo sapiens cDNA Homo sapiens 38,538 12-MAR-1997 clone IMAGE:627232 5′ similar to gb: D13748 EUKARYOTIC INITIATION FACTOR 4A-I(HUMAN);, mRNA sequence. rxa01304 609 GB_HTG2: AC006779 119562 AC006779Caenorhabditis elegans clone Y47D7, *** SEQUENCING IN PROGRESS ***, 32Caenorhabditis elegans 32,888 25-Feb-99 unordered pieces. GB_HTG2:AC006779 119562 AC006779 Caenorhabditis elegans clone Y47D7, ***SEQUENCING IN PROGRESS ***, Caenorhabditis elegans 32,888 25-Feb-99 32unordered pieces. GB_VI: BHT1UL 37000 Z78205 Bovine herpesvirus type 1UL22-35 genes. Bovine herpesvirus 1 38,047 14-Aug-96 rxa01306 1131GB_GSS8: AQ047475 420 AQ047475 cLM-1c5-t cLM Giardia intestinalisgenomic, genomic survey sequence. Giardia intestinalis 38,902 14-Jul-98GB_PL1: CR1433P 1464 X79445 C. reinhardtii mRNA for 14-3-3 protein.Chlamydomonas reinhardtii 39,64 06-OCT-1995 GB_PR3: HSJ878I13 122400AL049591 Human DNA sequence from clone 878I13 on chromosome Xq23-25Contains Homo sapiens 35,624 23-Nov-99 a pseudogene similar to alphatubulin, ESTs, STSs, GSSs, complete sequence. rxa01310 450 GB_HTG3:AC010530 274508 AC010530 Homo sapiens chromosome 16 cloneRPCI-11_167P11, *** SEQUENCING Homo sapiens 38,462 15-Sep-99 IN PROGRESS***, 19 unordered pieces. GB_HTG3: AC010530 274508 AC010530 Homo sapienschromosome 16 clone RPCI-11_167P11, *** SEQUENCING IN Homo sapiens38,462 15-Sep-99 PROGRESS ***, 19 unordered pieces. GB_HTG3: AC010530274508 AC010530 Homo sapiens chromosome 16 clone RPCI-11_167P11, ***SEQUENCING IN Homo sapiens 32,063 15-Sep-99 PROGRESS ***, 19 unorderedpieces. rxa01313 rxa01315 774 GB_BA2: AF031037 1472 AF031037 Neisseriameningitidis chloramphenicol acetyltransferase gene, complete cds.Neisseria meningitidis 35,638 21-Apr-98 GB_GSS11: AQ326599 662 AQ326599nbxb0037P01r CUGI Rice BAC Library Oryza sativa genomic clonenbxb0037P01r, Oryza sativa 34,817 8-Jan-99 genomic survey sequence.GB_HTG1: PFMAL13PA 80518 AL109815 Plasmodium falciparum chromosome 13strain 3D7, *** SEQUENCING IN Plasmodium falciparum 34,935 19-Aug-99PROGRESS ***, in unordered pieces. rxa01316 426 GB_HTG3: AC010133 154773AC010133 Homo sapiens clone NH0118E09, *** SEQUENCING IN PROGRESS ***,Homo sapiens 33,414 13-Sep-99 5 unordered pieces. GB_HTG3: AC010133154773 AC010133 Homo sapiens clone NH0118E09, *** SEQUENCING IN PROGRESS***, Homo sapiens 33,414 13-Sep-99 5 unordered pieces. GB_HTG3: AC010133154773 AC010133 Homo sapiens clone NH0118E09, *** SEQUENCING IN PROGRESS***, Homo sapiens 38,186 13-Sep-99 5 unordered pieces. rxa01317 543GB_BA2: U67560 12215 U67560 Methanococcus jannaschii section 102 of 150of the complete genome. Methanococcus jannaschii 38,476 28-Jan-98GB_BA2: U67560 12215 U67560 Methanococcus jannaschii section 102 of 150of the complete genome. Methanococcus jannaschii 35,867 28-Jan-98rxa01318 1425 GB_BA1: MTV038 16094 AL021933 Mycobacterium tuberculosisH37Rv complete genome; segment 24/162. Mycobacterium 51,266 17-Jun-98tuberculosis GB_IN1: CELC41A3 37149 U41541 Caenorhabditis elegans cosmidC41A3. Caenorhabditis elegans 36,887 08-DEC-1995 GB_HTG3: AC011298205637 AC011298 Homo sapiens clone NH0118M12, *** SEQUENCING IN PROGRESS***, Homo sapiens 35,76 05-OCT-1999 19 unordered pieces. rxa01326 489GB_BA1: PAL249201 3390 AJ249201 Prevotella albensis ftsQ (partial), ftsAand ftsZ genes and ORF-fts (partial). Prevotella albensis 37,70827-Aug-99 GB_BA1: PAL249201 3390 AJ249201 Prevotella albensis ftsQ(partial), ftsA and ftsZ genes and ORF-fts (partial). Prevotellaalbensis 37,474 27-Aug-99 rxa01330 rxa01331 2520 GB_HTG1: HSAJ02553142807 AJ002553 Homo sapiens chromosome 11 clone 1118i22 map q13, ***SEQUENCING IN Homo sapiens 26,237 14-Nov-97 PROGRESS ***, in unorderedpieces. GB_HTG1: HSAJ02553 142807 AJ002553 Homo sapiens chromosome 11clone 1118i22 map q13, *** SEQUENCING IN Homo sapiens 26,237 14-Nov-97PROGRESS ***, in unordered pieces. GB_PR3: AC005304 164017 AC005304 Homosapiens chromosome 17, clone hRPK.131_K_5, complete sequence. Homosapiens 35,318 25-Jul-98 rxa01333 1128 GB_BA1: CGU43536 3464 U43536Corynebacterium glutamicum heat shock, ATP-binding protein (clpB) gene,Corynebacterium 38,075 13-MAR-1997 complete cds. glutamicum GB_OM:BTPRLP 924 X15975 Bovine mRNA for prolactin (PRL) related protein. Boataurus 40,901 22-DEC-1994 GB_OM: BTPRLP 924 X15975 Bovine mRNA forprolactin (PRL) related protein. Boa taurus 39,58 22-DEC-1994 rxa01336726 GB_BA1: AP000064 247695 AP000064 Aeropyrum pernix genomic DNA,section 7/7. Aeropyrum pernix 37,881 22-Jun-99 GB_BA1: AP000064 247695AP000064 Aeropyrum pernix genomic DNA, section 7/7. Aeropyrum pernix36,161 22-Jun-99 GB_EST1: T05458 363 T05458 EST03347 Fetal brain,Stratagene (cat#936206) Homo sapiens cDNA Homo sapiens 43,798 30-Jun-93clone HFBCY86, mRNA sequence. rxa01337 1536 GB_PR2: AP000215 100000AP000215 Homo sapiens genomic DNA, chromosome 21q22.3-ter, Ter region,Homo sapiens 36,438 20-Nov-99 clone f27E1-T1136, segment 1/4, completesequence. GB_PR2: AP000215 100000 AP000215 Homo sapiens genomic DNA,chromosome 21q22.3-ter, Ter region, clone Homo sapiens 35,827 20-Nov-99f27E1-T1136, segment 1/4, complete sequence. GB_PR2: AP000337 53553AP000337 Homo sapiens genomic DNA, chromosome 21q22.3-ter. Tar region,clone: T1957, Homo sapiens 36,043 20-Nov-99 complete sequence. rxa01342626 GB_EST35: AI814229 544 AI814229 wj70e01.x1 NCI_CGAP_Lu19 Homosapiens cDNA clone Homo sapiens 36,803 24-Aug-99 IMAGE: 2408184 3′, mRNAsequence. GB_EST35: AI814229 544 AI814229 wj70e01.x1 NCI_CGAP_Lu19 Homosapiens cDNA clone IMAGE: Homo sapiens 36,688 24-Aug-99 2408184 3′, mRNAsequence. rxa01348 615 GB_HTG3: AC011246 210407 AC011246 Homo sapiensclone NH0498O20, *** SEQUENCING IN PROGRESS ***, Homo sapiens 39,10104-OCT-1999 29 unordered pieces. GB_HTG3: AC011246 210407 AC011246 Homosapiens clone NH0498O20, *** SEQUENCING IN PROGRESS ***, Homo sapiens39,101 04-OCT-1999 29 unordered pieces. GB_PL1: ZMB32120 3093 X54212 Z.mays mRNA for b-32 protein, putative regulatory factor of zeinexpression Zea mays 35,902 18-Jan-93 (clone b-32.120). rxa01349 900GB_IN1: CELK10G6 33588 AF016669 Caenorhabditis elegans cosmid K10G6.Caenorhabditis elegans 40,251 8-Aug-97 GB_IN1: CELK10G6 33588 AF016669Caenorhabditis elegans cosmid K10G6. Caenorhabditis elegans 36,8428-Aug-97 rxa01357 426 GB_BA1: MTCY274 39991 Z74024 Mycobacteriumtuberculosis H37Rv complete genome; segment 126/162. Mycobacterium36,058 19-Jun-98 tuberculosis GB_BA1: MLCB250 40603 Z97369 Mycobacteriumleprae cosmid B250. Mycobacterium leprae 59,294 27-Aug-99 GB_BA2:SKZ86111 7860 Z86111 Streptomyces lividans rpsP, trmD, rplS, sipW, sipX,sipY, sipZ, mutT genes and Streptomyces lividans 57,882 27-OCT-1999 4open reading frames. rxa01359 1305 GB_BA1: D87820 7217 D87820 Vibriocholerae non-O1 gene for N-acetylglucosamine 6-phosphate Vibrio choleraenon-O1 38,152 17-OCT-1997 deacetylase, NagC, NagE, complete cds. GB_PR3:AC004540 131757 AC004540 Homo sapiens PAC clone DJ1066K24 from 7p15,complete sequence. Homo sapiens 35,714 9-Apr-98 GB_PR2: HSU44119 450U44119 Human der(9) chromosome breakpoint region: alpha 1(V) collagenchain (COL5A1) Homo sapiens 38,085 14-Jan-97 gene, partial intron 24,and imperfect LINE-1 element of Xp21.2. rxa01362 3677 GB_EST30: AI665031602 AI665031 605005H05.x1 605 - Endosperm cDNA library from Schmidt labZea mays Zea mays 42,308 11-MAY-1999 cDNA, mRNA sequence. GB_EST34:AI795319 661 AI795319 605005H05.y2 605 - Endosperm cDNA library fromSchmidt lab Zea mays cDNA, Zea mays 38,729 2-Jul-99 mRNA sequence.GB_HTG3: AC008387 151804 AC008387 Homo sapiens chromosome 5 cloneCIT-HSPC_229P9, *** SEQUENCING IN Homo sapiens 38,023 3-Aug-99 PROGRESS***, 74 unordered pieces. rxa01366 513 GB_IN1: AF007166 1392 AF007166Anopheles gambiae serine protease 14D mRNA, complete cds. Anophelesgambiae 41,379 14-Jul-97 GB_GSS13: AQ475498 476 AQ475498CITBI-E1-2589F13.TR CITBI-E1 Homo sapiens genomic clone 2589F13, genomicHomo sapiens 40,511 23-Apr-99 survey sequence. GB_IN1: AF007166 1392AF007166 Anopheles gambiae serine protease 14D mRNA, complete cds.Anopheles gambiae 40 14-Jul-97 rxa01367 525 GB_EST28: AI489958 591AI489958 EST248297 tomato ovary. TAMU Lycopersicon esculentum cDNA cloneLycopersicon esculentum 38,186 29-Jun-99 cLED14O8, mRNA sequence.GB_GSS13: AQ475498 476 AQ475498 CITBI-E1-2589F13.TR CITBI-E1 Homosapiens genomic clone 2589F13, genomic Homo sapiens 37,405 23-Apr-99survey sequence. GB_EST28: AI489958 591 AI489958 EST248297 tomato ovary.TAMU Lycopersicon esculentum cDNA clone cLED14O8, Lycopersiconesculentum 35,882 29-Jun-99 mRNA sequence. rxa01370 rxa01372 614GB_HTG5: AC011644 164746 AC011644 Homo sapiens clone 14_K_21, ***SEQUENCING IN PROGRESS ***, Homo sapiens 33,715 5-Nov-99 8 unorderedpieces. GB_HTG5: AC011644 164746 AC011644 Homo sapiens clone 14_K_21,*** SEQUENCING IN PROGRESS ***, Homo sapiens 35,821 5-Nov-99 8 unorderedpieces. rxa01378 1878 GB_IN1: DM8R42I17 155168 AL121806 Drosophilamelanogaster clone BACR42I17. Drosophila melanogaster 36,373 10-OCT-1999GB_IN2: AC005714 177740 AC005714 Drosophila melanogaster, chromosome 2R,region 58D4-58E2, BAC clone Drosophila melanogaster 36,234 01-MAY-1999BACR48M13, complete sequence. GB_IN2: AC005639 188288 AC005639Drosophila melanogaster, chromosome 2R, region 59E3-59F4, BAC cloneDrosophila melanogaster 36,275 6-Jan-99 BACR48M01, complete sequence.rxa01379 1042 GB_HTG4: AC010031 132106 AC010031 Drosophila melanogasterchromosome 3L/70C1 clone RPCI98-2M20, Drosophila melanogaster 35,36816-OCT-1999 *** SEQUENCING IN PROGRESS ***, 69 unordered pieces.GB_HTG4: AC010031 132106 AC010031 Drosophila melanogaster chromosome3L/70C1 clone RPCI98-2M20, Drosophila melanogaster 35,368 16-OCT-1999*** SEQUENCING IN PROGRESS ***, 69 unordered pieces. GB_HTG3: AC00993268745 AC009932 Homo sapiens clone 114_O_12, LOW-PASS SEQUENCE SAMPLING.Homo sapiens 36,337 05-OCT-1999 rxa01380 2322 GB_BA1: SC5F2A 40105AL049587 Streptomyces coelicolor cosmid 5F2A. Streptomyces coelicolor39,699 24-MAY-1999 GB_BA1: BPTEX 2701 X95386 B. pertussis tex gene.Bordetella pertussis 59,687 31-Jul-96 GB_BA1: SC5F2A 40105 AL049587Streptomyces coelicolor cosmid 5F2A. Streptomyces coelicolor 41,02424-MAY-1999 rxa01384 1839 GB_GSS15: AQ613816 598 AQ613816HS_5118_B1_F06_T7A RPCI-11 Homo sapiens 39,3 15-Jun-99 Human Male BACLibrary Homo sapiens genomic clone Plate = 694 Col = 11 Row = L, genomicsurvey sequence. GB_GSS15: AQ613816 598 AQ613816 HS_5118_B1_F06_T7ARPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 36,45515-Jun-99 genomic clone Plate = 694 Col = 11 Row = L, genomic surveysequence. rxa01390 780 GB_BA2: CGL012293 2952 AJ012293 Corynebacteriumglutamicum ilvD gene. Corynebacterium 40,413 01-OCT-1999 glutamicumGB_PR4: AC006213 160754 AC006213 Homo sapiens, clone hRPK.15_A_1,complete sequence. Homo sapiens 35,724 16-Jan-99 GB_PL2: ATF24G24 99856AL049488 Arabidopsis thaliana DNA chromosome 4, BAC clone F24G24 (ESSAproject). Arabidopsis thaliana 35,925 27-Aug-99 rxa01391 813 GB_HTG2:AC006171 44733 AC006171 Homo sapiens chromosome 10 cloneLA10NC01_15_E_11 map 10q26.3, Homo sapiens 35,031 09-DEC-1998 ***SEQUENCING IN PROGRESS ***, 3 unordered pieces. GB_HTG2: AC006171 44733AC006171 Homo sapiens chromosome 10 clone LA10NC01_15_E_11 map 10q26.3,Homo sapiens 35,031 09-DEC-1998 *** SEQUENCING IN PROGRESS ***, 3unordered pieces. GB_HTG2: AC006171 44733 AC006171 Homo sapienschromosome 10 clone LA10NC01_15_E_11 map 10q26.3, Homo sapiens 38,03509-DEC-1998 *** SEQUENCING IN PROGRESS ***, 3 unordered pieces. rxa01396381 GB_BA2: AE000775 14358 AE000775 Aquifex aeolicus section 107 of 109of the complete genome. Aquifex aeolicus 43,085 25-MAR-1998 GB_EST26:AI329024 471 AI329024 a9c02ne.f1 Neurospora crassa evening cDNA libraryNeurospora crassa cDNA Neurospora crassa 39,288 28-DEC-1998 clonea9c02ne 5′, mRNA sequence. GB_EST26: AI329043 401 AI329043 a9d06ne.f1Neurospora crassa evening cDNA library Neurospora crassa cDNA Neurosporacrassa 44,484 28-DEC-1998 clone a9d06ne 5′, mRNA sequence. rxa01397 543GB_BA2: AE000775 14358 AE000775 Aquifex aeolicus section 107 of 109 ofthe complete genome. Aquifex aeolicus 41,121 25-MAR-1998 GB_BA1:BSTMSPRS 3211 X16518 B. subtilis prs, tms, and ctc (partial) genes forPRPP synthetase and two Bacillus subtilis 41,255 30-Sep-93 undefinedgene products. GB_EST4: H21691 382 H21691 yI29b01.r1 Soares breast3NbNBst Homo sapiens cDNA clone IMAGE: 159625 Homo sapiens 35,4076-Jul-95 5′ similar to SP: XPEC_CERAE P33194 POSSIBLE DNA-REPAIR PROTEINXP-E;, mRNA sequence. rxa01400 1623 GB_GSS11: AQ264714 353 AQ264714CITBI-E1-2502C17.TR CITBI-E1 Homo sapiens genomic clone 2502C17, Homosapiens 40,227 27-OCT-1998 genomic survey sequence. GB_BA1: TFENTRA 2803M58480 Thiobacillus ferrooxidans nitrogen metabolism regulator (ntrA)gene, complete cds. Thiobacillus ferrooxidans 39,96 26-Apr-93 GB_BA1:NPSDHCDBA 5596 Y07709 N. pharaonis sdhC, sdhD, sdhB and sdhA genes.Natronomonas pharaonis 38,003 2-Sep-96 rxa01401 384 GB_HTG4: AC006583110000 AC006583 Homo sapiens chromosome 3p21.3 clone RPCI11-491D6, Homosapiens 32,718 21-OCT-1999 *** SEQUENCING IN PROGRESS ***, 90 unorderedpieces. GB_HTG4: AC006583 110000 AC006583 Homo sapiens chromosome 3p21.3clone RPCI11-491D6, *** SEQUENCING IN Homo sapiens 32,718 21-OCT-1999PROGRESS ***, 90 unordered pieces. GB_HTG4: AC011291 173585 AC011291Homo sapiens chromosome unknown clone NH0067G07, WORKING DRAFT Homosapiens 33,596 29-OCT-1999 SEQUENCE, in unordered pieces. rxa01402 597GB_BA1: CAJ10319 5368 AJ010319 Corynebacterium glutamicum amtP. glnB,glnD genes and partial ftsY and srp genes. Corynebacterium 39,38914-MAY-1999 glutamicum GB_HTG4: AC010066 187240 AC010066 Drosophilamelanogaster chromosome 3L/72A4 clone RPCI98-25O1, Drosophilamelanogaster 33,681 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 70unordered pieces. GB_HTG4: AC010066 187240 AC010066 Drosophilamelanogaster chromosome 3L/72A4 clone RPCI98-25O1, Drosophilamelanogaster 33,681 18-OCT-1999 *** SEQUENCING IN PROGRESS ***, 70unordered pieces. rxa01403 771 GB_BA1: SC6E10 23990 AL109661Streptomyces coelicolor cosmid 6E10. Streptomyces coelicolor 39,1365-Aug-99 A3(2) GB_GSS12: AQ396728 608 AQ396728 mgxb0002E02f CUGI RiceBlast BAC Library Magnaporthe grisea genomic Magnaporthe grisea 36,62606-MAR-1999 clone mgxb0002E02f, genomic survey sequence. GB_BA1: SC6E1023990 AL109661 Streptomyces coelicolor cosmid 6E10. Streptomycescoelicolor 41,403 5-Aug-99 A3(2) rxa01405 579 GB_PL2: AF111709 52684AF111709 Oryza sativa subsp. indica Retrosat 1 retrotransposon andTy3-Gypsy type Retrosat 2 Oryza sativa subsp. indica 34,888 26-Apr-99retrotransposon, complete sequences; and unknown genes. GB_GSS3: B88760696 B88760 RPCI11-24L19.TPC RPCI-11 Homo sapiens genomic cloneRPCI-11-24L19, Homo sapiens 37,204 9-Apr-99 genomic survey sequence.GB_STS: G52436 696 G52436 SHGC-85004 Human Homo sapiens STS genomic,sequence tagged site. Homo sapiens 37,204 25-Jun-99 rxa01409 845GB_HTG5: AC008019 190459 AC008019 Mus musculus, *** SEQUENCING INPROGRESS ***, 16 unordered pieces. Mus musculus 39,924 16-Nov-99 GB_PR4:AC006236 127593 AC006236 Homo sapiens chromosome 17, clonehCIT.162_E_12, complete sequence. Homo sapiens 33,907 29-DEC-1998GB_HTG5: AC008019 190459 AC008019 Mus musculus, *** SEQUENCING INPROGRESS ***, 16 unordered pieces. Mus musculus 40,819 16-Nov-99rxa01413 723 GB_OV: AF038947 1617 AF038947 Ambystoma tigrinum red conevisual pigment mRNA, complete cds. Ambystoma tigrinum 35,846 16-DEC-1998GB BA1: MSGB577COS 37770 L01263 M. leprae genomic dna sequence, cosmidb577. Mycobacterium leprae 38,042 14-Jun-96 GB_PR3: AC002558 102064AC002558 Homo sapiens chromosome 17, clone hRPC867C24, completesequence. Homo sapiens 36,82 31-OCT-1997 rxa01414 630 GB_PL1: SC561037730 Z38060 S. cerevisiae chromosome IX sequence derived from lambdaclones 5610-5004. Saccharomyces cerevisiae 38,782 20-Aug-97 GB_PL1:YSCDIN1 2969 M58012 S. cerevisiae ribonucleotide reductase DNAdamage-inducible regulatory subunit Saccharomyces cerevisiae 35,87727-Apr-93 (DIN1) gene, 5′ end. GB_EST18: AA689161 624 AA689161 ET2100Trypanosoma brucei rhodesiense ZAP II library Trypanosoma bruceiTrypanosoma brucei 37,15 15-DEC-1997 rhodesiense cDNA 5′, mRNA sequence.rhodesiense rxa01417 720 GB_PL1: SC8419 30507 Z49701 S. cerevisiaechromosome IV cosmid 8419. Saccharomyces cerevisiae 36,248 11-Aug-97GB_PL1: SCPRP28G 2452 X56934 S. cerevisiae PRP28 gene. Saccharomycescerevisiae 45,036 9-Feb-95 GB_BA1: BACPEPFA 4654 M29035 B. subtilisbacillopeptidase F (bpr) gene, complete cds. Bacillus subtilis 37,32406-MAR-1995 rxa01421 rxa01422 1095 GB_EST24: AU033392 344 AU033392AU033392 Dictyostelium discoideum SL (H. Urushihara) Dictyosteliumdiscoideum 38,953 28-Apr-99 Dictyostelium discoideum cDNA clone SLA715,mRNA sequence. GB_EST14: AA399243 301 AA399243 zt57d02.s1Soares_testis_NHT Homo sapiens cDNA clone IMAGE: Homo sapiens 45,18312-Aug-97 726435 3′ similar to SW: NIDO_HUMAN P14543 NIDOGEN PRECURSOR;,mRNA sequence. GB_PR2: AC002037 53897 AC002037 Human Chromosome 11Overlapping Cosmids cSRL72g7 and cSRL140b8, complete Homo sapiens 37,56-Aug-97 sequence. rxa01425 1008 GB_PR4: AC005908 196501 AC005908 Homosapiens 12p13.3 BAC RPCI11-476M19 (Roswell Park Cancer Homo sapiens34,41 20-Jan-99 Institute Human BAC Library) complete sequence. GB_PR4:AF111169 183916 AF111169 Homo sapiens chromosome 14 BAC containing genefor KIAA0759 and other Homo sapiens 40,635 19-Jul-99 possible newtranscripts, complete sequence. GB_HTG2: AC008284 146797 AC008284Drosophila melanogaster chromosome 3 clone BACR03M22 (D1000) RPCI-98Drosophila melanogaster 35,822 2-Aug-99 03.M.22 map 96C-96D strain y; cnbw sp, *** SEQUENCING IN PROGRESS ***, 137 unordered pieces. rxa01429741 GB_EST25: AI300084 635 AI300084 qn59f02.x1 NCI_CGAP_Kid5 Homosapiens cDNA Homo sapiens 37,753 1-Feb-99 clone IMAGE: 1902555 3′, mRNAsequence. GB_EST18: AA706612 949 AA706612 ah26c02.s1Soares_parathyroid_tumor_NbHPA Homo sapiens cDNA Homo sapiens 37,36112-Jan-99 clone 1239938 3′, mRNA sequence. GB_EST35: AI817084 598AI817084 wj76g07.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE: Homosapiens 38,627 24-Aug-99 2408796 3′, mRNA sequence. rxa01434 3075GB_PL1: CAC49C10 37825 AL033497 C. albicans cosmid Ca49C10. Candidaalbicans 34,724 10-Nov-98 GB_GSS3: B10423 1217 B10423 F19F22-T7 IGFArabidopsis thaliana genomic clone F19F22, genomic survey Arabidopsisthaliana 36,003 14-MAY-1997 sequence. GB_PL1: CAC49C10 37825 AL033497 C.albicans cosmid Ca49C10. Candida albicans 33,794 10-Nov-98 rxa01439 669GB_BA2: AF049897 9196 AF049897 Corynebacterium glutamicumN-acetylglutamylphosphate reductase (argC), ornithine Corynebacterium41,564 1-Jul-98 acetyltransferase (argJ), N-acetylglutamate kinase(argB), acetylornithine transaminase glutamicum (argD), ornithinecarbamoyltransferase (argF), arginine repressor (argR),argininosuccinate synthase (argG), and argininosuccinate lyase (argH)genes, complete cds. GB_BA1: CGARGCJBD 4355 X86157 C. glutamicum argC,argJ, argB, argD, and argF genes. Corynebacterium 41,564 25-Jul-96glutamicum GB_BA2: AF049897 9196 AF049897 Corynebacterium glutamicumN-acetylglutamylphosphate reductase (argC), ornithine Corynebacterium39,486 1-Jul-98 acetyltransferase (argJ), N-acetylglutamate kinase(argB), acetylornithine transaminase glutamicum (argD), ornithinecarbamoyltransferase (argF), arginine repressor (argR),argininosuccinate synthase (argG), and argininosuccinate lyase (argH)genes, complete cds. rxa01440 1131 GB_PAT: E16763 2517 E16763 gDNAencoding aspartate transferase (AAT). Corynebacterium 42,188 28-Jul-99glutamicum GB_EST20: AA870569 423 AA870569 vq23c09.r1 Barstead stromalcell line MPLRB8 Mus musculus cDNA clone Mus musculus 42,066 16-MAR-1998IMAGE: 1095088 5′ similar to TR: Q14468 Q14468 KIAA0047;, mRNA sequence.GB_EST18: AA726390 436 AA726390 vu40b04.r1 Barstead mouse myotubesMPLRB5 Mus musculus cDNA clone Mus musculus 41,228 2-Jan-98 IMAGE:1193839 5′, mRNA sequence. rxa01441 1152 GB_EST32: AV053763 252 AV053763AV053763 Mus musculus pancreas C57BL/6J adult Mus musculus cDNA Musmusculus 45,238 23-Jun-99 clone 1810028E06, mRNA sequence. GB_EST20:AA870569 423 AA870569 vq23c09.r1 Barstead stromal cell line MPLRB8 Musmusculus cDNA clone IMAGE: Mus musculus 39,643 16-MAR-1998 1095088 5′similar to TR: Q14468 Q14468 KIAA0047;, mRNA sequence. GB_EST18:AA726390 436 AA726390 vu40b04.r1 Barstead mouse myotubes MPLRB5 Musmusculus cDNA clone Mus musculus 39,953 2-Jan-98 IMAGE: 1193839 5′, mRNAsequence. rxa01445 1116 GB_PR4: AC007786 229061 AC007786 Homo sapienschromosome 19, BAC 41855 (CIT-B-32o4), complete sequence. Homo sapiens39,545 11-Jun-99 GB_PR3: AC003957 126581 AC003957 Homo sapienschromosome 17, clone hCIT.457_L_16, complete sequence. Homo sapiens36,579 09-MAY-1998 GB_OV: AF108420 46626 AF108420 Fugu rubripesprohormone convertase PACE4 (PACE4) gene, partial cds; and Fugu rubripes39,187 17-MAR-1999 1-aminocyclopropane-carboxilate synthase (ACC),recombination-activating protein 1 (RAG1), and recombination-activatingprotein 2 (RAG2) genes, complete cds. rxa01447 972 GB_PL2: AF049112 1436AF049112 Zea mays retrotransposon Cinful prpol mRNA, partial cds. Zeamays 38,268 1-Feb-99 GB_EST36: AV190070 360 AV190070 AV190070 YujiKohara unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditiselegans 40,39 22-Jul-99 Caenorhabditis elegans cDNA clone yk566e10 5′,mRNA sequence. GB_EST9: AA103228 477 AA103228 mo22h07.r1 Life Tech mouseembryo 13 5dpc 10666014 Mus musculus cDNA clone Mus musculus 40,41129-OCT-1996 IMAGE: 554365 5′ similar to gb: J00068 ACTIN, ALPHA SKELETALMUSCLE (HUMAN); gb: M12866 Mouse skeletal muscle actin mRNA, completecds (MOUSE);, mRNA sequence. rxa01448 1290 GB_BA1: CGFDA 3371 X17313Corynebacterium glutamicum fda gene for fructose-bisphosphate aldolaseCorynebacterium 100 12-Sep-93 (EC 4.1.2.13). glutamicum GB_PL2: ENU754284443 U75428 Emericella nidulans acid trehalase precursor (treA) gene,complete cds. Emericella nidulans 36,271 15-MAY-1997 GB_BA1: CGFDA 3371X17313 Corynebacterium glutamicum fda gene for fructose-bisphosphatealdolase Corynebacterium 37,872 12-Sep-93 (EC 4.1.2.13). glutamicumrxa01452 402 GB_BA1: MTV017 67200 AL021897 Mycobacterium tuberculosisH37Rv complete genome; segment 48/162. Mycobacterium 57,246 24-Jun-99tuberculosis GB_BA1: MLCB1222 34714 AL049491 Mycobacterium leprae cosmidB1222. Mycobacterium leprae 34,872 27-Aug-99 GB_BA2: S71532 914 S71532che = cholesterol esterase [Streptomyces lavendulae, H646-SY2, Genomic,914 nt]. Streptomyces lavendulae 38,701 8-Nov-94 rxa01456 645 GB_GSS3:B16150 663 B16150 347A15.TP CIT978SKA1 Homo sapiens genomic cloneA-347A15, genomic Homo sapiens 34,394 4-Jun-98 survey sequence. GB_HTG3:AC004157 132090 AC004157 Plasmodium falciparum chromosome 12 clone 3D7,*** SEQUENCING IN Plasmodium falciparum 34,165 23-Sep-99 PROGRESS ***, 9unordered pieces. GB_HTG3: AC004157 132090 AC004157 Plasmodiumfalciparum chromosome 12 clone 3D7, *** SEQUENCING IN Plasmodiumfalciparum 34,165 23-Sep-99 PROGRESS ***, 9 unordered pieces. rxa01457798 GB_HTG3: AC011009 158335 AC011009 Homo sapiens clone 2_I_22,LOW-PASS SEQUENCE SAMPLING. Homo sapiens 39,49 29-Sep-99 GB_HTG3:AC011009 158335 AC011009 Homo sapiens clone 2_I_22, LOW-PASS SEQUENCESAMPLING. Homo sapiens 39,49 29-Sep-99 GB_HTG3: AC011009 158335 AC011009Homo sapiens clone 2_I_22, LOW-PASS SEQUENCE SAMPLING. Homo sapiens39,125 29-Sep-99 rxa01459 933 GB_HTG3: AC008670 113564 AC008670 Homosapiens chromosome 5 clone CIT978SKB_36O1, *** SEQUENCING IN Homosapiens 39,022 3-Aug-99 PROGRESS ***, 43 unordered pieces. GB_HTG3:AC008670 113564 AC008670 Homo sapiens chromosome 5 clone CIT978SKB_36O1,*** SEQUENCING IN Homo sapiens 39,022 3-Aug-99 PROGRESS ***, 43unordered pieces. GB_IN2: CELT05A8 33896 AF040652 Caenorhabditis eleganscosmid T05A8. Caenorhabditis elegans 35,699 16-Jun-99 rxa01460 417GB_HTG3: AC009186 48600 AC009186 Homo sapiens chromosome 5 cloneCIT978SKB_148I14, Homo sapiens 41,278 07-OCT-1999 *** SEQUENCING INPROGRESS ***, 3 ordered pieces. GB_HTG3: AC009186 48600 AC009186 Homosapiens chromosome 5 clone CIT978SKB_148I14, *** SEQUENCING Homo sapiens41,278 07-OCT-1999 IN PROGRESS ***, 3 ordered pieces. GB_HTG3: AC00918648600 AC009186 Homo sapiens chromosome 5 clone CIT978SKB_148I14, ***SEQUENCING Homo sapiens 35,162 07-OCT-1999 IN PROGRESS ***, 3 orderedpieces. rxa01463 1287 GB_PR3: HS326L13 127247 Z82170 Human DNA sequencefrom PAC 326L13 containing brain-4 mRNA ESTs Homo sapiens 37,95623-Nov-99 and polymorphic CA repeat. GB_HTG1: HS439A6 49379 AL031723Homo sapiens chromosome 16 clone LA16-439A6, *** SEQUENCING Homo sapiens38,035 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: HS439A649379 AL031723 Homo sapiens chromosome 16 clone LA16-439A6, ***SEQUENCING IN Homo sapiens 38,035 23-Nov-99 PROGRESS ***, in unorderedpieces. rxa01469 1155 GB_EST31: AI701691 349 AI701691 we81c04.x1Soares_NFL_T_GBC_S1 Homo sapiens 39,806 3-Jun-99 Homo sapiens cDNA cloneIMAGE: 2347494 3′ similar to gb: L19686_rna1 MACROPHAGE MIGRATIONINHIBITORY FACTOR (HUMAN):, mRNA sequence. GB_EST15: AA480256 389AA480256 ne31f04.s1 NCI_CGAP_Co3 Homo sapiens cDNA clone IMAGE: 8989753′ similar Homo sapiens 42,705 14-Aug-97 to gb: L19686_rna1 MACROPHAGEMIGRATION INHIBITORY FACTOR (HUMAN);, mRNA sequence. GB_IN2: AF1532691308 AF153269 Tetrahymena thermophila dynein heavy chain (DYH10) gene,partial cds. Tetrahymena thermophila 32,489 10-Jun-99 rxa01470 549GB_PL2: ATF3L17 94319 AL080283 Arabidopsis thaliana DNA chromosome 4,BAC clone F3L17 (ESSA project). Arabidopsis thaliana 37,615 24-Jun-99GB_PL2: ATF3L17 94319 AL080283 Arabidopsis thaliana DNA chromosome 4,BAC clone F3L17 (ESSA project). Arabidopsis thaliana 35,946 24-Jun-99rxa01471 930 GB_EST11: AA233898 460 AA233898 zr49b12.s1 Soares_NhHMPu_S1Homo sapiens cDNA Homo sapiens 40,57 6-Aug-97 clone IMAGE: 666719 3′,mRNA sequence. GB_EST11: AA234033 428 AA234033 zr49b12.r1Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE: Homo sapiens 36,2776-Aug-97 666719 5′ similar to contains Alu repetitive element;, mRNAsequence. GB_PL2: AF084971 1874 AF084971 Catharanthus roseus G-boxbinding protein 1 (GBF1) mRNA, complete cds. Catharanthus roseus 36,8217-Jul-99 rxa01472 rxa01473 888 GB_PL2: AC002329 76170 AC002329 DNAsequence of Arabidopsis thaliana BAC F5J6 from chromosome IV,Arabidopsis thaliana 35,78 18-Nov-97 complete sequence. GB_HTG3:AC009485 190706 AC009485 Homo sapiens clone NH0324G03, *** SEQUENCING INPROGRESS ***, Homo sapiens 39,649 04-OCT-1999 6 unordered pieces.GB_HTG3: AC009485 190706 AC009485 Homo sapiens clone NH0324G03, ***SEQUENCING IN PROGRESS ***, Homo sapiens 39,649 04-OCT-1999 6 unorderedpieces. rxa01474 669 GB_PR2: HSP373C6 85654 AL022393 Homo sapiens DNAsequence from P1 p373c6 on chromosome Homo sapiens 33,934 22-Nov-996p21.31-21.33. Contains zinc finger proteins, pseudogenes, ESTs and STS.GB_EST4: H30893 485 H30893 yp43e11.r1 Soares retina N2b5HR Homo sapienscDNA clone IMAGE: 190220 5′ Homo sapiens 37,866 16-Aug-95 similar tocontains Alu repetitive element;, mRNA sequence. GB_PL2: ATAC00539880238 AC005398 Arabidopsis thaliana chromosome II BAC T6B13 genomicsequence, complete Arabidopsis thaliana 38,64 30-OCT-1998 sequence.rxa01475 549 GB_PL1: AB024028 70952 AB024028 Arabidopsis thalianagenomic DNA, chromosome 3, TAC clone: K1G2, Arabidopsis thaliana 40,5220-Nov-99 complete sequence. GB_HTG2: AC007940 159279 AC007940 Homosapiens clone 44_C_14, *** SEQUENCING IN PROGRESS ***, Homo sapiens36,044 1-Jul-99 12 unordered pieces. GB_HTG2: AC007940 159279 AC007940Homo sapiens clone 44_C_14, *** SEQUENCING IN PROGRESS ***, Homo sapiens36,044 1-Jul-99 12 unordered pieces. rxa01476 465 GB_PL1: AB009087 1074AB009087 Chlamydomonas sp. mRNA for alternative oxidase, partial cds.Chlamydomonas sp. 38,596 05-DEC-1997 GB_PL1: AB009087 1074 AB009087Chlamydomonas sp. mRNA for alternative oxidase, partial cds.Chlamydomonas sp. 39,519 05-DEC-1997 rxa01479 363 GB_HTG1: HSJ136J15148579 AL118496 Homo sapiens chromosome X clone RP1-136J15, ***SEQUENCING Homo sapiens 39,886 23-Nov-99 IN PROGRESS ***, in unorderedpieces. GB_HTG1: HSJ136J15 148579 AL118496 Homo sapiens chromosome Xclone RP1-136J15, *** SEQUENCING Homo sapiens 39,886 23-Nov-99 INPROGRESS ***, in unordered pieces. GB_HTG2: AC007579 134344 AC007579Drosophila melanogaster chromosome 2 clone BACR07M03 (D607) RPCI-98Drosophila melanogaster 39,266 2-Aug-99 07.M.3 map 53A-53B strain y; cnbw sp, *** SEQUENCING IN PROGRESS ***, 108 unordered pieces. rxa01484669 GB_PR3: AF064858 193387 AF064858 Homo sapiens chromosome 21q22.3 BAC28F9, complete sequence. Homo sapiens 38,281 2-Jun-98 GB_GSS10: AQ207755496 AQ207755 HS_3026_B1_G04_T7 CIT Approved Human Homo sapiens 37,1518-Sep-98 Genomic Sperm Library D Homo sapiens genomic clone Plate =3026 Col = 7 Row = N, genomic survey sequence. GB_PR3: AF064858 193387AF064858 Homo sapiens chromosome 21q22.3 BAC 28F9, complete sequence.Homo sapiens 38,379 2-Jun-98 rxa01485 2175 GB_IN1: CEY50E8A 61864AL117200 Caenorhabditis elegans cosmid Y50E8A, complete sequence.Caenorhabditis elegans 39,617 19-Nov-99 GB_IN1: CEY50E8A 61864 AL117200Caenorhabditis elegans cosmid Y50E8A, complete sequence. Caenorhabditiselegans 34,349 19-Nov-99 GB_PL1: AB028606 61510 AB028606 Arabidopsisthaliana genomic DNA, chromosome 5, BAC clone: F16F17, Arabidopsisthaliana 34,858 20-Nov-99 complete sequence. rxa01488 1071 GB_BA1:CGPROMF10 60 X90358 C. glutamicum DNA for promoter fragment F10.Corynebacterium 65 4-Nov-96 glutamicum GB_EST10: AA183656 465 AA183656mt20f08.r1 Soares mouse 3NbMS Mus musculus cDNA clone IMAGE: 621639 Musmusculus 35,333 17-Feb-97 5′ similar to WP: T02C12.2 CE01062;, mRNAsequence. GB_EST9: AA110912 309 AA110912 mm02c01.r1 Stratagene mousekidney (#937315) Mus musculus cDNA clone IMAGE: Mus musculus 37,6624-Feb-97 520320 5′ similar to WP: T02C12.2 CE01062;, mRNA sequence.rxa01492 927 GB_EST16: AA589576 567 AA589576 vl49b06.s1 Stratagene mouseskin (#937313) Mus musculus cDNA Mus musculus 34,104 16-Sep-97 cloneIMAGE: 975539 3′ similar to gb: M63488 REPLICATION PROTEIN A 70 KDDNA-BINDING SUBUNIT (HUMAN);, mRNA sequence. GB_EST28: AU051490 865AU051490 AU051490 Sugano mouse brain mncb Mus musculus cDNA cloneMNCb-2105 5′, Mus musculus 29,837 18-MAR-1999 mRNA sequence. GB_EST32:AI738234 609 AI738234 606044C01.x2 606 - Ear tissue cDNA library fromSchmidt lab Zea mays cDNA, Zea mays 38,291 16-Jun-99 mRNA sequence.rxa01494 1119 GB_PR4: AC007106 172188 AC007106 Homo sapiens chromosome 4clone C0383J20 map 4p16, complete sequence. Homo sapiens 35,108 2-Jun-99GB_BA2: AE001093 14097 AE001093 Archaeoglobus fulgidus section 14 of 172of the complete genome. Archaeoglobus fulgidus 38,113 15-DEC-1997GB_PR4: AC007106 172188 AC007106 Homo sapiens chromosome 4 cloneC0383J20 map 4p16, complete sequence. Homo sapiens 34,657 2-Jun-99rxa01497 1041 GB_BA2: SCJ1 36925 AL109962 Streptomyces coelicolor cosmidJ1. Streptomyces coelicolor 50,722 24-Sep-99 A3(2) GB_BA1: MTY20B1136330 Z95121 Mycobacterium tuberculosis H37Rv complete genome; segment139/162. Mycobacterium 40,238 17-Jun-98 tuberculosis GB_BA1: PAU128914062 U12891 Pseudomonas aeruginosa PAO substrain OT684 pyoverdine genetranscriptional Pseudomonas aeruginosa 39,856 03-OCT-1996 regulator PvdS(pvdS) gene, complete cds. rxa01501 411 GB_PAT: I78757 2203 I78757Sequence 13 from patent U.S. Pat. No. 5693781. Unknown. 61,364 3-Apr-98GB_PAT: I92046 2203 I92046 Sequence 13 from patent U.S. Pat. No.5726299. Unknown. 61,364 01-DEC-1998 GB_PR4: AC002427 101098 AC002427Homo sapiens BAC clone GS011E15 from 5q31, complete sequence. Homosapiens 42,25 02-DEC-1998 rxa01504 732 GB_HTG3: AC008954 23046 AC008954Homo sapiens chromosome 5 clone CITB-H1_2340N2, *** SEQUENCING Homosapiens 37,83 3-Aug-99 IN PROGRESS ***, 51 unordered pieces. GB_HTG3:AC008954 23046 AC008954 Homo sapiens chromosome 5 clone CITB-H1_2340N2,*** SEQUENCING Homo sapiens 37,83 3-Aug-99 IN PROGRESS ***, 51 unorderedpieces. GB_BA1: QPHQSOP 4068 L28041 Plasmid QpH1 (from Coxiellaburnetii) qsopA and qsopB genes, promoter region. Plasmid QpH1 37,51714-Jul-95 rxa01505 621 GB_SY: SYNM13GAL 66 M10216 Bacteriophage M13gt102N-terminal beta-galactosidase gene (lac+ phenotype). unidentifiedcloning vector 62,121 27-Apr-93 GB_SY: SYNM13GAL 66 M10216 BacteriophageM13gt102 N-terminal beta-galactosidase gene (lac+ phenotype).unidentified cloning vector 62,121 27-Apr-93 GB_BA2: BJU56817 2892U56817 Bradyrhizobium japonicum aconitase (acnA) gene, complete cds.Bradyrhizobium japonicum 40,214 13-Nov-96 rxa01506 534 GB_BA1: MTCY9831225 Z83860 Mycobacterium tuberculosis H37Rv complete genome; segment103/162. Mycobacterium 38,274 17-Jun-98 tuberculosis GB_BA1: MTCY9831225 Z83860 Mycobacterium tuberculosis H37Rv complete genome; segment103/162. Mycobacterium 33,71 17-Jun-98 tuberculosis rxa01507 546 GB_RO:D89731 1815 D89731 Rattus norvegicus mRNA for AIM-1, complete cds.Rattus norvegicus 38,125 7-Feb-99 GB_RO: D89731 1815 D89731 Rattusnorvegicus mRNA for AIM-1, complete cds. Rattus norvegicus 34,6 7-Feb-99rxa01518 rxa01519 870 GB_HTG2: AC007929 123885 AC007929 Drosophilamelanogaster chromosome 3 clone BACR05C11 (D759) Drosophila melanogaster34,075 2-Aug-99 RPCI-98 05.C.11 map 95A-95C strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 85 unordered pieces. GB_HTG2: AC007929123885 AC007929 Drosophila melanogaster chromosome 3 clone BACR05C11(D759) RPCI-98 Drosophila melanogaster 34,075 2-Aug-99 05.C.11 map95A-95C strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 85 unorderedpieces. GB_PL2: AC011437 95310 AC011437 Arabidopsis thaliana chromosomeIII BAC F7O18 genomic sequence, Arabidopsis thaliana 37,28 2-Nov-99complete sequence. rax01520 rxa01523 1074 GB_GSS11: AQ270206 389AQ270206 HS_2037_A1_G10_T7 CIT Homo sapiens 38,046 3-Nov-98 ApprovedHuman Genomic Sperm Library D Homo sapiens genomic clone Plate = 2037Col = 19 Row = M, genomic survey sequence. GB_GSS14: AQ588624 480AQ588624 CITBI-E1-2643C9.TF CITBI-E1 Homo sapiens genomic clone 2643C9,Homo sapiens 36,875 7-Jun-99 genomic survey sequence. GB_HTG1: CEY80D3245017 AL020988 Caenorhabditis elegans chromosome V clone Y80D3, ***SEQUENCING Caenorhabditis elegans 35,646 6-Sep-99 IN PROGRESS ***, inunordered pieces. rxa01525 1845 GB_PR3: HS560B9 99074 Z98751 Human DNAsequence from PAC 560B9 on chromosome 1q24-1q25. Contains Homo sapiens37,981 23-Nov-99 profilin-like pseudogene, 60S ribosomal protein L4pseudogene RNA binding protein, ESTs, GSS. GB_PR3: HS560B9 99074 Z98751Human DNA sequence from PAC 560B9 on chromosome 1q24-1q25. Contains Homosapiens 37,982 23-Nov-99 profilin-like pseudogene, 60S ribosomal proteinL4 pseudogene RNA binding protein, ESTs, GSS. rxa01527 rxa01536 1365GB_HTG3: AC010745 193862 AC010745 Homo sapiens clone NH0549D18, ***SEQUENCING IN PROGRESS ***, Homo sapiens 35,277 21-Sep-99 30 unorderedpieces. GB_HTG3: AC010745 193862 AC010745 Homo sapiens clone NH0549D18,*** SEQUENCING IN PROGRESS ***, Homo sapiens 35,277 21-Sep-99 30unordered pieces. GB_HTG3: AC010745 193862 AC010745 Homo sapiens cloneNH0549D18, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,958 21-Sep-9930 unordered pieces. rxa01539 2289 GB_BA1: CGPROMF10 60 X90358 C.glutamicum DNA for promoter fragment F10. Corynebacterium 61,6674-Nov-96 glutamicum GB_HTG3: AC011577 151996 AC011577 Homo sapiens clone12_P_19, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 35,554 07-OCT-1999GB_HTG3: AC011577 151996 AC011577 Homo sapiens clone 12_P_19, LOW-PASSSEQUENCE SAMPLING. Homo sapiens 35,554 07-OCT-1999 rxa01540 825GB_EST10: AA152819 491 AA152819 mq67e04.r1 Soares 2NbMT Mus musculuscDNA clone IMAGE: 583806 5′, Mus musculus 39,04 18-Feb-97 mRNA sequence.GB_EST29: AI616027 481 AI616027 mq67e04.y1 Soares 2NbMT Mus musculuscDNA clone IMAGE: 583806 5′, Mus musculus 36,688 21-Apr-99 mRNAsequence. GB_GSS6: AQ843942 468 AQ843942 LMAJFV1_Im03d08.x2 Leishmaniamajor FV1 random genomic library Leishmania major 40,899 04-OCT-1999Leishmania major genomic clone LMAJFV1_Im03d08 3′, genomic surveysequence. rxa01543 2889 GB_BA2: ECOUW67_0 110000 U18997 Escherichia coliK-12 chromosomal region from 67.4 to 76.0 minutes. Escherichia coli36,618 15-Sep-99 GB_BA2: ECOUW67_0 110000 U18997 Escherichia coli K-12chromosomal region from 67.4 to 76.0 minutes. Escherichia coli 38,41515-Sep-99 GB_BA2: AE000397 14820 AE000397 Escherichia coli K-12 MG1655section 287 of 400 of the complete genome. Escherichia coli 37,59412-Nov-98 rxa01544 723 GB_EST37: AI977486 479 AI977486 EST272080Schistosoma mansoni male, Phil LoVerde/Joe Schistosoma mansoni 44,15827-Aug-99 Merrick Schistosoma mansoni cDNA clone SMMAM80 5′ end, mRNAsequence. GB_VI: AF056119 564 AF056119 HIV-1 isolate z560 from Zimbabwe,envelope glycoprotein V3-V5 region (env) gene, Human immunodeficiency35,874 26-Sep-98 partial cds. virus type 1 GB_VI: AF056119 564 AF056119HIV-1 isolate z560 from Zimbabwe, envelope glycoprotein V3-V5 region(env) gene, Human immunodeficiency 37,229 26-Sep-98 partial cds. virustype 1 rxa01545 1374 GB_HTG1: CEY53C10_1 110000 Z93340 Caenorhabditiselegans chromosome I clone Y53C10, *** SEQUENCING Caenorhabditis elegans36,885 4-Nov-98 IN PROGRESS ***, in unordered pieces. GB_HTG1:CEY53C10_1 110000 Z93340 Caenorhabditis elegans chromosome I cloneY53C10, *** SEQUENCING IN Caenorhabditis elegans 36,885 4-Nov-98PROGRESS ***, in unordered pieces. GB_HTG1: CEY47H9_1 110000 Z92853Caenorhabditis elegans chromosome I clone Y47H9, *** SEQUENCING INCaenorhabditis elegans 30,285 4-Sep-98 PROGRESS ***, in unorderedpieces. rxa01546 819 GB_GSS3: B58207 420 B58207 CIT-HSP-2012C11.TRCIT-HSP Homo sapiens genomic clone 2012C11, genomic Homo sapiens 45,22820-Jun-98 survey sequence. GB_IN1: HAU02678 623 U02578 Helicoverpaarmigera mitochondrion D-loop, partial 12S rRNA gene, and MitochondrionHelicoverpa 37,5 27-OCT-1993 partial tRNA-Met gene. armigera GB_EST19:AA769027 473 AA769027 oa78g01.s1 NCI_CGAP_GCB1 Homo sapiens cDNA cloneIMAGE: 1318416 3′ Homo sapiens 39,583 28-Jan-98 similar to TR: Q92617Q92617 MYELOBLAST KIAA0220;, mRNA sequence. rxa01547 786 GB_EST26:AU002373 837 AU002373 AU002373 Bombyx mori p50(Daizo) Bombyx mori cDNAclone mg0832, Bombyx mori 37,698 15-Jan-99 mRNA sequence. GB_EST30:AV025617 494 AV025617 AV025617 Mus musculus adult C57BL/6J lung Musmusculus cDNA clone Mus musculus 38,316 31-Aug-99 1200014J18, mRNAsequence. GB_EST26: AU002373 837 AU002373 AU002373 Bombyx morip50(Daizo) Bombyx mori cDNA clone Bombyx mori 36,767 15-Jan-99 mg0832,mRNA sequence. rxa01548 1131 GB_IN1: PFARBPCA 8841 M88097 Plasmodiumvivax retyculocyte binding protein 1 gene, complete cds. Plasmodiumvivax 37,077 26-Apr-93 GB_PAT: I55034 1985 I55034 Sequence 2 from patentU.S. Pat. No. 5646247. Unknown. 38,25 07-OCT-1997 GB_OV: GGNEUROMP 1112Y09597 G. gallus mRNA for NeuroM protein. Gallus gallus 37,10415-OCT-1997 rxa01549 1727 GB_PR4: HSLONPG01 2443 AF059296 Homo sapiensLON protease (LON) gene, nuclear gene encoding Homo sapiens 39,40111-Apr-99 mitochondrial protein, exon 1. GB_EST33: AI770254 555 AI770254SAL2.F12 Black Tiger Shrimp Whole Cephalothorax UniZap library Penaeusmonodon 40,325 28-Jun-99 Penseus monodon cDNA clone SAL2.F12 5′ similarto muscle myosin heavy chain, mRNA sequence. GB_PR1: HSU02389 3179U02389 Human hLON ATP-dependent protease mRNA, nuclear gene encodingHomo sapiens 38,868 27-Jan-95 mitochondrial protein, complete cds.rxa01552 1101 GB_HTG4: AC011192 144277 AC011192 Homo sapiens clonehRPK.53_A_1, *** SEQUENCING IN Homo sapiens 36,296 19-OCT-1999 PROGRESS***, 9 unordered pieces. GB_HTG4: AC011192 144277 AC011192 Homo sapiensclone hRPK.53_A_1, *** SEQUENCING IN Homo sapiens 36,296 19-OCT-1999PROGRESS ***, 9 unordered pieces. GB_HTG3: AC011203 70518 AC011203 Homosapiens chromosome 3 clone 78_O_24 map 3, LOW-PASS Homo sapiens 36,4403-OCT-1999 SEQUENCE SAMPLING. rxa01554 2265 GB_EST27: AA957437 340AA957437 UI-R-E1-fy-g-02-0-UI.s1 UI-R-E1 Rattus norvegicus cDNA cloneRattus norvegicus 39,039 4-Jul-99 UI-R-E1-fy-g-02-0-UI 3′, mRNAsequence. GB_PL2: SPBC19G7 37727 AL021839 S. pombe chromosome II cosmidc19G7. Schizosaccharomyces 36,991 17-Nov-99 pombe GB_PL1: HVPROTZ 703X05902 Barley mRNA fragment for protein Z. Hordeum vulgare 36,3913-Jul-95 rxa01557 939 GB_EST24: AI167051 429 AI167051 xylem.est.822Poplar xylem Lambda ZAPII library Populus balsamifera subsp. Populusbalsamifera 40,326 03-DEC-1998 trichocarpa cDNA 5′, mRNA sequence.subsp. trichocarpa GB_PL2: AC007259 97146 AC007259 Arabidopsis thalianachromosome I BAC T28P6 genomic sequence, complete Arabidopsis thaliana34,442 17-Aug-99 sequence. GB_PL2: AC007259 97146 AC007259 Arabidopsisthaliana chromosome I BAC T28P6 genomic sequence, complete Arabidopsisthaliana 34,967 17-Aug-99 sequence. rxa01560 rxa01574 1158 GB_PR3:AC005242 160262 AC005242 Homo sapiens chromosome 17, clonehRPK.118_F_13, complete sequence. Homo sapiens 35,727 22-Jul-98 GB_PR3:AC005242 160262 AC005242 Homo sapiens chromosome 17, clonehRPK.118_F_13, complete sequence. Homo sapiens 33,969 22-Jul-98 GB_HTG2:AC007604 167373 AC007604 Homo sapiens chromosome 16 clone 344L6, ***SEQUENCING IN PROGRESS***, Homo sapiens 36,028 20-MAY-1999 85 unorderedpieces. rxa01575 1143 GB_PR4: AC004738 147404 AC004738 Homo sapiensChromosome 15q11-q13 PAC clone pDJ351h23 from the Prader- Homo sapiens37,312 25-Nov-98 Willi/Angelman Syndrome region, complete sequence.GB_PR3: AC005250 94336 AC005250 Homo sapiens BAC clone RG318M05 from7q22-q31.1, complete sequence. Homo sapiens 38,201 3-Jul-98 GB_GSS11:AQ300376 487 AQ300376 HS_2206_A2_D05_MR CIT Approved Human Genomic SpermLibrary D Homo sapiens 35,345 16-DEC-1998 Homo sapiens genomic clonePlate = 2206 Col = 10 Row = G, genomic survey sequence. rxa01577 498GB_BA1: MTY15C10 33050 Z95436 Mycobacterium tuberculosis H37Rv completegenome; segment 154/162. Mycobacterium 58,385 17-Jun-98 tuberculosisGB_BA2: AF030975 2511 AF030975 Aeromonas salmonicida chaperonin GroESand chaperonin GroEL genes, Aeromonas salmonicida 41,322 2-Apr-98complete cds. GB_EST7: W33355 488 W33355 mb97g01.r1 Soares mouse p3NMF19.5 Mus musculus cDNA clone IMAGE: Mus musculus 40,23 11-Sep-96 3373925′ similar to gb: X58196_cds1 M. musculus H19 mRNA (MOUSE);, mRNAsequence. rxa01579 507 GB_GSS1: GGA300114 662 AJ231964 Gallus gallusanonymous sequence from Cosmid mapping to chicken chromosome 3 Gallusgallus 38,023 25-Aug-98 (Cosmid 30 - Contig 14), genomic surveysequence. GB_GSS1: GGA300114 662 AJ231964 Gallus gallus anonymoussequence from Cosmid mapping to chicken chromosome 3 Gallus gallus38,608 25-Aug-98 (Cosmid 30 - Contig 14), genomic survey sequence.rxa01585 750 GB_PR4: AC004815 120538 AC004815 Homo sapiens clone 82F9,complete sequence. Homo sapiens 35,383 8-Sep-99 GB_PR2: AP000151 100000AP000151 Homo sapiens genomic DNA, chromosome 21q22.2, DSCR region,clone D47-S479, Homo sapiens 39,722 20-Nov-99 segment 3/16, completesequence. GB_PR2: AP000151 100000 AP000151 Homo sapiens genomic DNA,chromosome 21q22.2, DSCR region, clone D47-S479, Homo sapiens 34,68320-Nov-99 segment 3/16, complete sequence. rxa01586 392 GB_GSS5:AQ791385 522 AQ791385 HS_5268_A2_C05_T7A RPCI-11 Human Male BAC LibraryHomo sapiens Homo sapiens 43,235 3-Aug-99 genomic clone Plate = 844 Col= 10 Row = E, genomic survey sequence. GB_EST15: AA463774 255 AA463774aa09f10.r1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE: 812779 5′Homo sapiens 42,045 10-Jun-97 similar to gb: X07868_rna1 PUTATIVEINSULIN-LIKE GROWTH FACTOR II ASSOCIATED (HUMAN); contains element PTR7repetitive element;, mRNA sequence. GB_PR1: AP000010 100000 AP000010Homo sapiens genomic DNA of 21q22.2 Down Syndrome region, segment 3/13.Homo sapiens 38,684 24-Apr-99 rxa01590 rxa01592 1425 GB_HTG2: AC008163135300 AC008163 Homo sapiens clone NH0005B09, *** SEQUENCING IN PROGRESS***, Homo sapiens 34,141 31-Jul-99 1 unordered pieces. GB_HTG2: AC008163135300 AC008163 Homo sapiens clone NH0005B09, *** SEQUENCING IN PROGRESS***, Homo sapiens 34,141 31-Jul-99 1 unordered pieces. GB_HTG3: AC009231181006 AC009231 Homo sapiens clone NH0350124, *** SEQUENCING IN PROGRESS***, Homo sapiens 36,767 6-Aug-99 2 unordered pieces. rxa01595 1083GB_BA1: MTCI125 37432 Z98268 Mycobacterium tuberculosis H37Rv completegenome; segment 76/162. Mycobacterium 57,955 17-Jun-98 tuberculosisGB_BA1: MTHYPROT 2544 X98295 M. Tuberculosis TlyA gene. Mycobacterium57,955 2-Jun-98 tuberculosis GB_BA1: U00021 39193 U00021 Mycobacteriumleprae cosmid L247. Mycobacterium leprae 35,261 29-Sep-94 rxa01597 1305GB_HTG3: AC009462 103046 AC009462 Drosophila melanogaster chromosome 3clone BACR27G04 (D985) RPCI-98 27.G.4 Drosophila melanogaster 38,89830-Aug-99 map 90E—90E strain y; cn bw sp, *** SEQUENCING IN PROGRESS***,88 unordered pieces. GB_HTG3: AC009462 103046 AC009462 Drosophilamelanogaster chromosome 3 clone BACR27G04 (D985) RPCI-98 27.G.4Drosophila melanogaster 38,898 30-Aug-99 map 90E—90E strain y; cn bw sp,*** SEQUENCING IN PROGRESS***, 88 unordered pieces. GB_HTG2: AC006889267118 AC006889 Caenorhabditis elegans clone Y65B4, *** SEQUENCING INPROGRESS ***, Caenorhabditis elegans 36,236 26-Feb-99 6 unorderedpieces. rxa01598 1086 GB_EST2: R02663 397 R02663 ye80a04.r1 Soares fetalliver spleen 1NFLS Homo sapiens cDNA clone IMAGE: Homo sapiens 36,27231-MAR-1995 124014 5′, mRNA sequence. GB_EST6: W03663 346 W03663za65b08.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA cloneIMAGE: Homo sapiens 42,775 19-Apr-96 297399 5′, mRNA sequence. GB_IN2:AC007765 163403 AC007765 Drosophila melanogaster, chromosome 2L, region23C1-23C5, P1 clones DS02190 Drosophila melanogaster 38,351 9-Jun-99 andDS00906, complete sequence. rxa01600 792 GB_STS: G39530 822 G39530Z22942 Zebrafish AB Danio rerio STS genomic, sequence tagged site. Daniorerio 41,242 31-Jul-98 GB_STS: G39530 822 G39530 Z22942 Zebrafish ABDanio rerio STS genomic, sequence tagged site. Danio rerio 41,24231-Jul-98 GB_PR3: HSDJ991C6 128995 AL078599 Human DNA sequence fromclone 991C6 on chromosome 6q14.1-15, Homo sapiens 35,188 23-Nov-99complete sequence. rxa01602 1653 GB_EST38: AW033000 685 AW033000EST276559 tomato callus, TAMU Lycopersicon esculentum cDNA cloneLycopersicon esculentum 44,706 15-Sep-99 cLEC19N6, mRNA sequence.GB_PL2: SPAC3C7 35052 Z99568 S. pombe chromosome I cosmid c3C7.Schizosaccharomyces 38,158 29-Nov-99 pombe GB_PL2: SPAC3C7 35052 Z99568S. pombe chromosome I cosmid c3C7. Schizosaccharomyces 37,888 28-Nov-99pombe rxa01605 1638 GB_HTG3: AC008689 145122 AC008689 Homo sapienschromosome 5 clone CIT978SKB_61G23, *** SEQUENCING IN Homo sapiens35,448 3-Aug-99 PROGRESS ***, 44 unordered pieces. GB_HTG3: AC008689145122 AC008689 Homo sapiens chromosome 5 clone CIT978SKB_61G23, ***SEQUENCING IN Homo sapiens 35,448 3-Aug-99 PROGRESS ***, 44 unorderedpieces. GB_HTG3: AC009175 233932 AC009175 Homo sapiens chromosome 5clone RPCI-PAC_241C15, *** SEQUENCING IN Homo sapiens 37,423 3-Aug-99PROGRESS ***, 94 unordered pieces. rxa01610 852 GB_BA1: ECU82664 139818U82664 Escherichia coli minutes 9 to 11 genomic sequence. Escherichiacoli 34,198 11-Jan-97 GB_BA1: ECU82664 139818 U82664 Escherichia coliminutes 9 to 11 genomic sequence. Escherichia coli 36,949 11-Jan-97GB_BA1: D90845 19366 D90845 E. coli genomic DNA, Kohara clone#356(46.1-46.5 min.). Escherichia coli 39,808 21-MAR-1997 rxa01611 480GB_PR3: AC005581 39601 AC005581 Homo sapiens chromosome 19, cosmidR31237, complete sequence. Homo sapiens 38,901 1-Sep-98 GB_EST35:AI809560 443 AI809560 wf30h09.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNAclone IMAGE: Homo sapiens 35,989 7-Jul-99 2357153 3′, mRNA sequence.GB_EST25: AI279953 416 AI279953 qh90b02.x1 Soares_NFL_T_GBC_S1 Homosapiens cDNA clone IMAGE: Homo sapiens 35,276 27-Jan-99 1854219 3′, mRNAsequence. rxa01612 rxa01618 507 GB_GSS14: AQ506815 616 AQ506815RPCI-11-316B19.TV RPCI-11 Homo sapiens genomic clone RPCI-11-316B19,Homo sapiens 41,901 29-Apr-99 genomic survey sequence. GB_HTG2: AC007512168140 AC007512 Homo sapiens clone hRPK.96_A_1, *** SEQUENCING INPROGRESS ***, Homo sapiens 39,549 07-MAY-1999 14 unordered pieces.GB_HTG2: AC007512 168140 AC007512 Homo sapiens clone hRPK.96_A_1, ***SEQUENCING IN PROGRESS ***, Homo sapiens 39,549 07-MAY-1999 14 unorderedpieces. rxa01619 1098 GB_BA1: ECOUW93 338534 U14003 Escherichia coliK-12 chromosomal region from 92.8 to 00.1 minutes. Escherichia coli39,459 17-Apr-96 GB_BA2: AE000497 10334 AE000497 Escherichia coli K-12MG1655 section 387 of 400 of the complete genome. Escherichia coli39,459 12-Nov-98 GB_BA1: ECOLEUX 2147 M96355 Escherichia coli leucinetRNA gene and ORF1 gene, complete cds. Escherichia coli 41,434 26-Jul-95rxa01622 726 GB_PR4: AC007664 162470 AC007664 Homo sapiens, completesequence. Homo sapiens 37,006 18-Sep-99 GB_PR4: AC002472 147100 AC002472Homo sapiens Chromosome 22q11.2 PAC Clone p_n5 In BCRL2-GGT Region, Homosapiens 33,058 13-Sep-99 complete sequence. GB_BA1: SYCSLRG 135638D64005 Synechocystis sp. PCC6803 complete genome, 24/27,3002966-3138603. Synechocystis sp. 38,755 13-Feb-99 rxa01623 834GB_HTG4: AC007422 156484 AC007422 Homo sapiens clone hRPK.68_A_1, ***SEQUENCING IN PROGRESS ***, Homo sapiens 36,759 23-OCT-1999 3 unorderedpieces. GB_HTG4: AC007422 156484 AC007422 Homo sapiens clonehRPK.68_A_1, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,75923-OCT-1999 3 unordered pieces. GB_HTG4: AC007422 156484 AC007422 Homosapiens clone hRPK.68_A_1, *** SEQUENCING IN PROGRESS ***, Homo sapiens33,495 23-OCT-1999 3 unordered pieces. rxa01624 468 GB_BA2: AE00181610007 AE001816 Thermotoga maritima section 128 of 136 of the completegenome. Thermotoga maritima 38,852 2-Jun-99 GB_RO: CCPH20 2152 X56332Cavia cobaya mRNA for PH-20 protein. Cavia porcellus 38,293 20-Feb-91GB_PAT: I89388 2152 I89388 Sequence 1 from patent U.S. Pat. No. 5721348.Unknown. 38,293 10-Aug-98 rxa01628 1137 GB_BA1: CGPROPGEN 2936 Y12537 C.glutamicum proP gene. Corynebacterium 37,882 17-Nov-98 glutamicumGB_IN1: CET06E6 33238 Z81117 Caenorhabditis elegans cosmid T06E6,complete sequence. Caenorhabditis elegans 38,33 2-Sep-99 GB_HTG2:AC006916 157093 AC006916 Caenorhabditis elegans clone Y9C9, ***SEQUENCING IN PROGRESS ***, Caenorhabditis elegans 36,519 24-Feb-99 3unordered pieces. rxa01630 1200 GB_PR3: AC004945 167372 AC004945 Homosapiens PAC clone DJ0997N05 from 7q11.23-q21.1, complete sequence. Homosapiens 34,996 26-Sep-98 GB_PR4: AC006385 173508 AC006385 Homo sapiensclone NH0559J05, complete sequence. Homo sapiens 32,525 05-MAY-1999GB_PR3: AC004945 167372 AC004945 Homo sapiens PAC clone DJ0997N05 from7q11.23-q21.1, complete sequence. Homo sapiens 37,972 26-Sep-98 rxa01634675 GB_PR4: AC005901 156763 AC005901 Homo sapiens chromosome 17, clonehRPK.15_K_2, complete sequence. Homo sapiens 35,736 20-Jan-99 GB_PR4:AC005901 156763 AC005901 Homo sapiens chromosome 17, clone hRPK.15_K_2,complete sequence. Homo sapiens 35,549 20-Jan-99 rxa01635 864 GB_HTG3:AC008590 268470 AC008590 Homo sapiens chromosome 5 cloneCIT-HSPC_575D19, *** SEQUENCING IN Homo sapiens 35,37 3-Aug-99 PROGRESS***, 235 unordered pieces. GB_HTG3: AC008590 268470 AC008590 Homosapiens chromosome 5 clone CIT-HSPC_575D19, *** SEQUENCING IN Homosapiens 35,37 3-Aug-99 PROGRESS ***, 235 unordered pieces. GB_HTG3:AC008590 268470 AC008590 Homo sapiens chromosome 5 cloneCIT-HSPC_575D19, *** SEQUENCING IN Homo sapiens 38,571 3-Aug-99 PROGRESS***, 235 unordered pieces. rxa01638 1023 GB_HTG3: AC008261 93735AC008261 Arabidopsis thaliana chromosome III clone TAMU-T4P13, ***SEQUENCING IN Arabidopsis thaliana 37,2 10-Aug-99 PROGRESS ***, 1ordered pieces. GB_HTG3: AC008261 93735 AC008261 Arabidopsis thalianachromosome III clone TAMU-T4P13, *** SEQUENCING IN Arabidopsis thaliana37,2 10-Aug-99 PROGRESS ***, 1 ordered pieces. GB_HTG3: AC008261 93735AC008261 Arabidopsis thaliana chromosome III clone TAMU-T4P13, ***SEQUENCING IN Arabidopsis thaliana 32,637 10-Aug-99 PROGRESS ***, 1ordered pieces. rxa01641 1494 GB_PR3: HS681N20 130263 AL031670 Human DNAsequence from clone 681N20 on chromosome 20p12.1-13 Contains Homosapiens 34,676 23-Nov-99 FTLL1(ferritin, light polypeptide-like 1), agene similar to Zinc finger, C3HC4 type (RING finger), weakly similar toSW: GOLI_DROME Q06003 GOLIATH PROTEIN, ESTs, STS, GSS, CA repeat(D20S889), CpG Islands, complete sequence. GB_HTG4: AC011177 168660AC011177 Homo sapiens clone 11_L_8, *** SEQUENCING IN PROGRESS ***, Homosapiens 36,234 29-OCT-1999 7 unordered pieces. GB_HTG4: AC011177 168660AC011177 Homo sapiens clone 11_L_8, *** SEQUENCING IN PROGRESS ***, Homosapiens 36,234 29-OCT-1999 7 unordered pieces. rxa01642 1365 GB_BA1:MTY15F10 38204 Z94121 Mycobacterium tuberculosis H37Rv complete genome;segment 161/162. Mycobacterium 37,723 17-Jun-98 tuberculosis GB_BA1:SC3C3 31382 AL031231 Streptomyces coelicolor cosmid 3C3. Streptomycescoelicolor 39,602 10-Aug-98 GB_BA1: SCU33176 1238 U33176 Streptomycescoelicolor serine protease gene, complete cds. Streptomyces coelicolor41,467 9-Jan-96 rxa01643 549 GB_IN1: CEZC101 26147 Z93395 Caenorhabditiselegans cosmid ZC101, complete sequence. Caenorhabditis elegans 36,2823-Jul-99 GB_EST16: C47058 360 C47058 C47058 Yuji Kohara unpublishedcDNA: Strain N2 hermaphrodite embryo Caenorhabditis elegans 39,94418-OCT-1999 Caenorhabditis elegans cDNA clone yk432e11 5′, mRNAsequence. GB_HTG1: CEY54E2_1 110000 Z92861 Caenorhabditis eleganschromosome II clone Y54E2, *** SEQUENCING IN Caenorhabditis elegans36,28 29-Jul-98 PROGRESS ***, in unordered pieces. rxa01645 729 GB_BA1:MTV025 121125 AL022121 Mycobacterium tuberculosis H37Rv complete genome;segment 155/162. Mycobacterium 60,31 24-Jun-99 tuberculosis GB_BA1:MLCB2407 35615 AL023596 Mycobacterium leprae cosmid B2407. Mycobacteriumleprae 37,378 27-Aug-99 GB BA1: MSGB577COS 37770 L01263 M. lepraegenomic dna sequence, cosmid b577. Mycobacterium leprae 57,829 14-Jun-96rxa01646 942 GB BA1: MSGB577COS 37770 L01263 M. leprae genomic dnasequence, cosmid b577. Mycobacterium leprae 53,781 14-Jun-96 GB_BA1:MLCB2407 35615 AL023596 Mycobacterium leprae cosmid B2407. Mycobacteriumleprae 39,348 27-Aug-99 GB_BA1: MTV025 121125 AL022121 Mycobacteriumtuberculosis H37Rv complete genome; segment 155/162. Mycobacterium53,503 24-Jun-99 tuberculosis rxa01647 1293 GB_GSS1: CNS010VB 837AL099473 Drosophila melanogaster genome survey sequence T7 end of BACBACN05B20 Droasophila melanogaster 39,412 26-Jul-99 of DrosBAC libraryfrom Drosophila melanogaster (fruit fly), genomic survey sequence.GB_EST1: T55021 429 T55021 yb42e09.r1 Stratagene fetal spleen (#937205)Homo sapiens cDNA clone IMAGE: Homo sapiens 39,73 6-Feb-95 73864 5′,mRNA sequence. GB_EST38: AL120803 505 AL120803 DKFZp762E202_r1 762(synonym: hmel2) Homo sapiens cDNA clone Homo sapiens 40,476 27-Sep-99DKFZp762E202 5′, mRNA sequence. rxa01656 1020 GB_BA1: MTCY1A10 25949Z95387 Mycobacterium tuberculosis H37Rv complete genome; segment117/162. Mycobacterium 37,771 17-Jun-98 tuberculosis GB_BA1: MLCL58136225 Z96801 Mycobacterium leprae cosmid L581. Mycobacterium leprae40,041 24-Jun-97 GB_PL2: ATAC003028 106448 AC003028 Arabidopsis thalianachromosome II BAC F16M14 genomic sequence, Arabidopsis thaliana 57,69222-Jul-98 complete sequence. rxa01658 1856 GB_BA1: MTV014 58280 AL021646Mycobacterium tuberculosis H37Rv complete genome; segment 137/162.Mycobacterium 38,877 18-Jun-98 tuberculosis GB_BA1: MTV030 29256AL021428 Mycobacterium tuberculosis H37Rv complete genome; segment4/162. Mycobacterium 57,048 17-Jun-98 tuberculosis GB_BA1: MTV014 58280AL021646 Mycobacterium tuberculosis H37Rv complete genome; segment137/162. Mycobacterium 40,511 18-Jun-98 tuberculosis rxa01659 669GB_HTG3: AC008604 136016 AC008604 Homo sapiens chromosome 5 cloneCIT978SKB_109F8, *** SEQUENCING Homo sapiens 35,106 3-Aug-99 IN PROGRESS***, 79 unordered pieces. GB_HTG3: AC008604 136016 AC008604 Homo sapienschromosome 5 clone CIT978SKB_109F8, *** SEQUENCING Homo sapiens 35,1063-Aug-99 IN PROGRESS ***, 79 unordered pieces. GB_HTG3: AC011403 124903AC011403 Homo sapiens chromosome 5 clone CIT978SKB_3P13, *** SEQUENCINGIN Homo sapiens 33,997 06-OCT-1999 PROGRESS ***, 7 ordered pieces.rxa01663 981 GB_HTG2: AC006799 278007 AC006799 Caenorhabditis elegansclone Y51H7, *** SEQUENCING IN PROGRESS ***, Caenorhabditis elegans34,787 23-Feb-99 7 unordered pieces. GB_HTG2: AC006799 278007 AC006799Caenorhabditis elegans clone Y51H7, *** SEQUENCING IN PROGRESS ***,Caenorhabditis elegans 34,787 23-Feb-99 7 unordered pieces. GB_HTG2:AC006799 278007 AC006799 Caenorhabditis elegans clone Y51H7, ***SEQUENCING IN PROGRESS ***, Caenorhabditis elegans 39,148 23-Feb-99 7unordered pieces. rxa01665 843 GB_BA1: CGU43535 2531 U43535Corynebacterium glutamicum multidrug resistance protein (cmr) gene,complete cds. Corynebacterium 37,353 9-Apr-97 glutamicum GB_IN2:AF062971 359 AF062971 Anoplodactylus portus 28S ribosomal RNA gene,partial sequence. Anoplodactylus portus 42,462 20-Apr-99 GB_EST31:AU062109 544 AU062109 AU062109 Dictyostelium discoideum SL (H.Urushihara) Dictyostelium discoideum Dictyostelium discoideum 34,8120-MAY-1999 cDNA clone SLH629, mRNA sequence. rxa01669 1038 GB_BA2:CGU89648 1105 U89648 Corynebacterium glutamicum unidentified sequenceinvolved in histidine Corynebacterium 65,152 30-MAR-1999 biosynthesis,partial sequence. glutamicum GB_IN1: DMC86E4 29352 AL021086 Drosophilamelanogaster cosmid clone 86E4. Drosophila melanogaster 39,289 27-Apr-99GB_PL1: ENY13759 3141 Y13759 Emericella nidulans abfB gene. Emericellanidulans 38,552 05-MAR-1999 rxa01671 1272 GB_PH: MPU46938 15664 U46938Mycobacterium phage DS6A, Spe1/Nhel G fragment sequence. Mycobacteriumphage 60,751 29-Jun-96 DS6A GB_PAT: I31047 15664 I31047 Sequence 3 frompatent U.S. Pat. No. 5582969. Unknown. 60,751 6-Feb-97 GB_PAT: I3686315664 I36863 Sequence 3 from patent U.S. Pat. No. 5612182. Unknown.60,751 13-MAY-1997 rxa01672 465 GB_GSS14: AQ512046 462 AQ512046HS_5113_B1_B10_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 40,882 05-MAY-1999 genomic clone Plate = 689 Col = 19 Row = D,genomic survey sequence. GB_GSS13: AQ475012 253 AQ475012CITBI-E1-2592A3.TR CITBI-E1 Homo sapiens genomic clone 2592A3, genomicHomo sapiens 35,417 23-Apr-99 survey sequence. GB_GSS14: AQ512046 462AQ512046 HS_5113_B1_B10_SP6E RPCI-11 Human Male BAC Library Homo sapiensHomo sapiens 35,106 05-MAY-1999 genomic clone Plate = 689 Col = 19 Row =D, genomic survey sequence. rxa01673 1158 GB_HTG5: AC010988 176452AC010988 Homo sapiens clone NH0570F04, WORKING DRAFT SEQUENCE, Homosapiens 37,489 11-Nov-99 1 unordered pieces. GB_HTG5: AC010988 176452AC010988 Homo sapiens clone NH0570F04, WORKING DRAFT SEQUENCE, Homosapiens 35,492 11-Nov-99 1 unordered pieces. rxa01675 534 GB_EST19:AA797620 497 AA797620 vw26b03.r1 Soares mouse mammary gland NbMMG Musmusculus cDNA clone Mus musculus 44,318 10-Feb-98 IMAGE: 1244909 5′,mRNA sequence. GB_IN2: AF076597 846 AF076597 Dictyostelium discoideumublquitin-conjugating enzyme protein UbcC (ubcC) mRNA, Dictyosteliumdiscoideum 37,149 30-Jul-98 complete cds. GB_EST22: C94466 698 C94466C94466 Dictyostelium discoideum SS (H. Urushihara) Dictyosteliumdiscoideum Dictyostelium discoideum 33,647 15-Jun-98 cDNA clone SSL136,mRNA sequence. rxa01676 879 GB_IN1: CELR03H10 35080 U29382Caenorhabditis elegans cosmid R03H10. Caenorhabditis elegans 40,95122-Jun-95 GB_EST37: AI998397 584 AI998397 701545552 A. thaliana,Columbia Col-0, rosette-2 Arabidopsis thaliana cDNA clone Arabidopsisthaliana 37,333 8-Sep-99 701545552, mRNA sequence. GB_GSS14: AQ551731577 AQ551731 RPCI-11-383J4.TJ RPCI-11 Homo sapiens genomic cloneRPCI-11-383J4, genomic Homo sapiens 39,321 28-MAY-1999 survey sequence.rxa01677 867 GB_PL2: ATF6I18 122322 AL022198 Arabidopsis thaliana DNAchromosome 4, BAC clone F6I18 (ESSA project). Arabidopsis thaliana34,335 27-Aug-99 GB_PL2: ATF6I18 122322 AL022198 Arabidopsis thalianaDNA chromosome 4, BAC clone F6I18 (ESSA project). Arabidopsis thaliana34,895 27-Aug-99 GB_OV: XLSDK2 2306 Y10350 X. laevis mRNA for nuclearprotein SDK2. Xenopus laevis 36,538 2-Apr-98 rxa01681 756 GB_HTG3:AC010798 172575 AC010798 Homo sapiens chromosome 18 clone 470_B_24 map18, *** SEQUENCING IN Homo sapiens 37,116 23-Sep-99 PROGRESS ***, 7unordered pieces. GB_HTG3: AC010798 172575 AC010798 Homo sapienschromosome 18 clone 470_B_24 map 18, *** SEQUENCING IN Homo sapiens37,116 23-Sep-99 PROGRESS ***, 7 unordered pieces. GB_PL2: AF085231 3158AF085231 Arabidopsis thaliana phytochelatin synthase 1 (AtPCS1) gene,complete cds. Arabidopsis thaliana 42,149 3-Jun-99 rxa01685 702 GB_HTG1:CEY48A6 296699 Z92854 Caenorhabditis elegans chromosome III clone Y48A6,*** SEQUENCING IN Caenorhabditis elegans 37,393 31-Jul-98 PROGRESS ***,in unordered pieces. GB_HTG1: CEY48A6 296699 Z92854 Caenorhabditiselegans chromosome III clone Y48A6, *** SEQUENCING IN Caenorhabditiselegans 37,393 31-Jul-98 PROGRESS ***, in unordered pieces. GB_HTG1:CEY48A6 296699 Z92854 Caenorhabditis elegans chromosome III clone Y48A6,*** SEQUENCING IN Caenorhabditis elegans 32,946 31-Jul-98 PROGRESS ***,in unordered pieces. rxa01686 564 GB_EST35: AV156415 240 AV156415AV156415 Mus musculus head C57BL/6J 12-day embryo Mus musculus cDNAclone Mus musculus 40,417 7-Jul-99 3000002G04, mRNA sequence. GB_GSS15:AQ611518 597 AQ611518 HS_5084_B2_H01_T7A RPCI-11 Human Male BAC LibraryHomo sapiens Homo sapiens 41,848 15-Jun-99 genomic clone Plate = 660 Col= 2 Row = P, genomic survey sequence. GB_BA1: PDIORAB 5467 Z48918 P.diminuta iorA and iorB genes for isoquinoline 1-oxidoreductase.Brevundimonas diminuta 36,709 15-Aug-95 rxa01693 1545 GB_IN1: CEF46B636616 Z70780 Caenorhabditis elegans cosmid F46B6, complete sequence.Caenorhabditis elegans 36,856 04-DEC-1998 GB_EST5: L44364 362 L44364HUMEST1G5 Human thymus NSTH II Homo sapiens cDNA, mRNA sequence. Homosapiens 38,136 17-Jan-96 GB_PR2: AF009282 414 AF009282 Homo sapiensclone FBF3 Cri-du-chat region mRNA. Homo sapiens 46,809 17-Aug-97rxa01694 1023 GB_BA1: CGA224946 2408 AJ224946 Corynebacterium glutamicumDNA for L-Malate: quinone oxidoreductase. Corynebacterium 100 11-Aug-98glutamicum GB_EST7: W22650 715 W22650 71B2 Human retina cDNATsp509I-cleaved sublibrary Homo sapiens cDNA not Homo sapiens 37,53806-MAY-1996 directional, mRNA sequence. GB_PR4: AC005343 137213 AC005343Homo sapiens Chromosome 12p13.3 BAC RPCI11-21K20 (Roswell Park CancerHomo sapiens 38,048 2-Apr-99 Institute Human BAC Library) completesequence. rxa01696 1302 GB_BA1: MSGB1529CS 36985 L78824 Mycobacteriumleprae cosmid B1529 DNA sequence. Mycobacterium leprae 67,442 15-Jun-96GB_BA1: SC6A5 43632 AL049485 Streptomyces coelicolor cosmid 6A5.Streptomyces coelicolor 66,821 24-MAR-1999 GB_BA1: MTV003 13246 AL008883Mycobacterium tuberculosis H37Rv complete genome; segment 125/162.Mycobacterium 38,802 17-Jun-98 tuberculosis rxa01697 1080 GB_PL2:HNNHAHR 2559 L76588 Helianthus annuus homeodomain protein 1 mRNA,complete cds. Helianthus annuus 38,257 02-OCT-1997 GB_PL2: HNNHAHR 2559L76588 Helianthus annuus homeodomain protein 1 mRNA, complete cds.Helianthus annuus 37,196 02-OCT-1997 rxa01701 472 GB_BA2: AF069748 2103AF069748 Pseudomonas chlororaphis polyurethanase esterase A (pueA) gene,complete cds. Pseudomonas chlororaphis 39,13 4-Apr-99 GB_BA2: AF0697482103 AF069748 Pseudomonas chlororaphis polyurethanase esterase A (pueA)gene, complete cds. Pseudomonas chlororaphis 40,271 4-Apr-99 rxa017031236 GB_BA1: CGFDA 3371 X17313 Corynebacterium glutamicum fda gene forfructose-bisphosphate aldolase Corynebacterium 100 12-Sep-93 (EC4.1.2.13). glutamicum GB_EST18: AA728419 340 AA728419 33598 CD4-6Arabidopsis thaliana cDNA clone K2C9RP, mRNA sequence. Arabidopsisthaliana 36,176 5-Jan-98 GB_PL2: ATU90439 93639 U90439 Arabidopsisthaliana chromosome II BAC T06D20 genomic sequence, Arabidopsis thaliana35,381 21-Jul-97 complete sequence. rxa01709 555 GB_OV: AF033670 2353AF033670 Gallus gallus T-Box protein 4 (TBX4) mRNA, Gallus gallus 37,9179-Jun-98 complete cds. GB_EST5: H85635 533 H85635 ys88c04.r1 Soaresretina N2b5HR Homo sapiens cDNA clone IMAGE: 221862 5′, Homo sapiens36,735 14-Nov-95 mRNA sequence. GB_EST35: AI829867 427 AI829867wj58c05.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE: 2407016 3′, Homosapiens 40,299 26-Aug-99 mRNA sequence. rxa01711 1281 GB_GSS10: AQ217798441 AQ217798 HS_2007_A1_A04_MR CIT Approved Human Genomic Sperm LibraryD Homo Homo sapiens 38,292 19-Sep-98 sapiens genomic clone Plate = 2007Col = 7 Row = A, genomic survey sequence. GB_PAT: E05055 2053 E05055 DNAencoding D-threonine aldolase(DTA). Xanthomonas oryzae 36,475 29-Sep-97GB_PR3: HSJ570L12 143508 AL049589 Human DNA sequence from clone 570L12on chromosome Xq13.1-21.1. Contains the Homo sapiens 36,262 23-Nov-99PGK1 gene for phosphoglycerate kinase 1, the gene for a novel proteinsimilar to TAF2G (TATA box binding protein (TBP)-associated factor, RNApolymerase II, G, 32 kD) (TAFII31)), ESTs, STS, GSSs and a putative CpGisland, complete sequence. rxa01714 rxa01715 819 GB_BA1: MTCY441 35187Z80225 Mycobacterium tuberculosis H37Rv complete genome; segment118/162. Mycobacterium 36,216 18-Jun-98 tuberculosis GB_BA1: SC1B5 14866AL023517 Streptomyces coelicolor cosmid 1B5. Streptomyces coelicolor56,807 11-MAY-1998 GB_BA1: MSGB1912CS 38503 L01536 M. leprae genomic dnasequence, cosmid b1912. Mycobacterium leprae 55,651 14-Jun-96 rxa01729642 GB_BA2: CORCSLYS 2821 M89931 Corynebacterium glutamicum beta C-Slyase (aecD) and branched-chain amino acid Corynebacterium 41,9934-Jun-98 uptake carrier (brnQ) genes, complete cds, and hypotheticalprotein Yhbw glutamicum (yhbw) gene, partial cds. GB_HTG4: AC010037166249 AC010037 Drosophila melanogaster chromosome 3L/66B6 cloneRPCI98-6E4, Drosophila melanogaster 34,951 16-OCT-1999 *** SEQUENCING INPROGRESS ***, 52 unordered pieces. GB_HTG4: AC010037 166249 AC010037Drosophila melanogaster chromosome 3L/66B6 clone RPCI98-6E4, Drosophilamelanogaster 34,951 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 52unordered pieces. rxa01731 822 GB_GSS3: B83621 616 B83621RPCI11-16H17.TPB RPCI-11 Homo sapiens genomic clone RPCI-11-16H17, Homosapiens 40,899 9-Apr-99 genomic survey sequence. GB_GSS3: B82563 586B82563 RPCI11-16N17.TP RPCI-11 Homo sapiens genomic clone RPCI-11-16N17,Homo sapiens 40,235 9-Apr-99 genomic survey sequence. GB_HTG3: AC00907445999 AC009074 Homo sapiens chromosome 16 clone RPCI-11_323C21, ***SEQUENCING IN Homo sapiens 36,783 3-Aug-99 PROGRESS ***, 27 unorderedpieces. rxa01734 657 GB_GSS14: AQ545618 327 AQ545618 CITBI-E1-2636O13.TRCITBI-E1 Homo sapiens genomic clone 2636O13, Homo sapiens 38,15428-MAY-1999 genomic survey sequence. GB_HTG2: AC006629 27659 AC006629Caenorhabditis elegans clone F12E12, *** SEQUENCING IN PROGRESS***,Caenorhabditis elegans 35,658 23-Feb-99 1 unordered pieces. GB_HTG2:AC006629 27659 AC006629 Caenorhabditis elegans clone F12E12, ***SEQUENCING IN PROGRESS ***, Caenorhabditis elegans 35,714 23-Feb-99 1unordered pieces. rxa01738 837 GB_HTG1: CNS01DSB 222193 AL121768 Homosapiens chromosome 14 clone R-976B16, *** SEQUENCING IN Homo sapiens36,978 05-OCT-1999 PROGRESS ***, in ordered pieces. GB_HTG1: CNS01DSB222193 AL121768 Homo sapiens chromosome 14 clone R-976B16, ***SEQUENCING IN Homo sapiens 36,978 05-OCT-1999 PROGRESS ***, in orderedpieces. GB_HTG5: AC011170 171788 AC011170 Homo sapiens clone 10_L_13,*** SEQUENCING IN Homo sapiens 35,259 5-Nov-99 PROGRESS ***, 14unordered pieces. rxa01741 921 GB_IN1: CEK04G11 34190 Z78544Caenorhabditis elegans cosmid K04G11, complete sequence. Caenorhabditiselegans 35,055 6-Sep-99 GB_HTG2: AC005995 170023 AC005995 Homo sapiensclone DJ0042M02, *** SEQUENCING IN Homo sapiens 33,624 23-Apr-99PROGRESS ***, 13 unordered pieces. GB_HTG2: AC005995 170023 AC005995Homo sapiens clone DJ0042M02, *** SEQUENCING IN Homo sapiens 33,62423-Apr-99 PROGRESS ***, 13 unordered pieces. rxa01742 627 GB_EST30:AI658116 497 AI658116 fc22e07.y1 Zebrafish WashU MPIMG EST Danio reriocDNA 5′ similar to TR: Danio rerio 35,604 06-MAY-1999 Q15883 Q15883X104.;, mRNA sequence. GB_HTG1: CEY60A9 275370 AL022281 Caenorhabditiselegans chromosome X clone Y60A9, *** SEQUENCING IN Caenorhabditiselegans 35,61 2-Sep-99 PROGRESS ***, in unordered pieces. GB_HTG1:CEY60A9 275370 AL022281 Caenorhabditis elegans chromosome X clone Y60A9,*** SEQUENCING IN Caenorhabditis elegans 35,61 2-Sep-99 PROGRESS ***, inunordered pieces. rxa01748 903 GB_GSS13: AQ447364 439 AQ447364mgxb0006N01r CUGI Rice Blast BAC Library Magnaporthe grisea genomicMagnaporthe grisea 34,889 8-Apr-99 clone mgxb0006N01r, genomic surveysequence. GB_PR2: HSJ247G22 120487 AL096866 Human DNA sequence fromclone RP1-247G22 on chromosome 6p12.2-21.2, Homo sapiens 39,31 22-Nov-99complete sequence. GB_GSS5: AQ811603 375 AQ811603 HS_5460_B1_C09_SP6ERPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 38,13325-Aug-99 genomic clone Plate = 1036 Col = 17 Row = F, genomic surveysequence. rxa01749 1740 GB_HTG5: AC009544 211057 AC009544 Homo sapienschromosome 11 clone RP11-85D24 map 11, WORKING Homo sapiens 37,43319-Nov-99 DRAFT SEQUENCE, 14 unordered pieces. GB_HTG5: AC009544 211057AC009544 Homo sapiens chromosome 11 clone RP11-85D24 map 11, WORKINGHomo sapiens 37,069 19-Nov-99 DRAFT SEQUENCE, 14 unordered pieces.rxa01750 rxa01752 1584 GB_PR1: HUMPROFILX 17630 M96943 Humanprofilaggrin gene exons 1-3, 5′ end. Homo sapiens 36,352 27-Apr-93GB_PL2: AF049174 535 AF049174 Tolypocladium inflatum NRRL 28024 28Sribosomal RNA gene, partial sequence. Tolypocladium inflatum 40,18703-MAR-1999 GB_BA1: MLCL458 43839 AL049478 Mycobacterium leprae cosmidL458. Mycobacterium leprae 40,322 27-Aug-99 rxa01753 1662 GB_PR1:HUMPROFILX 17630 M96943 Human profilaggrin gene exons 1-3, 5′ end. Homosapiens 36,794 27-Apr-93 GB_PL1: YSCFBPA 2202 J03207 S. cerevisiaefructose-1,6-bisphosphatase (FBP) gene, complete cds. Saccharomycescerevisiae 37,762 27-Apr-93 GB_PL2: YSCL8039 31806 U19103 Saccharomycescerevisiae chromosome XII cosmid 8039. Saccharomyces cerevisiae 37,68522-Aug-97 rxa01754 rxa01760 405 GB_IN1: CELF43C9 34037 U40427Caenorhabditis elegans cosmid F43C9. Caenorhabditis elegans 40,94516-Nov-95 GB_IN1: CELF43C9 34037 U40427 Caenorhabditis elegans cosmidF43C9. Caenorhabditis elegans 35,484 16-Nov-95 GB_RO: MUSOP5F 3405D14816 Mouse osteopontin gene, 5′ flanking region. Mus musculus 35,2644-Feb-99 rxa01761 4587 GB_PR4: AC004600 133863 AC004600 Homo sapiensChromosome 15q11-q13 PAC clone pDJ373b1 containing Homo sapiens 37,03711-MAR-1999 Angelman Syndrome gene (UBE3A), complete sequence. GB_PR3:AC004259 118684 AC004259 Human Chromosome 15q11-q13 PAC clone pDJ14i12containing Angelman Homo sapiens 37,037 3-Jun-98 Syndrome gene (UBE3A),complete sequence. GB_PR4: AC004600 133863 AC004600 Homo sapiensChromosome 15q11-q13 PAC clone pDJ373b1 containing Homo sapiens 35,99511-MAR-1999 Angelman Syndrome gene (UBE3A), complete sequence. rxa017651065 GB_EST31: AI694883 370 AI694883 we52h02.x1 NCI_CGAP_Co3 Homosapiens cDNA clone IMAGE: 2344755 Homo sapiens 39,566 3-Jun-99 3′, mRNAsequence. GB_EST6: W08057 341 W08057 mb37e05.r1 Soares mouse p3NMF19.5Mus musculus cDNA clone IMAGE: 331616 Mus musculus 37,353 5-Sep-96 5′similar to gb: Z23090 HEAT SHOCK 27 KD PROTEIN (HUMAN); gb: L11609 Musmusculus heat shock protein 25 (MOUSE);, mRNA sequence. GB_IN1:CELC39D10 40897 U39678 Caenorhabditis elegans cosmid C39D10.Caenorhabditis elegans 39,59 2-Nov-95 rxa01767 588 GB_IN1: CEF16H9 21721Z50005 Caenorhabditis elegans cosmid F16H9, complete sequence.Caenorhabditis elegans 36,667 2-Sep-99 GB_IN1: CECC4 32063 Z81490Caenorhabditis elegans cosmid CC4, complete sequence. Caenorhabditiselegans 35,094 2-Sep-99 GB_HTG1: CEY26D4 156152 AL022595 Caenorhabditiselegans chromosome I clone Y2604, *** SEQUENCING IN Caenorhabditiselegans 33,276 7-Sep-99 PROGRESS ***, in unordered pieces. rxa01768rxa01769 564 GB_HTG4: AC010034 130818 AC010034 Drosophila melanogasterclone RPCI98-4O3,*** SEQUENCING IN Drosophila melanogaster 35,7416-OCT-1999 PROGRESS ***, 63 unordered pieces. GB_HTG4: AC010034 130818AC010034 Drosophila melanogaster clone RPCI98-4O3, *** SEQUENCING INDrosophila melanogaster 35,74 16-OCT-1999 PROGRESS ***, 63 unorderedpieces. GB_EST1: D36647 360 D36647 CELK035EZF Yuji Kohara unpublishedcDNA Caenorhabditis elegans cDNA clone Caenorhabditis elegans 37,878-Aug-94 yk35e12 5′, mRNA sequence. rxa01770 3888 GB_IN1: SUSENDO16C4692 L34680 Strongylocentrotus purpuratus calcium-binding protein(endo16) mRNA, Strongylocentrotus 39,337 21-Jul-94 complete cds.purpuratus GB_EST31: AF121176 535 AF121176 AF121176 Homo sapiens liver(Chang L-Y) Homo sapiens cDNA clone Homo sapiens 39,626 24-MAY-1999PFTTA2-2, mRNA sequence. GB_PR1: AB011149 5134 AB011149 Homo sapiensmRNA for KIAA0577 protein, complete cds. Homo sapiens 38,279 10-Apr-98rxa01771 825 GB_BA1: CGPROPGEN 2936 Y12537 C. glutamicum proP gene.Corynebacterium 100 17-Nov-98 glutamicum GB_EST33: AI778471 545 AI778471EST259350 tomato susceptible, Cornell Lycopersicon esculentum cDNA cloneLycopersicon esculentum 41,187 29-Jun-99 cLES5M16, mRNA sequence.GB_IN1: CET11F9 37714 Z74042 Caenorhabditis elegans cosmid T11F9,complete sequence. Caenorhabditis elegans 38,077 23-Nov-98 rxa01773 600GB_HTG2: U82212 46387 U82212 Homo sapiens chromosome 10 cloneLA10NC01_23_C_3 map 10q26.1-10q26.2, Homo sapiens 42,142 09-DEC-1998 ***SEQUENCING IN PROGRESS ***, 1 ordered pieces. GB_HTG2: U82212 46387U82212 Homo sapiens chromosome 10 clone LA10NC01_23_C_3 map10q26.1-10q26.2, Homo sapiens 42,142 09-DEC-1998 *** SEQUENCING INPROGRESS ***, 1 ordered pieces. GB_HTG2: U82212 46387 U82212 Homosapiens chromosome 10 clone LA10NC01_23_C_3 map 10q26.1-10q26.2, Homosapiens 37,748 09-DEC-1998 *** SEQUENCING IN PROGRESS ***, 1 orderedpieces. rxa01774 849 GB_HTG1: HSA557H15 228174 AL078590 Homo sapienschromosome 6 clone RP11-557H15, *** SEQUENCING IN Homo sapiens 38,05423-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1: HSA557H15 228174AL078590 Homo sapiens chromosome 6 clone RP11-557H15, *** SEQUENCING INHomo sapiens 38,054 23-Nov-99 PROGRESS ***, in unordered pieces. GB_PL2:YSCH9998 35600 U00030 Saccharomyces cerevisiae chromosome VIII cosmid9998. Saccharomyces cerevisiae 39,11 2-Sep-97 rxa01775 687 GB_PR3:HS37J18 131427 Z98747 Human DNA sequence from clone 37J18 on chromosome1p36.2-36.3. Contains a Homo sapiens 35,036 23-Nov-99 putative novelgene. ESTs and GSSs, complete sequence. GB_HTG2: AC007475 185087AC007475 Drosophila melanogaster chromosome 2 clone BACR04E21 (D592)RPCI-98 04.E.21 Drosophila melanogaster 37,333 2-Aug-99 map 49A-49Bstrain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 36 unordered pieces.GB_HTG2: AC007475 185087 AC007475 Drosophila melanogaster chromosome 2clone BACR04E21 (D592) RPCI-98 04.E.21 Drosophila melanogaster 37,3332-Aug-99 map 49A-49B strain y; cn bw sp, *** SEQUENCING IN PROGRESS***,36 unordered pieces. rxa01776 1575 GB_GSS10: AQ174954 416 AQ174954HS_3211_22_C03_MR CIT Approved Human Genomic Sperm Library D Homo Homosapiens 43,171 17-OCT-1998 sapiens genomic clone Plate = 3211 Col = 6Row = F, genomic survey sequence. GB_PR1: HSFGF6 1032 X57075 H. sapiensFGF6 gene. Homo sapiens 41,196 15-Feb-95 GB_PR2: HSAC000055 93578AC000055 Human PAC clone DJ073F11 from Xq23, complete sequence. Homosapiens 35,08 14-Nov-96 rxa01777 582 GB_BA2: AF076997 15398 AF076997Comamonas testosteroni PtL5 cryptic plasmid pPT1, complete sequence.Comamonas testosteroni 37,805 30-Nov-99 GB_BA2: AF076997 15398 AF076997Comamonas testosteroni PtL5 cryptic plasmid pPT1, complete sequence.Comamonas testosteroni 35,529 30-Nov-99 rxa01778 1260 GB_PR3: AC002981153568 AC002981 Homo sapiens Xp22 BAC GS279A12 (Genome Systems) completesequence. Homo sapiens 37,305 22-Jan-98 GB_EST29: AI587176 384 AI587176tr54c10.x1 NCI_CGAP_Pan1 Homo sapiens cDNA clone IMAGE: 2222130 3′, Homosapiens 37,24 14-MAY-1999 mRNA sequence. GB_PR1: HSCP450 1346 X65962 H.sapiens mRNA for cytochrome P-450. Homo sapiens 38,906 29-MAY-1992rxa01779 1542 GB_EST19: AA202518 661 AA202518 LD02757.5prime LDDrosophila melanogaster embryo BlueScript Drosophila Drosophilamelanogaster 40,212 27-Nov-98 melanogaster cDNA clone LD02757 5prime,mRNA sequence. GB_EST34: AI805834 453 AI805834 te52b03.x1Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone IMAGE: Homo sapiens 387-Jul-99 2090285 3′ similar to contains Alu repetitive element;, mRNAsequence. GB_EST30: AI648920 754 AI648920 uk32h03.x1 Sugano mouse kidneymkia Mus musculus cDNA clone IMAGE: Mus musculus 36,967 30-Apr-991970741 3′ similar to WP: Y76A2B.5 CE19277;, mRNA sequence. rxa01780 498GB_GSS8: AQ038759 670 AQ038759 CIT-HSP-2325O13.TV CIT-HSP Homo sapiensgenomic clone Homo sapiens 32,645 11-Jul-98 2325O13, genomic surveysequence. GB_GSS8: AQ038759 670 AQ038759 CIT-HSP-2325O13.TV CIT-HSP Homosapiens genomic clone Homo sapiens 39,474 11-Jul-98 2325O13, genomicsurvey sequence. rxa01781 384 GB_IN1: CELF52G3 42696 AF026212Caenorhabditis elegans cosmid F52G3. Caenorhabditis elegans 39,31425-Sep-97 GB_GSS14: AQ579313 877 AQ579313 nbxb0084O07r CUGI Rice BACLibrary Oryza sativa genomic clone Oryza sativa 36,053 2-Jun-99nbxb0084O07r, genomic survey sequence. GB_VI: HAV19AE3 3441 X95259 Humanadenovirus type 19a early region 3 genes. Human adenovirus type 38,6249-Jul-97 19a rxa01782 519 GB_IN1: DMSED5 930 X78219 D. melanogaster(Barton) SED5 mRNA. Drosophila melanogaster 38,372 21-Apr-95 GB_IN2:L49408 83527 L49408 Drosophila melanogaster DNA sequence (P1 DS02740(D27)), complete sequence. Drosophila melanogaster 35,992 17-Jul-98GB_STS: G46002 398 G46002 Z556_1 Zebrafish AB Danio rerio STS genomicclone Z556 5′, sequence tagged site. Danio rerio 33,92 23-MAR-1999rxa01783 360 GB_VI: CITV18420 19259 Y18420 Citrus tristeza viruscomplete genome, isolate T385. Citrus tristeza virus 41,457 6-Apr-99GB_IN1: DMSED5 930 X78219 D. melanogaster (Barton) SED5 mRNA. Drosophilamelanogaster 45,802 21-Apr-95 GB_VI: CTY18368 2759 Y18368 Citrustristeza virus defective RNA, strain T411. Citrus tristeza virus 41,4576-Apr-99 rxa01785 699 GB_BA2: AF121000 19751 AF121000 Corynebacteriumglutamicum strain 22243 R-plasmid pAG1, complete sequence.Corynebacterium 40,529 14-Apr-99 glutamicum GB_PR2: HS1014D13 71263AL022311 Human DNA sequence from clone 1014D13 on chromosome22q13.1-13.2 Homo sapiens 35,362 23-Nov-99 Contains ESTs, STSs, and aCpG island, complete sequence. GB_BA2: AF121000 19751 AF121000Corynebacterium glutamicum strain 22243 R-plasmid pAG1, completesequence. Corynebacterium 38,012 14-Apr-99 glutamicum rxa01787 816GB_RO: RATSIALYLA 1128 L13445 Rat sialyltransferase gene family relatedmRNA, complete cds. Rattus norvegicus 35,012 26-Jul-93 GB_PR3: HSN75H1246144 Z84496 Human DNA sequence from cosmid N75H12 on chromosome22q12-qter. Homo sapiens 37,738 23-Nov-99 GB_GSS13: AQ496514 532AQ496514 HS_5118_B2_F05_SP6E RPCI-11 Human Male BAC Library Homo Homosapiens 39,238 28-Apr-99 sapiens genomic clone Plate = 694 Col = 10 Row= L, genomic survey sequence. rxa01788 rxa01789 765 GB_BA1: MTV029 3279AL021427 Mycobacterium tuberculosis H37Rv complete genome; segment1/162. Mycobacterium 39,229 17-Jun-98 tuberculosis GB_BA1: MTORIREP 8400X92504 M. tuberculosis origin of replication and genes rnpA, rpmH, dnaA,dnaN, recF. Mycobacterium 36,328 26-Aug-97 tuberculosis GB_GSS4:AQ729452 763 AQ729452 HS_5474_A1_G07_T7AHS_5474_A1 RPCI-11 Human MaleBAC Library Homo Homo sapiens 39,451 15-Jul-99 sapiens genomic clonePlate = 1050 Col = 13 Row = M, genomic survey sequence. rxa01790 183GB_EST37: AI935426 436 AI935426 wo84d02.x1 NCI_CGAP_Kid11 Homo sapienscDNA clone IMAGE: 2462019 Homo sapiens 39,877 2-Sep-99 3′ similar to TR:O00193 O00193 SMALL ACIDIC PROTEIN.;, mRNA sequence. GB_GSS11: AQ265301621 AQ265301 CITBI-E1-2509K16.TF CITBI-E1 Homo sapiens genomic clone2509K16, Homo sapiens 45,856 27-OCT-1998 genomic survey sequence.GB_HTG2: AC007596 199300 AC007596 Homo sapiens chromosome 16 clone116B6, *** SEQUENCING Homo sapiens 37,572 20-MAY-1999 IN PROGRESS ***,42 unordered pieces. rxa01791 486 GB_PL2: ATAC004521 104797 AC004521Arabidopsis thaliana chromosome II BAC F4I1 genomic sequence, completeArabidopsis thaliana 43,167 12-MAY-1998 sequence. GB_GSS13: AQ436125 508AQ436125 HS_5049_B2_G12_T7A RPCI-11 Human Male BAC Library Homo Homosapiens 32,762 31-MAR-1999 sapiens genomic clone Plate = 625 Col = 24Row = N, genomic survey sequence. GB_GSS12: AQ342410 674 AQ342410RPCI11-121E5.TJ RPCI-11 Homo sapiens genomic clone RPCI-11-121E5, Homosapiens 37,269 06-MAY-1999 genomic survey sequence. rxa01792 396 GB_STS:KLAJ9905 178 AJ229905 Kluyveromyces lactis DNA fragment for sequencetagged site, clone okam5e06r. Kluyveromyces lactis 42,697 20-Nov-98GB_STS: KLAJ9905 178 AJ229905 Kluyveromyces lactis DNA fragment forsequence tagged site, clone okam5e06r. Kluyveromyces lactis 42,69720-Nov-98 GB_GSS15: AQ612295 472 AQ612295 HS_5121_A2_D09_SP6E RPCI-11Human Male BAC Library Homo sapiens Homo sapiens 40,885 15-Jun-99genomic clone Plate = 697 Col = 18 Row = G, genomic survey sequence.rxa01793 357 GB_GSS3: B82515 613 B82515 RPCI11-16J10.TV RPCI-11 Homosapiens genomic clone RPCI-11-16J10, Homo sapiens 40,164 9-Apr-99genomic survey sequence. GB_PR2: CNS0000B 196287 AL049829 Humanchromosome 14 DNA sequence *** IN PROGRESS *** BAC R-124D2 Homo sapiens33,621 27-OCT-1999 of RPCI-11 library from chromosome 14 of Homo sapiens(Human), complete sequence. GB_OV: AF001393 4329 AF001393 Oryziaslatipes Medaka OG-12 (MOG-12) mRNA, complete cds. Oryzias latipes 35,51130-Sep-99 rxa01794 357 GB_GSS15: AQ644157 665 AQ644157RPCI93-Dpnll-29O12.TV RPCI93-Dpnll Trypanosoma brucei genomic cloneTrypanosoma brucei 39,894 8-Jul-99 RPCI93-Dpnll-29O12, genomic surveysequence. GB_GSS15: AQ657704 665 AQ657704 Sheared DNA-24C24.TR ShearedDNA Trypanosoma brucei genomic clone Trypanosoma brucei 37,11 23-Jun-99Sheared DNA-24C24, genomic survey sequence. GB_OV: GGU25125 6418 U25125Gallus gallus preprogastrin gene, complete cds. Gallus gallus 40,58406-MAY-1995 rxa01796 897 GB_PR3: HS404G5 119737 AL035695 Human DNAsequence from clone 404G5 on chromosome 6q24.1-25.2. Homo sapiens 34,79323-Nov-99 Contains part of a human estrogen receptor gene, STSs andGSSs, complete sequence. GB_PR1: HSPTP1CHG 8545 X82818 H. sapiensPTP1C/HCP gene. Homo sapiens 35,531 26-Jun-97 GB_PR3: HS404G5 119737AL035695 Human DNA sequence from clone 404G5 on chromosome 6q24.1-25.2.Homo sapiens 37,058 23-Nov-99 Contains part of a human estrogen receptorgene, STSs and GSSs, complete sequence. rxa01799 1317 GB_HTG3: AC01086938000 AC010869 Leishmania major chromosome 35 clone L7195 strainFriedlin, Leishmania major 40,522 02-OCT-1999 *** SEQUENCING IN PROGRESS***, 4 unordered pieces. GB_HTG3: AC010869 38000 AC010869 Leishmaniamajor chromosome 35 clone L7195 strain Friedlin, Leishmania major 40,52202-OCT-1999 *** SEQUENCING IN PROGRESS ***, 4 unordered pieces. GB_OM:SSU12574 2190 U12574 Sus scrofa myogenic regulatory factor MyoD (myoD)gene, complete cds. Sus scrofa 37,068 10-Feb-96 rxa01800 843 GB_PH:C2PVCG 22172 L48605 Bacteriophage c2 complete genome. Lactococcusbacteriophage 36,747 14-MAR-1996 c2 GB_EST38: AW066009 641 AW066009687004F08.y1 687 - Early embryo from Delaware Zea mays cDNA, mRNAsequence. Zea mays 40 12-OCT-1999 GB_PH: C2PVCG 22172 L48605Bacteriophage c2 complete genome. Lactococcus bacteriophage 36,86714-MAR-1996 c2 rxa01803 1083 GB_BA2: SCJ1 36925 AL109962 Streptomycescoelicolor cosmid J1. Streptomyces coelicolor 54,267 24-Sep-99 A3(2)GB_BA1: PAU12891 4062 U12891 Pseudomonas aeruginosa PAO substrain OT684pyoverdine gene transcriptional Pseudomonas aeruginosa 37,84103-OCT-1996 regulator PvdS (pvdS) gene, complete cds. GB_HTG6: AC010203230460 AC010203 Homo sapiens clone RP11-175P13, *** SEQUENCING Homosapiens 35,185 03-DEC-1999 IN PROGRESS ***, 48 unordered pieces.rxa01804 444 GB_EST24: AI189912 784 AI189912 qd33e07.x1Soares_placenta_8to9weeks_2NbHP8to9W Homo sapiens cDHA clone Homosapiens 40 28-OCT-1996 IMAGE: 1725540 3′ similar to gb: Z23064_cds1HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN G (HUMAN);, mRNA sequence.GB_EST24: AI189912 784 AI189912 qd33e07.x1Soares_placenta_8to9weeks_2NbNP8to9W Homo sapiens cDNA clone Homosapiens 35,294 28-OCT-1998 IMAGE: 1725540 3′ similar to gb: Z23064_cds1HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN G (HUMAN);, mRNA sequence.rxa01805 453 GB_PR2: HSU73628 32289 U73628 Human chromosome 11 101h11cosmid, complete sequence. Homo sapiens 36,099 19-Jun-97 GB_PR2:HSU73628 32289 U73628 Human chromosome 11 101h11 cosmid, completesequence. Homo sapiens 35,227 19-Jun-97 rxa01806 603 GB_IN1: CELK02E736535 AF025465 Caenorhabditis elegans cosmid K02E7. Caenorhabditiselegans 37,479 23-Sep-97 GB_HTG3: AC011217 157261 AC011217 Homo sapiensclone 7_J_14, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 33,33303-OCT-1999 GB_HTG3: AC011217 157261 AC011217 Homo sapiens clone 7_J_14,LOW-PASS SEQUENCE SAMPLING. Homo sapiens 33,333 03-OCT-1999 rxa018091299 GB_HTG3: AC010759 155875 AC010759 Homo sapiens clone 1_K_15, ***SEQUENCING IN Homo sapiens 37,92 22-Sep-99 PROGRESS ***, 15 unorderedpieces. GB_HTG3: AC010759 155875 AC010759 Homo sapiens clone 1_K_15, ***SEQUENCING IN Homo sapiens 37,92 22-Sep-99 PROGRESS ***, 15 unorderedpieces. GB_HTG2: AC006235 190842 AC006235 Homo sapiens clonehRPK.520_J_4, *** SEQUENCING IN Homo sapiens 36,019 17-Jul-99 PROGRESS***, 5 unordered pieces. rxa01813 789 GB_PR4: AC004047 134649 AC004047Homo sapiens chromosome 4 clone B150J4 map 4q25, complete sequence. Homosapiens 36,205 01-DEC-1998 GB_HTG2: HS1012F16 74539 AL080274 Homosapiens chromosome 20 clone RP5-1012F16, *** SEQUENCING Homo sapiens35,032 03-DEC-1999 IN PROGRESS ***, in unordered pieces. GB_HTG2:HS1012F16 74539 AL080274 Homo sapiens chromosome 20 clone RP5-1012F16,*** SEQUENCING Homo sapiens 35,032 03-DEC-1999 IN PROGRESS ***, inunordered pieces. rxa01815 915 GB_PR3: AC005740 186780 AC005740 Homosapiens chromosome 5p, BAC clone 50g21 (LBNL H154), complete sequence.Homo sapiens 37,315 01-OCT-1998 GB_HTG3: AC008328 114617 AC008328Drosophila melanogaster chromosome 2 clone BACR09A04 (D860) Drosophilamelanogaster 30,516 6-Aug-99 RPCI-98 09.A.4 map 28B-28C strain y; cn bwsp, *** SEQUENCING IN PROGRESS ***, 74 unordered pieces. GB_HTG3:AC008328 114617 AC008328 Drosophila melanogaster chromosome 2 cloneBACR09A04 (D860) Drosophila melanogaster 30,516 6-Aug-99 RPCI-98 09.A.4map 28B-28C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 74unordered pieces. rxa01816 855 GB_PR3: AC003101 208396 AC003101 Homosapiens chromosome 17, clone HRPC41C23, complete sequence. Homo sapiens34,272 5-Jun-98 GB_EST23: AI144656 492 AI144656 UI-R-BT0-pl-f-04-0-UI.s1UI-R-BT0 Rattus norvegicus cDNA clone Rattus norvegicus 37,526 5-Jul-99UI-R-BT0-pl-f-04-0-UI 3′, mRNA sequence. GB_GSS11: AQ341706 506 AQ341706RPCI11-120J20.TJ RPCI-11 Homo sapiens genomic clone Homo sapiens 40,78906-MAY-1999 RPCI-11-120J20, genomic survey sequence. rxa01817 756GB_BA2: AF030176 7000 AF030176 Rhodococcus opacus putative transposasegene, partial cds; and Rhodococcus opacus 42,577 5-Aug-98 putative FADsynthetase, putative short-chain dehydrogenase/reductase, maleylacetatereductase (macA), and putative transcription factor genes, complete cds.GB_EST19: AA263350 423 AA263350 LD06495.5prime LD Drosophilamelanogaster embryo BlueScript Drosophila Drosophila melanogaster 38,95527-Nov-98 melanogaster cDNA clone LD06495 5prime, mRNA sequence.GB_EST19: AA202194 368 AA202194 LD02304.5prime LD Drosophilamelanogaster embryo BlueScript Drosophila Drosophila melanogaster 39,89127-Nov-98 melanogaster cDNA clone LD02304 5prime, mRNA sequence.rxa01820 1497 GB_BA2: AF030176 7000 AF030176 Rhodococcus opacus putativetransposase gene, partial cds; and putative Rhodococcus opacus 41,7995-Aug-98 FAD synthetase, putative short-chain dehydrogenase/reductase,maleylacetate reductase (macA), and putative transcription factor genes,complete cds. GB_EST32: AI728582 666 AI728582 BNLGHi11124 Six-day Cottonfiber Gossypium hirsutum cDNA 5′ Gossypium hirsutum 37,915 11-Jun-99similar to (U64918) ATGP1 [Arabidopsis thaliana], mRNA sequence. GB_BA2:AF030176 7000 AF030176 Rhodococcus opacus putative transposase gene,partial cds; and putative Rhodococcus opacus 37,127 5-Aug-98 FADsynthetase, putative short-chain dehydrogenase/reductase, maleylacetatereductase (macA), and putative transcription factor genes, complete cds.rxa01825 393 GB_HTG1: HSJCF13 293368 AJ239320 Homo sapiens chromosome Xclone cosmid 244B12 map Xq13, *** SEQUENCING Homo sapiens 34,74828-Sep-99 IN PROGRESS ***, in ordered pieces. GB_HTG1: HSJCF13 293368AJ239320 Homo sapiens chromosome X clone cosmid 244B12 map Xq13, ***SEQUENCING Homo sapiens 34,748 28-Sep-99 IN PROGRESS ***, in orderedpieces. GB_HTG1: AP000568 136627 AP000568 Homo sapiens chromosome 21clone B753B2 map 21q21.2, *** SEQUENCING Homo sapiens 34,884 07-OCT-1999IN PROGRESS ***, in unordered pieces. rxa01831 585 GB_IN2: AF047757 408AF047757 Trichogramma australicum internal transcribed spacer 2,complete sequence. Trichogramma australicum 38,39 10-Jul-98 GB_EST18:AA687516 513 AA687516 ns58h11.r1 NCI_CGAP_Pr22 Homo sapiens cDNA cloneIMAGE: 1187877 5′ Homo sapiens 35,057 11-DEC-1997 similar to gb: X15341CYTOCHROME C OXIDASE POLYPEPTIDE VIA-LIVER (HUMAN);, mRNA sequence.GB_EST18: AA687516 513 AA687516 ns58h11.r1 NCI_CGAP_Pr22 Homo sapienscDNA clone IMAGE: 1187877 5′ Homo sapiens 37,624 11-DEC-1997 similar togb: X15341 CYTOCHROME C OXIDASE POLYPEPTIDE VIA-LIVER (HUMAN);, mRNAsequence. rxa01834 825 GB_PL2: T8F5 87192 AC004512 Arabidopsis thalianachromosome 1 BAC T8F5 sequence, complete sequence. Arabidopsis thaliana38,101 22-Jul-98 GB_PR4: AC007677 166949 AC007677 Homo sapiens cloneNH0086N01, complete sequence. Homo sapiens 35,888 28-Sep-99 GB_PR4:AC007677 166949 AC007677 Homo sapiens clone NH0086N01, completesequence. Homo sapiens 36,906 28-Sep-99 rxa01842 1041 GB_HTG3: AC009183145694 AC009183 Drosophila melanogaster chromosome 3 clone BACR39F04(D839) Drosophila melanogaster 40,43 16-Sep-99 RPCI-98 39.F.4 map85F-85F strain y; cn bw sp. *** SEQUENCING IN PROGRESS***, 139 unorderedpieces. GB_HTG3: AC009183 145694 AC009183 Drosophila melanogasterchromosome 3 clone BACR39F04 (D839) Drosophila melanogaster 40,4316-Sep-99 RPCI-98 39.F.4 map 85F-85F strain y; cn bw sp, *** SEQUENCINGIN PROGRESS ***, 139 unordered pieces. GB_HTG5: AC008338 136685 AC008338Drosophila melanogaster chromosome X clone BACR30J04 (D908) Drosophilamelanogaster 40,527 15-Nov-99 RPCI-98 30.J.4 map 19C-19E strain y; cn bwsp, *** SEQUENCING IN PROGRESS ***, 93 unordered pieces. rxa01844 303GB_HTG2: AC007597 163880 AC007597 Homo sapiens chromosome 16 cloneRPCI-11_137H10, *** SEQUENCING Homo sapiens 34,564 20-Jul-99 IN PROGRESS***, 3 ordered pieces. GB_HTG2: AC007597 163880 AC007597 Homo sapienschromosome 16 clone RPCI-11_137H10, *** SEQUENCING IN Homo sapiens34,564 20-Jul-99 PROGRESS ***, 3 ordered pieces. GB_HTG3: AC009998163590 AC009998 Homo sapiens chromosome 15 clone BAC 573G7 map 15q24,Homo sapiens 40,816 10-Sep-99 LOW-PASS SEQUENCE SAMPLING. rxa01845 531GB_OV: AF012348 4921 AF012348 Gallus gallus smooth muscle gamma actin(gamma actin) gene, complete cds. Gallus gallus 37,333 17-MAR-1998GB_BA1: D85417 7984 D85417 Propionibacterium freudenreichii hemY, hemH,hemB, hemX, hemR and hemL Propionibacterium 45,243 6-Feb-99 genes,complete cds. freudenielchii GB_BA1: D85417 7984 D85417Propionibacterium freudenreichii hemY, hemH, hemB, hemX, hemR and hemLPropionibacterium 40,232 6-Feb-99 genes, complete cds. freudenreichiirxa01846 382 GB_HTG1: HSJ323A24 278948 AL121750 Homo sapiens chromosome4 clone RP3-323A24, *** SEQUENCING Homo sapiens 34,84 23-Nov-99 INPROGRESS ***, in unordered pieces. GB_HTG1: HSJ323A24 278948 AL121750Homo sapiens chromosome 4 clone RP3-323A24, *** SEQUENCING Homo sapiens34,84 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_PR2: HS181C992472 Z98743 Human DNA sequence from clone 181C9 on chromosome Homosapiens 42,48 23-Nov-99 22q13.2-13.33. Contains a PHAPI2 Leucine RichAcidic Nuclear Protein pseudogene, part of a putative novel gene, ESTs,STSs and GSSs, complete sequence. rxa01847 858 GB_PR3: AC004893 103738AC004893 Homo sapiens PAC clone DJ0808A01 from 7q21.1-q31.1, completesequence. Homo sapiens 38,321 03-OCT-1998 GB_HTG4: AC010182_3 110000AC010182 Homo sapiens chromosome 12q seeders clone RPCI11-185N2, ***SEQUENCING Homo sapiens 36,998 15-Sep-99 IN PROGRESS ***, 172 unorderedpieces. GB_HTG4: AC010182_3 110000 AC010182 Homo sapiens chromosome 12qseeders clone RPCI11-185N2, *** SEQUENCING Homo sapiens 36,998 15-Sep-99IN PROGRESS ***, 172 unordered pieces. rxa01856 669 GB_GSS15: AQ612487433 AQ612487 HS_5122_A1_B07_SP6E RPCI-11 Human Male BAC Library Homosapiens Homo sapiens 39,723 15-Jun-99 genomic clone Plate = 698 Col = 13Row = C, genomic survey sequence. GB_PR4: AC005876 89817 AC005876citb_188_i_5, complete sequence. Homo sapiens 39,567 5-Nov-99 GB_PR4:AC005876 89817 AC005876 citb_188_i_5, complete sequence. Homo sapiens36,677 5-Nov-99 rxa01857 774 GB_PR3: HS742C19 122748 AL031846 Human DNAsequence from clone RP4-742C19 on Homo sapiens 33,506 29-Nov-99chromosome 22, complete sequence. GB_PR2: HSJ1100I6 161525 AL110503Human DNA sequence from clone RP5-1100I6 on chromosome 20 Homo sapiens37,45 22-Nov-99 Contains a novel mRNA, GSSs and a CpG Island, completesequence. GB_HTG6: AC009893 186769 AC009893 Homo sapiens chromosomes 8clone RP11-4P3, *** SEQUENCING Homo sapiens 37,368 23-Nov-99 IN PROGRESS***, 5 unordered pieces. rxa01858 rxa01870 798 GB_RO: AC004155 128026AC004155 Mus musculus DNA from BAC 10818 containing the Ercc-4 gene,complete sequence. Mus musculus 37,387 19-Feb-98 GB_RO: AC004155 128026AC004155 Mus musculus DNA from BAC 10818 containing the Ercc-4 gene,complete sequence. Mus musculus 37,707 19-Feb-98 GB_BA2: AF144563 5971AF144563 Thermobilida fusca beta-1,4-exocellulase E6 precursor (celF)gene, Thermobifida fusca 38,619 21-Jun-99 complete cds; and unknowngenes. rxa01871 1086 GB_BA2: AF079304 3350 AF079304 Eikenella corrodenstype IV pilin (pilA1), type IV pilin (pilA2), putative Eikeneliacorrodens 40,465 15-Jul-99 fimbrial prbtein (pilB), and putativehemagglutinin protein (hagA) genes, complete cds. GB_BA1: ECECPHAG 3589Z12609 E. corrodens ecpA and ecpB genes encoding type 4N-methylphenylalanine pilin and Eikenelia corrodens 40,517 5-Aug-92 hag1gene for hemagglutinin protein. GB_BA2: AE001707 19518 AE001707Thermotoga maritima section 19 of 136 of the complete genome. Thermotogamaritima 38,124 2-Jun-99 rxa01874 448 GB_EST6: N51407 505 N51407yz17a08.s1 Soares_multiple_sclerosis_2NbHMSP Homo sapiens Homo sapiens35,735 14-Feb-96 cDNA clone IMAGE: 283286 3′, mRNA sequence. GB_EST29:AI619782 374 AI619782 ty53b03.x1 NCI_CGAP_Ut2 Homo sapiens cDNA cloneHomo sapiens 38,966 21-Apr-99 IMAGE: 2282765 3′, mRNA sequence.GB_EST36: AI885047 466 AI865047 wl89a01.x1 NCI_CGAP_Brn25 Homo sapienscDNA clone Homo sapiens 37,419 1-Sep-99 IMAGE: 2432040 3′, mRNAsequence. rxa01875 969 GB_EST13: AA356276 291 AA356276 EST64843 JurkatT-cells VI Homo sapiens cDNA 5′ end, mRNA sequence. Homo sapiens 41,66721-Apr-97 GB_EST22: AI050653 443 AI050653 ub38f03.r1 Soares 2NbMT Musmusculus cDNA clone Mus musculus 38,851 9-Jul-98 IMAGE: 1380029 5′, mRNAsequence. GB_GSS1: CNS0022Z 1101 AL061786 Drosophila melanogaster genomesurvey sequence T7 end of BAC # Drosophila melanogaster 39,039 3-Jun-99BACR05B21 of RPCI-98 library from Drosophila melanogaster (fruit fly),genomic survey sequence. rxa01877 1194 GB_HTG4: AC009849 114993 AC009849Drosophila melanogaster chromosome 2 clone BACR07H08 (D864) Drosophilamelanogaster 37,274 25-OCT-1999 RPCI-98 07.H.8 map 31B-31C strain y; cnbw sp, *** SEQUENCING IN PROGRESS***, 55 unordered pieces. GB_HTG4:AC009849 114993 AC009849 Drosophila melanogaster chromosome 2 cloneBACR07H08 (D864) Drosophila melanogaster 37,274 25-OCT-1999 RPCI-9807.H.8 map 31B-31C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***,55 unordered pieces. GB_IN2: AC005454 84367 AC005454 Drosophilamelanogaster, chromosome 2R, region 31C1-31D6, Drosophila melanogaster38,679 15-DEC-1998 P1 clone DS08879, complete sequence. rxa01879 1056GB_PR2: CNS0000Q 192932 AL049874 Human chromosome 14 DNA sequence *** INPROGRESS *** BAC Homo sapiens 37,094 7-Jul-99 R-1042B17 of RPCI-11library from chromosome 14 of Homo sapiens (Human), complete sequence.GB_HTG2: AC006732 159453 AC006732 Caenorhabditis elegans clone Y32G9,*** SEQUENCING Caenorhabditis elegans 34,862 23-Feb-99 IN PROGRESS ***,9 unordered pieces. GB_HTG2: AC006732 159453 AC006732 Caenorhabditiselegans clone Y32G9, *** SEQUENCING Caenorhabditis elegans 34,86223-Feb-99 IN PROGRESS ***, 9 unordered pieces. rxa01896 759 GB_BA1:SC2G5 38404 AL035478 Streptomyces coelicolor cosmid 2G5. Streptomycescoelicolor 38,42 11-Jun-99 GB_PL1: AP000570 157903 AP000570 Oryza sativagenomic DNA, Oryza sativa 40,272 03-DEC-1999 chromosome 1, clone:P0711E10. GB_BA1: SC2G5 38404 AL035478 Streptomyces coelicolor cosmid2G5. Streptomyces coelicolor 40,27 11-Jun-99 rxa01899 909 GB_BA1: MTV00256414 AL008967 Mycobacterium tuberculosis H37Rv complete genome; segment122/162. Mycobacterium 38,702 17-Jun-98 tuberculosis GB_BA1: MTV00256414 AL008967 Mycobacterium tuberculosis H37Rv complete genome; segment122/162. Mycobacterium 38,229 17-Jun-98 tuberculosis rxa01902 1182GB_HTG6: AC009893 186769 AC009893 Homo sapiens chromosome 8 cloneRP11-4P3, *** SEQUENCING Homo sapiens 34,868 23-Nov-99 IN PROGRESS ***,5 unordered pieces. GB_OV: D84063 2363 D84063 Oryzias latipes Bf/C2mRNA, complete cds. Oryzias latipes 38,074 6-Feb-99 GB_HTG6: AC009893186769 AC009893 Homo sapiens chromosome 8 clone RP11-4P3, *** SEQUENCINGHomo sapiens 35,616 23-Nov-99 IN PROGRESS ***, 5 unordered pieces.rxa01903 302 GB_BA1: MSGILVB 4210 L49392 Mycobacterium aviumacetolactate synthase (ilvBN) and acetohydroxy acid Mycobacterium avium38,667 11-DEC-1996 isomeroreductase (ilvC) gene, complete cds. GB_PR3:AC004833 68890 AC004833 Homo sapiens PAC clone DJ0547C10 from 7p21-p22,complete sequence. Homo sapiens 34,815 5-Nov-98 GB_PR3: AC004833 68890AC004833 Homo sapiens PAC clone DJ0547C10 from 7p21-p22, complelesequence. Homo sapiens 42,712 5-Nov-98 rxa01904 546 GB_HTG2: AC006740200965 AC006740 Caenorhabditis elegans clone Y38B5, *** SEQUENCINGCaenorhabditis elegans 34,074 25-Feb-99 IN PROGRESS ***, 12 unorderedpieces. GB_HTG2: AC006695 33622 AC006695 Caenorhabditis elegans cloneW06H8, *** SEQUENCING Caenorhabditis elegans 35,556 23-Feb-99 INPROGRESS ***, 1 unordered pieces. GB_HTG2: AC006695 33622 AC006695Caenorhabditis elegans clone W06H8, *** SEQUENCING Caenorhabditiselegans 35,556 23-Feb-99 IN PROGRESS ***, 1 unordered pieces. rxa01905654 GB_IN1: CEW04G3 32158 Z68014 Caenorhabditis elegans cosmid W04G3,complete sequence. Caenorhabditis elegans 38,73 2-Sep-99 GB_PL2:AF067082 6947 AF067082 Apium graveolens mannitol dehydrogenase (Mtd)gene, complete cds. Apium graveolens 38,242 30-Sep-98 GB_IN1: CEW04G332158 Z68014 Caenorhabditis elegans cosmid W04G3, complete sequence.Caenorhabditis elegans 38,834 2-Sep-99 rxa01906 588 GB_PL1: AB01224278973 AB012242 Arabidopsis thaliana genomic DNA, chromosome 5, TACclone: Arabidopsis thaliana 39,071 20-Nov-99 K24G6, complete sequence.GB_EST6: N49608 454 N49608 yy58g01.s1 Soares_multiple_sclerosis_2NbHMSPHomo sapiens cDNA Homo sapiens 43,603 14-Feb-96 clone IMAGE: 277776 3′,mRNA sequence. GB_EST6: N49609 452 N49609 yy58g02.s1Soares_multiple_sclerosis_2NbHMSP Homo sapiens cDNA Homo sapiens 43,30714-Feb-98 clone IMAGE: 277778 3′, mRNA sequence. rxa01907 735 GB_HTG3:AC009437 159691 AC009437 Homo sapiens chromosome 11 clone 56_G_09 map11, *** SEQUENCING Homo sapiens 36,226 22-Aug-99 IN PROGRESS ***, 10unordered pieces. GB_HTG3: AC009437 159691 AC009437 Homo sapienschromosome 11 clone 56_G_09 map 11, *** SEQUENCING Homo sapiens 36,22622-Aug-99 IN PROGRESS ***, 10 unordered pieces. GB_HTG3: AC009437 159691AC009437 Homo sapiens chromosome 11 clone 56_G_09 map 11, *** SEQUENCINGHomo sapiens 38,483 22-Aug-99 IN PROGRESS ***, 10 unordered pieces.rxa01908 969 GB_PR3: HS90G24 154414 AL008723 Human DNA sequence fromclone 90G24 on chromosome 22. Homo sapiens 37,331 23-Nov-99 Contains theRFPL2 gene for RET finger protein-like 2, an Immunoglobulin Lambda LightChain C region (IGLC) pseudogene, the gene for SAAT1 (low affinitysodium glucose cotransporter (sodium: solute symporter family)) and aCleavage and Polyadenylation Specific Factor CPSF 160 kD subunitpseudogene. Contains ESTs, GSSs and three putative CpG islands, completesequence. GB_EST25: AI316482 972 AI316482 uj60g12.y1 Sugano mouse livermlia Mus musculus cDNA clone IMAGE: Mus musculus 36,8 17-DEC-19981924390 5′ similar to gb: M12529 APOLIPOPROTEIN E PRECURSOR (HUMAN); gb:D00466 Mouse apolipoprotein E gene (MOUSE);, mRNA sequence. GB_EST27:AI398904 556 AI398904 NCW10G7T7 Westergaards Neurospora crassa cDNANeurospora crassa 38,095 8-Feb-99 clone W10G7 3′, mRNA sequence.rxa01909 970 GB_HTG1: HSJ658I14 133423 AL109845 Homo sapiens chromosome1 clone RP4-658I14, *** SEQUENCING Homo sapiens 40,52 23-Nov-99 INPROGRESS ***, in unordered pieces. GB_HTG1: HSJ658I14 133423 AL109845Homo sapiens chromosome 1 clone RP4-658I14, *** SEQUENCING Homo sapiens40,52 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: HSJ658I14133423 AL109845 Homo sapiens chromosome 1 clone RP4-658I14, ***SEQUENCING Homo sapiens 36,364 23-Nov-99 IN PROGRESS ***, in unorderedpieces. rxa01910 969 GB_PR2: CNS00008 218956 AL049831 Human chromosome14 DNA sequence *** IN PROGRESS *** Homo sapiens 35,393 29-Jun-99 BACR-330O19 of RPCI-11 library from chromosome 14 of Homo sapiens (Human),complete sequence. GB_PR2: CNS00008 218956 AL049831 Human chromosome 14DNA sequence *** IN PROGRESS *** Homo sapiens 38,405 29-Jun-99 BACR-330O19 of RPCI-11 library from chromosome 14 of Homo sapiens (Human),complete sequence. GB_HTG5: AC009217 118561 AC009217 Drosophilamelanogaster chromosome X clone BACR41N19 (D907) Drosophila melanogaster36,765 16-Nov-99 RPCI-98 41.N.19 map 19A-19C strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 78 unordered pieces. rxa01911 1062 GB_HTG2:AC002317 94882 AC002317 Homo sapiens chromosome 17 clone HCIT7H10 map17, *** SEQUENCING Homo sapiens 36,654 20-Feb-98 IN PROGRESS ***, 8unordered pieces. GB_HTG2: AC002317 94882 AC002317 Homo sapienschromosome 17 clone HCIT7H10 map 17, *** SEQUENCING Homo sapiens 36,65420-Feb-98 IN PROGRESS ***, 8 unordered pieces. GB_HTG2: AC002317 94882AC002317 Homo sapiens chromosome 17 clone HCIT7H10 map 17, ***SEQUENCING Homo sapiens 37,012 20-Feb-98 IN PROGRESS ***, 8 unorderedpieces. rxa01923 873 GB_HTG2: AC006844 299782 AC006844 Caenorhabditiselegans clone Y108G3Y, *** SEQUENCING Caenorhabditis elegans 37,17624-Feb-99 IN PROGRESS ***, 4 unordered pieces. GB_HTG2: AC006844 299782AC006844 Caenorhabditis elegans clone Y108G3Y, *** SEQUENCINGCaenorhabditis elegans 37,176 24-Feb-99 IN PROGRESS ***, 4 unorderedpieces. GB_BA1: ECOUW76 225419 U00039 E. coli chromosomal region from76.0 to 81.5 minutes. Escherichia coli 38,902 7-Nov-98 rxa01930 1074GB_BA1: CGPAN 2164 X96580 C. glutamicum panB, panC & xylB genes.Corynebacterium 100 11-MAY-1999 glutamicum GB_HTG2: AC007598 248427AC007598 Homo sapiens chromosome 16 clone 165M1, *** SEQUENCING Homosapiens 38,469 20-MAY-1999 IN PROGRESS ***, 105 unordered pieces.GB_HTG2: AC007598 248427 AC007598 Homo sapiens chromosome 16 clone165M1, *** SEQUENCING Homo sapiens 38,469 20-MAY-1999 IN PROGRESS ***,105 unordered pieces. rxa01931 777 GB_IN1: CEH12I19 37427 Z98851Caenorhabditis elegans cosmid H12I19, complete sequence. Caenorhabditiselegans 32,763 18-DEC-1998 GB_HTG1: CEY37A1 316170 Z93243 Caenorhabditiselegans chromosome IV clone Y37A1, *** SEQUENCING Caenorhabditis elegans32,763 03-DEC-1998 IN PROGRESS ***, in unordered pieces. GB_HTG1:CEY37A1 316170 Z93243 Caenorhabditis elegans chromosome IV clone Y37A1,*** SEQUENCING Caenorhabditis elegans 32,763 03-DEC-1998 IN PROGRESS***, in unordered pieces. rxa01941 558 GB_EST25: AI313927 520 AI313927uj38h06.x1 Sugano mouse kidney mkia Mus musculus cDNA clone Mus musculus41,148 17-DEC-1998 IMAGE: 1922267 3′ similar to TR: O09047 O09047COMPLEMENT COMPONENT 3A RECEPTOR 1;, mRNA sequence. GB_RO: AF053757 8308AF053757 Mus musculus complement C3a anaphylatoxin receptor (C3ar) gene,complete cds. Mus musculus 38,649 30-Jul-98 GB_RO: MMU77461 2657 U77461Mus musculus anaphylatoxin C3a receptor gene, complete cds. Mus musculus38,649 28-MAY-1997 rxa01942 723 GB_BA1: BRLPTSG 3163 L18875Brevibacterium lactofermentum phosphoenolpyruvate sugar Brevibacterium67,407 01-OCT-1993 phosphotransferase (ptsG) gene, complete cds.lactofermentum GB_BA1: CORPTSMA 2656 L18874 Corynebacterium glutamicumphosphoenolpyruvate sugar Corynebacterium 100 24-Nov-94phosphotransferase (ptsM) mRNA, complete cds. glutamicum GB_BA1:CORPTSMA 2656 L18874 Corynebacterium glutamicum phosphoenolpyruvatesugar Corynebacterium 37,008 24-Nov-94 phosphotransferase (ptsM) mRNA,complete cds. glutamicum rxa01944 1095 GB_HTG2: AC004840 162485 AC004840Homo sapiens clone DJ0607J02, *** SEQUENCING Homo sapiens 36,28712-Jun-98 IN PROGRESS ***, 12 unordered pieces. GB_HTG2: AC004840 162485AC004840 Homo sapiens clone DJ0607J02, *** SEQUENCING Homo sapiens36,287 12-Jun-98 IN PROGRESS ***, 12 unordered pieces. GB_VI:MCU60315190289 U60315 Molluscum contagiosum virus subtype 1, complete genome.Molluscum contagiosum 37,65 17-Aug-96 virus subtype 1 rxa01945 2115GB_GSS15: AQ632158 445 AQ632158 RPCI-11-473F7.TJ RPCI-11 Homo sapiensgenomic clone Homo sapiens 38,095 17-Jun-99 RPCI-11-473F7, genomicsurvey sequence. GB_GSS15: AQ632158 445 AQ632158 RPCI-11-473F7.TJRPCI-11 Homo sapiens genomic clone Homo sapiens 40,275 17-Jun-99RPCI-11-473F7, genomic survey sequence. rxa01957 585 GB_EST16: C35275300 C35275 C35275 Yuji Kohara unpublished cDNA: Strain N2 hermaphroditeembryo Caenorhabditis elegans 37,698 18-OCT-1999 Caenorhabditis eleganscDNA clone yk427e6 3′, mRNA sequence. GB_IN2: CELC29H12 42635 U23169Caenorhabditis elegans cosmid C29H12. Caenorhabditis etegans 34,47713-Jul-95 GB_GSS1: CNS00GP0 1101 AL072364 Drosophila melanogaster genomesurvey sequence T7 end of BAC: Drosophila melanogaster 34,321 3-Jun-99BACR33I08 of RPCI-98 library from Drosophila melanogaster (fruit fly),genomic survey sequence. rxa01958 630 GB_PR1: HSIL1RECA 12565 X64532 H.sapiens gene for interleukin-1 receptor antagonist. Homo sapiens 42,07925-Jun-97 GB_PR3: HSU65590 33414 U65590 Homo sapiens IL-1 receptorantagonist IL-1Ra (IL-1RN) gene, Homo sapiens 42,079 21-DEC-1997alternatively spliced forms, complete cds. GB_GSS11: AQ293677 476AQ293677 HS_2254_A2_C03_MF CIT Approved Human Genomic Sperm Library DHomo sapiens 36,772 15-DEC-1998 Homo sapiens genomic clone Plate = 2254Col = 6 Row = E. genomic survey sequence. rxa01959 rxa01960 rxa01961 603GB_BA2: U67460 12589 U67460 Methanococcus jannaschii section 2 of 150 ofthe complete genome. Methanococcus jannaschii 36,013 26-Jan-98 GB_EST25:AI260761 626 AI260761 LP04729.3prime LP Drosophila melanogasterlarval-early pupal pOT2 Drosophila melanogaster 39,13 17-Nov-98Drosophila melanogaster cDNA clone LP04729 3prime, mRNA sequence.GB_EST25: AI294890 554 AI294890 LP08371.3prime LP Drosophilamelanogaster larval-early pupal pOT2 Drosophila melanogaster 38,9401-DEC-1998 Drosophila melanogaster cDNA clone LP08371 3prime. mRNAsequence. rxa01962 693 GB_BA2: U67460 12589 U67460 Methanococcusjannaschii section 2 of 150 of the complete genome. Methanococcusjannaschii 34,795 28-Jan-98 GB_BA2: U67460 12589 U67460 MethanococcusJannaschii section 2 of 150 of the complete genome. MethanococcusJannaschii 37,666 26-Jan-98 rxa01963 784 GB_PR4: AC006397 91460 AC006397Homo sapiens BAC clone GS170I02 from 7p21-p15.1, complete sequence. Homosapiens 35,401 17-Feb-99 GB_PR3: AC005565 39441 AC005565 Homo sapienschromosome 16, cosmid clone 444B9 (LANL), complete sequence. Homosapiens 37,891 30-Aug-98 GB_PR2: D86999 40778 D86999 Homo sapiensimmunoglobulin lambda gene locus DNA, clone: 22A12. Homo sapiens 38,2125-Nov-99 rxa01964 1426 GB_GSS13: AQ465174 437 AQ465174HS_5109_A2_C07_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 40,084 23-Apr-99 genomic clone Plate = 685 Col = 14 Row = E,genomic survey sequence. GB_GSS13: AQ457528 599 AQ457528HS_5087_A1_H06_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 36,728 23-Apr-99 genomic clone Plate = 663 Col = 11 Row = O,genomic survey sequence. GB_GSS13: AQ454028 527 AQ454028HS_5171_B1_D12_T7A RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 37,137 21-Apr-99 genomic clone Plate = 747 Col = 23 Row = H,genomic survey sequence. rxa01965 684 GB_IN2: AC004283 80095 AC004283Drosophila melanogaster DNA sequence (P1 DS05557 (D152)), completesequence. Drosophila melanogaster 36,982 29-Aug-98 GB_EST25: AI541584585 AI541584 SD02734.5prime SD Drosophila melanogaster Schneider L2 cellculture Drosophila melanogastar 38,375 22-MAR-1999 pOT2 Drosophilamelanogaster cDNA clone SD02734 5prime, mRNA sequence. GB_EST22:AI013385 434 AI013385 EST208060 Normalized rat spleen, Bento SoaresRattus sp. cDNA clone Rattus sp. 42,126 31-Jan-99 RSPBK32 3′ end, mRNAsequence. rxa01966 780 GB_GSS1: CNS00AMI 810 AL055260 Drosophilamelanogaster genome survey sequence TET3 end of BAC # Drosophilamelanogaster 37,592 4-Jun-99 BACR21F10 of RPCI-98 library fromDrosophila melanogaster (fruit fly), genomic survey sequence. GB_HTG3:AC009567 164147 AC009587 Homo sapiens chromosome 4 clone 21_G_20 map 4,*** SEQUENCING Homo sapiens 35,844 29-Sep-99 IN PROGRESS ***, 14unordered pieces. GB_HTG3: AC009567 164147 AC009567 Homo sapienschromosome 4 clone 21_G_20 map 4, *** SEQUENCING Homo sapiens 35,84429-Sep-99 IN PROGRESS ***, 14 unordered pieces. rxa01968 1281 GB_PR4:AC005146 157653 AC005146 Homo sapiens 12q24.2 PAC RPCI1.157K6 (RoswellPark Cancer Homo sapiens 40,62 11-Nov-98 Institute Human PAC library)complete sequence. GB_PR4: AC006549 174844 AC006549 Homo sapiens,complete sequence. Homo sapiens 34,202 26-Nov-99 GB_PR2: HSAC002070165197 AC002070 Human BAC clone 7E17 from 12q, complete sequence. Homosapiens 36,482 12-MAY-1997 rxa01969 489 GB_SY: SCU53587 4546 U53587Artificial Corynebacterium glutamicum IS1207-derived transposonsynthetic construct 98,16 06-MAY-1996 transposase genes, complete cds,and 3′5″-aminoglycoside phosphotransferase (aphA-3) gene, complete cds.GB_PAT: I43826 1452 I43826 Sequence 1 from patent U.S. Pat. No. 5633154.Unknown. 98,963 07-OCT-1997 GB_BA1: CGIS1207 1453 X96962 C. glutamicumInsertion sequence IS1207 and transposase gene. Corynebacterium 98,75501-MAY-1997 glutamicum rxa01973 rxa01974 1908 GB_PL1: SC9320A 24000Z68329 S. cerevisiae chromosome IV cosmid 9320A. Saccharomycescerevisiae 36,528 11-Aug-97 GB_PL1: SC9320X 22253 Z70202 S. cerevisiaechromosome IV cosmid 9320X. Saccharomyces cerevisiae 36,528 11-Aug-97GB_PR4: AC006210 186986 AC006210 Homo sapiens Xp22-150 BAC GSHB-309P15(Genome Systems Homo sapiens 38,351 31-DEC-1998 Human BAC Library)complete sequence. rxa01976 1644 GB_BA2: CGU13922 4412 U13922Corynebacterium glutamicum putative type II 5-cytosoine Corynebacterium47,727 3-Feb-98 methyltransferase (cgliM) and putative type IIrestriction endonuclease (cgIIR) and glutamicum putative type I or typeIII restriction endonuclease CglIIR) genes, complete cds. GB_BA2:CGU13922 4412 U13922 Corynebacterium glutamicum putative type II5-cytosoine methyltransferase (cglIM) Corynebacterium 37,515 3-Feb-98and putative type II restriction endonuclease (cgIIR) and putative typeI or type glutamicum III restriction endonuclease (clgIIR) genes,complete cds. rxa01977 699 GB_PR3: HS426F10 91640 AL023586 Human DNAsequence from clone 426F10 on chromosome Homo sapiens 38,295 23-Nov-991p36.21-36.33 Contains EST, CA repeat, STS, complete sequence. GB_GSS6:AQ823696 587 AQ823696 HS_3228_A1_D10_T7C CIT Approved Human GenomicSperm Homo sapiens 37,637 26-Aug-99 Library D Homo sapiens genomic clonePlate = 3228 Col = 19 Row = G, genomic survey sequence. GB_VI: HS3DNA1892 M29629 Varicella-zoster virus (VZV) DNA, 5′end. Human herpesvirus 333,857 2-Aug-93 rxa01982 1281 GB_EST8: AA009257 472 AA009257 mh02g07.r1Soares mouse embryo NbME13.5 14.5 Mus musculus cDNA clone Mus musculus36,017 26-Jul-96 IMAGE: 441372 5′, mRNA sequence. GB_EST8: AA009257 472AA009257 mh02g07.r1 Soares mouse embryo NbME13.5 14.5 Mus musculus cDNAclone Mus musculus 38,71 26-Jul-96 IMAGE: 441372 5′, mRNA sequence.rxa01987 336 GB_PR4: AC009330 174768 AC009330 Homo sapiens cloneRP11-83M17 from 7q31, complete sequence. Homo sapiens 33,036 09-DEC-1999GB_HTG6: AC007300 171472 AC007300 Drosophila melanogaster chromosome 2clone BACRO9I15(D570) Drosophila melanogaster 38,782 07-DEC-1999 RPCI-9809.I.15 map 32A-32A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***,43 unordered pieces. GB_HTG3: AC009542 160367 AC009542 Homo sapienschromosome 7, *** SEQUENCING IN Homo sapiens 35,065 27-Aug-99 PROGRESS***, 17 unordered pieces. rxa01988 549 GB_IN1: AC002446 50978 AC002446Drosophila melanogaster (P1 DS06754 (D83)) DNA sequence, completesequence. Drosophila melanogaster 38,92 19-Aug-97 GB_PR3: HSU19H10 43303AL021182 Human DNA sequence from cosmid U19H10 on chromosome X. Homosapiens 39,006 23-Nov-99 Contains ESTs and CA repeat. GB_PR3: HSU19H1043303 AL021182 Human DNA sequence from cosmid U19H10 on chromosome X.Homo sapiens 38,447 23-Nov-99 Contains ESTs and CA repeat. rxa01990 1022GB_GSS9: AQ100628 382 AQ100628 HS_3054_B2_A05_MF CIT Approved HumanGenomic Sperm Library Homo sapiens 38,32 27-Aug-98 D Homo sapiensgenomic clone Plate = 3054 Col = 10 Row = B, genomic survey sequence.GB_EST14: AA406679 338 AA406679 MBAFCZ2F12T3A Brugla malayi adult femalecDNA(SAW96MLW-BmAF) Brugia malayi 38,039 01-MAY-1997 Brugia malayi cDNAclone AFCZ2F12 5′, mRNA sequence. GB_EST21: AA991134 600 AA991134BSBmMFSZ06C1SK Brugia malayi microfilaria cDNA Brugia alayi 40,095-Jun-88 (SAW94LS-BmMf) Brugia malayi cDNA clone BSBmMFSZ06C1 5′, mRNAsequence. rxa01991 996 GB_HTG3: AC007559 156374 AC007559 Homo sapiensclone NH0364J06, *** SEQUENCING IN Homo sapiens 35,931 13-Aug-99PROGRESS ***, 29 unordered pieces. GB_HTG3: AC007559 156374 AC007559Homo sapiens clone NH0364J06, *** SEQUENCING IN Homo sapiens 35,93113-Aug-99 PROGRESS ***, 29 unordered pieces. GB_HTG3: AC007559 156374AC007559 Homo sapiens clone NH0364J06, *** SEQUENCING Homo sapiens 36,1213-Aug-99 IN PROGRESS ***, 29 unordered pieces. rxa01992 rxa01996 660GB_BA1: XCXPSGEN 5324 X59079 X. campestris xps E, F, G, H, I, and Jgenes for protein secretion Xanthomonas campestris 38,447 12-Sep-93 andpathogenicity functions. GB_GSS15: AQ659461 394 AQ659461 ShearedDNA-5C7.TR Sheared DNA Trypanosoma brucel Trypanosoma brucei 49,1823-Jun-99 genomic clone Sheared DNA-5C7, genomic survey sequence.GB_GSS4: AQ741049 713 AQ741049 HS_2272_A2_B02_MR CIT Approved HumanGenomic Sperm Homo sapiens 39,614 16-Jul-99 Library D Homo sapiensgenomic clone Plate = 2272 Col = 4 Row = C, genomic survey sequence.rxa01999 594 GB_HTG2: AC007321 159558 AC007321 Homo sapiens cloneNH0507C01, *** SEQUENCING IN Homo sapiens 34,524 16-Apr-99 PROGRESS ***,4 unordered pieces. GB_HTG2: AC007321 159558 AC007321 Homo sapiens cloneNH0507C01, *** SEQUENCING IN Homo sapiens 34,524 16-Apr-99 PROGRESS ***,4 unordered pieces. GB_HTG2: AC007321 159558 AC007321 Homo sapiens cloneNH0507C01, *** SEQUENCING IN Homo sapiens 35,094 16-Apr-99 PROGRESS ***,4 unordered pieces. rxa02001 1281 GB_BA1: D90917 154619 D90917Synechocystis sp. PCC6803 complete genome, 27/27, 3418852-3573470.Synechocystis sp. 50,474 7-Feb-99 GB_BA1: MTV016 53662 AL021841Mycobacterium tuberculosis H37Rv complete genome; segment 143/162.Mycobacterium 39,223 23-Jun-99 tuberculosis GB_BA1: BSUB0006 210440Z99109 Bacillus subtilis complete genome (section 6 of 21): from 999501to 1209940. Bacillus subtilis 36,445 26-Nov-97 rxa02004 230 GB_HTG3:AC011491 162134 AC011491 Homo sapiens chromosome 19 cloneCIT978SKB_180A7, *** SEQUENCING Homo sapiens 37,383 07-OCT-1999 INPROGRESS ***, 161 unordered pieces. GB_HTG3: AC011491 162134 AC011491Homo sapiens chromosome 19 clone CIT978SKB_180A7, Homo sapiens 37,38307-OCT-1999 *** SEQUENCING IN PROGRESS ***, 161 unordered pieces.GB_HTG3: AC011357 160676 AC011357 Homo sapiens chromosome 5 cloneCIT-HSPC_362D12, *** SEQUENCING IN Homo sapiens 54,585 06-OCT-1999PROGRESS ***, 42 unordered pieces. rxa02006 595 GB_HTG2: AC006901 294136AC006901 Caenorhabditis elegans clone Y74A11X, *** SEQUENCINGCaenorhabditis elegans 37,5 26-Feb-99 IN PROGRESS ***, 81 unorderedpieces. GB_HTG2: AC006901 294136 AC006901 Caenorhabditis elegans cloneY74A11X, *** SEQUENCING IN Caenorhabditis elegans 37,5 26-Feb-99PROGRESS ***, 81 unordered pieces. GB_HTG1: CEY70C5 224525 Z98878Caenorhabditis elegans chromosome V clone Y70C5, *** SEQUENCINGCaenorhabditis elegans 36,021 28-Aug-97 IN PROGRESS ***, in unorderedpieces. rxa02007 756 GB_BA2: CGL012293 2952 AJ012293 Corynebacteriumglutamicum ilvD gene. Corynebacterium 100 01-OCT-1999 glutamicum GB_PR4:AC006285 150172 AC006285 Homo sapiens, complete sequence. Homo sapiens38,74 15-Nov-99 GB_PR4: AC006285 150172 AC006285 Homo sapiens, completesequence. Homo sapiens 38,701 15-Nov-99 rxa02009 223 GB_PR4: AC004926153556 AC004926 Homo sapiens PAC clone DJ0910H09 from 7q21.1-q21.2,complete sequence. Homo sapiens 38,462 17-Feb-99 GB_PR2: AP000053 100000AP000053 Homo sapiens genomic DNA, chromosome 21q22.1, segment 24/28,complete Homo sapiens 37,674 20-Nov-99 sequence. GB_PR2: AP000121 100000AP000121 Homo sapiens genomic DNA of 21q22.1, GART and AML related, Homosapiens 37,674 25-Sep-99 SLC5A3-f4A4 region, segment 4/8, completesequence. rxa02013 649 GB_BA1: MTCI237 27030 Z94752 Mycobacteriumtuberculosis H37Rv complete genome; segment 46/162. Mycobacterium 39,30817-Jun-98 tuberculosis GB_HTG4: AC010885 201581 AC010885 Homo sapienschromosome unknown Homo sapiens 37,206 29-OCT-1999 clone NH0368K23,WORKING DRAFT SEQUENCE, in unordered pieces. GB_HTG4: AC010885 201581AC010885 Homo sapiens chromosome unknown clone NH0368K23, Homo sapiens37,208 29-OCT-1999 WORKING DRAFT SEQUENCE, In unordered pieces. rxa02014630 GB_HTG3: AC010769 119431 AC010769 Homo sapiens chromosome 15 clone28_B_17 map 15, Homo sapiens 33,816 22-Sep-99 LOW-PASS SEQUENCESAMPLING. GB_HTG3: AC010769 119431 AC010769 Homo sapiens chromosome 15clone 28_B_17 map 15, Homo sapiens 33,816 22-Sep-99 LOW-PASS SEQUENCESAMPLING. GB_EST34: AI783738 320 AI783738 tu45b07.x1 NCI_CGAP_Pr28 Homosapiens cDNA clone Homo sapiens 37,855 1-Jul-99 IMAGE: 2253973 3′, mRNAsequence. rxa02019 524 GB_EST15: AA473289 318 AA473289 vd44g09.r1Barstead MPLRB1 Mus musculus cDNA Mus musculus 38,153 18-Jun-97 cloneIMAGE: 803488 5′, mRNA sequence. GB_HTG1: CEY102A5_3 110000 Z99711Caenorhabditis elegans chromosome V clone Y102A5, Caenorhabditis elegans38,867 9-Jun-98 *** SEQUENCING IN PROGRESS ***, in unordered pieces.GB_HTG1: CEY102A5_3 110000 Z99711 Caenorhabditis elegans chromosome Vclone Y102A5, *** SEQUENCING Caenorhabditis elegans 38,867 9-Jun-98 INPROGRESS ***, in unordered pieces. rxa02021 1071 GB_BA1: CGDNAAROP 2612X85965 C. glutamicum ORF3 and aroP gene. Corynebacterium 99,90530-Nov-97 glutamicum GB_BA1: CGDAPE 1966 X81379 C. glutamicum dapE geneand orf2. Corynebacterium 36,406 8-Aug-95 glutamicum GB_BA1: SCI7 34893AL096743 Streptomyces coelicolor cosmid 17. Streptomyces coelicolor36,782 1-Jul-99 rxa02023 891 GB_BA1: CGDAPE 1966 X81379 C. glutamicumdapE gene and orf2. Corynebacterium 99,864 8-Aug-95 glutamicum GB_PR3:AC004067 161326 AC004067 Homo sapiens chromosome 4 clone B366O24 map4q25, complete sequence. Homo sapiens 39,651 8-Nov-98 GB_HTG3: AC009725145005 AC009725 Mus musculus chromosome 6 clone 388_N_17 map 6, Musmusculus 38,215 01-OCT-1999 *** SEQUENCING IN PROGRESS ***, 2 orderedpieces. rxa02032 693 GB_PR4: AC006961 171419 AC006961 Homo sapienschromosome 18, clone RP11-31P16, complete sequence. Homo sapiens 37,70319-Nov-99 GB_PR4: AC006961 171419 AC006961 Homo sapiens chromosome 18,clone RP11-31P16, complete sequence. Homo sapiens 40,839 19-Nov-99rxa02036 504 GB_PR2: HSDJ799G3 127639 AL078624 Human DNA sequence fromclone RP4-799G3 on Homo sapiens 35,657 22-Nov-99 chromosome1q42.11-42.3, complete sequence. GB_BA1: AOPCZA361 37941 AJ223998Amycolatopsis orientalis cosmid PCZA361. Amycolatopsis orientalis 46,34129-MAR-1999 GB_PL1: ATDNADAL1 8747 Y14851 Arabidopsis thaliana dal1gene. Arabidopsis thaliana 35,223 23-Sep-97 rxa02039 863 GB_PR3:AC005609 157970 AC005609 Homo sapiens chromosome 5, BAC clone 203o13(LBNL H155), complete sequence. Homo sapiens 37,176 4-Sep-98 GB_HTG3:AC008468 245016 AC008468 Homo sapiens chromosome 5 clone CIT-HSPC_365B8,Homo sapiens 36,842 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 14unordered pieces. GB_HTG3: AC008468 245016 AC008468 Homo sapienschromosome 5 clone CIT-HSPC_365B8, Homo sapiens 36,842 3-Aug-99 ***SEQUENCING IN PROGRESS ***, 14 unordered pieces. rxa02040 551 GB_HTG3:AC009303 198549 AC009303 Homo sapiens clone NH0098C01, *** SEQUENCING INHomo sapiens 35,424 13-Aug-99 PROGRESS ***, 2 unordered pieces. GB_HTG3:AC009303 198549 AC009303 Homo sapiens clone NH0098C01, *** SEQUENCING INHomo sapiens 35,424 13-Aug-99 PROGRESS ***, 2 unordered pieces. GB_HTG3:AC009303 198549 AC009303 Homo sapiens clone NH0098C01, *** SEQUENCING INHomo sapiens 32,597 13-Aug-99 PROGRESS ***, 2 unordered pieces. rxa02045384 GB_EST3: R23812 459 R23812 yh34g05.r1 Soares placenta Nb2HP Homosapiens cDNA clone Homo sapiens 47,273 20-Apr-95 IMAGE: 131672 5′, mRNAsequence. GB_EST19: AA778733 611 AA778733 af88d02.s1 Soares_testis_NHTHomo sapiens Homo sapiens 38,806 5-Feb-98 cDNA clone 1049091 3′, mRNAsequence. GB_PR2: HSU59185 2529 U59185 Human putative monocarboxylatetransporter (MCT) mRNA, complete cds. Homo sapiens 43,164 03-OCT-1997rxa02046 540 GB_HTG3: AC005507 196595 AC005507 Plasmodium falciparumchromosome 12 clone 3D7, Plasmodium falciparum 37,218 23-Sep-99 ***SEQUENCING IN PROGRESS ***, 3 unordered pieces. GB_HTG3: AC005507 196595AC005507 Plasmodium falciparum chromosome 12 clone 3D7, Plasmodiumfalciparum 37,218 23-Sep-99 *** SEQUENCING IN PROGRESS ***, 3 unorderedpieces. GB_EST1: T09984 330 T09984 0540m7 gmbPfHB3.1, G. Roman ReddyPlasmodium falciparum Plasmodium falciparum 32,121 29-Nov-93 genomicclone 0540m, mRNA sequence. rxa02049 732 GB_PL1: ATHCOLR 1098 M37778 A.thaliana middle repetative sequence. Arabidopsis thaliana 33,75527-Apr-93 GB_PL2: ATAC006954 87035 AC006954 Arabidopsis thalianachromosome II BAC F25P17 Arabidopsis thaliana 33,755 7-Apr-99 genomicsequence, complete sequence. GB_EST33: AI779067 495 AI779067 EST259946tomato susceptible, Cornell Lycopersicon Lycopersicon esculentum 35,22329-Jun-99 esculentum cDNA clone cLES7C7, mRNA sequence. rxa02050 918GB_HTG2: AC008307 91654 AC008307 Drosophila melanogaster chromosome 3clone Drosophila melanogaster 36,182 2-Aug-99 BACR03D22 (D709) RPCI-9803.D.22 map 86F-87A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***,94 unordered pieces. GB_HTG2: AC008307 91654 AC008307 Drosophilamelanogaster chromosome 3 clone BACR03D22 (D709) RPCI-98 03.D.22Drosophila melanogaster 36,182 2-Aug-99 map 86F-87A strain y; cn bw sp,*** SEQUENCING IN PROGRESS ***, 94 unordered pieces. GB_EST31: AU060923663 AU060923 AU060923 Dictyostelium discoideum SL (H. Urushihara)Dictyostelium discoideum 39,388 20-MAY-1999 Dictyostelium discoideumcDNA clone SLC248, mRNA sequence. rxa02051 621 GB_EST16: C43898 369C43896 C43896 Yuji Kohara unpublished cDNA: Caenorhabditis elegans 41,1618-OCT-1999 Strain N2 hermaphrodite embryo Caenorhabditis elegans cDNAclone yk336c10 5′, mRNA sequence. GB_EST16: C40413 360 C40413 C40413Yuji Kohara unpublished cDNA: Caenorhabditis elegans 42,09 18-OCT-1999Strain N2 hermaphrodite embryo Caenorhabditis elegans cDNA clone yk230e75′, mRNA sequence. GB_EST36: AV191515 360 AV191515 AV191515 Yuji Koharaunpublished cDNA: Strain N2 Caenorhabditis elegans 40,833 22-Jul-99hermaphrodite embryo Caenorhabditis elegans cDNA clone yk594g6 5′, mRNAsequence. rxa02053 702 GB_IN1: AF035264 6397 AF035264 Drosophilamelanogaster POU domain Drosophila melanogaster 36,888 04-DEC-1997protein (pdm-1) gene, promoter region and exon 1. GB_BA1: MTV036 24055AL021931 Mycobacterium tuberculosis H37Rv complete genome; segment19/162. Mycobacterium 37,647 17-Jun-98 tuberculosis GB_EST30: AI658116497 AI658116 fc22e07.y1 Zebrafish WashU MPIMG EST Danio rerio Daniorerio 41,129 06-MAY-1999 cDNA 5′ similar to TR: Q15883 Q15883 X104.;,mRNA sequence. rxa02057 654 GB_PAT: E14601 4394 E14601 Brevibacteriumlactofermentum gene for alpha-ketoglutaric acid dehydrogenase.Corynebacterium 96,667 28-Jul-99 glutamicum GB_BA1: D84102 4394 D84102Corynebacterium glutamicum DNA for 2-oxoglutarate dehydrogenase,complete cds. Corynebacterium 96,667 6-Feb-99 glutamicum GB_PAT: E146014394 E14601 Brevibacterium lactofermentum gene for alpha-ketoglutaricacid dehydrogenase. Corynebacterium 38,199 28-Jul-99 glutamicum rxa02058675 GB_GSS9: AQ129748 432 AQ129748 HS_2254_B1_H03_MF CIT Approved HumanHomo sapiens 40 23-Sep-98 Genomic Sperm Library D Homo sapiens genomicclone Plate = 2254 Col = 5 Row = P, genomic survey sequence. GB_PL2:T15B16 90596 AF104919 Arabidopsis thaliana BAC T15B16. Arabidopsisthaliana 35,338 11-Nov-98 GB_PL2: AC007138 120185 AC007138 Arabidopsisthaliana BAC T7B11 from chromosome IV near 10 cM, complete Arabidopsisthaliana 39,426 1-Apr-99 sequence. rxa02059 618 GB_HTG3: AC008672 131573AC008672 Homo sapiens chromosome 5 clone CIT978SKB_3B12, Homo sapiens40,871 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 71 unordered pieces.GB_HTG3: AC008672 131573 AC008672 Homo sapiens chromosome 5 cloneCIT978SKB_3B12, Homo sapiens 40,871 3-Aug-99 *** SEQUENCING IN PROGRESS***, 71 unordered pieces. GB_IN1: DDU06228 2695 U06228 Dictyosteliumdiscoideum CRAC (dagA) gene, complete cds. Dictyostelium discoideum36,513 1-Feb-95 rxa02066 615 GB_PR2: CNS01DRA 198444 AL110505 Humanchromosome 14 DNA sequence *** IN PROGRESS Homo sapiens 36,903 11-Nov-99*** BAC R-816J8 of RPCI-11 library from chromosome 14 of Homo sapiens(Human), complete sequence. GB_PR2: HS230G1 125515 Z84468 Homo sapiensDNA sequence from PAC 230G1 on chromosome Homo sapiens 41,751 23-Nov-99Xp11.3. Contains EST, STS and GSS, complete sequence. GB_PR2: CNS01DRA198444 AL110505 Human chromosome 14 DNA sequence *** IN PROGRESS *** BACR-816J8 of Homo sapiens 36,589 11-Nov-99 RPCI-11 library from chromosome14 of Homo sapiens (Human), complete sequence. rxa02067 579 GB_HTG3:AC009543 159209 AC009543 Homo sapiens chromosome 11 clone 63_H_13 map11, *** Homo sapiens 35,366 07-OCT-1999 SEQUENCING IN PROGRESS ***, 12unordered pieces. GB_HTG3: AC009543 159209 AC009543 Homo sapienschromosome 11 clone 63_H_13 map 11, *** Homo sapiens 35,366 07-OCT-1999SEQUENCING IN PROGRESS ***, 12 unordered pieces. GB_PR2: HS230G1 125515Z84486 Homo sapiens DNA sequence from PAC 230G1 on chromosome Homosapiens 36,348 23-Nov-99 Xp11.3. Contains EST, STS and GSS, completesequence. rxa02069 702 GB_BA1: MTCI61 13540 Z98260 Mycobacteriumtuberculosis H37Rv complete genome; segment 53/162. Mycobacterium 36,64217-Jun-98 tuberculosis GB_BA1: MTCI61 13540 Z98260 Mycobacteriumtuberculosis H37Rv complete genome: segment 53/162. Mycobacterium 39,47417-Jun-98 tuberculosis rxa02070 1245 GB_BA2: AE001112 14704 AE001112Archaeoglobus fulgidus section 167 of 172 of the complete genome.Archaeoglobus fulgidus 39,352 15-DEC-1997 GB_PR3: HSDJ47M23 129320AL096816 Human DNA sequence *** SEQUENCING IN PROGRESS Homo sapiens40,413 23-Nov-99 *** from clone dJ47M23, complete sequence. GB_HTG3:AC009139 152666 AC009139 Homo sapiens chromosome 16 cloneRPCI-11_538|12, Homo sapiens 35,275 3-Aug-99 *** SEQUENCING IN PROGRESS***, 27 unordered pieces. rxa02076 657 GB_EST34: AI789138 594 AI789138uk51e02.y1 Sugano mouse kidney mkia Mus musculus cDNA Mus musculus43,041 2-Jul-99 clone IMAGE: 1972538 5′ similar to WP: R10H10.7 CE06298TYROSINE-PROTEIN KINASE LIKE;, mRNA sequence. GB_GSS1: FR0013995 552AL005239 F. rubripes GSS sequence, clone 137O18aC6, genomic surveysequence. Fugu rubripes 37,079 18-Sep-97 GB_GSS3: B27548 642 B27548F19J9TFB IGF Arabidopsis thaliana genomic clone F19J9, genomic surveysequence. Arabidopsis thaliana 37,056 13-OCT-1997 rxa02080 930 GB_GSS15:AQ652136 411 AQ652136 Sheared DNA-7M23.TR Sheared DNA Trypanosoma bruceiTrypanosoma brucel 39,259 22-Jun-99 genomic clone Sheared DNA-7M23,genomic survey sequence. GB_GSS15: AQ652498 450 AQ652498 ShearedDNA-22K16.TR Sheared DNA Trypanosoma brucel Trypanosoma brucei 39,59722-Jun-99 genomic clone Sheared DNA-22K16, genomic survey sequence.GB_HTG3: AC009683 171597 AC009683 Homo sapiens chromosome 8 clone 76_N_5map 8, Homo sapiens 37,053 29-Sep-99 *** SEQUENCING IN PROGRESS ***, 10unordered pieces. rxa02081 1752 GB_OV: BSU43200 2070 U43200 Boreogadussaida antifreeze glycopeptide Boreogadus saida 37,016 12-MAY-1997 AFGPpolyprotein precursor gene, complete cds. GB_BA2: AE001615 12401AE001615 Chlamydia pneumoniae section 31 of 103 of the complete genome.Chlamydophila pneumoniae 36,385 08-MAR-1999 GB_OV: BSU43200 2070 U43200Boreogadus saida antifreeze glycopeptide Boreogadus saida 37,67212-MAY-1997 AFGP polyprotein precursor gene, complete cds. rxa02084 468GB_PR4: AC007382 80547 AC007382 Homo sapiens Homo sapiens 41,1388-Sep-99 clone NH0288C18, complete sequence. GB_GSS4: AQ731530 508AQ731530 HS_5543_A2_A05_T7A RPCI-11 Human Male Homo sapiens 36,24515-Jul-99 BAC Library Homo sapiens genomic clone Plate = 1119 Col = 10Row = A, genomic survey sequence. GB_PR4: AC007382 80547 AC007382 Homosapiens clone NH0288C18, complete sequence. Homo sapiens 35,398 8-Sep-99rxa02089 594 GB_PR2: AP000031 149298 AP000031 Homo sapiens genomic DNA,chromosome 21q22.1, segment 2/28, complete Homo sapiens 38,699 20-Nov-99sequence. GB_PR2: AP000135 111894 AP000135 Homo sapiens genomic DNA of21q22.1, GART and AML, Homo sapiens 38,699 25-Sep-99 f43D11-119B8region, segment 10/10, complete sequence. GB_PR2: AP000213 100000AP000213 Homo sapiens genomic DNA, chromosome 21q22.1, Homo sapiens38,699 20-Nov-99 D21S226-AML region, clone f43D11-119B8, segment 11/12,complete sequence. rxa02090 924 GB_PL2: ATAC006841 123183 AC006841Arabidopsis thaliana chromosome II BAC F3K23 Arabidopsis thaliana 39,8266-Apr-99 genomic sequence, complete sequence. GB_PL1: SCXV55KB 54719Z70678 S. cerevisiae chromosome XV DNA, 54.7 kb region. Saccharomycescerevisiae 37,817 16-MAY-1997 GB_PR1: D87675 301692 D87675 Homo sapiensDNA for amyloid precursor protein, complete cds. Homo sapiens 39,1422-Sep-97 rxa02091 774 GB_BA2: AF031929 2675 AF031929 Lactobacillushelveticus cochaperonin GroES and chaperonin GroEL Lactobacillushelveticus 35,509 8-Aug-98 genes, complete cds; and DNA mismatch repairenzyme (hexA) gene, partial cds. GB_BA1: CGU43536 3464 U43536Corynebacterium glutamicum heat shock, ATP-binding Corynebacterium39,124 13-MAR-1997 protein (clpB) gene, complete cds. glutamicum GB_BA1:RCFBC 3874 X03476 Rhodopseudomonas sphaeroides fbc operon (fbcF, fbcB,fbcC genes). Rhodobacter sphaeroides 36,478 10-Feb-99 rxa02094 840GB_RO: MMHC188A7 120990 AF109719 Mus musculus casein kinase 2 betasubunit (gMCK2) gene, Mus musculus 38,118 25-OCT-1999 partial cds; BAT4,NG20 (NG20), BAT3, BAT2, AIF-1, B144, lymphotoxin beta, TNF, and TNFbeta genes, complete cds; IKBL gene, partial cds; and unknown gene.GB_EST10: AA168948 549 AA168948 ms39c08.r1 Life Tech mouse embryo 135dpc 10666014 Mus musculus 40,789 19-DEC-1996 Mus musculus cDNA cloneIMAGE: 613934 5′ similar to gb: U15980 Mus musculus (MOUSE);, mRNAsequence. GB_EST24: AI101223 348 AI101223 EST210512 Normalized ratbrain, Bento Soares Rattus sp. Rattus sp. 40,634 31-Jan-99 cDNA cloneRBRBK04 3′ end, mRNA sequence. rxa02097 3495 GB_BA2: RMU31512 1974U31512 Rhizobium meliloti RmDEGP (degP) gene, complete cds.Sinorhizobium meliloti 39,159 05-MAR-1996 GB_EST15: AA502050 346AA502050 ng57c04.s1 NCI_CGAP_Lip2 Homo sapiens cDNA Homo sapiens 40,75118-Aug-97 clone IMAGE: 938886 similar to contains Alu repetitiveelement;, mRNA sequence. GB_EST16: AA589883 400 AA589883 vl80h08.r1Stratagene mouse diaphragm (#937303) Mus musculus 35,427 16-Sep-97 Musmusculus cDNA clone IMAGE: 987039 5′ similar to gb: M75716 Mus musculusalpha-1 protease inhibitor 2 (MOUSE);, mRNA sequence. rxa02102 1281GB_IN2: AF135118 10830 AF135118 Drosophila melanogaster laminin alpha1,2(wing blister) mRNA, complete cds. Drosophila melanogaster 36,92623-MAY-1999 GB_IN1: AC002516 48158 AC002516 Drosophila melanogaster (P1DS01068 (D37)) DNA sequence, complete sequence. Drosophila melanogaster37,838 28-Aug-97 GB_GSS3: B09866 1194 B09866 T16G20-Sp6 TAMU Arabidopsisthaliana genomic clone Arabidopsis thaliana 35,332 14-MAY-1997 T16G20,genomic survey sequence. rxa02103 519 GB_GSS3: B09866 1194 B09866T16G20-Sp6 TAMU Arabidopsis thaliana genomic Arabidopsis thaliana 36,3114-MAY-1997 clone T16G20, genomic survey sequence. GB_EST34: AV165661290 AV165661 AV165661 Mus musculus head C57BL/6J 13-day embryo Musmusculus Mus musculus 37,716 6-Jul-99 cDNA clone 3110038F04, mRNAsequence. GB_RO: AC002121 84056 AC002121 Genomic sequence from Mouse 11,complete sequence. Mus musculus 39,096 10-Jul-97 rxa02104 1245 GB_BA2:ECOUW67_0 110000 U18997 Escherichia coli K-12 chromosomal region from67.4 to 76.0 minutes. Escherichia coli 39,024 22-Dec-94 GB_BA2: AE00039412221 AE000394 Escherichia coli K-12 MG1655 section 284 of 400 of thecomplete genome. Escherichia coli 39,024 12-Nov-98 GB_BA1: ECORNPBW 4434D90212 E. coli rnpB gene and ORFs. Escherichia coli 45,255 7-Feb-99rxa02107 rxa02108 732 GB_BA1: D90912 128598 D90912 Synechocystis sp.PCC6803 complete genome, 14/27, 1719644-1848241. Synechocystis sp.38,095 7-Feb-99 GB_GSS13: AQ498890 431 AQ498890 HS_5154_A1_E06_SP6ERPCI-11 Human Male Homo sapiens 37,15 28-Apr-99 BAC Library Homo sapiensgenomic clone Plate = 730 Col = 11 Row = I, genomic survey sequence.GB_BA1: D90912 128598 D90912 Synechocystis sp. PCC6803 complete genome,14/27, 1719644-1848241. Synechocystis sp. 38,781 7-Feb-99 rxa02109 1044GB_IN2: AC001658 91019 AC001658 Drosophila melanogaster DNA sequence (P1DS00913 (D24)), complete sequence. Drosophila melanogaster 35,68717-Jul-98 GB_EST19: AA802304 581 AA802304 GM04170.5prime GM Drosophilamelanogaster Drosophila melanogaster 40,451 25-Nov-98 ovary BlueScriptDrosophila melanogaster cDNA clone GM04170 5prime, mRNA sequence.GB_EST35: AI822653 733 AI822653 L0-1173T3 Ice plant Lambda Uni-Zap XRexpression library, 0 hours NaCl treatment Mesembryanthemum 36,95712-Jul-99 Mesembryanthemum crystallinum cDNA clone L0-1173 crystallinum5′ similar to Profilin 1 (AF092547) [Ricinus communis, mRNA sequence.rxa02114 509 GB_BA1: SMU94899 2379 U94899 Sinorhizobium melilotidissimilatory nitrous oxide reduction proteins Sinorhizobium meliloti42,744 6-Sep-97 NosY, NosL and NosX genes, complete cds. GB_BA1:SMU94899 2379 U94899 Sinorhizobium meliloti dissimilatory nitrous oxidereduction Sinorhizobium meliloti 39,486 6-Sep-97 proteins NosY, NosL andNosX genes, complete cds. rxa02117 597 GB_BA2: AF094575 18754 AF094575Streptococcus pneumoniae serotype 19A DexB (dexB) gene, partialsequence; capsular Streptococcus pneumoniae 40,48 9-Sep-99polysaccharide biosynthesis operon, complete sequence; and oligopeptidepermease AliA (aliA) gene, partial cds. GB_BA2: AF105113 5832 AF105113Streptococcus pneumoniae type 19A putative oligosaccharide repeat unittransporter Streptococcus pneumoniae 40,652 9-Sep-99 (cps19AJ) gene,partial cds; UDP-N-acetyl glucosamine-2-epimerase (cps19AK),glucose-1-phosphate thymidylyl transferase (cps19AL), dTDP-4-keto-6-deoxyglucose-3,5-epimerase (cps19AM), dTDP-glucose-4,6 dehydratase(cps19AN), and dTDP-L-rhamnose synthase (cps19AO) genes, complete cds;and AliA (aliA) gene, partial cds. GB_EST9: AA073381 429 AA073381mm93a12.r1 Stratagene mouse heart (#937316) Mus musculus cDNA clone Musmusculus 46,341 15-Feb-97 IMAGE: 535966 5′ similar to gb: X03765 MousemRNA for cytoplasmatic beta-actin (MOUSE):, mRNA sequence. rxa02121 828GB_PR4: AC004874 95983 AC004874 Homo sapiens PAC clone DJ0744D13 from7q11, complete sequence. Homo sapiens 40,791 21-Nov-98 GB_EST14:AA418305 440 AA418305 zv96g05.s1 Soares_NhHMPu_S1 Homo sapiens cDNAclone Homo sapiens 40,093 16-OCT-1997 IMAGE: 767672 3′, mRNA sequence.GB_BA2: U32763 12021 U32763 Haemophilus influenzae Rd section 78 of 163of the complete genome. Haemophilus influenzae Rd 37,715 29-MAY-1998rxa02123 1494 GB_BA1: MTCY10D7 39800 Z79700 Mycobacterium tuberculosisH37Rv complete genome; segment 44/162. Mycobacterium 62,083 17-Jun-98tuberculosis GB_BA1: MTCY10D7 39800 Z79700 Mycobacterium tuberculosisH37Rv complete genome; segment 44/162. Mycobacterium 38,462 17-Jun-98tuberculosis GB_GSS15: AQ639831 649 AQ639831 927P1-20A2.TV 927P1Trypanosoma brucei Trypanosoma brucei 36,124 8-Jul-99 genomic clone927P1-20A2, genomic survey sequence. rxa02124 2079 GB_PR2: HS242N11167514 AL023655 Human DNA sequence from clone 242N11 on chromosome Homosapiens 33,866 23-Nov-99 6p22.3-23. Contains ESTs, STSs, GSSs, genomicmarker D6S285, and ca and gaaa repeat polymorphisms, complete sequence.GB_PR2: HS242N11 167514 AL023655 Human DNA sequence from clone 242N11 onchromosome 6p22.3-23. Homo sapiens 36,342 23-Nov-99 Contains ESTs, STSs,GSSs, genomic marker D6S285, and ca and gaaa repeat polymorphisms,complete sequence. rxa02125 924 GB_HTG1: CEY116A8_4 110000 Z98858Caenorhabditis elegans chromosome IV clone Y116A8, Caenorhabditiselegans 36,615 23-Jan-98 *** SEQUENCING IN PROGRESS ***, in unorderedpieces. GB_IN1: CEY116A8B 29344 AL021469 Caenorhabditis elegans cosmidY116A8B, complete sequence. Caenorhabditis elegans 36,615 23-Nov-98GB_HTG1: CEY116A8_4 110000 Z98858 Caenorhabditis elegans chromosome IVclone Y116A8, Caenorhabditis elegans 36,615 23-Jan-98 *** SEQUENCING INPROGRESS ***, in unordered pieces. rxa02129 357 GB_HTG5: AC007809 141122AC007809 Drosophila melanogaster chromosome 3 clone BACR45M03 Drosophilamelanogaster 37,255 16-Nov-99 (D718) RPCI-98 45.M.3 map 88C-88C strainy; cn bw sp. *** SEQUENCING IN PROGRESS ***, 98 unordered pieces.GB_IN2: CELT02C5 36267 U55374 Caenorhabditis elegans cosmid T02C5.Caenorhabditis elegans 41,834 08-OCT-1999 GB_IN1: CEZC101 26147 Z93395Caenorhabditis elegans cosmid ZC101, complete sequence. Caenorhabditiselegans 38,873 23-Jul-99 rxa02132 rxa02137 921 GB_EST16: C48630 360C48630 C48630 Yuji Kohara unpublished cDNA: Strain N2 hermaphroditeCaenorhabditis elegans 39,326 18-OCT-1999 embryo Caenorhabditis eleganscDNA clone yk459c11 5′, mRNA sequence. GB_GSS12: AQ381854 597 AQ381854RPCI11-137P5.TJ RPCI-11 Homo sapiens genomic Homo sapiens 37,87921-MAY-1999 clone RPCI-11-137P5, genomic survey sequence. GB_HTG3:AC010253 74835 AC010253 Homo sapiens chromosome 5 clone CIT-HSPC_432B14,*** SEQUENCING IN Homo sapiens 35,082 15-Sep-99 PROGRESS ***, 34unordered pieces. rxa02138 465 GB_BA1: SC6G10 36734 AL049497Streptomyces coelicolor cosmid 6G10. Streptomyces coelicolor 40,04724-MAR-1999 GB_BA1: MSGB1554CS 36548 L78814 Mycobacterium leprae cosmidB1554 DNA sequence. Mycobacterium leprae 60,991 15-Jun-96 GB_BA1:MSGB1551CS 36548 L78813 Mycobacterium leprae cosmid B1551 DNA sequence.Mycobacterium leprae 60,991 15-Jun-96 rxa02141 531 GB_HTG2: AC00311898940 AC003118 Homo sapiens chromosome 1, *** SEQUENCING IN PROGRESS***, Homo sapiens 34,008 24-Nov-97 3 unordered pieces. GB_HTG2: AC00311898940 AC003118 Homo sapiens chromosome 1, *** SEQUENCING IN Homo sapiens34,008 24-Nov-97 PROGRESS ***, 3 unordered pieces. GB_PR3: HS395P12147724 AL022310 Human DNA sequence from clone 395P12 on chromosome1q24-25. Contains Homo sapiens 34,008 23-Nov-99 the TXGP1 gene fortax-transcriptionally activated glycoprotein 1 (34 kD) (OX40 ligand,OX40L) and a GOT2 (Aspartate Aminotransferase, mitochondrial precursor,EC 2.6.1.1, Transaminase A, Glutamate Oxaloacetate Transaminase-2)pseudogene. Contains ESTs, STSs and GSSs, complete sequence. rxa02146750 GB_BA1: SC6G10 36734 AL049497 Streptomyces coelicolor cosmid 6G10.Streptomyces coelicolor 36,167 24-MAR-1999 GB_HTG6: AC008224 199774AC008224 Drosophila melanogaster chromosome 3 clone BACR29J02 (D817)Drosophila melanogaster 36,437 24-Nov-99 RPCI-98 29.J.2 map 83D-83Dstrain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 37 unordered pieces.GB_GSS12: AQ407179 476 AQ407179 HS_5088_A2_G01_T7A RPCI-11 Human MaleBAC Library Homo sapiens 37,143 17-MAR-1999 Homo sapiens genomic clonePlate = 664 Col = 2 Row = M, genomic survey sequence. rxa02151 1311GB_PR3: AC000074 44450 AC000074 Homo sapiens Chromosome 22q11.2 CosmidClone 20b In DGCR Homo sapiens 37,798 31-OCT-1998 Region, completesequence. GB_PR2: HSAC002122 79931 AC002122 Human unknown clone GS293J04from 5p15.2, complete sequence. Homo sapiens 36,064 27-MAY-1997 GB_PR2:HSAC002122 79931 AC002122 Human unknown clone GS293J04 from 5p15.2,complete sequence. Homo sapiens 35,051 27-MAY-1997 rxa02152 525 GB_PAT:AR009990 2793 AR009990 Sequence 1 from patent U.S. Pat. No. 5756677.Unknown. 44,311 04-DEC-1998 GB_IN1: AF027735 3060 AF027735 Nephilaclavipes minor ampullate silk protein MiSp1 mRNA, partial cds. Nephilaclavipes 44,311 23-Apr-98 GB_PAT: I95876 2793 I95876 Sequence 1 frompatent U.S. Pat. No. 5733771. Unknown. 44,311 01-DEC-1998 rxa02163 876GB_PR3: HSJ1175I6 96276 AL049538 Human DNA sequence from clone 1175I6 onchromosome 20. Homo sapiens 36,385 23-Nov-99 Contains the gene for Rasinhibitor JC265 (Ras association (RalGDS/AF-6) domain containingprotein), ESTs, STSs, GSSs and two putative CpG Islands, completesequence. GB_GSS4: AQ690740 975 AQ690740 nbxb0082N18f CUGI Rice BACLibrary Oryza sativa genomic Oryza sativa 39,474 1-Jul-99 clonenbxb0082N18f, genomic survey sequence. GB_PH: SVVWBORF 6051 X72092Streptomyces venezuelae bacteriophage VWB orfs. Bacteriophage VWB 41,41624-Aug-95 rxa02164 1698 GB_BA2: AF000579 8931 AF000579 Bordeteliabronchiseptica LysR transcriptional Bordetella bronchiseptica 38,00523-Feb-98 activator homolog (bbuR), urease accessory protein D (ureD),urease structural subunit A (ureA), urease accessory protein J (ureJ),urease structural subunits B (ureB) and C (ureC), urease accessoryproteins EF (ureEF) and G (ureG) genes, complete cds. GB_PR3: HS431P23147971 AL009178 Human DNA sequence from clone 431P23 on chromosome 6q27.Homo sapiens 35,604 23-Nov-99 Contains the first coding exon of theMLLT4 gene for myeloid/lymphoid or mixed-lineage leukemia (trithorax(Drosophila) homolog); translocated to, 4 (AF-6, Afadin, MLLT-4, ALL-1fusion partner), and a Serine Palmitoyltransferase 2 (EC 2.3.1.50, LongChain Base Biosynthesis protein 2, LCB-2, SPT-2) pseudogene. ContainsESTs, STas, GSSs, and a putative CpG island, complete sequence. GB_PR2:AB016897 331211 AB016897 Homo sapiens genomic DNA, chromosome 6q27,complete sequence. Homo sapiens 38,314 20-Nov-99 rxa02165 735 GB_IN2:AF079177 2159 AF079177 Theileria parva strain KNP2 p67 surface antigen(p67) gene, complete cds. Theileria parva 39,207 09-MAR-1999 GB_IN2:AF079176 2285 AF079176 Theileria parva strain Hluhluwe3 p67 surfaceantigen (p67) gene, complete cds. Theileria parva 39,049 09-MAR-1999GB_EST27: AI397572 482 AI397572 NCSC5G2T3 Subtracted Conidial NeurosporaNeurospora crassa 38,936 8-Feb-99 crassa cDNA clone SC5G2 5′, mRNAsequence. rxa02166 300 GB_BA1: MLCB1351 38936 Z95117 Mycobacteriumleprae cosmid B1351. Mycobacterium leprae 37,627 24-Jun-97 GB_BA1:MLCB1351 38936 Z95117 Mycobacterium leprae cosmid B1351. Mycobacteriumleprae 40,741 24-Jun-97 rxa02168 2937 GB_BA1: MAFASGEN 10520 X87822 B.ammoniagenes FAS gene. Corynebacterium 61,515 03-OCT-1996 ammoniagenesGB_BA1: MLCL458 43839 AL049478 Mycobacterium leprae cosmid L458.Mycobacterium leprae 50,292 27-Aug-99 GB_PR3: HSL19H1 40145 Z68164 HumanDNA sequence from cosmid L19H1, Huntington's Disease Homo sapiens 37,62123-Nov-99 Region, chromosome 4p16.3, containing multiple EST matches.rxa02169 969 GB_RO: MMA3CA212 4784 X94406 Mus musculus partial b3 genefor alpha3 subunit of L-type Ca2+ channel, exons 2-13. Mus musculus37,62 24-Nov-99 GB_RO: RATCACH3B 2525 M88751 Rat calcium channel betasubunit-III mRNA, complete cds. Rattus norvegicus 36,345 27-MAY-1994GB_RO: MMU20372 2469 U20372 Mus musculus voltage-dependent calciumchannel beta-3 Mus musculus 36,865 02-MAR-1996 subunit (CCHB3) mRNA,complete cds. rxa02170 897 GB_HTG6: AC005497 212097 AC005497 Homosapiens chromosome 17 clone RP11-952N18 map 17, Homo sapiens 36,10120-Nov-99 *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. GB_HTG6:AC005497 212097 AC005497 Homo sapiens chromosome 17 clone RP11-952N18map 17, *** SEQUENCING Homo sapiens 37,57 20-Nov-99 IN PROGRESS ***, 2ordered pieces. GB_PR2: AP000104 100000 AP000104 Homo sapiens genomicDNA of 21q22.1, GART and AML related, Q78C10-149C3 Homo sapiens 34,87125-Sep-99 region, segment 7/20, complete sequence. rxa02172 462GB_EST24: AI170522 367 AI170522 EST216450 Normalized rat lung, BentoSoares Rattus sp. cDNA Rattus sp. 38,904 20-Jan-99 clone RLUCO75 3′ end,mRNA sequence. GB_GSS13: AQ430048 538 AQ430048 HS_5061_B2_G09_T7ARPCI-11 Human Male BAC Library Homo sapiens 37,143 31-MAR-1999 Homosapiens genomic clone Plate = 637 Col = 18 Row = N, genomic surveysequence. GB_GSS4: AQ701704 589 AQ701704 HS_2130 A1_E03_MR CIT ApprovedHuman Genomic Sperm Library D Homo Homo sapiens 35,28 7-Jul-99 sapiensgenomic clone Plate = 2130 Col = 5 Row = I, genomic survey sequence.rxa02177 1056 GB_HTG4: AC009403 198495 AC009403 Homo sapiens cloneDJ1015O24, *** SEQUENCING Homo sapiens 37,154 28-OCT-1999 IN PROGRESS***, 3 unordered pieces. GB_HTG4: AC009403 198495 AC009403 Homo sapiensclone DJ1015O24, *** SEQUENCING Homo sapiens 37,154 28-OCT-1999 INPROGRESS ***, 3 unordered pieces. GB_PR2: AP000094 100000 AP000094 Homosapiens genomic DNA of 21q22.1, GART and AML related, Homo sapiens38,536 25-Sep-99 B335D16-P10G11 region, segment 4/7, complete sequence.rxa02178 rxa02180 1581 GB_BA1: SC6C5 18160 AL034492 Streptomycescoelicolor cosmid 6C5. Streptomyces coelicolor 53,635 14-DEC-1998GB_HTG4: AC011121 172050 AC011121 Homo sapiens chromosome 11 clone364_C_06 map 11, *** Homo sapiens 37,17 14-OCT-1999 SEQUENCING INPROGRESS ***, 9 ordered pieces. GB_HTG4: AC011121 172050 AC011121 Homosapiens chromosome 11 clone 364_C_06 map 11, *** SEQUENCING Homo sapiens37,17 14-OCT-1999 IN PROGRESS ***, 9 ordered pieces. rxa02181 801GB_PL1: STU76701 3049 U76701 Solanum tuberosum NADH nitrate reductase(StNR2) mRNA, complete cds. Solanum tuberosum 38,846 18-Nov-96 GB_EST36:AI896605 633 AI896605 EST266048 tomato callus, TAMU Lycopersiconesculentum Lycopersicon esculentum 39,671 27-Jul-99 cDNA clonecLEC16C12, mRNA sequence. GB_EST38: AW035744 620 AW035744 EST281898tomato callus, TAMU Lycopersicon Lycopersicon esculentum 40,55515-Sep-99 esculentum cDNA clone cLEC36M13, mRNA sequence. rxa02183rxa02185 702 GB_BA1: MTV043 68848 AL022004 Mycobacterium tuberculosisH37Rv complete genome; segment 40/162. Mycobacterium 38,793 24-Jun-99tuberculosis GB_BA1: MSGB1935CS 40085 L04666 M. leprae genomic sequence,cosmid b1935. Mycobacterium leprae 38,067 14-Jun-96 GB_BA1: MLCB57 38029Z99494 Mycobacterium leprae cosmid B57. Mycobacterium leprae 38,06710-Feb-99 rxa02186 321 GB_BA2: CNSPAX03 307120 AJ248285 Pyrococcusabyssi complete genome; segment 3/6. Pyrococcus abyssi 35,873 9-Sep-99GB_HTG3: AC010677 116108 AC010677 Homo sapiens clone MS2304L04, ***SEQUENCING IN Homo sapiens 39,145 04-OCT-1999 PROGRESS ***, 4 unorderedpieces. GB_HTG3: AC010677 116108 AC010677 Homo sapiens clone MS2304L04,*** SEQUENCING Homo sapiens 39,145 04-OCT-1999 IN PROGRESS ***, 4unordered pieces. rxa02187 2322 GB_EST33: AI779784 362 AI779784EST260663 tomato susceptible, Cornell Lycopersicon esculentumLycopersicon esculentum 41,011 29-Jun-99 cDNA clone cLES9K1, mRNAsequence. GB_EST33: AI779784 362 AI779784 EST260663 tomato susceptible,Cornell Lycopersicon Lycopersicon esculentum 41,011 29-Jun-99 esculentumcDNA clone cLES9K1, mRNA sequence. rxa02199 693 GB_PR3: AC005274 205150AC005274 Homo sapiens chromosome 17, clone hRPK.1090_M_7, completesequence. Homo sapiens 36,337 29-Jul-98 GB_HTG2: AC007732 110348AC007732 Homo sapiens chromosome 17 clone hRPC.1030_A_12 Homo sapiens35,924 5-Jun-99 map 17, *** SEQUENCING IN PROGRESS ***, 7 unorderedpieces. GB_IN1: DMU11052 4871 U11052 Drosophila melanogaster peroxidasinprecursor mRNA, complete cds. Drosophila melanogaster 39,873 26-Jan-95rxa02203 501 GB_EST17: AA642571 323 AA642571 nq73c08.s1 NCI_CGAP_Pr22Homo sapiens cDNA clone IMAGE: 1157966 Homo sapiens 49,485 27-OCT-19973′ similar to TR: G9372 G9372 UBIQUITIN;, mRNA sequence. GB_EST27:AI425489 312 AI425489 my32e11.y1 Barstead mouse pooled organs MPLRB4 Musmusculus cDNA Mus musculus 40,514 09-MAR-1999 clone IMAGE: 697580 5′,mRNA sequence. GB_EST23: AI154481 308 AI154481 ua03h07.r1 Soares 2NbMTMus musculus cDNA clone Mus musculus 42,748 30-Sep-98 IMAGE: 1345693 5′,mRNA sequence. rxa02206 1059 GB_PR2: AP000269 70932 AP000269 Homosapiens genomic DNA, chromosome 21q22.1, D21S226-AML region, Homosapiens 39,306 20-Nov-99 clone: T293, complete sequence. GB_PL1: D321401360 D32140 Cyanidioschyzon merolae DNA for actin, complete cds.Cyanidioschyzon merolae 37,331 7-Feb-99 GB_PR2: AP000269 70932 AP000269Homo sapiens genomic DNA, chromosome 21q22.1, D21S226-AML Homo sapiens35,481 20-Nov-99 region, clone: T293, complete sequence. rxa02207 898GB_EST21: AA982901 442 AA982901 vx59f07.r1 Stratagene mouse macrophage(#937306) Mus musculus 42,141 27-MAY-1998 Mus musculus cDNA clone IMAGE:1279525 5′ similar to gb: X59543_ma1RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASEM1 CHAIN (HUMAN); gb: K02927 Mouse ribonucleotide reductase subunit M1mRNA, complete (MOUSE);, mRNA sequence. GB_EST8: W85369 558 W85369mf48h04.r1 Soares mouse embryo NbME13.5 14.5 Mus musculus cDNA Musmusculus 39,964 12-Sep-96 clone IMAGE: 408343 5′ similar to gb: K02927Mouse ribonucleotide reductase subunit M1 mRNA, complete (MOUSE);, mRNAsequence. GB_PAT: E14824 2379 E14824 cDNA encoding M1 subunit of humanribonucleotide reductase. Homo sapiens 36,812 28-Jul-99 rxa02211rxa02212 621 GB_HTG3: AC009518 241128 AC009518 Homo sapiens chromosome7, *** SEQUENCING IN Homo sapiens 36,542 1-Sep-99 PROGRESS ***, 68unordered pieces. GB_HTG3: AC009518 241128 AC009518 Homo sapienschromosome 7, *** SEQUENCING IN Homo sapiens 36,542 1-Sep-99 PROGRESS***, 68 unordered pieces. GB_HTG3: AC009518 241128 AC009518 Homo sapienschromosome 7, *** SEQUENCING Homo sapiens 41,362 1-Sep-99 IN PROGRESS***, 68 unordered pieces. rxa02216 329 GB_HTG2: AC007641 102402 AC007641Mus musculus chromosome 10 clone 644_M_8 map Mus musculus 31,30722-MAY-1999 10, *** SEQUENCING IN PROGRESS ***, 7 unordered pieces.GB_HTG2: AC007641 102402 AC007641 Mus musculus chromosome 10 clone644_M_8 map 10, *** SEQUENCING Mus musculus 31,307 22-MAY-1999 INPROGRESS ***, 7 unordered pieces. GB_HTG2: AC007641 102402 AC007641 Musmusculus chromosome 10 clone 644_M_8 map 10, *** SEQUENCING Mus musculus32,198 22-MAY-1999 IN PROGRESS ***, 7 unordered pieces. rxa02217 786GB_RO: RNU91516 1540 U91516 Rattus norvegicus oxytocin receptor (OTR)gene, promoter region. Rattus norvegicus 36,256 25-Nov-97 GB_RO:RNU91516 1540 U91516 Rattus norvegicus oxytocin receptor (OTR) gene,promoter region. Rattus norvegicus 37,176 25-Nov-97 rxa02218 390GB_HTG3: AC008656 43033 AC008656 Homo sapiens chromosome 5 cloneCIT978SKB_194J6, *** SEQUENCING Homo sapiens 39,894 3-Aug-99 IN PROGRESS***, 64 unordered pieces. GB_HTG3: AC008656 43033 AC008656 Homo sapienschromosome 5 clone CIT978SKB_194J6, *** SEQUENCING IN Homo sapiens39,894 3-Aug-99 PROGRESS ***, 64 unordered pieces. rxa02219 1509 GB_PR3:HS475N16 113109 AL035587 Human DNA sequence from clone 475N16 onchromosome Homo sapiens 36,266 23-Nov-99 6p12.3-21.2, complete sequence.GB_PR3: HS475N16 113109 AL035587 Human DNA sequence from clone 475N16 onHomo sapiens 35,255 23-Nov-99 chromosome 6p12.3-21.2, complete sequence.GB_EST10: AA142336 411 AA142336 ms07f02.r1 Stratagene mouse skin(#937313) Mus musculus cDNA Mus musculus 38,398 12-Feb-97 clone IMAGE:606267 5′ similar to SW: RCA1_YEAST P40341 MITOCHONDRIAL RESPIRATORYCHAIN COMPLEXES ASSEMBLY PROTEIN RCA1;, mRNA sequence. rxa02221 1485GB_PR3: AC002422 160091 AC002422 Human Chromosome X, complete sequence.Homo sapiens 38,435 30-Jan-98 GB_HTG2: AC006755 199917 AC006755Caenorhabditis elegans clone Y40C5, *** SEQUENCING Caenorhabditiselegans 39,229 23-Feb-99 IN PROGRESS ***, 1 unordered pieces. GB_HTG2:AC006755 199917 AC006755 Caenorhabditis elegans clone Y40C5, ***SEQUENCING Caenorhabditis elegans 39,229 23-Feb-99 IN PROGRESS ***, 1unordered pieces. rxa02223 601 GB_HTG6: AC008224 199774 AC008224Drosophila melanogaster chromosome 3 clone Drosophila melanogaster35,333 24-Nov-99 BACR29J02 (D817) RPCI-98 29.J.2 map 83D-83D strain y;cn bw sp, *** SEQUENCING IN PROGRESS ***, 37 unordered pieces. GB_HTG3:AC011511 158296 AC011511 Homo sapiens chromosome 19 cloneCITB-H1_2369P2, Homo sapiens 35,593 07-OCT-1999 *** SEQUENCING INPROGRESS ***, 57 unordered pieces. GB_HTG3: AC011511 158296 AC011511Homo sapiens chromosome 19 clone CITB-H1_2369P2, *** SEQUENCING Homosapiens 35,593 07-OCT-1999 IN PROGRESS ***, 57 unordered pieces.rxa02226 1156 GB_HTG2: AC006890 298195 AC006890 Caenorhabditis elegansclone Y67D8x, *** SEQUENCING Caenorhabditis elegans 36,81 24-Feb-99 INPROGRESS ***, 23 unordered pieces. GB_HTG2: AC006890 298195 AC006890Caenorhabditis elegans clone Y67D8x, *** SEQUENCING Caenorhabditiselegans 35,433 24-Feb-99 IN PROGRESS ***, 23 unordered pieces. GB_HTG2:AC006890 298195 AC006890 Caenorhabditis elegans clone Y67D8x, ***SEQUENCING Caenorhabditis elegans 36,81 24-Feb-99 IN PROGRESS ***, 23unordered pieces. rxa02227 741 GB_EST5: H98835 440 H98835 yx14f12.s1Soares melanocyte 2NbHM Homo sapiens cDNA Homo sapiens 38,18215-DEC-1995 clone IMAGE: 261743 3′, mRNA sequence. GB_EST5: N25530 586N25530 yx76c03.s1 Soares melanocyte 2NbHM Homo sapiens cDNA clone Homosapiens 37,543 29-DEC-1995 IMAGE: 267652 3′, mRNA sequence. GB_BA1:CGU43535 2531 U43535 Corynebacterium glutamicum multidrug resistanceCorynebacterium 38,812 9-Apr-97 protein (cmr) gene, complete cds.glutamicum rxa02230 660 GB_EST16: AA570388 527 AA570388 nk62c08.s1NCI_CGAP_Sch1 Homo sapiens cDNA Homo sapiens 41,096 9-Sep-97 cloneIMAGE: 1018094 3′ similar to contains element MSR1 repetitive element;,mRNA sequence. GB_PR2: HSU43030 1539 U43030 Human cardiotrophin-1 (CTF1)mRNA, complete cds. Homo sapiens 36,335 9-Jan-96 GB_IN1: CELK08B5 35728U41022 Caenorhabditis elegans cosmid K08B5. Caenorhabditis elegans35,387 30-Nov-95 rxa02231 879 GB_PL2: ATAC006429 94818 AC006429Arabidopsis thaliana chromosome II BAC F15K19 Arabidopsis thaliana33,687 23-Apr-99 genomic sequence, complete sequence. GB_PR3: AC004554195142 AC004554 Homo sapiens Xp22 BAC GSHB-590J6 (Genome Systems Homosapiens 38,921 30-MAY-1998 Human BAC library) complete sequence.GB_HTG2: AC007853 116280 AC007853 Drosophila melanogaster chromosome 3clone Drosophila melanogaster 36,237 2-Aug-99 BACR03L02 (D766) RPCI-9803.L.2 map 96B-96C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***,80 unordered pieces. rxa02238 408 GB_BA1: MTCY21BA 39150 Z80108Mycobacterium tuberculosis H37Rv Mycobacterium 52,206 23-Jun-98 completegenome; segment 62/162. tuberculosis GB_BA1: MTCY21B4 39150 Z80108Mycobacterium tuberculosis H37Rv Mycobacterium 36,935 23-Jun-98 completegenome; segment 62/162. tuberculosis GB_VI: AF105451 801 AF105451 HIV-1isolate A-DII-07 from Italy, envelope glycoprotein, C2-V5 region Humanimmunodeficiency 40,864 25-Apr-99 (env) gene, partial cds. virus type 1rxa02244 1656 GB_PR1: AB016195 10558 AB016195 Homo sapiens ELK1pseudogene (ELK2) and immunoglobulin Homo sapiens 38,929 9-Apr-99 heavychain gamma pseudogene (IGHGP). GB_PR3: HSN21F1 39212 Z94162 Human DNAsequence from cosmid N21F1 on chromosome 22 Contains Homo sapiens 38,76323-Nov-99 exon trap and STS, complete sequence. GB_IN1: DMAC001648 51989AC001648 Drosophila melanogaster (P1 DS03431 (D102)) DNA Drosophilamelanogaster 36,884 22-Apr-97 sequence, complete sequence. rxa02254 800GB_GSS12: AQ360240 541 AQ360240 HS_5035_A2_E07_T7 RPCI11 Human Male Homosapiens 36,386 06-MAR-1999 BAC Library Homo sapiens genomic clone Plate= 611 Col = 14 Row = I, genomic survey sequence. GB_GSS11: AQ258453 620AQ258453 nbxb0020L15f CUGI Rice BAC Library Oryza sativa genomic cloneOryza sativa 36,271 23-OCT-1998 nbxb0020L15f, genomic survey sequence.GB_GSS14: AQ577777 568 AQ577777 nbxb0091L17f CUGI Rice BAC Library Oryzasativa genomic clone Oryza sativa 39,456 2-Jun-99 nbxb0091L17f, genomicsurvey sequence. rxa02255 1059 GB_PR4: AC006332 153477 AC006332 Homosapiens clone NH0376O14, complete sequence. Homo sapiens 35,01911-Nov-99 GB_PAT: E02669 1197 E02669 DNA encoding Bacillus sp. L-lacticacid dehydrogenase. Bacillus sp. 39,719 29-Sep-97 GB_PL1: YSCBOI2 3201D38310 Yeast BOI2 gene for Boi2p. Saccharomyces cerevisiae 35,7698-Feb-99 rxa02266 636 GB_BA1: REGIONB 4961 Z13995 N. meningitidis lipAand lipB genes for LipA and LipB proteins. Neisseria meningitidis 35,69129-DEC-1993 GB_HTG1: AP000568 136627 AP000568 Homo sapiens chromosome 21clone B753B2 map 21q21.2, Homo sapiens 37,5 07-OCT-1999 *** SEQUENCINGIN PROGRESS ***, in unordered pieces. GB_HTG1: AP000568 136627 AP000568Homo sapiens chromosome 21 clone B753B2 map 21q21.2, *** SEQUENCING Homosapiens 37,5 07-OCT-1999 IN PROGRESS ***, in unordered pieces. rxa02267996 GB_PR4: AC007283 127361 AC007283 Homo sapiens clone NH0536I18,complete sequence. Homo sapiens 37,155 28-Sep-99 GB_IN1: CEC54C6 35500Z77131 Caenorhabditis elegans cosmid C54C6, complete sequence.Caenorhabditis elegans 38,28 23-Nov-98 GB_HTG3: AC008905 129915 AC008905Homo sapiens chromosome 5 clone CITB-H1_2259I14, *** SEQUENCING Homosapiens 35,895 3-Aug-99 IN PROGRESS ***, 40 unordered pieces. rxa02271681 GB_HTG3: AC007441 219832 AC007441 Drosophila melanogaster chromosome3 clone BACR10E03 Drosophila melanogaster 33,284 08-OCT-1999 (D690)RPCI-98 10.E.3 map 88A-88B strain y; cn bw sp, *** SEQUENCING INPROGRESS***, 188 unordered pieces. GB_HTG3: AC007441 219832 AC007441Drosophila melanogaster chromosome 3 clone BACR10E03 (D690) Drosophilamelanogaster 33,284 08-OCT-1999 RPCI-98 10.E.3 map 88A-88B strain y; cnbw sp, *** SEQUENCING IN PROGRESS ***, 188 unordered pieces. GB_HTG2:AC008029 123186 AC008029 Drosophila melanogaster chromosome 3 cloneBACR01C11 (D819) RPCI-96 01.C.11 Drosophila melanogaster 34,315 2-Aug-99map 84D-84D strain y: cn bw sp, *** SEQUENCING IN PROGRESS ***, 92unordered pieces. rxa02279 1581 GB_IN1: AC003121 69822 AC003121Drosophila melanogaster (P1 DS00329 (D89)) DNA Drosophila melanogaster38,046 26-Nov-97 sequence, complete sequence. GB_IN1: AC003121 69822AC003121 Drosophila melanogaster (P1 DS00329 (D89)) DNA Drosophilamelanogaster 39,22 26-Nov-97 sequence, complete sequence. GB_BA1: MTCY3938500 Z74025 Mycobacterium tuberculosis H37Rv Mycobacterium 39,68517-Jun-98 complete genome; segment 89/162. tuberculosis rxa02280rxa02286 672 GB_BA1: MTV025 121125 AL022121 Mycobacterium tuberculosisH37Rv complete genome; segment 155/162. Mycobacterium 36,953 24-Jun-99tuberculosis GB_PL2: AC002130 114738 AC002130 The sequence of BAC F1N21from Arabidopsis thaliana chromosome Arabidopsis thaliana 39,2168-Jan-98 1, complete sequence. GB_PL2: AC007259 97146 AC007259Arabidopsis thaliana chromosome I BAC T28P6 genomic sequence,Arabidopsis thaliana 36,09 17-Aug-99 complete sequence. rxa02287 675GB_HTG3: AC009281 221178 AC009281 Homo sapiens chromosome 15 clone8_C_22 map 15, Homo sapiens 35,565 12-Aug-99 *** SEQUENCING IN PROGRESS***, 49 unordered pieces. GB_HTG3: AC009281 221178 AC009281 Homo sapienschromosome 15 clone 8_C_22 map 15, *** SEQUENCING Homo sapiens 35,56512-Aug-99 IN PROGRESS ***, 49 unordered pieces. GB_RO: MUSMURINC 4597M65736 Mouse murinoglobulin mRNA, complete cds. Mus musculus 38,48527-Apr-93 rxa02294 498 GB_EST19: AA813194 398 AA813194 ai80g12.s1Soares_testis_NHT Homo sapiens cDNA clone Homo sapiens 36,79731-DEC-1998 1377190 3′, mRNA sequence. GB_EST19: AA813194 398 AA813194ai80g12.s1 Soares_testis_NHT Homo sapiens cDNA clone Homo sapiens 33,41731-DEC-1998 1377190 3′, mRNA sequence. rxa02295 903 GB_PAT: I89451 18318I89451 Sequence 6 from patent US 5721354. Unknown. 38,839 10-Aug-98GB_VI: HCU33331 18535 U33331 Human cytomegalovirus Toledo strain UL/b′region. human herpesvirus 5 38,839 27-Jan-96 GB_PR3: HS550H1 108803AL035420 Human DNA sequence from clone 550H1 on chromosome 20q11.1-11.22Contains Homo sapiens 38,796 23-Nov-99 a pseudogene similar to HIGHMOBILITY GROUP PROTEIN 2A, a novel mRNA, ESTs, STSs, GSSs and CpGIslands, complete sequence. rxa02296 612 GB_BA2: AF065312 1694 AF065312Yersinia pestis hypothetical protein (yceG) gene, partial cds;thymidylate Yersinia pestis 41,351 16-Nov-99 kinase (tmk) gene, completecds; and putative DNA polymerase III delta' subunit (hoIB) gene, partialcds. GB_PR3: HS550H1 108803 AL035420 Human DNA sequence from clone 550H1on chromosome 20q11.1-11.22 Contains Homo sapiens 37,919 23-Nov-99 apseudogene similar to HIGH MOBILITY GROUP PROTEIN 2A, a novel mRNA,ESTs, STSs, GSSs and CpG Islands, complete sequence. GB_PR3: HS550H1108803 AL035420 Human DNA sequence from clone 550H1 on chromosome20q11.1-11.22 Contains Homo sapiens 37,607 23-Nov-99 a pseudogenesimilar to HIGH MOBILITY GROUP PROTEIN 2A, a novel mRNA, ESTs, STSs,GSSs and CpG Islands, complete sequence. rxa02297 1260 GB_BA2: AF0653121694 AF065312 Yersinia pestis hypothetical protein (yceG) gene, partialcds; Yersinia pestis 39,683 16-Nov-99 thymidylate kinase (tmk) gene,complete cds; and putative DNA polymerase III delta' subunit (hoIB)gene, partial cds. GB_RO: AF007836 5655 AF007836 Rattus norvegicus rab3effector (RIM) mRNA, alternatively spliced, complete cds. Rattusnorvegicus 37,844 15-Aug-97 GB_IN2: EGU27015 2394 U27015 Echinococcusgranulosus 18S ribosomal RNA gene, complete sequence. Echinococcusgranulosus 38,71 16-Jul-96 rxa02298 1782 GB_BA2: AF116184 540 AF116184Corynebacterium glutamicum L-aspartate-alpha-decarboxylase precursorCorynebacterium 44,231 02-MAY-1999 (panD) gene, complete cds. glutamicumGB_BA2: AF116184 540 AF116184 Corynebacterium glutamicumL-aspartate-alpha-decarboxylase precursor Corynebacterium 42,00702-MAY-1999 (panD) gene, complete cds. glutamicum rxa02300 456 GB_BA2:AF116184 540 AF116184 Corynebacterium glutamicumL-aspartate-alpha-decarboxylase precursor Corynebacterium 46,2502-MAY-1999 (panD) gene, complete cds. glutamicum GB_BA1: MTV004 69350AL009198 Mycobacterium tuberculosis H37Rv complete Mycobacterium 39,60218-Jun-98 genome; segment 144/162. tuberculosis GB_EST22: AI048692 172AI048692 ub30g04.r1 Soares 2NbMT Mus musculus cDNA clone IMAGE: 13792865′, Mus musculus 43,284 8-Jul-98 mRNA sequence. rxa02301 840 GB_HTG3:AC008573 205755 AC008573 Homo sapiens chromosome 5 cloneCIT-HSPC_551I11, *** SEQUENCING Homo sapiens 35,115 3-Aug-99 IN PROGRESS***, 95 unordered pieces. GB_HTG3: AC008573 205755 AC008573 Homo sapienschromosome 5 clone CIT-HSPC_551I11, *** SEQUENCING Homo sapiens 35,1153-Aug-99 IN PROGRESS ***, 95 unordered pieces. GB_HTG3: AC008573 205755AC008573 Homo sapiens chromosome 5 clone CIT-HSPC_551I11, *** SEQUENCINGHomo sapiens 36,527 3-Aug-99 IN PROGRESS ***, 95 unordered pieces.rxa02302 1002 GB_HTG6: AC008076 200000 AC008076 Homo sapiens chromosome4, *** SEQUENCING IN Homo sapiens 34,884 02-DEC-1999 PROGRESS ***, 18unordered pieces. GB_HTG3: AC008930 258026 AC008930 Homo sapienschromosome 5 clone CITB-H1_2292M9, *** SEQUENCING Homo sapiens 36,9453-Aug-99 IN PROGRESS ***, 166 unordered pieces. GB_HTG3: AC008930 258026AC008930 Homo sapiens chromosome 5 clone CITB-H1_2292M9, *** SEQUENCINGHomo sapiens 36,945 3-Aug-99 IN PROGRESS ***, 166 unordered pieces.rxa02303 rxa02304 1014 GB_PAT: A69720 53789 A69720 Sequence 3 fromPatent WO9807868. unidentified 36,915 07-MAY-1999 GB_BA1: AMM22301253784 AJ223012 Amycolatopsis mediterranel genes encoding rifamycinpolyketide Amycolatopsis 36,915 9-Feb-98 synthases, ORFs 1 to 5.mediterranel GB_BA2: AF040570 76199 AF040570 Amycolatopsis mediterranelrifamycin Amycolatopsis 36,915 15-Feb-98 biosynthetic gene cluster.mediterranel rxa02307 rxa02308 552 GB_HTG3: AC009340 110415 AC009340Drosophila melanogaster chromosome 2 clone BACR04E19 Drosophilamelanogaster 36,066 27-Aug-99 (D1026) RPCI-98 04.E.19 map 34A-34E strainy; cn bw sp, *** SEQUENCING IN PROGRESS ***, 103 unordered pieces.GB_HTG3: AC009340 110415 AC009340 Drosophila melanogaster chromosome 2clone BACR04E19 Drosophila melanogaster 36,066 27-Aug-99 (D1026) RPCI-9804.E.19 map 34A-34E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***,103 unordered pieces. GB_IN2: AC005656 48443 AC005656 Drosophilamelanogaster, chromosome 2R, region 34B6-34C2, Drosophila melanogaster46,154 6-Feb-99 P1 clone DS08787, complete sequence. rxa02314 564GB_HTG5: AC011247 206436 AC011247 Homo sapiens clone NH0541E12, WORKINGDRAFT Homo sapiens 36,201 13-Nov-99 SEQUENCE, 1 unordered pieces.GB_HTG5: AC011247 206436 AC011247 Homo sapiens clone NH0541E12, WORKINGDRAFT Homo sapiens 35,036 13-Nov-99 SEQUENCE, 1 unordered pieces.GB_HTG3: AC011152 142616 AC011152 Homo sapiens clone 7_H_4, Homo sapiens35,548 01-OCT-1999 LOW-PASS SEQUENCE SAMPLING. rxa02324 1209 GB_BA2:AF110185 20302 AF110185 Burkholderia pseudomallei strain 1026b DbhB(dbhB), Burkholderia pseudomallei 39,67 2-Aug-99 general secretorypathway protein D (gspD), general secretory pathway protein E (gspE),general secretory pathway protein F (gspF), GspC (gspC), generalsecretory pathway protein G (gspG), general secretory pathway protein H(gspH), general secretory pathway protein I (gspI), general secretorypathway protein J (gspJ), general secretory pathway protein K (gspK),general secretory pathway protein L (gspL), general secretory pathwayprotein M (gspM), and general secretory pathway protein N (gspN) genes,complete cds; and unknown genes. GB_BA1: PSEAMNH 5215 D90216 P.chlororaphis genes for amidase (EC 3.5.1.4) Pseudomonas chlororaphis51,254 7-Feb-99 and for nitrile hydratase (EC 4.2.1.84). GB_PAT: E125194775 E12519 Nucleotide sequence of Rhodococcus rhodochrous genomicRhodococcus rhodochrous 51,646 24-Jun-98 DNA region containing amidaseand nitrilehydratase genes. rxa02325 990 GB_BA1: CGPYC 3728 Y09548Corynebacterium glutamicum pyc gene. Corynebacterium 100 08-MAY-1998glutamicum GB_PR4: AC006079 178109 AC006079 Homo sapiens chromosome 17,clone Homo sapiens 37,807 12-DEC-1998 hRPK.855_D_21, complete sequence.GB_GSS8: AQ036832 441 AQ036832 CIT-HSP-2334L1.TF CIT-HSP Homo sapiensgenomic Homo sapiens 42,359 11-Jul-98 clone 2334L1, genomic surveysequence. rxa02331 489 GB_PL1: YSKGA11 4159 M68870 Kluyveromyces lactistranscriptional Kluyveromyces lactis 40,252 14-MAY-1993 activator(GAL11) gene, complete cds. GB_PR2: HSAY18950 584 Y18950 Homo sapienspartial gene for Homo sapiens 40,529 08-OCT-1999 caspase-9, intronicsequence (584 bp). GB_PL1: YSKGA11 4159 M68870 Kluyveromyces lactistranscriptional activator Kluyveromyces lactis 38,679 14-MAY-1993(GAL11) gene, complete cds. rxa02336 303 GB_BA1: CGU35023 3195 U35023Corynebacterium glutamicum thiosulfate Corynebacterium 35,548 16-Jan-97sulfurtransferase (thtR) gene, partial cds, acyl CoA glutamicumcarboxylase (accBC) gene, complete cds. GB_PL2: AF114171 183990 AF114171Sorghum bicolor BAC clone 25.M18, complete sequence. Sorghum bicolor41,414 25-Apr-99 GB_PR4: AC006324 157310 AC006324 Homo sapiens cloneDJ1164F05, complete sequence. Homo sapiens 41,786 11-Nov-99 rxa023371446 GB_BA1: CGU35023 3195 U35023 Corynebacterium glutamicum thiosulfateCorynebacterium 100 16-Jan-97 sulfurtransferase (thtR) gene, partialcds, acyl CoA carboxylase glutamicum (accBC) gene, complete cds. GB_BA1:MTCY22G8 22550 Z95585 Mycobacterium tuberculosis H37Rv Mycobacterium38,072 17-Jun-98 complete genome; segment 49/162. tuberculosis GB_PR2:HSAY18950 584 Y18950 Homo sapiens partial gene for caspase-9, Homosapiens 42,949 08-OCT-1999 Intronic sequence (584 bp). rxa02339 515GB_PR2: HS149A16 173354 AL021937 Human DNA sequence from clone 149A16Homo sapiens 37,376 23-Nov-99 on chromosome 22q12-13. Contains an IGLC(Immunoglobulin Lambda Chain C) pseudogene, the RFPL3 and RFPL3S genesfor Ret finger protein-like 3 and Ret finger protein-like 3 antisenserespectively, a gene for a novel Immunoblobulin Lambda Chain V familyprotein, a novel gene for a protein similar to mouse RGDS (RALGDS,RALGEF, Guanine Nucleotide Dissoclation Stimulator A) and rabbitoncogene RSC, a novel gene for the human ortholog of worm F16A11.2 andbacterial and archea-bacterial predicted proteins, a novel gene for aprotein similar to BPI (Bacterial Permeability-Increasing Protein) andrabbit LBP (Liposaccharide-Binding Protein), and a the 5′ part of anovel gene. Contains ESTs, STSs, GSSs, genomic marker D22S1175, a carepeat polymorphism and putative CpG islands, complete sequence.GB_HTG3: AC009726 177618 AC009726 Homo sapiens chromosome 18 clone263_O_14 map 18, Homo sapiens 37,037 29-Aug-99 *** SEQUENCING INPROGRESS ***, 12 unordered pieces. GB_HTG3: AC009726 177618 AC009726Homo sapiens chromosome 18 clone 263_O_14 map 18, Homo sapiens 37,03729-Aug-99 *** SEQUENCING IN PROGRESS ***, 12 unordered pieces. rxa023401188 GB_VI: AF063866 236120 AF063866 Melanoplus sanguinipesentomopoxvirus, complete genome. Melanoplus sanguinipes 34,4822-DEC-1998 entomopoxvirus GB_HTG4: AC011089 171283 AC011089 Homosapiens chromosome 2 clone 303_K_20 map 2, Homo sapiens 37,75714-OCT-1999 *** SEQUENCING IN PROGRESS ***, 25 ordered pieces. GB_HTG4:AC011089 171283 AC011089 Homo sapiens chromosome 2 clone 303_K_20 map 2,Homo sapiens 37,757 14-OCT-1999 *** SEQUENCING IN PROGRESS ***, 25ordered pieces. rxa02341 609 GB_GSS14: AQ580594 303 AQ580594RPCI-11-452K5.TJ RPCI-11 Homo sapiens genomic clone Homo sapiens 38,3057-Jun-99 RPCI-11-452K5, genomic survey sequence. GB_GSS12: AQ393454 561AQ393454 CITBI-E1-2556E3.TR CITBI-E1 Homo sapiens genomic clone Homosapiens 37,882 06-MAR-1999 2556E3, genomic survey sequence. GB_GSS14:AQ507468 627 AQ507468 RPCI-11-298O19.TJ RPCI-11 Homo sapiens genomicclone Homo sapiens 38,48 29-Apr-99 RPCI-11-298O19, genomic surveysequence. rxa02347 444 GB_PR3: AC005549 147416 AC005549 Homo sapienschromosome 17, clone Homo sapiens 39,909 22-Sep-98 hRPK.215_E_13,complete sequence. GB_PR3: AC005549 147416 AC005549 Homo sapienschromosome 17, clone Homo sapiens 33,784 22-Sep-98 hRPK.215_E_13,complete sequence. GB_GSS8: B92789 742 B92789 CIT-HSP-2164J8.TR CIT-HSPHomo sapiens genomic clone Homo sapiens 39,409 25-Jun-98 2164J8, genomicsurvey sequence. rxa02349 rxa02352 578 GB_EST19: AA738949 396 AA738949vv68d12.r1 Stratagene mouse skin (#937313) Mus musculus Mus musculus36,023 14-Jan-98 cDNA clone IMAGE: 1227575 5′, mRNA sequence. GB_GSS14:AQ526017 500 AQ526017 HS_5329_A2_F02_T7A RPCI-11 Homo sapiens 38,53711-MAY-1999 Human Male BAC Library Homo sapiens genomic clone Plate =905 Col = 4 Row = K, genomic survey sequence. GB_PR3: U82695 167460U82695 Homo sapiens cosmid LM1937 from Xq28. Homo sapiens 38,4213-Jan-98 rxa02358 1119 GB_BA1: MTCY16B7 43430 Z81331 Mycobacteriumtuberculosis H37Rv complete Mycobacterium 39,087 17-Jun-98 genome;segment 123/162. tuberculosis GB_BA1: SRMSIK 2384 Y08921 S. reticuligene encoding Msik protein and orf1. Streptomyces reticuli 58,35621-MAR-1997 GB_BA1: MSGY414A 40121 AD000007 Mycobacterium tuberculosissequence from clone y414a. Mycobacterium 58,423 03-DEC-1996 tuberculosisrxa02358 414 GB_BA1: BSUB0021 215534 Z99124 Bacillus subtilis completegenome (section 21 of 21): from 3999281 to 4214814. Bacillus subtilis36,829 26-Nov-97 GB_PR3: HSDA22P16 103367 AL049641 Human DNA sequence*** SEQUENCING IN PROGRESS *** from clone Homo sapiens 36,43 23-Nov-99DA22P16, complete sequence. GB_BA1: BSUB0021 215534 Z99124 Bacillussubtilis complete genome (section 21 of 21): from 3999281 to 4214814.Bacillus subtilis 37,44 26-Nov-97 rxa02360 2556 GB_EST21: AA970555 420AA970555 oo94h05.s1 NCI_CGAP_Kid5 Homo sapiens cDNA clone IMAGE: Homosapiens 36,905 20-MAY-1998 1573881 3′ similar to gb: X61970 PROTEASOMEZETA CHAIN (HUMAN);, mRNA sequence. GB_GSS4: AQ739589 909 AQ739589HS_5381_B2_G06_T7A RPCI-11 Human Male BAC Library Homo sapiens 44,91216-Jul-99 Homo sapiens genomic clone Plate = 957 Col = 12 Row = N,genomic survey sequence. GB_IN1: CEY53H1C 37004 AL117201 Caenorhabditiselegans cosmid Y53H1C, complete sequence. Caenorhabditis elegans 38,43619-Nov-99 rxa02361 774 GB_IN2: CELK04F10 35413 AF039719 Caenorhabditiselegans cosmid K04F10. Caenorhabditis elegans 36,891 26-MAY-1999 GB_PL1:AB011477 78181 AB011477 Arabidopsis thaliana genomic DNA, chromosome 5,P1 clone: MHK7, Arabidopsis thaliana 37,095 20-Nov-99 complete sequence.GB_PL1: AB011477 78181 AB011477 Arabidopsis thaliana genomic DNA,chromosome 5, P1 clone: MHK7, Arabidopsis thaliana 36,794 20-Nov-99complete sequence. rxa02362 3822 GB_EST10: AA178985 357 AA178985zp12g08.s1 Stratagene fetal retina 937202 Homo sapiens cDNA Homo sapiens39,875 31-DEC-1996 clone IMAGE: 609278 3′, mRNA sequence. GB_GSS4:AQ710468 555 AQ710468 HS_5336_A2_B09_T7A RPCI-11 Human Male BAC LibraryHomo sapiens 39,82 13-Jul-99 Homo sapiens genomic clone Plate = 912 Col= 18 Row = C, genomic survey sequence. GB_EST37: AI986900 380 AI986900rs19a09.y1 Sommer Pristionchus Pristionchus pacificus cDNA clone IMAGE:Pristionchus pacificus 42,105 1-Sep-99 5′ similar to WP: C06A1.1 CE02114TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE HOMOLOG 1:, mRNA sequence.rxa02367 732 GB_BA2: SCF78 18292 AL121600 Streptomyces coelicolor cosmidF76. Streptomyces coelicolor 40,195 29-Sep-99 A3(2) GB_SY: SCU53587 4546U53587 Artificial Corynebacterium glutamicum IS1207-derived transposonsynthetic construct 36,755 06-MAY-1996 transposase genes, complete cds,and 3′5″-aminoglycoside phosphotransferase (aphA-3) gene, complete cds.GB_PAT: E16763 2517 E16763 gDNA encoding aspartate transferase (AAT).Corynebacterium 38,687 28-Jul-99 glutamicum rxa02368 rxa02374 744GB_PL2: AC010924 80442 AC010924 Arabidopsis thaliana chromosome 1 BAC724D18 Arabidopsis thaliana 39,261 6-Nov-99 sequence, complete sequence.GB_VI: HE1CG 152261 X14112 Herpes simplex virus (HSV) type 1 completegenome. human herpesvirus 1 39,856 17-Apr-97 GB_VI: HS1ULR 108360 D10879Herpes simplex virus type 1 long unique region UL. human herpesvirus 139,856 3-Feb-99 rxa02381 1146 GB_BA1: CGPROAGEN 1783 X82929 C.glutamicum proA gene. Corynebacterium 98,974 23-Jan-97 glutamicumGB_BA1: CGPROAGEN 1783 X82929 C. glutamicum proA gene. Corynebacterium37,156 23-Jan-97 glutamicum GB_GSS10: AQ215523 445 AQ215523HS_2259_B2_F03_MR CIT Approved Human Genomic Homo sapiens 40,67419-Sep-98 Sperm Library D Homo sapiens genomic clone Plate = 2259 Col =6 Row = L, genomic survey sequence. rxa02383 736 GB_EST35: AI810729 450AI810729 tt86h09.x1 NCI_CGAP_Pr28 Homo sapiens cDNA Homo sapiens 41,5687-Jul-99 clone IMAGE: 2248481 3′, mRNA sequence. GB_EST22: AI048725 347AI048725 ub31d01.r1 Soares 2NbMT Mus musculus cDNA clone IMAGE: 13793295′, Mus musculus 39,412 8-Jul-98 mRNA sequence. GB_EST15: AA466288 431AA466288 vh34c01.r1 Barstead mouse pooled organs MPLRB4 Mus musculuscDNA clone Mus musculus 39,336 11-Jun-97 IMAGE: 888864 5′, mRNAsequence. rxa02387 885 GB_PR3: AC004687 175120 AC004687 Homo sapienschromosome 17, clone Homo sapiens 34,518 26-Jun-98 hRPC.1171_I_10,complete sequence. GB_PR3: AC004687 175120 AC004687 Homo sapienschromosome 17, clone Homo sapiens 38,551 26-Jun-98 hRPC.1171_I_10,complete sequence. GB_GSS15: AQ604975 536 AQ604975 HS_2135_B2_G04_T7CCIT Approved Human Genomic Homo sapiens 39,321 10-Jun-98 Sperm Library DHomo sapiens genomic clone Plate = 2135 Col = 8 Row = N, genomic surveysequence. rxa02390 792 GB_BA2: SC51A 42527 AL121596 Streptomycescoelicolor cosmid 51A. Streptomyces coelicolor 38,804 28-Sep-99 A3(2)GB_BA2: AF073776 5138 AF073776 Pseudomonas aeruginosa MexZ (mexZ),complete cds; Pseudomonas aeruginosa 37,245 19-OCT-1998 and mexGHoperon, complete sequence. GB_BA1: AB015853 5461 AB015853 Pseudomonasaeruginosa gene for MexX and MexY, complete cds. Pseudomonas aeruginosa40,641 13-Nov-98 rxa02393 405 GB_BA1: RCU57682 86896 U57682 Rhodobactercapsulatus cosmids 143-147, complete sequence. Rhodobacter capsulatus44,246 7-Feb-97 GB_PL2: T2K10 88037 AC005966 Arabidopsis thalianachromosome 1 BAC T2K10 sequence, complete sequence. Arabidopsis thaliana42,455 10-Feb-99 GB_PL2: T24H24 88848 AF075598 Arabidopsis thaliana BACT24H24. Arabidopsis thaliana 34,826 3-Aug-98 rxa02395 2013 GB_BA1:SC5F2A 40105 AL049587 Streptomyces coelicolor cosmid 5F2A. Streptomycescoelicolor 51,688 24-MAY-1999 GB_BA1: CGBETPGEN 2339 X93514 C.glutamicum betP gene. Corynebacterium 48,877 8-Sep-97 glutamicum GB_PL2:AF015436 682 AF015436 Liquidambar formosana internal transcribed spacer1, 5.8S Liquidambar formosana 36,217 1-Feb-99 ribosomal RNA gene; andinternal transcribed spacer 2, complete sequence. rxa02396 402 GB_BA2:AE000070 9973 AE000070 Rhizobium sp. NGR234 plasmid Rhizobium sp. NGR23435,572 12-DEC-1997 pNGR234a, section 7 of 46 of the complete plasmidsequence. GB_BA2: AE000070 9973 AE000070 Rhizobium sp. NGR234 plasmidpNGR234a, section 7 Rhizobium sp. NGR234 37,436 12-DEC-1997 of 46 of thecomplete plasmid sequence. GB_BA1: CVAJ677 1087 AJ000677 Chromatiumvinosum recA gene. Allochromatium vinosum 37,5 8-Aug-97 rxa02398 1725GB_PR1: HUMJUNA 3622 J04111 Human c-jun proto oncogene (JUN), completecds, clone hCJ-1. Homo sapiens 37,806 6-Jan-95 GB_EST35: AL041724 462AL041724 DKFZp434O0317_r1 434 (synonym: htes3) Homo sapiens cDNA Homosapiens 40,26 29-Sep-99 clone DKFZp434O0317 5′, mRNA sequence. GB_PAT:I96176 3622 I96176 Sequence 13 from patent US 5734039. Unknown. 37,80601-DEC-1998 rxa02403 888 GB_BA1: CGACEB 3024 X78491 C. glutamicum (ATCC13032) aceB gene. Corynebacterium 47,41 13-Jan-95 glutamicum GB_BA1:CORACEB 2725 L27123 Corynebacterium glutamicum malate synthase (aceB)gene, complete cds. Corynebacterium 43,981 8-Jun-95 glutamicum GB_IN1:CEK06A4 34006 Z70755 Caenorhabditis elegans cosmid K06A4, completesequence. Caenorhabditis elegans 37,875 23-Nov-98 rxa02406 672 GB_EST22:AI062160 629 AI062160 GH01261.5prime GH Drosophila melanogaster headDrosophila melanogaster 37,687 24-Nov-98 pOT2 Drosophila melanogastercDNA clone GH01261 5prime, mRNA sequence. GB_PR1: HSRPIILS 6732 X63564H. sapiens mRNA for RNA polymerase II largest subunit. Homo sapiens36,486 13-Feb-92 GB_PR1: HSRPIILS 6732 X63564 H. sapiens mRNA for RNApolymerase II largest subunit. Homo sapiens 38,813 13-Feb-92 rxa02407495 GB_BA1: MTCY130 32514 Z73902 Mycobacterium tuberculosis H37Rvcomplete genome; segment 59/162. Mycobacterium 54,321 17-Jun-98tuberculosis GB_BA1: MSGY151 37036 AD000018 Mycobacterium tuberculosissequence from clone y151. Mycobacterium 40 10-DEC-1996 tuberculosisGB_EST19: AA391133 474 AA391133 LD10081.5prime LD Drosophilamelanogaster embryo BlueScript Drosophila melanogaster 38,015 27-Nov-98Drosophila melanogaster cDNA clone LD0081 5prime, mRNA sequence.rxa02408 1035 GB_PAT: I92047 551 I92047 Sequence 14 from patent US5726299. Unknown. 46 01-DEC-1998 GB_PAT: I78759 549 I78759 Sequence 15from patent US 5693781. Unknown. 45,438 3-Apr-98 GB_PAT: I92048 549I92048 Sequence 15 from patent US 5726299. Unknown. 45,438 01-DEC-1998rxa02409 660 GB_EST19: AA438982 672 AA438982 LD13390.5prime LDDrosophila melanogaster embryo Drosophila melanogaster 36,13 27-Nov-98BlueScript Drosophila melanogaster cDNA clone LD13390 5prime, mRNAsequence, GB_EST28: AI513795 635 AI513795 GH26887.5prime GH Drosophilamelanogaster head Drosophila melanogaster 38,84 16-MAR-1999 pOT2Drosophila melanogaster cDNA clone GH26887 5prime, mRNA sequence.GB_HTG3: AC009601 40300 AC009601 Leishmania major chromosome 35 cloneL165 strain Friedlin, Leishmania major 35,759 30-Sep-99 *** SEQUENCINGIN PROGRESS ***, 2 ordered pieces. rxa02412 603 GB_BA1: AB020624 1605AB020624 Corynebacterium glutamicum murl gene for D-glutamateCorynebacterium 40,237 24-Jul-99 racemase, complete cds. glutamicumGB_EST19: AA756805 646 AA756805 vv72b10.r1 Stratagene mouse skin(#937313) Mus musculus cDNA Mus musculus 34,483 21-Jan-98 clone IMAGE:1227931 5′ similar to gb: D21261 SM22-ALPHA HOMOLOG (HUMAN);, mRNAsequence. GB_RO: AF149291 1388 AF149291 Mus musculus transgelin mRNA,complete cds. Mus musculus 37,54 8-Jun-99 rxa02417 2247 GB_GSS14:AQ554774 813 AQ554774 RPCI-11-436G15.TV RPCI-11 Homo sapiens genomicHomo sapiens 34,649 28-MAY-1999 clone RPCI-11-436G15, genomic surveysequence. GB_GSS4: AQ713076 500 AQ713076 HS_5384_A2_C05_SP6E RPCI-11Human Male BAC Library Homo sapiens 35,2 13-Jul-99 Homo sapiens genomicclone Plate = 960 Col = 10 Row = E, genomic survey sequence. GB_STS:G47161 448 G47161 Z15758_1 Zebrafish AB Danio rerio STS genomic cloneZ15758 5′, Danio rerio 39,91 23-MAR-1999 sequence tagged site. rxa02421933 GB_HTG2: AC005708 76712 AC005708 Drosophila melanogaster chromosome2 clone DS08537 (D425) Drosophila melanogaster 36,207 15-Jan-99 map50C1-50C2 strain y2; cn bw sp, *** SEQUENCING IN PROGRESS ***, 20unordered pieces. GB_HTG3: AC005812 76721 AC005812 Drosophilamelanogaster chromosome 2 clone DS07345 (D445) map Drosophilamelanogaster 36,205 20-Sep-99 50C1-50C2 strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 8 unordered pieces. GB_HTG2: AC005673 77023AC005673 Drosophila melanogaster chromosome 2 clone DS00096 (D427) mapDrosophila melanogaster 39,321 30-Jul-99 50C1-50C4 strain y; cn bw sp,*** SEQUENCING IN PROGRESS ***, 12 unordered pieces. rxa02425 653GB_BA1: PFPHCOAHL 2700 Y13067 Pseudomonas fluorescens genes encodingp-hydroxycinnamoyl CoA Pseudomonas fluorescens 40,854 05-MAY-1998hydratase/lyase and vanillin: NAD+ oxidoreductase. GB_EST27: AI438343610 AI438343 SWOvAFCAP31F09SK Onchocerca volvulus adult female cDNAOnchocerca volvulus 41,244 09-MAR-1999 (SAW98MLW-OvAF) Onchocercavolvulus cDNA clone SWOvAFCAP31F09 5′, mRNA sequence. GB_BA1: XANHRPA1A1824 M99173 Xanthomonas campstris HrpA1 gene, complete cds. Xanthomonascampestris 37,52 14-Sep-93 rxa02427 510 GB_OV: CCA245635 2455 AJ245635Cyprinus carpio IL-1 gene for interleukin-1-beta. Cyprinus carpio 35,6145-Aug-99 GB_OV: AB010701 1213 AB010701 Cyprinus carpio mRNA forinterleukin-1 beta, complete cds. Cyprinus carpio 36,821 29-Jan-98GB_OV: CCA245635 2455 AJ245835 Cyprinus carpio IL-1 gene forinterleukin-1-beta. Cyprinus carpio 35,06 5-Aug-99 rxa02428 1257 GB_IN1:CEY40B1B 29313 AL032636 Caenorhabditis elegans cosmid Y40B1B, completesequence. Caenorhabditis elegans 37,068 12-Nov-99 GB_GSS12: AQ374513 640AQ374513 RPCI11-145N15.TJ RPCI-11 Homo sapiens genomic clone Homosapiens 35,636 20-MAY-1999 RPCI-11-145N15, genomic survey sequence.GB_IN1: CEY40B1B 29313 AL032636 Caenorhabditis elegans cosmid Y40B1B,complete sequence. Caenorhabditis elegans 32,8 12-Nov-99 rxa02430 309GB_BA1: MTCY1A11 30850 Z78020 Mycobacterium tuberculosis H37Rv completegenome: segment 83/162. Mycobacterium 64,61 17-Jun-98 tuberculosisGB_PR4: AC004998 135572 AC004998 Homo sapiens clone DJ164D05, completesequence. Homo sapiens 41,118 17-Jun-99 GB_PR2: AC002091 161799 AC002091Genomic sequence from Human 17, complete sequence. Homo sapiens 36,3939-Sep-97 rxa02433 723 GB_HTG5: AC009754 212978 AC009754 Homo sapienschromosome 15 clone RP11-519C12, WORKING DRAFT Homo sapiens 33,00817-Nov-99 SEQUENCE, 16 ordered pieces. GB_HTG5: AC009754 212978 AC009754Homo sapiens chromosome 15 clone RP11-519C12, WORKING Homo sapiens39,716 17-Nov-99 DRAFT SEQUENCE, 16 ordered pieces. GB_PR4: HUAC003108164564 AC003108 Human Chromosome 16 BAC clone Homo sapiens 35,1823-Nov-99 CIT987SK-327O24, complete sequence. rxa02437 933 GB_IN2:AC005650 60019 AC005650 Drosophila melanogaster, chromosome 2R, region59B4-59B7, Drosophila melanogaster 40,397 30-Jan-99 P1 clone DS02885,complete sequence. GB_IN2: AC005650 60019 AC005650 Drosophilamelanogaster, chromosome 2R, region Drosophila melanogaster 37,71930-Jan-99 59B4-59B7, P1 clone DS02885, complete sequence. GB_RO:AF081193 2250 AF081193 Mus musculuscalcium and DAG-regulated guaninenucleotide Mus musculus 37,835 28-Nov-98 exchange factor I mRNA,complete cds. rxa02443 1077 GB_HTG4: AC009370 59409 AC009370 Drosophilamelanogaster chromosome 3L/75C1 clone Drosophila melanogaster 35,4616-OCT-1999 RPCI98-35F4, *** SEQUENCING IN PROGRESS ***, 40 unorderedpieces. GB_HTG4: AC009370 59409 AC009370 Drosophila melanogasterchromosome 3L/75C1 clone RPCI98-35F4, Drosophila melanogaster 35,4616-OCT-1999 *** SEQUENCING IN PROGRESS ***, 40 unordered pieces.GB_EST9: AA081445 311 AA081445 zn18a01.r1 Stratagene neuroepitheliumNT2RAMI 937234 Homo sapiens cDNA clone Homo sapiens 36,334 21-OCT-1996IMAGE: 547752 5′, mRNA sequence. rxa02444 1401 GB_BA2: SCF76 18292AL121600 Streptomyces coelicolor cosmid F76. Streptomyces coelicolor39,226 29-Sep-99 A3(2) GB_PR2: HS1022J11 137658 AL049765 Human DNAsequence from clone 1022J11 on chromosome 20q13.13-13.2, complete Homosapiens 35,444 23-Nov-99 sequence. GB_HTG1: AC002345 132645 AC002345Homo sapiens chromosome 17 clone 20D5, *** SEQUENCING IN PROGRESS ***,Homo sapiens 35,106 25-Aug-97 10 unordered pieces. rxa02452 303GB_GSS14: AQ579499 825 AQ579499 nbxb0084D17f CUGI Rice BAC Library Oryzasativa genomic clone nbxb0084D17f, Oryza sativa 39,535 2-Jun-99 genomicsurvey sequence. GB_GSS14: AQ579499 825 AQ579499 nbxb0084D17f CUGI RiceBAC Library Oryza sativa genomic clone nbxb0084D17f, Oryza sativa 36,2132-Jun-99 genomic survey sequence. rxa02454 1365 GB_HTG3: AC007810 140175AC007810 Drosophila melanogaster chromosome 3 clone BACR14A01 (D720)RPCI-98 14.A.1 Drosophila melanogaster 33,931 17-Sep-99 map 90C—90Cstrain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 89 unordered pieces.GB_HTG3: AC007810 140175 AC007810 Drosophila melanogaster chromosome 3clone BACR14A01 (D720) RPCI-98 14.A.1 Drosophila melanogaster 33,93117-Sep-99 map 90C—90C strain y; cn bw sp, *** SEQUENCING IN PROGRESS***,89 unordered pieces. GB_PR3: AC005339 32360 AC005339 Homo sapienschromosome 19, cosmid R33729, complete sequence. Homo sapiens 38,13130-Jul-98 rxa02457 1233 GB_HTG3: AC009346 105005 AC009346 Drosophilamelanogaster chromosome 3 clone BACR03P13 (D672) RPCI-98 03.P.13Drosophila melanogaster 36,829 27-Aug-99 map 83A-83B strain y; cn bw sp,*** SEQUENCING IN PROGRESS ***, 83 unordered pieces. GB_EST20: AA820427436 AA820427 LD24042.5prime LD Drosophila melanogaster embryo pOT2Drosophila Drosophila melanogaster 38,018 25-Feb-99 melanogaster cDNAclone LD24042 5prime, mRNA sequence. GB_HTG3: AC009346 105005 AC009346Drosophila melanogaster chromosome 3 clone BACR03P13 (D672) RPCI-98Drosophila melanogaster 36,829 27-Aug-99 03.P.13 map 83A-83B strain y;cn bw sp, *** SEQUENCING IN PROGRESS ***, 83 unordered pieces. rxa02459858 GB_BA2: AF114233 1852 AF114233 Corynebacterium glutamicum5-enolpyruvylshikimate 3-phosphate synthase Corynebacterium 99,2487-Feb-99 (aroA) gene, complete cds. glutamicum GB_HTG1: CEY45F10_2110000 Z93245 Caenorhabditis elegans chromosome IV clone Y45F10, ***SEQUENCING IN Caenorhabditis elegans 35,621 17-Sep-97 PROGRESS ***, inunordered pieces. GB_HTG1: CEY45F10_2 110000 Z93245 Caenorhabditiselegans chromosome IV clone Y45F10, *** SEQUENCING IN Caenorhabditiselegans 35,621 17-Sep-97 PROGRESS ***, in unordered pieces. rxa02460rxa02461 531 GB_EST10: AA153371 590 AA153371 ms02a12.r1 Stratagene mouseembryonic carcinoma (#937317) Mus musculus Mus musculus 39,203 11-Feb-97cDNA clone IMAGE: 605758 5′ similar to gb: M24194 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT-LIKE PROTEIN (HUMAN); gb: X75313 M.musculus (MOUSE);, mRNA sequence. GB_EST10: AA153371 590 AA153371ms02a12.r1 Stratagene mouse embryonic carcinoma (#937317) Mus musculus41,92 11-Feb-97 Mus musculus cDNA clone IMAGE: 605758 5′ similar to gb:M24194 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT-LIKE PROTEIN(HUMAN); gb: X75313 M. musculus (MOUSE):, mRNA sequence. rxa02464 1323GB_HTG4: AC008754 86446 AC008754 Homo sapiens chromosome 19 cloneCITB-E1_3023J11, Homo sapiens 36,064 31-OCT-1999 *** SEQUENCING INPROGRESS ***, 73 unordered pieces. GB_HTG4: AC008754 86446 AC008754 Homosapiens chromosome 19 clone CITB-E1_3023J11, Homo sapiens 36,06431-OCT-1999 *** SEQUENCING IN PROGRESS ***, 73 GB_HTG4: AC008754 86446AC008754 Homo sapiens chromosome 19 clone CITB-E1_3023J11, Homo sapiens37,589 31-OCT-1999 *** SEQUENCING IN PROGRESS ***, 73 unordered pieces.rxa02465 522 GB_PR3: AC004960 143834 AC004960 Homo sapiens PAC cloneDJ1098B01 from 7q11.23-q21, complete sequence. Homo sapiens 35,015-Nov-98 GB_GSS9: AQ122158 428 AQ122158 HS_3083_A1_E10_MR CIT ApprovedHuman Genomic Sperm Library D Homo sapiens 39,72 22-Sep-98 Homo sapiensgenomic clone Plate = 3083 Col = 19 Row = I, genomic survey sequence.GB_BA2: AF053227 840 AF053227 Photobacterium leiognathi probable flavinreductase (luxG) gene, complete cds. Photobacterium leiognathi 37,57212-Jun-98 rxa02466 187 GB_EST21: AA942401 825 AA942401 LD26583.5prime LDDrosophila melanogaster embryo pOT2 Drosophila melanogaster 37,70525-Nov-98 Drosophila melanogaster cDNA clone LD26583 5prime, mRNAsequence. GB_GSS12: AQ400564 485 AQ400564 HS_5064_A1_G09_T7A RPCI-11Human Male BAC Library Homo sapiens 38,043 13-MAR-1999 Homo sapiensgenomic clone Plate = 640 Col = 17 Row = M, genomic survey sequence.GB_GSS12: AQ400564 485 AQ400564 HS_5064_A1_G09_T7A RPCI-11 Human MaleBAC Library Homo sapiens 37,647 13-MAR-1999 Homo sapiens genomic clonePlate = 640 Col = 17 Row = M, genomic survey sequence. rxa02467 348GB_HTG2: AC005718 149592 AC005718 Drosophila melanogaster chromosome 2clone DS02336 (D440) map 60C8-60D2 Drosophila melanogaster 40,52530-Jul-99 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 68unordered pieces. GB_HTG2: AC005718 149592 AC005718 Drosophilamelanogaster chromosome 2 clone DS02336 (D440) map 60C8-60D2 Drosophilamelanogaster 40,525 30-Jul-99 strain y; cn bw sp, *** SEQUENCING INPROGRESS ***, 68 unordered pieces. GB_PR3: AC004217 103319 AC004217 Homosapiens 12q24.1 PAC RPCI3-521E19 (Roswell Park Cancer Homo sapiens37,389 2-Jun-98 Institute Human PAC library) complete sequence. rxa02472414 GB_GSS12: AQ413964 550 AQ413964 RPCI-11-207C17.TV RPCI-11 Homosapiens genomic clone RPCI-11-207C17, Homo sapiens 37,87 23-MAR-1999genomic survey sequence. GB_IN2: CELR09H3 10687 U58740 Caenorhabditiselegans cosmid R09H3. Caenorhabditis elegans 37,408 26-MAY-1999GB_GSS13: AQ488397 734 AQ488397 RPCI-11-243H14.TV RPCI-11 Homo sapiensgenomic clone RPCI-11-243H14, Homo sapiens 37,569 24-Apr-99 genomicsurvey sequence. rxa02473 864 GB_HTG1: CEY7A5 235922 AL021576Caenorhabditis elegans chromosome X clone Y7A5, *** SEQUENCINGCaenorhabditis elegans 38,561 19-Aug-99 IN PROGRESS ***, in unorderedpieces. GB_HTG1: CEY7A5 235922 AL021576 Caenorhabditis eleganschromosome X clone Y7A5, *** SEQUENCING Caenorhabditis elegans 38,56119-Aug-99 IN PROGRESS ***, in unordered pieces. GB_IN1: CEY7A5A 68270AL034489 Caenorhabditis elegans cosmid Y7A5A, complete sequence.Caenorhabditis elegans 38,081 18-DEC-1998 rxa02475 1278 GB_BA1: AB0090782686 AB009078 Brevibacterium saccharolyticum gene for L-2.3-butanediolBrevibacterium 99,217 13-Feb-99 dehydrogenase, complete cds.saccharolytlcum GB_PH: AF074945 15644 AF074945 Mycoplasma arthritidisbacteriophage MAV1, complete genome. Mycoplasma arthritidis 36,87627-Jul-99 bacteriophage MAV1 GB_BA1: MTV008 63033 AL021246 Mycobacteriumtuberculosis H37Rv complete genome; segment 108/162. Mycobacterium 37,5217-Jun-98 tuberculosis rxa02478 1338 GB_HTG1: AC002419 128340 AC002419Homo sapiens chromosome X clone bWXD40, *** SEQUENCING IN Homo sapiens34,7 12-Aug-97 PROGRESS ***, 2 unordered pieces. GB_PR3: AC004073 79612AC004073 Human Chromosome X, complete sequence. Homo sapiens 34,729-Jan-98 GB_HTG1: AC002419 128340 AC002419 Homo sapiens chromosome Xclone bWXD40, *** SEQUENCING IN Homo sapiens 34,7 12-Aug-97 PROGRESS***, 2 unordered pieces. rxa02482 933 GB_OV: AF077329 1645 AF077329Coturnix coturnix pro-alpha2(I) collagen mRNA, partial cds. Coturnixcoturnix 40,202 3-Feb-99 GB_PL2: SFU59150 2854 U59150 Sartorya fumigatanucleolar protein AfCbf5p (AfCBF5p) mRNA, complete cds. Aspergillusfumigatus 36,789 1-Jan-98 GB_BA2: AE000106 12554 AE000106 Rhizobium sp.NGR234 plasmid pNGR234a, section 43 of 46 of the complete Rhizobium sp.NGR234 36,63 12-DEC-1997 plasmid sequence. rxa02483 936 GB_HTG1:AC002345 132645 AC002345 Homo sapiens chromosome 17 clone 20D5, ***SEQUENCING IN PROGRESS***, Homo sapiens 37,942 25-Aug-97 10 unorderedpieces. GB_HTG1: AC002345 132645 AC002345 Homo sapiens chromosome 17clone 20D5, *** SEQUENCING IN Homo sapiens 37,942 25-Aug-97 PROGRESS***, 10 unordered pieces. GB_PR4: AF118569 24070 AF118569 Homo sapiensangiotensin I converting enzyme precursor (DCP1) gene, alternative Homosapiens 37,352 28-OCT-1999 splice products, complete cds. rxa02484 624GB_BA1: RLSPRLVCP 3696 Y09534 R. leguminosarum Symblosis Plasmid DNA,rlvCP gene. Rhizobium leguminosarum 38,003 26-Feb-97 GB_BA2: RLU230403931 U23040 Rhizobium leguminosarum bv. viciae putativeglycerol-3-phosphate transport Rhizobium leguminosarum 38,003 26-Aug-96protein (ugpC) gene, partial cds, and chemoreceptor protein (mcpA),putative 2-hydroxychromene-2-carboxylate bv. viciae isomerase, andputative alcohol dehydrogenase genes, complete cds. GB_BA1: NGORBKGME1580 L07845 Neisseria gonorrhoeae ribokinase (rbk) gene, 3′ end;ADP-L-glycero-D- Neisseria gonorrhoeae 46,939 11-OCT-1995 mannoheptoseepimerase (gme) gene, complete cds. rxa02486 759 GB_IN1: CELM02D8 40876U41034 Caenorhabditis elegans cosmid M02D8. Caenorhabditis elegans38,358 30-Nov-95 GB_IN2: CELC36C5 41596 AF016444 Caenorhabditis eleganscosmid C36C5. Caenorhabditis elegans 38,482 08-OCT-1999 GB_HTG3:AC011467 188118 AC011467 Homo sapiens chromosome 19 cloneCIT-HSPC_457E21, *** SEQUENCING Homo sapiens 37,954 07-OCT-1999 INPROGRESS ***, 59 unordered pieces. rxa02488 392 GB_HTG2: AC006765 274498AC006765 Caenorhabditis elegans clone Y43H11, *** SEQUENCING IN PROGRESS***, Caenorhabditis elegans 38,961 23-Feb-99 7 unordered pieces.GB_HTG2: AC006765 274498 AC006765 Caenorhabditis elegans clone Y43H11,*** SEQUENCING IN PROGRESS ***, Caenorhabditis elegans 38,961 23-Feb-997 unordered pieces. GB_HTG4: AC010035 173152 AC010035 Drosophilamelanogaster chromosome 3L/74B2 clone RPCO98- Drosophila melanogaster38,01 16-OCT-1999 6H1, *** SEQUENCING IN PROGRESS ***, 60 unorderedpieces. rxa02489 724 GB_GSS8: AQ050210 796 AQ050210 nbxb0003cD08r CUGIRice BAC Library Oryza Sativa genomic clone Oryza sativa 40,20124-MAR-1999 nbxb0003H15r, genomic survey sequence. GB_PL1: D87819 2036D87819 Oryza sativa mRNA for sucrose transporter, complete cds. Oryzasativa 39,356 26-DEC-1997 GB_STS: G53565 627 G53565 SHGC-83995 HumanHomo sapiens STS genomic, sequence tagged site. Homo sapiens 40,23725-Jun-99 rxa02495 2691 GB_BA1: MTCY19H9 20679 Z83857 Mycobacteriumtuberculosis H37Rv complete genome; segment 129/162. Mycobacterium40,853 18-Jun-98 tuberculosis GB_BA1: MTCY19H9 20679 Z83857Mycobacterium tuberculosis H37Rv complete genome; segment 129/162.Mycobacterium 40,358 18-Jun-98 tuberculosis GB_HTG1: HSDJ901O8 114599AL078461 Homo sapiens chromosome 20 clone RP5-901O8 map q11.1-11.23,Homo sapiens 34,059 25-Nov-99 *** SEQUENCING IN PROGRESS ***, inunordered pieces. rxa02496 930 GB_EST36: AV201062 373 AV201062 AV201062Yuji Kohara unpublished cDNA Caenorhabditis elegans cDNA cloneCaenorhabditis elegans 41,287 26-Jul-99 yk250f11 5′, mRNA sequence.GB_IN1: CELC10F3 40172 AF022968 Caenorhabditis elegans cosmid C10F3.Caenorhabditis elegans 35,217 10-Sep-97 GB_EST29: AI612578 357 AI612578TENG0372 T. Cruzi epimastigote normalised cDNA Library Trypanosoma cruziTrypanosoma cruzi 39,474 7-Jul-99 cDNA clone n715.r 5′, mRNA sequence.rxa02498 927 GB_BA2: CGU31225 1817 U31225 Corynebecterium glutamicumL-proline: NADP+ 5-oxidoreductase (proC) Corynebacterium 92,58 2-Aug-96gene, complete cds. glutamicum GB_PR2: AP000197 100000 AP000197 Homosapiens genomic DNA, chromosome 21q22.1, D21S226-AML region, Homosapiens 36,344 20-Nov-99 clone B355D16-T1073, segment 3/8, completesequence. GB_PR2: AP000093 100000 AP000093 Homo sapiens genomic DNA of21q22.1, GART and AML related, Homo sapiens 36,344 25-Sep-99B335D16-P10G11 region, segment 3/7, complete sequence. rxa02500 222GB_BA1: MTCY20G9 37218 Z77162 Mycobacterium tuberculosis H37Rv completegenome; segment 25/162. Mycobacterium 58,257 17-Jun-98 tuberculosisGB_BA1: U00018 42991 U00018 Mycobacterium leprae cosmid B2168.Mycobacterium leprae 44,776 01-MAR-1994 GB_BA1: SCE68 38084 AL079345Streptomyces coelicolor cosmid E68. Streptomyces coelicolor 37,62416-Jul-99 A3(2) rxa02505 294 GB_RO: MM2B4J 289 X00621 Mouse hybridoma2B4 gene fragment (J-region) for T-cell receptor. Mus musculus 36,36410-Nov-95 GB_RO: MUSTCBJB1 2276 K02802 Mouse T-cell receptor germlinebeta-chain J-beta-2 gene cluster, including J-beta- Mus musculus 32,86227-Apr-93 [2.1,2.2,2.3,2.4,2.5,2.psi,2.6] genes. GB_RO: MMAE000665199101 AE000665 Mus musculus TCR beta locus from bases 501860 to 700960(section 3 of 3) Mus musculus 36,879 4-Sep-97 of the complete sequence.rxa02506 rxa02510 759 GB_OM: PIGMTNADP 1585 M86719 Pig mitochondrialNADP-isocitrate dehydrogenase mRNA, 3′ end. Sus scrofa 36,963 12-Jun-93GB_EST17: AA629042 359 AA629042 zu77d08.s1 Soares_testis_NHT Homosapiens cDNA clone IMAGE: 744015 3′, Homo sapiens 37,184 16-OCT-1997mRNA sequence. GB_EST20: AA837524 528 AA837524 oe31d07.s1 NCI_CGAP_Pr25Homo sapiens cDNA clone IMAGE: 1410157 similar Homo sapiens 40,03926-Feb-98 to gb: X69391 60S RIBOSOMAL PROTEIN L6 (HUMAN);, mRNAsequence. rxa02514 857 GB_PR2: CNS01DS9 175148 AL121694 Human chromosome14 DNA sequence *** IN PROGRESS *** BAC R-701B16 of Homo sapiens 35,1858-Nov-99 RPCI-11 library from chromosome 14 of Homo sapiens (Human),complete sequence. GB_PR4: AC006222 165643 AC006222 Homo sapiens, clonehRPK.12_A_1, complete sequence. Homo sapiens 33,411 15-Jan-99 GB_PR4:AC006222 165643 AC006222 Homo sapiens, clone hRPK.12_A_1, completesequence. Homo sapiens 35,629 15-Jan-99 rxa02518 534 GB_BA1: MTV00732806 AL021184 Mycobacterium tuberculosis H37Rv complete genome; segment64/162. Mycobacterium 57,965 17-Jun-98 tuberculosis GB_EST16: AA576027231 AA576027 nm57e05.s1 NCI_CGAP_Br3 Homo sapiens cDNA clone IMAGE:1072352 Homo sapiens 47,674 9-Sep-97 3′ similar to TR: G1001455 G1001455HYPOTHETICAL 141.7 KD PROTEIN. ;, mRNA sequence. GB_BA2: AE000226 10466AE000226 Escherichia coli K-12 MG1655 section 116 of 400 of the completegenome. Escherichia coli 38,447 12-Nov-98 rxa02519 1752 GB_IN2: DMNRG28574 AF050085 Drosophila melanogaster neuroglian (nrg) gene, exons 3-6,7a, 7b and alternatively Drosophila melanogaster 38,498 5-Aug-98 splicedproducts, complete cds. GB_IN2: AC004322 32480 AC004322 Drosophilamelanogaster DNA sequence (P1 DS01962 (D216)), complete sequence.Drosophila melanogaster 36,126 29-Aug-98 GB_HTG2: AC008188 129128AC008188 Drosophila melanogaster chromosome 2 clone BACR08I18 (D660)RPCI-98 08.I.18 Drosophila melanogaster 35,66 2-Aug-99 map 56A2-56B1strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 72 unordered pieces.rxa02520 807 GB_GSS3: B68449 228 B68449 CIT-HSP-2025P8.TF CIT-HSP Homosapiens genomic clone 2025P8, genomic Homo sapiens 42,544 21-Jun-98survey sequence. GB_HTG3: AC010642 45982 AC010642 Homo sapienschromosome 19 clone LLNL-R_245B6, *** SEQUENCING Homo sapiens 34,54316-Sep-99 IN PROGRESS ***, 26 unordered pieces. GB_HTG3: AC010642 45982AC010642 Homo sapiens chromosome 19 clone LLNL-R_245B6, *** SEQUENCINGHomo sapiens 34,543 16-Sep-99 IN PROGRESS ***, 26 unordered pieces.rxa02521 1566 GB_BA1: SCC22 22115 AL096839 Streptomyces coelicolorcosmid C22. Streptomyces coelicolor 40,885 12-Jul-99 GB_BA1: BSUB0017217420 Z99120 Bacillus subtilis complete genome (section 17 of 21): from3197001 to 3414420. Bacillus subtilis 38,441 26-Nov-97 GB_BA1: MLCL53636224 Z99125 Mycobacterium leprae cosmid L536. Mycobacterium leprae37,233 04-DEC-1998 rxa02524 813 GB_IN1: CELF42H10 28687 L08403 C.elegans cosmid F42H10. Caenorhabditis elegans 32,878 22-OCT-1993 GB_IN1:CEU02289 4824 U02289 Caenorhabditis elegans Bristol N2 GTPase-activatingprotein (CEGAP) Caenorhabditis elegans 34,457 11-Jun-94 mRNA, partialcds. GB_IN1: CELF42H10 28687 L08403 C. elegans cosmid F42H10.Caenorhabditis elegans 34,243 22-OCT-1993 rxa02525 501 GB_EST36:AU076280 416 AU076280 AU076280 Rice green shoot Oryza sativa cDNA cloneS10896_11A, mRNA Oryza sativa 42,671 27-Jul-99 sequence. GB_EST1: D34202355 D34202 CELK042E5R Yuji Kohara unpublished cDNA Caenorhabditiselegans cDNA Caenorhabditis elegans 42,553 8-Aug-94 clone yk42e5 3′,mRNA sequence. GB_EST1: D34202 355 D34202 CELK042E5R Yuji Koharaunpublished cDNA Caenorhabditis elegans cDNA Caenorhabditis elegans37,892 8-Aug-94 clone yk42e5 3′, mRNA sequence. rxa02534 927 GB_EST15:AA490533 426 AA490533 aa51h04.r1 NCI_CGAP_GCB1 Homo sapiens cDNA cloneIMAGE: 824503 5′, Homo sapiens 41,176 15-Aug-97 mRNA sequence. GB_PL2:ATFCA3 200252 Z97338 Arabidopsis thaliana DNA chromosome 4, ESSA I FCAArabidopsis thaliana 35,568 27-Aug-99 contig fragment No. 3. GB_PL2:ATFCA3 200252 Z97338 Arabidopsis thaliana DNA chromosome 4, ESSA I FCAcontig Arabidopsis thaliana 37,376 27-Aug-99 fragment No. 3. rxa02537585 GB_HTG4: AC009732 165576 AC009732 Drosophila melanogaster chromosome2 clone BACR05E17 (D1059) Drosophila melanogaster 30,727 26-OCT-1999RPCI-98 05.E.17 map 57F—57F strain y; cn bw sp, *** SEQUENCING INPROGRESS ***, 83 unordered pieces. GB_HTG4: AC009732 165576 AC009732Drosophila melanogaster chromosome 2 clone BACR05E17 (D1059) Drosophilamelanogaster 30,727 26-OCT-1999 RPCI-98 05.E.17 map 57F—57F strain y′,cn bw sp, *** SEQUENCING IN PROGRESS ***, 83 unordered pieces. GB_HTG4:AC009732 165576 AC009732 Drosophila melanogaster chromosome 2 cloneBACR05E17 (D1059) Drosophila melanogaster 36,46 26-OCT-1999 RPCI-9805.E.17 map 57F—57F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***,83 unordered pieces. rxa02538 795 GB_GSS15: AQ606090 658 AQ606090HS_5392_A1_E12_T7A RPCI-11 Human Male BAC Library Homo sapiens Homosapiens 39,369 10-Jun-99 genomic clone Plate = 968 Col = 23 Row = l,genomic survey sequence. GB_BA1: AXACE 5323 X94981 A. xylinum aceB,aceC, aceD, and aceE genes. Acetobacter xylinus 37,009 12-Feb-97 GB_BA1:AXACE 5323 X94981 A. xylinum aceB, aceC, aceD, and aceE genes.Acetobacter xylinus 37,879 12-Feb-97 rxa02540 561 GB_BA1: MTY13E10 35019Z95324 Mycobacterium tuberculosis H37Rv complete genome; segment 18/162.Mycobacterium 51,002 17-Jun-98 tuberculosis GB_BA1: MTDNAGRP 4644 X58406M. tuberculosis dnaK, grpE, and dnaJ genes. Mycobacterium 51,00221-OCT-1992 tuberculosis GB_BA1: AB007847 2400 AB007847 Rhodococcusrhodochrous gene for 3-ketosteroid-delta1-dehydrogenase, complete cds.Rhodococcus rhodochrous 53,723 13-Feb-99 rxa02544 1521 GB_PAT: E140412776 E14041 gDNA encoding laminaripentaose forming enzyme (LPHase).Streptomyces sp. 47,351 28-Jul-99 GB_HTG3: AC010592 45971 AC010592 Homosapiens chromosome 5 clone CIT-HSPC_459H20, *** SEQUENCING IN Homosapiens 37,689 16-Sep-99 PROGRESS ***, 38 unordered pieces. GB_HTG3:AC010592 45971 AC010592 Homo sapiens chromosome 5 clone CIT-HSPC_459H20,*** SEQUENCING IN Homo sapiens 37,689 16-Sep-99 PROGRESS ***, 38unordered pieces. rxa02545 681 GB_HTG3: AC009016 128095 AC009016 Homosapiens chromosome 5 clone P1_889E7, *** SEQUENCING Homo sapiens 34,7633-Aug-99 IN PROGRESS ***, 67 PROGRESS ***, 67 unordered pieces. GB_HTG3:AC009016 128095 AC009016 Homo sapiens chromosome 5 clone P1_889E7, ***SEQUENCING Homo sapiens 34,763 3-Aug-99 IN PROGRESS ***, 67 unorderedpieces. GB_HTG3: AC009010 72817 AC009010 Homo sapiens chromosome 5 cloneP1_1352A1, *** SEQUENCING Homo sapiens 34,763 3-Aug-99 IN PROGRESS ***,19 unordered pieces. rxa02546 1227 GB_HTG3: AC006519 134365 AC006519Homo sapiens clone RPCI5-951N9, *** SEQUENCING IN Homo sapiens 32,86816-Sep-99 PROGRESS ***, 41 unordered pieces. GB_BA1: D90738 17528 D90738Escherichia coli genomic DNA. (23.0-23.4 min). Escherichia coli 38,6747-Feb-99 GB_HTG3: AC006519 134365 AC006519 Homo sapiens cloneRPCI5-951N9, *** SEQUENCING IN PROGRESS ***, Homo sapiens 32,86816-Sep-99 41 unordered pieces. rxa02549 2826 GB_BA1: CGBPHI16 962 Y12472C. glutamicum DNA, attachment site bacteriophage Phi-16. Corynebacterium41,702 05-MAR-1999 glutamicum GB_BA2: AE001095 10592 AE001095Archaeoglobus fulgidus section 12 of 172 of the complete genome.Archaeoglobus fulgidus 36,817 15-DEC-1997 GB_EST20: AA887411 587AA887411 oj37d06.s1 NCI_CGAP_Lu5 Homo sapiens cDNA clone IMAGE: Homosapiens 41,738 9-Jun-98 1500491 3′ similar to gb: X69908_rna1 ATPSYNTHASE LIPID-BINDING PROTEIN P2 PRECURSOR (HUMAN);, mRNA sequence.rxa02552 918 GB_GSS9: AQ129371 377 AQ129371 HS_3045_A2_B07_MR CITApproved Human Genomic Sperm Library D Homo sapiens 42,857 23-Sep-98Homo sapiens genomic clone Plate = 3045 Col = 14 Row = C, genomic surveysequence. GB_GSS14: AQ566979 600 AQ566979 HS_2105_A2_D12_MR CIT ApprovedHuman Genomic Sperm Library D Homo sapiens 35,443 29-MAY-1999 Homosapiens genomic clone Plate = 2105 Col = 24 Row = G, genomic surveysequence. GB_IN1: MEPAP 4636 X54422 M. edulis gene for polyphenolicadhesive protein. Mytilus edulis 35,619 27-MAY-1992 rxa02554 747 GB_PR4:AC004882 171878 AC004882 Homo sapiens PAC clone DJ076B20 from 22,complele sequence. Homo sapiens 37,346 22-OCT-1999 GB_PR4: AC004882171878 AC004882 Homo sapiens PAC clone DJ076B20 from 22, completesequence. Homo sapiens 38,44 22-OCT-1999 GB_BA2: U32830 16388 U32830Haemophilus influenzae Rd section 145 of 163 of the complete genome.Haemophilus influenzae Rd 33,514 29-MAY-1998 rxa02555 726 GB_GSS1:FR0020618 466 AL013501 F. rubripes GSS sequence, clone 042H13bD8,genomic survey sequence. Fugu rubripes 40,215 10-DEC-1997 GB_GSS1:FR0020576 555 AL013459 F. rubripes GSS sequence, clone 042H13aE5,genomic survey sequence. Fugu rubripes 35,379 10-DEC-1997 GB_GSS1:FR0020585 431 AL013468 F. rubripes GSS sequence, clone 042H13aH5,genomic survey sequence. Fugu rubripes 39,718 10-DEC-1997 rxa02564 1125GB_PR3: AC004976 127425 AC004976 Homo sapiens PAC clone DJ1143H19 from7p14-p15, complete sequence. Homo sapiens 37,364 5-Nov-98 GB_PR2:HUAC002038 161973 AC002038 Homo sapiens chromosome 2 clone 101B6 map2p11, complete sequence. Homo sapiens 36,404 30-Jun-97 GB_HTG3: AC010791111643 AC010791 Homo sapiens chromosome 17 clone 6_M_14 map 17, ***SEQUENCING Homo sapiens 34,293 22-Sep-99 IN PROGRESS ***, 8 unorderedpieces. rxa02568 1753 GB_BA1: FT16SRNAA 1521 Z21931 F. tularensis 16SrRNA. Francisella tularensis 39,065 5-Jun-97 GB_BA1: FT16SRNAB 1520Z21932 F. tularensis 16S rRNA. Francisella tularensis 37,807 16-DEC-1997GB_BA1: FP16SRNAA 1518 Z21933 F. philomiragia 16S rRNA. Francisellaphilomiragia 36,38 5-Jun-97 rxa02569 873 GB_GSS13: AQ469518 553 AQ469518CITBI-E1-2596J20.TR CITBI-E1 Homo sapiens genomic clone 2596J20, genomicHomo sapiens 39,201 23-Apr-99 survey sequence. GB_GSS12: AQ403903 495AQ403903 HS_5058_B1_F07_T7A RPCI-11 Human Male BAC Library Homo sapiensHomo sapiens 36,049 13-MAR-1999 genomic clone Plate = 634 Col = 13 Row =L, genomic survey sequence. GB_PR2: AF004715 2889 AF004715 Homo sapiensjerky gene product homolog mRNA, complete cds. Homo sapiens 35,6896-Aug-97 rxa02570 765 GB_BA1: CGU43535 2531 U43535 Corynebacteriumglutamicum multidrug resistance protein (cmr) gene, complete cds.Corynebacterium 38,165 9-Apr-97 glutamicum GB_EST33: AI776398 499AI776398 EST257498 tomato resistant, Cornell Lycopersicon esculentumcDNA clone Lycopersicon esculentum 42,084 29-Jun-99 cLER18I10, mRNAsequence. GB_EST23: AI119807 431 AI119807 uc21a06.r1 Soares mousemammary gland NbMMG Mus musculus cDNA clone Mus musculus 40,281 2-Sep-98IMAGE: 1398610 5′, mRNA sequence. rxa02573 rxa02575 1258 GB_BA1: SCGD333779 AL096822 Streptomyces coelicolor cosmid GD3. Streptomycescoelicolor 39,742 8-Jul-99 GB_RO: AC002108 41125 AC002108 Genomicsequence from Mouse 4, complete sequence. Mus musculus 36,1 29-MAY-1997GB_PR1: HUMIDS 36845 L35485 Homo sapiens iduronate sulphate sulphatase(IDS) gene, complete cds. Homo sapiens 34,183 16-Aug-94 rxa02576 1545GB_GSS15: AQ618143 582 AQ618143 HS_5168_B1_H08_T7A RPCI-11 Human MaleBAC Library Homo sapiens Homo sapiens 34,874 15-Jun-99 genomic clonePlate = 744 Col = 15 Row = P, genomic survey sequence. GB_OV: XLFB1A12172 X64759 X. laevis mRNA for transcription factor (clone XLFB1a1).Xenopus laevis 38,589 26-Jan-93 GB_PR4: AC005039 151316 AC005039 Homosapiens clone NH0512E16, complete sequence. Homo sapiens 33,57514-Jan-99 rxa02577 1008 GB_PL2: AF034976 7130 AF034976 Pilayellalittoralis ribosomal protein S14 (rps14) gene, partial cds; ATPasesubunit Mitochondrion Pilayella 34,69 22-Jun-98 8 (atp8) gene, completecds; tRNA-Ser gene, complete sequence; ribosomal littoralis protein S10(rps10) and ribosomal protein L31 (rpl31) genes, complete cds; tRNA-Sergene, complete sequence; T7-like RNA polymerase (rpox) gene, completecds; and unknown genes, mitochondrial genes for mitochondrial products.GB_EST30: AI655188 456 AI655188 wb67g02.x1 NCI_CGAP_GC6 Homo sapienscDNA clone IMAGE: 2310770 3′, Homo sapiens 39,198 04-MAY-1999 mRNAsequence. GB_PL2: AF034976 7130 AF034976 Pilayella littoralis ribosomalprotein S14 (rps14) gene, partial cds; ATPase subunit MitochondrionPilayella 39,959 22-Jun-98 8 (atp8) gene, complete cds; tRNA-Ser gene,complete sequence; ribosomal protein littoralis S10 (rps10) andribosomal protein L31 (rpl31) genes, complete cds; tRNA-Ser gene,complete sequence; T7-like RNA polymerase (rpox) gene, complete cds; andunknown genes, mitochondrial genes for mitochondrial products. rxa02584474 GB_PR2: AP000191 100000 AP000191 Homo sapiens genomic DNA,chromosome 21q22.1, D21S226-AML region, Homo sapiens 37,199 20-Nov-99clone Q78C10-f32E9, segment 18/21, complete sequence. GB_EST13: AA349881293 AA349881 EST56832 infant brain Homo sapiens cDNA 5′ end similar toEST containing Homo sapiens 42,466 21-Apr-97 Alu repeat, mRNA sequence.GB_EST23: AI078215 404 AI078215 oz12h12.x1Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens cDNA clone Homo sapiens48,78 29-Sep-98 IMAGE: 1675175 3′similar to contains Alu repetitiveetement; contains element THR repetitive, element;, mRNA sequence.rxa02585 1104 GB_PR2: AP000115 100000 AP000115 Homo sapiens genomic DNAof 21q22.1, GART and AML related, Q78C10-149C3 Homo sapiens 35,50225-Sep-99 region, segment 18/20, complete sequence. GB_PR2: AP000191100000 AP000191 Homo sapiens genomic DNA, chromosome 21q22.1,D21S226-AML region, clone Homo sapiens 35,502 20-Nov-99 Q78C10-f32E9,segment 18/21, complete sequence. GB_PR2: AP000047 50188 AP000047 Homosapiens genomic DNA, chromosome 21q22.1, segment 18/28, Homo sapiens35,502 20-Nov-99 complete sequence. rxa02588 807 GB_BA1: MTCY8D5 39730Z92669 Mycobacterium tuberculosis H37Rv complete genome; segment 12/162.Mycobacterium 38,354 18-Jun-98 tuberculosis GB_BA1: MTCY349 43523 Z83018Mycobacterium tuberculosis H37Rv complete genome; segment 131/162.Mycobacterium 39,949 17-Jun-98 tuberculosis GB_HTG2: AC007879 158841AC007879 Homo sapiens clone NH0309L06, *** SEQUENCING IN PROGRESS ***,Homo sapiens 36,835 31-Jul-99 2 unordered pieces. rxa02591 1953 GB_BA1:MTCY8D5 39730 Z92669 Mycobacterium tuberculosis H37Rv complete genome;segment 12/162. Mycobacterium 65,398 18-Jun-98 tuberculosis GB_BA1:MLCL622 42498 Z95398 Mycobacterium leprae cosmid L622. Mycobacteriumleprae 63,875 24-Jun-97 GB_BA1: CHBATP2OP 5477 L08777 Chlorobiumlimicola atp2 operon. Chlorobium limicola 37,979 26-Apr-93 rxa02593 720GB_GSS1: CNS0056G 994 AL057090 Drosophila melanogaster genome surveysequence T7 end of BAC # BACR11M23 Drosophila melanogaster 27,2063-Jun-99 of RPCI-98 library from Drosophila melanogaster (fruit fly),genomic survey sequence. GB_GSS1: CNS0056G 994 AL057090 Drosophilamelanogaster genome survey sequence T7 end of BAC # BACR11M23 Drosophilamelanogaster 30,27 3-Jun-99 of RPCI-98 library from Drosophilamelanogaster (fruit fly), genomic survey sequence. rxa02598 714 GB_IN1:PFMAL3P5 86829 AL034556 Plasmodium falciparum MAL3P5, complete sequence.Plasmodium falciparum 40,057 04-OCT-1999 GB_PL1: AB024026 23026 AB024026Arabidopsis thaliana genomic DNA, chromosome 5, TAC clone: K15O15,Arabidopsis thaliana 38,865 20-Nov-99 complete sequence. GB_BA2:AE000930 15553 AE000930 Methanobacterium thermoautotrophicum from bases1592014 to 1607566 Methanobacterium 36,804 15-Nov-97 (section 136 of148) of the complete genome. thermoautotrophicum rxa02600 1521 GB_IN2:AC004301 68620 AC004301 Drosophila melanogaster DNA sequence (P1 DS07134(D192)), complete sequence. Drosophila melanogaster 36,063 29-MAY-1998GB_PL2: AC007504 125021 AC007504 Arabidopsis thaliana chromosome I BACF13F21 genomic sequence, Arabidopsis thaliana 37,074 9-Jul-99 completesequence. GB_PH: AF125520 61670 AF125520 Bacteriophage 933W, completegenome. Bacteriophage 933W 35,396 16-Apr-99 rxa02601 2112 GB_BA1: MTV02623740 AL022076 Mycobacterium tuberculosis H37Rv complete genome; segment157/162. Mycobacterium 38,676 24-Jun-99 tuberculosis GB_BA2: SSU731282331 U73128 Sphingomonas sp. A8AN3 catechol 2,3-dioxygenase gene,complete cds and Sphingomonas sp. A8AN3 40,02 1-Feb-99 2-hydroxymuconicsemialdehyde hydrolase and 2-hydroxymuconic semialdehyde dehydrogenasegenes, partial cds. GB_BA2: SSU73128 2331 U73128 Sphingomonas sp. A8AN3catechol 2,3-dioxygenase gene, complete cds and Sphingomonas sp. A8AN340,101 1-Feb-99 2-hydroxymuconic semialdehyde hydrolase and2-hydroxymuconic semialdehyde dehydrogenase genes, partial cds. rxa02602627 GB_PR3: AF006751 3106 AF006751 Homo sapiens ES/130 mRNA, completecds. Homo sapiens 37,582 10-Jul-98 GB_PR3: AF006751 3106 AF006751 Homosapiens ES/130 mRNA, complete cds. Homo sapiens 38,462 10-Jul-98GB_GSS9: AQ090116 404 AQ090116 HS_3000_B1_E09_MF CIT Approved HumanGenomic Sperm Library D Homo sapiens 39,481 26-Aug-98 Homo sapiensgenomic clone Plate = 3000 Col = 17 Row = J, genomic survey sequence.rxa02604 2199 GB_PL1: CREHIH3G 4358 L41841 Chlamydomonas reinhardtiihistone H3, histone H4, histone H2B, and histone H2A Chlamydomonasreinhardtii 37,5 16-MAY-1996 genes, complete cds. GB_GSS13: AQ455681 621AQ455681 HS_5068_B1_E01_T7A RPCI-11 Human Male BAC Library Homo Homosapiens 36,246 21-Apr-99 sapiens genomic clone Plate = 644 Col = 1 Row =J, genomic survey sequence. GB_GSS6: AQ829471 392 AQ829471HS_5442_A2_F11_SP6E RPCI-11 Human Male BAC Library Homo Homo sapiens42,347 27-Aug-99 sapiens genomic clone Plate = 1018 Col = 22 Row = K,genomic survey sequence. rxa02606 1494 GB_PAT: A26027 2547 A26027 C.melassecola gene for extracellular antigen PS1. Corynebacterium 42,8572-Apr-95 melassecola GB_BA1: CGCOP1G 2547 X66078 C. glutamicum cop1 genefor PS1. Corynebacterium 42,857 30-Jun-93 glutamicum GB_PR2: AP000134100000 AP000134 Homo sapiens genomic DNA of 21q22.1, GART and AML,f43D11-119B8 region, Homo sapiens 36,145 25-Sep-99 segment 9/10,complete sequence. rxa02609 372 GB_HTG3: AC009212 125452 AC009212Drosophila melanogaster chromosome 3 clone BACR01A18 (D669) RPCI-9801.A.18 Drosophila melanogaster 35,753 23-Aug-99 map 82E-82F strain y;cn bw sp, *** SEQUENCING IN PROGRESS***, 119 unordered pieces. GB_HTG3:AC009212 125452 AC009212 Drosophila melanogaster chromosome 3 cloneBACR01A18 (D669) RPCI-98 01.A.18 Drosophila melanogaster 35,75323-Aug-99 map 82E-82F strain y; cn bw sp, *** SEQUENCING IN PROGRESS***,119 unordered pieces. GB_HTG2: AC007589 134659 AC007589 Drosophilamelanogaster chromosome 3 clone BACR20D10 (D667) RPCI-98 20.D.10Drosophila melanogaster 35,484 2-Aug-99 map 82D-82E strain y; cn bw sp,*** SEQUENCING IN PROGRESS ***, 73 unordered pieces. rxa02610 1050GB_BA2: AF073776 5138 AF073776 Pseudomonas aeruginosa MexZ (mexZ),complete cds; and mexGH operon, Pseudomonas aeruginosa 38,32319-OCT-1998 complete sequence. GB_BA1: AB015853 5461 AB015853Pseudomonas aeruginosa gene for MexX and MexY, complete cds. Pseudomonasaeruginosa 38,447 13-Nov-98 GB_VI: HIM237805 2400 AJ237805 Humanimmunodeficiency virus type 1 partial envelope gene (gp160), isolateMP255. Human immunodeficiency 37,928 15-Jun-99 virus type 1 rxa02617 630GB_PR2: HSL81781 4041 L81781 Homo sapiens (subclone 7_e4 from P1 H25)DNA sequence, complete sequence. Homo sapiens 38,835 9-Apr-97 GB_HTG3:AC011430 106902 AC011430 Homo sapiens chromosome 5 clone P1_660D11, ***SEQUENCING IN Homo sapiens 38,662 06-OCT-1999 PROGRESS ***, 28 unorderedpieces. GB_HTG3: AC011430 106902 AC011430 Homo sapiens chromosome 5clone P1_660D11, *** SEQUENCING IN Homo sapiens 38,662 06-OCT-1999PROGRESS ***, 28 unordered pieces. rxa02619 1023 GB_BA1: CGL133719 1839AJ133719 Corynebacterium glutamicum yjcc gene, amtR gene and citE gene,partial. Corynebacterium 100 12-Aug-99 glutamicum GB_BA1: CGL133719 1839AJ133719 Corynebacterium glutamicum yjcc gene, amtR gene and citE gene,partial. Corynebacterium 100 12-Aug-99 glutamicum GB_EST18: AA734344 378AA734344 vv24f02.r1 Stratagene mouse heart (#937316) Mus musculus cDNAclone Mus musculus 37,968 7-Jan-98 IMAGE: 1223355 5′, mRNA sequence.rxa02620 789 GB_BA1: CGL133719 1839 AJ133719 Corynebacterium glutamicumyjcc gene, atmR gene and citE gene, partial. Corynebacterium 10012-Aug-99 glutamicum GB_BA1: CGL133719 1839 AJ133719 Corynebacteriumglutamicum yjcc gene, amtR gene and citE gene, partial. Corynebacterium100 12-Aug-99 glutamicum GB_EST16: C27457 252 C27457 C27457 Rice calluscDNA Oryza sativa cDNA clone C51917_1A, mRNA sequence. Oryza sativa39,044 6-Aug-97 rxa02624 1419 GB_HTG2: AC005995 170023 AC005995 Homosapiens clone DJ0042M02, *** SEQUENCING IN PROGRESS ***, Homo sapiens38,533 23-Apr-99 13 unordered pieces. GB_HTG2: AC005995 170023 AC005995Homo sapiens clone DJ0042M02, *** SEQUENCING IN PROGRESS ***, Homosapiens 38,533 23-Apr-99 13 unordered pieces. GB_PR4: AC004895 152927AC004895 Homo sapiens clone DJ0810E06, complete sequence. Homo sapiens38,533 29-MAY-1999 rxa02639 957 GB_BA1: MSGY409 41321 AD000017Mycobacterium tuberculosis sequence from clone y409. Mycobacterium 50,3710-DEC-1998 tuberculosis GB_BA1: MTCY409 30352 Z97188 Mycobacteriumtuberculosis H37Rv complete genome; segment 158/162. Mycobacterium38,039 17-Jun-98 tuberculosis GB_HTG2: AC006765 274498 AC006765Caenorhabditis elegans clone Y43H11, *** SEQUENCING IN PROGRESS***,Caenorhabditis elegans 35,225 23-Feb-99 7 unordered pieces. rxa02647 585GB_PAT: A45577 1925 A45577 Sequence 1 from Patent WO9519442.Corynebacterium 37,545 07-MAR-1997 glutamicum GB_PAT: A45579 1925 A45579Sequence 3 from Patent WO9519442. Corynebacterium 37,545 07-MAR-1997glutamicum GB_PAT: A45581 1925 A45581 Sequence 5 from Patent WO9519442.Corynebacterium 37,545 07-MAR-1997 glutamicum rxa02649 1125 GB_BA1:D90904 150894 D90904 Synechocystis sp. PCC6803 complete genome, 6/27,630555-781448. Synechocystis sp. 37,772 7-Feb-99 GB_PR3: HS941F9 127587Z95331 Human DNA sequence from BAC 941F9 on chromosome 22q11.2-qter.Homo sapiens 38,748 23-Nov-99 Contains ESTs, STSs and 3′ part ofFIBULIN-1 D PRECURSOR like gene, part of a Brain Protein E46 like geneand a CpG island, complete sequence. GB_BA1: D90904 150894 D90904Synechocystis sp. PCC6803 complete genome, 6/27, 630555-781448.Synechocystis sp. 36,364 7-Feb-99 rxa02652 702 GB_BA2: AF048749 24454AF048749 Bacteroides fragilis capsular polysaccharide biosynthesisBacteroides fragilis 37,464 25-Jun-99 operon, complete sequence.GB_HTG4: AC009244 318775 AC009244 Homo sapiens chromosome 7, ***SEQUENCING IN PROGRESS ***, Homo sapiens 35,447 26-OCT-1999 36 unorderedpieces. GB_HTG4: AC009244 318775 AC009244 Homo sapiens chromosome 7, ***SEQUENCING IN PROGRESS ***, Homo sapiens 35,447 26-OCT-1999 36 unorderedpieces. rxa02655 1107 GB_EST10: AA185699 290 AA185699 mt62d11.r1 Soares2NbMT Mus musculus cDNA clone IMAGE: Mus musculus 39,51 19-Feb-97 6344855′ similar to TR: G300372 G300372 CELL GROWTH REGULATING NUCLEOLARPROTEIN.;, mRNA sequence. GB_GSS13: AQ429764 439 AQ429764HS_5079_A2_C12_SP6E RPCI-11 Human Male BAC Library Homo sapiens 37,70131-MAR-1999 Homo sapiens genomic clone Plate = 655 Col = 24 Row = E,genomic survey sequence. GB_GSS8: AQ012380 646 AQ012380CIT-HSP-2300L9.TF CIT-HSP Homo sapiens genomic clone 2300L9, Homosapiens 38,874 6-Jun-98 genomic survey sequence. rxa02662 387 GB_HTG2:AC007802 118569 AC007802 Drosophila melanogaster chromosome 2 cloneBACR07I11 (D648) RPCI-98 Drosophila melanogaster 37,696 2-Aug-99 07.1.11map 58A1-58A2 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 70unordered pieces. GB_HTG2: AC007802 118569 AC007802 Drosophilamelanogaster chromosome 2 clone BACR07I11 (D648) Drosophila melanogaster37,696 2-Aug-99 RPCI-98 07.I.11 map 58A1-58A2 strain y; cn bw sp, ***SEQUENCING IN PROGRESS ***, 70 unordered pieces. GB_HTG2: AC007802118569 AC007802 Drosophila melanogaster chromosome 2 clone BACR07I11(D648) Drosophila melanogaster 35,616 2-Aug-99 RPCI-98 07.I.11 map58A1-58A2 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 70unordered pieces. rxa02665 603 GB_HTG1: AC002419 128340 AC002419 Homosapiens chromosome X clone bWXD40, *** SEQUENCING Homo sapiens 32,94112-Aug-97 IN PROGRESS***, 2 unordered pieces. GB_HTG1: AC002419 128340AC002419 Homo sapiens chromosome X clone bWXD40, *** SEQUENCING Homosapiens 32,941 12-Aug-97 IN PROGRESS ***, 2 unordered pieces. GB_GSS15:AQ655091 630 AQ655091 Sheared DNA-21B5.TF Sheared DNA Trypanosoma brucelTrypanosoma brucel 41,794 22-Jun-99 genomic clone Sheared DNA-21B5,genomic survey sequence. rxa02670 705 GB_HTG2: AC006450 177555 AC006450Homo sapiens chromosome 9 clone hRPK.85_O_21 map 9, Homo sapiens 41,37415-Jul-99 *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. GB_HTG2:AC006450 177555 AC006450 Homo sapiens chromosome 9 clone hRPK.85_O_21map 9, Homo sapiens 41,374 15-Jul-99 *** SEQUENCING IN PROGRESS ***, 2ordered pieces. GB_BA1: SPU86147 2268 U86147 Synechococcus PCC7942UDP-N-acetylmuramate-alanine ligase (murC) Synechococcus PCC7942 40,17715-Feb-97 gene, partial cds, UDP-N- acetylenolpyruvylglucosaminereductase (murB), and mercuric resistance operon regulatory protein(merR) genes, complete cds. rxa02672 1221 GB_BA1: MTV024 8189 AL022075Mycobacterium tuberculosis H37Rv complete Mycobacterium 53,197 17-Jun-98genome; segment 151/162. tuberculosis GB_BA1: MSGY23 40806 AD000016Mycobacterium tuberculosis Mycobacterium 37,5 10-DEC-1996 sequence fromclone y23. tuberculosis GB_EST38: AW029724 634 AW029724 EST272979 tomatocallus, TAMU Lycopersicon esculentum cDNA Lycopersicon esculentum 4015-Sep-99 clone cLEC28I17 similar to beta- ketoacyl-ACP synthase,putative, mRNA sequence. rxa02673 756 GB_GSS12: AQ356661 518 AQ356661CITBI-E1-2531G11.TF CITBI-E1 Homo sapiens genomic Homo sapiens 33,02224-Jan-99 clone 2531G11, genomic survey sequence. GB_IN1: CELC50A2 36582AF036689 Caenorhabditis elegans cosmid C50A2. Caenorhabditis elegans35,443 05-DEC-1997 GB_HTG2: AC006702 299864 AC006702 Caenorhabditiselegans clone Y104H12b, *** SEQUENCING Caenorhabditis elegans 35,44323-Feb-99 IN PROGRESS ***, 3 unordered pieces. rxa02678 1041 GB_HTG1:AP000452 83103 AP000452 Homo sapiens chromosome 11 clone PAC2 map 11q11,Homo sapiens 35,098 13-Sep-99 *** SEQUENCING IN PROGRESS ***, inunordered pieces. GB_HTG1: AP000452 83103 AP000452 Homo sepienschromosome 11 clone PAC2 map 11q11, Homo sapiens 35,098 13-Sep-99 ***SEQUENCING IN PROGRESS ***, in unordered pieces. GB_PR3: HS498I24 58190AL031057 Human DNA sequence from clone 498I24 on chromosome 6p22.1-22.3Homo sapiens 35,328 23-Nov-99 Contains STS, GSS and a CpG island,complete sequence. rxa02680 1407 GB_BA1: MLCB268 38859 AL022602Mycobacterium leprae cosmid B268. Mycobacterium leprae 37,797 27-Aug-99GB_BA1: MSGB1554CS 36548 L78814 Mycobacterium leprae cosmid B1554 DNAsequence. Mycobacterium leprae 36,9 15-Jun-96 GB_BA1: MSGB1551CS 36548L78813 Mycobacterium leprae cosmid B1551 DNA sequence. Mycobacteriumleprae 36,9 15-Jun-96 rxa02683 rxa02685 780 GB_HTG3: AC008640 198483AC008640 Homo sapiens chromosome 5 clone CIT978SKB_17P2, Homo sapiens37,299 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 70 unordered pieces.GB_HTG3: AC008640 198483 AC008640 Homo sapiens chromosome 5 cloneCIT978SKB_17P2, Homo sapiens 37,299 3-Aug-99 *** SEQUENCING IN PROGRESS***, 70 unordered pieces. GB_BA2: AE000945 11317 AE000945 Archaeoglobusfulgidus section 162 of 172 Archaeoglobus fulgidus 38,76 15-DEC-1997 ofthe complete genome. rxa02688 792 GB_BA1: CORPHEA 1088 M13774 C.glutamicum pheA gene encoding prephenate Corynebacterium 100 26-Apr-93dehydratase, complete cds. glutamicum GB_HTG2: AC007554 167095 AC007554Homo sapiens clone hRPK.74_A_1, Homo sapiens 35,226 14-MAY-1999 ***SEQUENCING IN PROGRESS ***, 10 unordered pieces. GB_HTG2: AC007554167095 AC007554 Homo sapiens clone hRPK.74_A_1, Homo sapiens 35,22614-MAY-1999 *** SEQUENCING IN PROGRESS ***, 10 unordered pieces.rxa02689 465 GB_GSS9: AQ110873 414 AQ110873 CIT-HSP-2378K10.TR CIT-HSPHomo sapiens genomic Homo sapiens 34,768 29-Aug-98 clone 2378K10,genomic survey sequence. GB_OV: DUKFASA 9138 M21635 Duck (A.platyrhynchos) S-acyl fatty acid synthase Anas platyrhynchos 39,17728-Apr-93 thioesterase gene, complete cds. GB_OV: DUKFASA 9138 M21635Duck (A. platyrhynchos) S-acyl fatty acid synthase Anas platyrhynchos35,022 28-Apr-93 thioesterase gene, complete cds. rxa02690 1221 GB_HTG4:AC010096 223607 AC010096 Homo sapiens chromosome unknown cloneNH0364A16, Homo sapiens 39,301 29-OCT-1999 WORKING DRAFT SEQUENCE, inunordered pieces. GB_HTG4: AC010096 223607 AC010096 Homo sapienschromosome unknown clone NH0364A16, Homo sapiens 39,301 29-OCT-1999WORKING DRAFT SEQUENCE, in unordered pieces. GB_BA2: AF132788 1411AF132788 Fischerella muscicola small subunit ribosomal RNA gene,Fischerella muscicola 36,156 1-Sep-99 partial sequence. rxa02693 1899GB_GSS5: AQ784372 542 AQ784372 HS_3181_A2_H12_T7C CIT Approved HumanGenomic Sperm Library Homo sapiens 41,546 3-Aug-99 D Homo sapiensgenomic clone Plate = 3181 Col = 24 Row = O, genomic survey sequence.GB_HTG4: AC010573 80511 AC010573 Drosophila melanogaster chromosome3L/70C12 clone RPCI98-2M13, Drosophila melanogaster 36,839 16-OCT-1999*** SEQUENCING IN PROGRESS ***, 45 unordered pieces. GB_EST18: AA696238640 AA696238 GM05354.5prime GM Drosophila melanogaster ovary BlueScriptDrosophila melanogaster 39,523 28-Nov-98 Drosophila melanogaster cDNAclone GM05354 5prime, mRNA sequence. rxa02696 579 GB_BA1: AB003132 4116AB003132 Corynebacterium glutamicum gene for Corynebacterium 1004-Aug-97 MurC, FtsQ, FtsZ, complete cds. glutamicum GB_PR4: AC00602490583 AC006024 Homo sapiens PAC clone DJ1166G19 from 7p12-p11.2, Homosapiens 36,049 20-Feb-99 complete sequence. GB_HTG1: HSJ657D12 315458AL109943 Homo sapiens chromosome X clone RP4-657D12 map q22.1-24, Homosapiens 36,475 24-Nov-99 *** SEQUENCING IN PROGRESS ***, in unorderedpieces. rxa02697 1650 GB_EST20: AA874010 365 AA874010 vw87b05.r1Stratagene mouse skin (#937313) Mus musculus cDNA Mus musculus 39,45219-MAR-1998 clone IMAGE: 1261905 5′, mRNA sequence. GB_EST30: AI658486599 AI658486 tu17a09.x1 NCI_CGAP_Pr28 Homo sapiens cDNA clone IMAGE:Homo sapiens 37,324 10-MAY-1999 2251288 3′, mRNA sequence. GB_EST20:AA874010 365 AA874010 vw87b05.r1 Stratagene mouse skin (#937313) Musmusculus Mus musculus 39,452 19-MAR-1998 cDNA clone IMAGE: 1261905 5′,mRNA sequence. rxa02700 1359 GB_BA1: SCF85 21420 AL110470 Streptomycescoelicolor cosmid F85. Streptomyces coelicolor 39,497 1-Sep-99 A3(2)GB_HTG5: AC011629 69344 AC011629 Homo sapiens chromosome 15 clone334_M_8 map 15, Homo sapiens 37,462 13-Nov-99 LOW-PASS SEQUENCESAMPLING. GB_HTG3: AC010106 157581 AC010106 Homo sapiens cloneNH0575J05, Homo sapiens 36,22 11-Sep-99 *** SEQUENCING IN PROGRESS ***,1 unordered pieces. rxa02701 1431 GB_BA1: MTCI65 34331 Z95584Mycobacterium tuberculosis H37Rv Mycobacterium 41,867 17-Jun-98 completegenome; segment 50/162. tuberculosis GB_BA1: MSGY348 40056 AD000020Mycobacterium tuberculosis Mycobacterium 43,338 10-DEC-1996 sequencefrom clone y348. tuberculosis GB_PR2: AP000117 151516 AP000117 Homosapiens genomic DNA of 21q22.1, GART and AML related, Homo sapiens36,037 25-Sep-99 Q78C10-149C3 region, segment 20/20, complete sequence.rxa02712 918 GB_BA2: AF124600 4115 AF124600 Corynebacterium glutamicumchorismate synthase (aroC), Corynebacterium 37,294 04-MAY-1999 shikimatekinase (aroK), and 3- glutamicum dehydroquinate synthase (aroB) genes,complete cds: and putative cytoplasmic peptidase (pepQ) gene, partialcds. GB_BA2: AF053071 1083 AF053071 Corynebacterium glutamicumdehydroquinate synthetase Corynebacterium 39,675 12-Sep-98 (aroB) gene,complete cds; glutamicum GB_BA1: BSTHRZ 19861 Z80360 B. subtilis thrZdownstream chromosomal region. Bacillus subtilis 34,002 24-Jun-98rxa02714 552 GB_PL2: ATF9F13 109936 AL080253 Arabidopsis thaliana DNAchromosome 4, BAC clone F9F13 (ESSA project). Arabidopsis thaliana39,252 16-Aug-99 GB_PL2: ATT29H11 87011 AL049659 Arabidopsis thalianaDNA chromosome 3, BAC clone T29H11. Arabidopsis thaliana 34,249 9-Jun-99GB_EST4: H37460 489 H37460 15589 Lambda-PRL2 Arabidopsis thalianaArabidopsis thaliana 45,869 30-DEC-1997 cDNA clone 181N17T7, mRNAsequence. rxa02715 513 GB_GSS13: AQ454067 534 AQ454067HS_5176_B1_A09_T7A RPCI-11 Homo sapiens 40,854 21-Apr-99 Human Male BACLibrary Homo sapiens genomic clone Plate = 752 Col = 17 Row = B, genomicsurvey sequence. GB_PR3: AC005495 185254 AC005495 Homo sapienschromosome 17, clone hRPK.293_K_20, complete sequence. Homo sapiens 33,230-OCT-1998 GB_PR3: AC005495 185254 AC005495 Homo sapiens chromosome 17,clone hRPK.293_K_20, complete sequence. Homo sapiens 36,273 30-OCT-1998rxa02720 825 GB_BA1: AB003132 4116 AB003132 Corynebacterium glutamicumgene for MurC, FtsQ, FtsZ, complete cds. Corynebacterium 98,788 4-Aug-97glutamicum GB_BA1: BLFTSZ 5546 Y08964 B. lactofermentum murC, ftsQ ordivD & ftsZ genes. Corynebacterium 100 08-OCT-1998 glutamicum GB_HTG4:AC009764 213581 AC009764 Homo sapiens chromosome 11 clone 381_O_22 map11, Homo sapiens 35,504 21-OCT-1999 *** SEQUENCING IN PROGRESS ***, 40unordered pieces. rxa02721 861 GB_BA1: BLFTSZ 5546 Y08964 B.lactofermentum murC, ftsQ or Corynebacterium 98,606 08-OCT-1998 divD &ftsZ genes. glutamicum GB_BA1: AB003132 4116 AB003132 Corynebacteriumglutamicum gene for MurC, FtsQ, FtsZ, complete cds. Corynebacterium97,561 4-Aug-97 glutamicum GB_BA1: SCI51 40745 AL109848 Strepomycescoelicolor cosmid I5t. Streptomyces coelicolor 39,11 16-Aug-99 A3(2)rxa02725 735 GB_BA1: CGU43535 2531 U43535 Corynebacterium glutamicummultidrug resistance protein (cmr) gene, complete cds. Corynebacterium42,043 9-Apr-97 glutamicum GB_EST1: D40448 361 D40448 RICS2437A Riceshoot Oryza sativa cDNA, mRNA sequence. Oryza sativa 41,944 11-Nov-94GB_BA2: AF030430 8330 AF038430 Thiobacillus neapolitanus carboxysomeoperon, complete sequence. Thiobacillus neapolitanus 39,202 21-Aug-98rxa02727 1035 GB_BA1: MTCY270 37586 Z95388 Mycobacterium tuberculosisH37Rv complete genome; segment 96/162. Mycobacterium 37,427 10-Feb-99tuberculosis GB_BA1: MTAG84 1458 X77129 M. tuberculosis Ag84 (CIE) gene.Mycobacterium 49,339 21-Jul-95 tuberculosis GB_BA1: AP000064 247695AP000064 Aeropyrum pernix genomic DNA, section 7/7. Aeropyrum pernix38,79 22-Jun-99 rxa02735 828 GB_BA1: TVCPT 1923 X56901 T. vulgaris cpTgene for carboxypeptidase T. Thermoactinomyces 37,688 30-OCT-1991vulgaris GB_GSS4: AQ682162 355 AQ682162 HS_5503_B2_C11_SP6E RPCI-11Human Homo sapiens 35,294 28-Jun-99 Male BAC Library Homo sapiensgenomic clone Plate = 1079 Col = 22 Row = F. genomic survey sequence.GB_EST21: AA915356 456 AA915356 vz29a08.r1 Soares 2NbMT Mus musculuscDNA clone IMAGE: Mus musculus 42,609 14-Apr-98 1327862 5′, mRNAsequence. rxa02736 1080 GB_PAT: E13655 2260 E13655 gDNA encodingglucose-6-phosphate dehydrogenase. Corynebacterium 99,62 24-Jun-98glutamicum GB_GSS13: AQ447106 711 AQ447106 mgxb0004P18f CUGI Rice BlastBAC Library Magnaporthe Magnaporthe grisea 38,158 8-Apr-99 griseagenomic clone mgxb0004P18f, genomic survey sequence. GB_EST36: AI900850670 AI900850 sb95c03.y1 Gm-c1012 Glycine max cDNA clone GENOME SYSTEMSGlycine max 37,479 08-DEC-1999 CLONE ID: Gm-c1012-413 5′ similar to SW:IF4Z_TOBAC Q40468 EUKARYOTIC INITIATION FACTOR 4A-15;, mRNA sequence.rxa02744 927 GB_PR1: AB026898 270000 AB026898 Homo sapiens DNA, DLEC1 toORCTL4 gene region, Homo sapiens 39,364 15-MAY-1999 section 1/2 (DLEC1,ORCTL3, ORCTL4 genes, complete cds). GB_PR1: AB026898 270000 AB026898Homo sapiens DNA, DLEC1 to ORCTL4 gene region, Homo sapiens 36,27515-MAY-1999 section 1/2 (DLEC1, ORCTL3, ORCTL4 genes, complete cds).GB_PR2: AP000498 100000 AP000498 Homo sapiens genomic DNA, chromosome3p21.3, clone: 603 to Homo sapiens 39,364 28-Sep-99 320, anti-oncogeneregion, section 1/3. rxa02751 597 GB_HTG4: AC010127 189552 AC010127 Homosapiens chromosome unknown clone Homo sapiens 36,149 29-OCT-1999NH0002I08, WORKING DRAFT SEQUENCE, in unordered pieces. GB_HTG4:AC010127 189552 AC010127 Homo sapiens chromosome unknown clone Homosapiens 36,149 29-OCT-1999 NH0002I08, WORKING DRAFT SEQUENCE, inunordered pieces. GB_HTG4: AC010127 189552 AC010127 Homo sapienschromosome unknown clone Homo sapiens 35,924 29-OCT-1999 NH0002I08,WORKING DRAFT SEQUENCE, in unordered pieces. rxa02756 1014 GB_RO:CRUGIPR 2785 D38103 Hamster mRNA for GIP (gastric inhibitory Cricetulussp. 38,501 8-Feb-99 polypeptide) receptor, complete cds. GB_HTG1:CNS01DRV 224372 AL118558 Homo sapiens chromosome 14 clone R-1017G21,Homo sapiens 38,667 15-OCT-1999 *** SEQUENCING IN PROGRESS ***, inunordered pieces. GB_HTG1: CNS01DRV 224372 AL118558 Homo sapienschromosome 14 clone R-1017G21, Homo sapiens 38,667 15-OCT-1999 ***SEQUENCING IN PROGRESS ***, in unordered pieces. rxa02757 669 GB_RO:RNU35245 2051 U35245 Rat vacuolar protein sorting Rattus norvegicus39,058 15-Jan-97 homolog r-vps33b mRNA, complete cds. GB_RO: RNU352452051 U35245 Rat vacuolar protein sorting homolog Rattus norvegicus37,481 15-Jan-97 r-vps33b mRNA, complete cds. rxa02765 882 GB_EST4:H46883 459 H46883 yo19f06.r1 Soares adult brain N2b5NB55Y Homo sapienscDNA Homo sapiens 40,132 31-Jul-95 clone IMAGE: 178403 5′, mRNAsequence. GB_PL1: NTA6235 3931 AJ006235 Nicotiana tabacum DNA fragmentfor K-alpha right T-DNA border. Nicotiana tabacum 34,247 6-Feb-99GB_HTG3: AC011519 57287 AC011519 Homo sapiens chromosome 19 cloneLLNL-F_192H5, Homo sapiens 38,497 07-OCT-1999 *** SEQUENCING IN PROGRESS***, 36 unordered pieces. rxa02766 516 GB_GSS13: AQ489419 554 AQ489419RPCI-11-246A3.TV RPCI-11 Homo sapiens genomic clone Homo sapiens 37,82124-Apr-99 RPCI-11-246A3, genomic survey sequence. GB_PR3: HS90L6 190837Z97353 Human DNA sequence from clone 90L6 on chromosome 22q11.21-11.23.Homo sapiens 38,16 23-Nov-99 Contains an RPL15 (60S Ribosomal ProteinL15) pseudogene, ESTs. STSs and GSSs, complete sequence. GB_BA1: MTCY37335516 Z73419 Mycobacterium tuberculosis H37Rv complete genome; segment57/162. Mycobacterium 36,701 17-Jun-98 tuberculosis rxa02770 1689GB_BA2: AF038651 4077 AF038651 Corynebacterium glutamicumdipeptide-binding protein Corynebacterium 100 14-Sep-98 (dciAE) gene,partial cds; adenine phosphoribosyltransferase (apt) and GTPpyrophosphokinase (rel) genes, complete cds; and glutamicum unknowngene. GB_OV: AF061275 6756 AF061275 Ictalurus punctatus estrogenreceptor type alpha mRNA, complete cds. Ictaturus punctatus 37,11731-OCT-1998 GB_RO: MMSCSELN4 3840 X61756 M. musculus rearranged T-cellreceptor beta variable region (Vb17a). Mus musculus 37,933 03-DEC-1991rxa02774 494 GB_HTG2: AF129408 138685 AF129408 Homo sapiens chromosome21 clone PAC 31K18 map 21q22.3, Homo sapiens 38,241 04-MAR-1999 ***SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: AF129408138685 AF129408 Homo sapiens chromosome 21 clone PAC 31K18 map 21q22.3,Homo sapiens 38,241 04-MAR-1999 *** SEQUENCING IN PROGRESS ***, inunordered pieces. GB_PR3: AF064859 122571 AF064859 Homo sapienschromosome 21q22.3 PAC 141B3, complete sequence, Homo sapiens 37,912-Jun-98 containing ribosomal protein homologue pseudogene L23a.rxa02775 348 GB_PR3: HSU19F10 31474 Z81145 Human DNA sequence fromcosmid U19F10, Homo sapiens 36,443 23-Nov-99 between markers DXS366 andDXS87 on chromosome X contains ESTs. GB_EST11: AA211850 293 AA211850zr90e04.s1 NCI_CGAP_GCB1 Homo sapiens cDNA clone Homo sapiens 30,47913-Aug-97 IMAGE: 682974 3′ similar to TR: G1224065 G1224065 MER37TRANSPOSABLE ELEMENT, COMPLETE CONSENSUS SEQUENCE.;, mRNA sequence.GB_EST13: AA372532 400 AA372532 EST84441 Colon adenocarcinoma IV Homosapiens Homo sapiens 40,104 21-Apr-97 cDNA 5′ end, mRNA sequence.rxa02776 465 GB_GSS9: AQ096114 383 AQ096114 HS_3030_A2_D11_MF CITApproved Human Genomic Homo sapiens 44,643 27-Aug-98 Sperm Library DHomo sapiens genomic clone Plate = 3030 Col = 22 Row = G, genomic surveysequence. GB_RO: AF139518 8827 AF139518 Rattus norvegicus A-kinaseanchor protein mRNA, complete cds. Rattus norvegicus 39,722 16-Jun-99GB_EST32: AI728295 564 AI728295 BNLGHi10386 Six-day Cotton fiberGossypium hirsutum cDNA Gossypium hirsutum 37,049 11-Jun-99 5′ similarto (AF076274) contains similarity to rat p47 protein (GB: AB002086)[Arabidopsis thaliana], mRNA sequence. rxa02777 1230 GB_HTG3: AC009407207973 AC009407 Homo sapiens clone NH0223I10, Homo sapiens 39,78421-Aug-99 *** SEQUENCING IN PROGRESS ***, 16 unordered pieces. GB_HTG3:AC009407 207973 AC009407 Homo sapiens clone NH0223I10, Homo sapiens39,784 21-Aug-99 *** SEQUENCING IN PROGRESS ***, 16 unordered pieces.GB_BA2: AE001137 44380 AE001137 Borrelia burgdorferi (section 23 of 70)of the complete genome. Borrelia burgdorferi 39,105 15-DEC-1997 rxa02778348 GB_EST37: AI940900 668 AI940900 sb79d08.y1 Gm-c1010 Glycine max cDNAclone Glycine max 35,036 3-Aug-99 GENOME SYSTEMS CLONE ID: Gm-c1010-11925′ similar to SW: ITRA_SOYBN P01070 TRYPSIN INHIBITORS A AND CPRECURSOR;, mRNA sequence. GB_HTG4: AC008940 131864 AC008940 Homosapiens chromosome 5 clone CITB-H1_2319M24, Homo sapiens 33,04331-OCT-1999 *** SEQUENCING IN PROGRESS ***, 3 ordered pieces. GB_HTG4:AC008940 131864 AC008940 Homo sapiens chromosome 5 cloneCITB-H1_2319M24, Homo sapiens 33,043 31-OCT-1999 *** SEQUENCING INPROGRESS ***, 3 ordered pieces. rxa02779 402 GB_PR1: AB020876 100000AB020876 Homo sapiens genomic DNA of 9q32 anti-oncogene of Homo sapiens35 21-MAY-1999 flat epitherium cancer, segment 8/10. GB_EST26: AI339126415 AI339126 qt06d03.x1 NCI_CGAP_GC4 Homo sapiens cDNA clone IMAGE: Homosapiens 35,876 29-DEC-1998 1946789 3′ similar to gb: L25444 60SRIBOSOMAL PROTEIN L35A (HUMAN);, mRNA sequence. GB_PR1: AB020876 100000AB020876 Homo sapiens genomic DNA of 9q32 anti-oncogene of Homo sapiens35,678 21-MAY-1999 flat epitherium cancer, segment 8/10. rxa02780 450GB_GSS14: AQ524732 591 AQ524732 HS_5236_A1_D09_SP6E RPCI-11 Human MaleBAC Homo sapiens 39,726 11-MAY-1999 Library Homo sapiens genomic clonePlate = 812 Col = 17 Row = G, genomic survey sequence. GB_PR4: AC00605138903 AC006051 Homo sapiens 12p13.3 PAC RPCI5-1103G8 (Roswell Homosapiens 35,068 26-Nov-98 Park Cancer Institute Human PAC Library)complete sequence. GB_PR4: AC006051 38903 AC006051 Homo sapiens 12p13.3PAC RPCI5-1103G8 (Roswell Homo sapiens 37,273 26-Nov-98 Park CancerInstitute Human PAC Library) complete sequence. rxa02781 1314 GB_VI:BHV1CGEN 135301 AJ004801 Bovine herpesvirus 1 complete genome. Bovineherpesvirus type 41,053 11-Jan-99 1.1 GB_BA1: SHGCPIR 107379 X86780 S.hygroscopicus gene cluster for Streptomyces 40,551 16-Aug-96 polyketideimmunosuppressant rapamycin. hygroscopicus GB_BA1: SHGCPIR 107379 X86780S. hygroscopicus gene cluster for Streptomyces 39,598 16-Aug-96polyketide immunosuppressant rapamycin. hygroscopicus rxa02782 1422GB_IN1: DSV28T23 5218 X60176 D. silvestris clone U28T2 non-LTRretrotransposon DNA (5218 bp). Drosophila silvestris 38,695 25-MAR-1992GB_IN1: DSV28T24 7779 X60177 D. silvestris clone U28T2 non-LTRretrotransposon DNA (7779 bp). Drosophila silvestris 38,844 30-Nov-93GB_BA2: MPU34795 24888 U34795 Mycoplasma pneumoniae cosmid pcosMPGT9 25kb EcoRI fragment. Mycoplasma pneumoniae 37,832 06-MAR-1996 rxa02783 672GB_EST2: R13483 481 R13483 yf77g03.r1 Soares Infant brain 1NIB Homosapiens cDNA clone Homo sapiens 36,243 12-Apr-95 IMAGE: 28494 5′, mRNAsequence. GB_HTG3: AC011333 159160 AC011333 Homo sapiens chromosome 5clone CIT-HSPC_229L21, Homo sapiens 38,246 06-OCT-1999 *** SEQUENCING INPROGRESS ***, 23 unordered pieces. GB_HTG3: AC011333 159160 AC011333Homo sapiens chromosome 5 clone CIT-HSPC_229L21, Homo sapiens 38,24606-OCT-1999 *** SEQUENCING IN PROGRESS ***, 23 unordered pieces.rxa02784 309 GB_PR3: HS474A14 107352 AL023285 Human DNA sequence fromclone 474A14 on chromosome 1q24.1-25.2 Homo sapiens 37,868 23-Nov-99Contains EST, CA repeat, 5′UTR (tenascin-R), GSS, complete sequence.GB_GSS12: AQ374565 441 AQ374565 RPCI11-159P12.TV RPCI.11 Homo sapiensgenomic clone RPCI-11-159P12, Homo sapiens 36,522 20-MAY-1999 genomicsurvey sequence. GB_GSS5: AQ780184 686 AQ780184 HS_3138_B1_F11_MR CITApproved Human Genomic Sperm Homo sapiens 44,186 2-Aug-99 Library D Homosapiens genomic clone Plate = 3138 Col = 21 Row = L, genomic surveysequence. rxa02786 830 GB_PL1: SCYBL033C 1794 Z35794 S. cerevisiaechromosome II reading frame ORF YBL033c. Saccharomyces cerevisiae 39,26411-MAR-1998 GB_PL1: ECRIB1GN 1747 Z21617 S. cerevisiae RIB1 geneencoding GTP cyclohydrolase II. Saccharomyces cerevisiae 37,11828-Jan-95 GB_PAT: A38763 1747 A38763 Sequence 1 from Patent WO9411515.Saccharomyces cerevisiae 37,118 05-MAR-1997 rxa02789 669 GB_EST34:AV146372 295 AV146372 AV146372 Mus musculus C57BL/6J 10-11 day Musmusculus 65,432 3-Jul-99 embryo Mus musculus cDNA clone 2810453K19, mRNAsequence. GB_GSS5: AQ785226 524 AQ785226 HS_2025_B2_A07_T7C CIT ApprovedHuman Genomic Homo sapiens 40,342 3-Aug-99 Sperm Library D Homo sapiensgenomic clone Plate = 2025 Col = 14 Row = B, genomic survey sequence.GB_BA1: SCE94 38532 AL049628 Streptomyces coelicolor cosmid E94.Streptomyces coelicolor 35,346 12-Apr-99 rxa02793 825 GB_HTG2: AC006514247029 AC006514 Homo sapiens clone RPCI11-656E20, Homo sapiens 33,7421-Apr-99 *** SEQUENCING IN PROGRESS ***, 90 unordered pieces. GB_HTG2:AC006514 247029 AC006514 Homo sapiens clone RPCI11-656E20, Homo sapiens33,742 1-Apr-99 *** SEQUENCING IN PROGRESS ***, 90 unordered pieces.GB_EST22: AI033150 384 AI033150 ow94b01.s1Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens 38,951 28-Aug-98 Homosapiens cDNA clone IMAGE: 1654441 3′ similar to TR: O02711 O02711PRO-POL-DUTPASE POLYPROTEIN;, mRNA sequence. rxa02796 672 GB_OV:AF172144 1101 AF172144 Xenopus laevis potassium channel beta 2 subunitmRNA, partial cds. Xenopus laevis 40 25-Sep-99 GB_HTG1: AP000572 84439AP000572 Homo sapiens chromosome 11 clone P28D2 map 11q13, Homo sapiens35,725 09-OCT-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces.GB_HTG1: AP000572 84439 AP000572 Homo sapiens chromosome 11 clone P28D2map 11q13, Homo sapiens 35,725 09-OCT-1999 *** SEQUENCING IN PROGRESS***, in unordered pieces. rxa02798 1548 GB_EST10: AA155097 322 AA155097mr24h12.r1 Soares mouse 3NbMS Mus musculus cDNA clone Mus musculus41,195 16-Feb-97 IMAGE: 598439 5′, mRNA sequence. GB_GSS9: AQ150317 489AQ150317 HS_3178_B1_F12_T7 CIT Approved Human Genomic Sperm Homo sapiens39,549 08-OCT-1998 Library D Homo sapiens genomic clone Plate = 3178 Col= 23 Row = L, genomic survey sequence. GB_BA2: AE001731 10186 AE001731Thermotoga maritima section 43 of 136 of the complete genome. Thermotogamaritima 35,747 2-Jun-99 rxa02799 396 GB_IN2: AF139876 1562 AF139876Giardia intestinalis histone H4 gene, complete cds. Giardia intestinalis34,848 02-OCT-1999 GB_HTG5: AC011614 176606 AC011614 Drosophilamelanogaster chromosome X clone BACR48L05 (D1142) Drosophilamelanogaster 38,817 19-Nov-99 RPCI-98 48.L.5 map 16F-17A strain y; cn bwsp, *** SEQUENCING IN PROGRESS ***, 114 unordered pieces. GB_GSS10:AQ254726 565 AQ254726 EP(3)3517 Drosophila melanogaster EP lineDrosophila melanogaster Drosophila melanogaster 38,798 28-Jun-99 genomicSequence recovered from Both 5′ and 3′ ends of P element, genomic surveysequence. rxa02812 rxa02815 552 GB_BA2: PAU32853 1961 U32853 Pseudomonasaeruginosa mucC and mucD genes, complete cds. Pseudomonas aeruginosa39,925 06-MAR-1996 GB_BA2: PAU49151 4587 U49151 Pseudomonas aeruginosaalternate sigma factor (algU), Pseudomonas aeruginosa 39,925 13-MAR-1996mucA, mucB, mucC and mucD genes, complete cds. GB_BA2: PAU49151 4587U49151 Pseudomonas aeruginosa alternate sigma factor (algU), Pseudomonasaeruginosa 35,922 13-MAR-1996 mucA, mucB, mucC and mucD genes, completecds. rxa02817 499 GB_BA1: CORAIA 4705 L09232 Corynebacterium glutamicumacetohydroxy acid synthase (ilvB) and Corynebacterium 38,554 23-Feb-95(ilvN) genes, and acetohydroxy glutamicum acid isomeroreductase (ilvC)gene, complete cds. GB_EST22: AI004214 475 AI004214 ot94h01.x1Soares_total_fetus_Nb2HF8_9w Homo sapiens 51,092 27-Aug-98 Homo sapienscDNA clone IMAGE: 1624465 3′, mRNA sequence. GB_EST27: AI457904 455AI457904 tj48b08.x1 Soares_NSF_F8_9W_OT_PA_P_S1 Homo sapiens 37,38113-Apr-99 Homo sapiens cDNA clone IMAGE: 2144727 3′, mRNA sequence.rxa02818 606 GB_PL1: MZEADH1CM 6167 M32984 Z. mays alcohol dehydrogenase(ADH-1 C-m allele) gene, complete cds. Zea mays 33,111 27-Apr-93 GB_PL1:ZMADH1ALL 6158 X17556 Z. mays DNA for Adh1-Cm allele. Zea mays 33,11123-Jan-92 GB_PL1: MZEADN1CM 6167 M32984 Z. mays alcohol dehydrogenase(ADH-1 C-m allele) gene, complete cds. Zea mays 38,065 27-Apr-93rxa02823 370 GB_PL2: AF077130 4392 AF077130 Oryza sativa receptor-likeprotein kinase gene, complete cds. Oryza sativa 33,243 25-Jul-98GB_HTG1: CNS00M8S 214599 AL079302 Homo sapiens chromosome 14 cloneR-1089B7, Homo sapiens 38,42 15-OCT-1999 *** SEQUENCING IN PROGRESS ***,in ordered pieces. GB_HTG1: CNS00M8S 214599 AL079302 Homo sapienschromosome 14 clone R-1089B7, Homo sapiens 38,42 15-OCT-1999 ***SEQUENCING IN PROGRESS ***, in ordered pieces. rxa02825 1962 GB_PL1:ZMU17350 1289 U17350 Zea mays thiamine biosynthetic enzyme (thi1-1)mRNA, complete cds. Zea mays 40,71 12-Apr-96 GB_GSS13: AQ440082 432AQ440082 HS_5080_B1_B12_SP6E RPCI-11 Human Homo sapiens 41,12131-MAR-1999 Male BAC Library Home sapiens genomic clone Plate = 656 Col= 23 Row = D, genomic survey sequence. GB_EST10: AA141278 579 AA141278CK01542.3prime CK Drosophila melanogaster embryo Drosophila melanogaster42,424 29-Nov-98 BlueScript Drosophila melanogaster cDNA clone CK015423prime, mRNA sequence. rxa02827 523 GB_BA2: AF054624 6984 AF054624Lactobacillus sakel transcription-repair coupling factor Lactobacillussakel 37,241 12-Jan-99 (mfd) gene, partial cds; L-lactate dehydrogenase(ldhL) gene, complete cds; and unknown genes. GB_BA2: AF023181 6616AF023181 Listeria monocytogenes transcription-repair coupling factorListeria monocytogenes 61,228 1-Jan-99 (mfdL), low temperaturerequirement B protein (ltrB), and DivlC homolog (divL) genes, completecds. GB_HTG3: AC009213 114735 AC009213 Drosophila melanogasterchromosome 3 clone BACR09F18 (D812) Drosophila melanogaster 32,42723-Aug-99 RPCI-98 09.F.18 map 98D-98D strain y; cn bw sp, *** SEQUENCINGIN PROGRESS ***, 109 unordered pieces. rxa02838 528 GB_BA2: AE00006912230 AE000069 Rhizobium sp. NGR234 plasmid pNGR234a, section 6 of 46Rhizobium sp. NGR234 57,803 12-DEC-1997 of the complete plasmidsequence. GB_OM: SSU19994 2004 U19994 Sus scrofa p55 TNF receptor mRNA,complete cds. Sus scrofa 34,848 30-Jan-96 GB_BA2: AE000069 12230AE000069 Rhizobium sp. NGR234 plasmid pNGR234a, section 6 of 46 of theRhizoblum sp. NGR234 36,505 12-DEC-1997 complete plasmid sequence.rxa02840 273 GB_BA2: ECU73857 128824 U73857 Escherichia coli chromosomeminutes 6-8. Escherichia coli 100 14-Jul-99 GB_BA2: AE000145 11448AE000145 Escherichia coli K-12 MG1655 section 35 of 400 of the completegenome. Escherichia coli 100 12-Nov-98 GB_BA1: ECORFABC 3044 X76979 E.coli orf302, 0rf303 and orf101 sequence. Escherichia coli 40,67228-Aug-96 rxa02841 558 GB_GSS4: AQ724171 407 AQ724171HS_5380_B1_H09_SP6E RPCI-11 Human Male BAC Library Homo sapiens 35,13514-Jul-99 Homo sapiens genomic clone Plate = 956 Col = 17 Row = P.genomic survey sequence. GB_PL1: PSFERR 1023 X64417 P. sativum mRNA forferritin. Pisum sativum 41,985 30-Jun-93 GB_PL1: PSFERRI 1023 X73369 P.sativum mRNA for ferritin. Pisum sativum 41,985 21-Jul-95 rxa02842 365GB_EST32: AI723928 435 AI723928 RHIZ1_35_B10.y1_A001 Rhizome1 Sorghumhalepense 32,616 11-Jun-99 Sorghum halepense cDNA, mRNA sequence.GB_PR2: HS212A2 212753 Z95114 Human DNA sequence from clone 212A2 onchromosome Homo sapiens 38,279 23-Nov-99 22q12 Contains gene forTNF-inducible protein CG12-1. 3′ end of a gene similar to apolipoproteinL, ESTs, STSs, CA repeat, GSSs and CpG islands, complete sequence.GB_OV: AF116856 4634 AF116856 Gallus gallus neurocan core proteinprecursor, mRNA, complete cds. Gallus gallus 41,176 20-MAY-1999 rxa02845615 GB_PR3: AC005934 43699 AC005934 Homo sapiens chromosome 19, cosmidR30813, complete sequence. Homo sapiens 35,225 5-Nov-98 GB_PR3: AC00534036705 AC005340 Homo sapiens chromosome 19, cosmid F19544, completesequence. Homo sapiens 35,225 30-Jul-98 GB_PR3: AC005934 43699 AC005934Homo sapiens chromosome 19, cosmid R30813, complete sequence. Homosapiens 39,163 5-Nov-98 rxa02846 873 GB_GSS5: AQ749564 838 AQ749564HS_5575_A1_B11_SP6 RPCI-11 Human Male Homo sapiens 36,286 19-Jul-99 BACLibrary Homo sapiens genomic clone Plate = 1151 Col = 21 Row = C,genomic survey sequence. GB_GSS5: AQ749564 838 AQ749564HS_5575_A1_B11_SP6 RPCI-11 Human Male BAC Homo sapiens 38,591 19-Jul-99Library Homo sapiens genomic clone Plate = 1151 Col = 21 Row = C,genomic survey sequence. rxa02847 1135 GB_BA1: MSGB13GS 42923 L78823Mycobacterium leprae cosmid B13 DNA sequence. Mycobacterium leprae47,559 15-Jun-96 GB_HTG4: AC009557 128590 AC009557 Homo sapienschromosome 15 clone 76_D_16 map 15, Homo sapiens 36,289 25-OCT-1999LOW-PASS SEQUENCE SAMPLING. GB_HTG4: AC009557 128590 AC009557 Homosapiens chromosome 15 clone 76_D_16 map 15, Homo sapiens 36,28925-OCT-1999 LOW-PASS SEQUENCE SAMPLING. rxa02848 499 GB_BA1: AB0185314961 AB018531 Corynebacterium glutamicum dtsR1 and dtsR2 genes, completecds. Corynebacterium 98,397 19-OCT-1998 glutamicum GB_PAT: E17019 4961E17019 Brevibacterium lactofermentum dtsR and dtsR2 genes.Corynebacterium 98,397 28-Jul-99 glutamicum GB_OM: CFU08596 1780 U08596Canis familiaris delayed rectifier K+ channel mRNA, partial cds. Canisfamiliaris 43,265 21-DEC-1994 rxa02849 305 GB_VI: AF121950 9395 AF121950Hepatitis G virus strain lowan, complete genome. Hepatitis G virus 33,1124-MAY-1999 GB_PAT: AR049304 9327 AR049304 Sequence 234 from patent US5824507. Unknown. 31,803 29-Sep-99 GB_PAT: AR026878 9327 AR026878Sequence 234 from patent US 5856134. Unknown. 31,803 29-Sep-99

TABLE 3 Corynebacterium and Brevibacterium Strains Which May be Used inthe Practice of the Invention Genus species ATCC FERM NRRL CECT NCIMBCBS NCTC DSMZ Brevibacterium ammoniagenes 21054 Brevibacteriumammoniagenes 19350 Brevibacterium ammoniagenes 19351 Brevibacteriumammoniagenes 19352 Brevibacterium ammoniagenes 19353 Brevibacteriumammoniagenes 19354 Brevibacterium ammoniagenes 19355 Brevibacteriumammoniagenes 19356 Brevibacterium ammoniagenes 21055 Brevibacteriumammoniagenes 21077 Brevibacterium ammoniagenes 21553 Brevibacteriumammoniagenes 21580 Brevibacterium ammoniagenes 39101 Brevibacteriumbutanicum 21196 Brevibacterium divaricatum 21792 P928 Brevibacteriumflavum 21474 Brevibacterium flavum 21129 Brevibacterium flavum 21518Brevibacterium flavum B11474 Brevibacterium flavum B11472 Brevibacteriumflavum 21127 Brevibacterium flavum 21128 Brevibacterium flavum 21427Brevibacterium flavum 21475 Brevibacterium flavum 21517 Brevibacteriumflavum 21528 Brevibacterium flavum 21529 Brevibacterium flavum B11477Brevibacterium flavum B11478 Brevibacterium flavum 21127 Brevibacteriumflavum B11474 Brevibacterium healii 15527 Brevibacterium ketoglutamicum21004 Brevibacterium ketoglutamicum 21089 Brevibacterium ketosoreductum21914 Brevibacterium lactofermentum 70 Brevibacterium lactofermentum 74Brevibacterium lactofermentum 77 Brevibacterium lactofermentum 21798Brevibacterium lactofermentum 21799 Brevibacterium lactofermentum 21800Brevibacterium lactofermentum 21801 Brevibacterium lactofermentum B11470Brevibacterium lactofermentum B11471 Brevibacterium lactofermentum 21086Brevibacterium lactofermentum 21420 Brevibacterium lactofermentum 21086Brevibacterium lactofermentum 31269 Brevibacterium linens 9174Brevibacterium linens 19391 Brevibacterium linens 8377 Brevibacteriumparaffinolyticum 11160 Brevibacterium spec. 717.73 Brevibacterium spec.717.73 Brevibacterium spec. 14604 Brevibacterium spec. 21860Brevibacterium spec. 21864 Brevibacterium spec. 21865 Brevibacteriumspec. 21866 Brevibacterium spec. 19240 Corynebacterium acetoacidophilum21476 Corynebacterium acetoacidophilum 13870 Corynebacteriumacetoglutamicum B11473 Corynebacterium acetoglutamicum B11475Corynebacterium acetoglutamicum 15806 Corynebacterium acetoglutamicum21491 Corynebacterium acetoglutamicum 31270 Corynebacterium acetophilumB3671 Corynebacterium ammoniagenes 6872 2399 Corynebacteriumammoniagenes 15511 Corynebacterium fujiokense 21496 Corynebacteriumglutamicum 14067 Corynebacterium glutamicum 39137 Corynebacteriumglutamicum 21254 Corynebacterium glutamicum 21255 Corynebacteriumglutamicum 31830 Corynebacterium glutamicum 13032 Corynebacteriumglutamicum 14305 Corynebacterium glutamicum 15455 Corynebacteriumglutamicum 13058 Corynebacterium glutamicum 13059 Corynebacteriumglutamicum 13060 Corynebacterium glutamicum 21492 Corynebacteriumglutamicum 21513 Corynebacterium glutamicum 21526 Corynebacteriumglutamicum 21543 Corynebacterium glutamicum 13287 Corynebacteriumglutamicum 21851 Corynebacterium glutamicum 21253 Corynebacteriumglutamicum 21514 Corynebacterium glutamicum 21516 Corynebacteriumglutamicum 21299 Corynebacterium glutamicum 21300 Corynebacteriumglutamicum 39684 Corynebacterium glutamicum 21488 Corynebacteriumglutamicum 21649 Corynebacterium glutamicum 21650 Corynebacteriumglutamicum 19223 Corynebacterium glutamicum 13869 Corynebacteriumglutamicum 21157 Corynebacterium glutamicum 21158 Corynebacteriumglutamicum 21159 Corynebacterium glutamicum 21355 Corynebacteriumglutamicum 31808 Corynebacterium glutamicum 21674 Corynebacteriumglutamicum 21562 Corynebacterium glutamicum 21563 Corynebacteriumglutamicum 21564 Corynebacterium glutamicum 21565 Corynebacteriumglutamicum 21566 Corynebacterium glutamicum 21567 Corynebacteriumglutamicum 21568 Corynebacterium glutamicum 21569 Corynebacteriumglutamicum 21570 Corynebacterium glutamicum 21571 Corynebacteriumglutamicum 21572 Corynebacterium glutamicum 21573 Corynebacteriumglutamicum 21579 Corynebacterium glutamicum 19049 Corynebacteriumglutamicum 19050 Corynebacterium glutamicum 19051 Corynebacteriumglutamicum 19052 Corynebacterium glutamicum 19053 Corynebacteriumglutamicum 19054 Corynebacterium glutamicum 19055 Corynebacteriumglutamicum 19056 Corynebacterium glutamicum 19057 Corynebacteriumglutamicum 19058 Corynebacterium glutamicum 19059 Corynebacteriumglutamicum 19060 Corynebacterium glutamicum 19185 Corynebacteriumglutamicum 13286 Corynebacterium glutamicum 21515 Corynebacteriumglutamicum 21527 Corynebacterium glutamicum 21544 Corynebacteriumglutamicum 21492 Corynebacterium glutamicum B8183 Corynebacteriumglutamicum B8182 Corynebacterium glutamicum B12416 Corynebacteriumglutamicum B12417 Corynebacterium glutamicum B12418 Corynebacteriumglutamicum B11476 Corynebacterium glutamicum 21608 Corynebacteriumlilium P973 Corynebacterium nitrilophilus 21419 11594 Corynebacteriumspec. P4445 Corynebacterium spec. P4446 Corynebacterium spec. 31088Corynebacterium spec. 31089 Corynebacterium spec. 31090 Corynebacteriumspec. 31090 Corynebacterium spec. 31090 Corynebacterium spec. 1595420145 Corynebacterium spec. 21857 Corynebacterium spec. 21862Corynebacterium spec. 21863ATCC: American Type Culture Collection, Rockville, MD, USAFERM: Fermentation Research Institute, Chiba, JapanNRRL: ARS Culture Collection, Northern Regional Research Laboratory,Peoria, IL, USACECT: Coleccion Espanola de Cultivos Tipo, Valencia, SpainNCIMB: National Collection of Industrial and Marine Bacteria Ltd.,Aberdeen, UKCBS: Centraalbureau voor Schimmelcultures, Baarn, NLNCTC: National Collection of Type Cultures, London, UKDSMZ: Deutsche Sammlung von Mikroorganismen und Zellkulturen,Braunschweig, GermanyFor reference see Sugawara, H. et al. (1993) World directory ofcollections of cultures of microorganisms: Bacteria, fungi and yeasts(4^(th) edn), World federation for culture collections world data centeron microorganisms, Saimata, Japen.

TABLE 2 GENES IDENTIFIED FROM GENBANK GenBank ™ Accession No. Gene NameGene Function Reference A09073 ppg Phosphoenol pyruvate carboxylaseBachmann, B. et al. “DNA fragment coding for phosphoenolpyruvatcorboxylase, recombinant DNA carrying said fragment, strains carryingthe recombinant DNA and method for producing L-aminino acids using saidstrains,” Patent: EP 0358940-A 3 Mar. 21, 1990 A45579, Threoninedehydratase Moeckel, B. et al. “Production of L-isoleucine by means ofrecombinant A45581, micro-organisms with deregulated threoninedehydratase,” Patent: WO 9519442-A 5 Jul. 20, 1995 A45583, A45585 A45587AB003132 murC; ftsQ; ftsZ Kobayashi, M. et al. “Cloning, sequencing, andcharacterization of the ftsZ gene from coryneform bacteria,” Biochem.Biophys. Res. Commun., 236(2): 383-388 (1997) AB015023 murC; ftsQ;Wachi, M. et al. “A murC gene from Coryneform bacteria,” Appl.Microbiol. Biotechnol., 51(2): 223-228 (1999) AB018530 dtsR Kimura, E.et al. “Molecular cloning of a novel gene, dtsR, which rescues thedetergent sensitivity of a mutant derived from Brevibacteriumlactofermentum,” Biosci. Biotechnol. Biochem., 60(10): 1565-1570 (1996)AB018531 dtsR1; dtsR2 AB020624 murI D-glutamate racemase AB023377 tkttransketolase AB024708 gltB; gltD Glutamine 2-oxoglutarateaminotransferase large and small subunits AB025424 acn aconitaseAB027714 rep Replication protein AB027715 rep; aad Replication protein;aminoglycoside adenyltransferase AF005242 argCN-acetylglutamate-5-semialdehyde dehydrogenase AF005635 glnA Glutaminesynthetase AF030405 hisF cyclase AF030520 argG Argininosuccinatesynthetase AF031518 argF Ornithine carbamolytransferase AF036932 aroD3-dehydroquinate dehydratase AF038548 pyc Pyruvate carboxylase AF038651dciAE;. apt; rel Dipeptide-binding protein; adenine Wehmeier, L. et al.“The role of the Corynebacterium glutamicum rel gene inphosphoribosyltransferase; GTP (p)ppGpp metabolism,” Microbiology, 144:1853-1862 (1998) pyrophosphokinase AF041436 argR Arginine repressorAF045998 impA Inositol monophosphate phosphatase AF048764 argHArgininosuccinate lyase AF049897 argC; argJ; argB;N-acetylglutamylphosphate reductase; argD; argF; argR; ornithineacetyltransferase; N- argG; argH acetylglutamate kinase; acetylornithinetransminase; ornithine carbamoyltransferase; arginine repressor;argininosuccinate synthase; argininosuccinate lyase AF050109 inhAEnoyl-acyl carrier protein reductase AF050166 hisG ATPphosphoribosyltransferase AF051846 hisAPhosphoribosylformimino-5-amino-1- phosphoribosyl-4-imidazolecarboxamideisomerase AF052652 metA Homoserine O-acetyltransferase Park, S. et al.“Isolation and analysis of metA, a methionine biosynthetic gene encodinghomoserine acetyltransferase in Corynebacterium glutamicum,” Mol.Cells., 8(3): 286-294 (1998) AF053071 aroB Dehydroquinate synthetaseAF060558 hisH Glutamine amidotransferase AF086704 hisEPhosphoribosyl-ATP- pyrophosphohydrolase AF114233 aroA5-enolpyruvylshikimate 3-phosphate synthase AF116184 panDL-aspartate-alpha-decarboxylase precursor Dusch, N. et al. “Expressionof the Corynebacterium glutamicum panD gene encodingL-aspartate-alpha-decarboxylase leads to pantothenate overproduction inEscherichia coli,” Appl. Environ. Microbiol., 65(4)1530-1539 (1999)AF124518 aroD; aroE 3-dehydroquinase; shikimate dehydrogenase AF124600aroC; aroK; aroB; Chorismate synthase; shikimate kinase; 3- pepQdehydroquinate synthase; putative cytoplasmic peptidase AF145897 inhAAF145898 inhA AJ001436 ectP Transport of ectoine, glycine betaine,Peter, H. et al. “Corynebacterium glutamicum is equipped with foursecondary proline carriers for compatible solutes: Identification,sequencing, and characterization of the proline/ ectoine uptake system,ProP, and the ectoine/proline/glycine betaine carrier, EctP,” J.Bacteriol., 180(22): 6005-6012 (1998) AJ004934 dapDTetrahydrodipicolinate succinylase Wehrmann, A. et al. “Different modesof diaminopimelate synthesis and their (incomplete^(i)) role in cellwall integrity: A study with Corynebacterium glutamicum,” J. Bacteriol.,180(12): 3159-3165 (1998) AJ007732 ppc; secG; amt; ocd;Phosphoenolpyruvate-carboxylase; ?; high soxA affinity ammonium uptakeprotein; putative ornithine-cyclodecarboxylase; sarcosine oxidaseAJ010319 ftsY, glnB, glnD; srp; Involved in cell division; PII protein;Jakoby, M. et al. “Nitrogen regulation in Corynebacterium glutamicum;amtP uridylyltransferase (uridylyl-removing Isolation of genes involvedin biochemical characterization of corresponding enzmye); signalrecognition particle; low proteins,” FEMS Microbial., 173(2): 303-310(1999) affinity ammonium uptake protein AJ132968 cat Chloramphenicolaceteyl transferase AJ224946 mqo L-malate: quinone oxidoreductaseMolenaar, D. et al. “Biochemical and genetic characterization of themembrane-associated malate dehydrogenase (acceptor) from Corynebacteriumglutamicum,” Eur. J. Biochem., 254(2): 395-403 (1998)

J238250 ndh NADH dehydrogenase AJ238703 porA Porin Lichtinger, T. et al.“Biochemical and biophysical characterization of the cell wall porin ofCorynebacterium glutamicum: The channel is formed by a low molecularmass polypeptide,” Biochemistry, 37(43): 15024-15032 (1998) D17429Transposable element IS31831 Vertes, A. A. et al. “Isolation andcharacterization of IS31831, a transposable element from Corynebacteriumglutamicum,” Mol. Microbiol., 11(4): 739-746 (1994) D84102 odhA2-oxoglutarate dehydrogenase Usuda, Y. et al. “Molecular cloning of theCorynebacterium glutamicum (Brevibacterium lactofermentum AJ12036) odhAgene encoding a novel type of 2-oxoglutarate dehydrogenase,”Microbiology, 142: 3347-3354 (1996) E01358 hdh; hk Homoserinedehydrogenase; homoserine Katsumata, R. et al. “Production ofL-thereonine and L-isoleucine,” Patent: JP 1987232392-A 1 Oct. 12, 1987kinase E01359 Upstream of the start codon of homoserine Katsumata, R. etal. “Production of L-thereonine and L-isoleucine,” Patent: JP kinasegene 1987232392-A 2 Oct. 12, 1987 E01375 Tryptophan operon E01376 trpL;trpE Leader peptide; anthranilate synthase Matsui, K. et al. “Tryptophanoperon, peptide and protein coded thereby, utilization of tryptophanoperon gene expression and production of tryptophan,” Patent: JP1987244382-A 1 Oct. 24, 1987 E01377 Promoter and operator regions ofMatsui, K. et al. “Tryptophan operon, peptide and protein coded thereby,tryptophan operon utilization of tryptophan operon gene expression andproduction of tryptophan,” Patent: JP 1987244382-A 1 Oct. 24, 1987E03937 Biotin-synthase Hatakeyama, K. et al. “DNA fragment containinggene capable of coding biotin synthetase and its utilization,” Patent:JP 1992278088-A 1 Oct. 02, 1992 E04040 Diamino pelargonic acidaminotransferase Kohama, K. et al. “Gene coding diaminopelargonic acidaminotransferase and desthiobiotin synthetase and its utilization,”Patent: JP 1992330284-A 1 Nov. 18, 1992 E04041 DesthiobiotinsynthetaseKohama, K. et al. “Gene coding diaminopelargonic acid aminotransferaseand desthiobiotin synthetase and its utilization,” Patent: JP1992330284-A 1 Nov. 18, 1992 E04307 Flavum aspartase Kurusu, Y. et al.“Gene DNA coding aspartase and utilization thereof,” Patent: JP1993030977-A 1 Feb. 09, 1993 E04376 Isocitric acid lyase Katsumata, R.et al. “Gene manifestation controlling DNA,” Patent: JP 1993056782-A 3Mar. 09, 1993 E04377 Isocitric acid lyase N-terminal fragment Katsumata,R. et al. “Gene manifestation controlling DNA,” Patent: JP 1993056782-A3 Mar. 09, 1993 E04484 Prephenate dehydratase Sotouchi, N. et al.“Production of L-phenylalanine by fermentation,” Patent: JP 1993076352-A2 Mar. 30, 1993 E05108 Aspartokinase Fugono, N. et al. “Gene DNA codingAspartokinase and its use,” Patent: JP 1993184366-A 1 Jul. 27, 1993E05112 Dihydro-dipichorinate synthetase Hatakeyama, K. et al. “Gene DNAcoding dihydrodipicolinic acid synthetase and its use,” Patent: JP1993184371-A 1 Jul. 27, 1993 E05776 Diaminopimelic acid dehydrogenaseKobayashi, M. et al. “Gene DNA coding Diaminopimelic acid dehydrogenaseand its use,” Patent: JP 1993284970-A 1 Nov. 02, 1993 E05779 Threoninesynthase Kohama, K. et al. “Gene DNA coding threonine synthase and itsuse,” Patent: JP 1993284972-A 1 Nov. 02, 1993 E06110 Prephenatedehydratase Kikuchi, T. et al. “Production of L-phenylalanine byfermentation method,” Patent: JP 1993344881-A 1 Dec. 27, 1993 E06111Mutated Prephenate dehydratase Kikuchi, T. et al. “Production ofL-phenylalanine by fermentation method,” Patent: JP 1993344881-A 1 Dec.27, 1993 E06146 Acetohydroxy acid synthetase Inui, M. et al. “Genecapable of coding Acetohydroxy acid synthetase and its use,” Patent: JP1993344893-A 1 Dec. 27, 1993 E06825 Aspartokinase Sugimoto, M. et al.“Mutant aspartokinase gene,” Patent: JP 1994062866-A 1 Mar. 08, 1994E06826 Mutated aspartokinase alpha subunit Sugimoto, M. et al. “Mutantaspartokinase gene,” Patent: JP 1994062866-A 1 Mar. 08, 1994 E06827Mutated aspartokinase alpha subunit Sugimoto, M. et al. “Mutantaspartokinase gene,” Patent: JP 1994062866-A 1 Mar. 08, 1994 E07701 secYHonno, N. et al. “Gene DNA participating in integration of membraneousprotein to membrane,” Patent: JP 1994169780-A 1 Jun. 21, 1994 E08177Aspartokinase Sato, Y. et al, “Genetic DNA capable of codingAspartokinase released from feedback inhibition and its utilization,”Patent: JP 1994261766-A 1 Sep. 20, 1994 E08178, Feedbackinhibition-released Aspartokinase Sato, Y. et al. “Genetic DNA capableof coding Aspartokinase released from E08179, feedback inhibition andits utilization,” Patent: JP 1994261766-A 1 Sep. 20, 1994 E08180,E08181, E08182 E08232, Acetohydroxy-acid isomeroreductase Inui, M. etal. “Gene DNA coding acetohydroxy acid isomeroreductase,” Patent: JP1994277067-A 1 Oct. 04, 1994 E08234 secE Asai, Y. et al. “Gene DNAcoding for translocation machinery of protein,” Patent: JP 1994277073-A1 Oct. 04, 1994 E08643 FT aminotransferase and desthiobiotin Hatakeyama,K. et al. “DNA fragment having promoter function in synthetase promoterregion coryneform bacterium,” Patent: JP 1995031476-A 1 Feb. 03, 1995E08646 Biotin synthetase Hatakeyama, K. et al. “DNA fragment havingpromoter function in coryneform bacterium,” Patent: JP 1995031476-A 1Feb. 03, 1995 E08649 Aspartase Kohama, K. et al “DNA fragment havingpromoter function in coryneform bacterium,” Patent: JP 1995031478-A 1Feb. 03, 1995 E08900 Dihydrodipicolinate reductase Madori, M. et al.“DNA fragment containing gene coding Dihydrodipicolinate acid reductaseand utilization thereof,” Patent: JP 1995075578-A 1 Mar. 20, 1995 E08901Diaminopimelic acid decarboxylase Madori, M. et al. “DNA fragmentcontaining gene coding Diaminopimelic acid decarboxylase and utilizationthereof,” Patent: JP 1995075579-A 1 Mar. 20, 1995 E12594 Serinehydroxymethyltransferase Hatakeyama, K. et al. “Production ofL-trypophan,” Patent: JP 1997028391-A 1 Feb. 04, 1997 E12760,transposase Moriya, M. et al. “Amplification of gene using artificialtransposon,” Patent: JP 1997070291-A Mar. 18, 1997 E12759, E12758 E12764Arginyl-tRNA synthetase; diaminopimelic Moriya, M. et al. “Amplificationof gene using artificial transposon,” Patent: acid decarboxylase JP1997070291-A Mar. 18, 1997 E12767 Dihydrodipicolinic acid synthetaseMoriya, M. et al. “Amplification of gene using artificial transposon,”Patent: JP 1997070291-A Mar. 18, 1997 E12770 aspartokinase Moriya, M. etal. “Amplification of gene using artificial transposon,” Patent: JP1997070291-A Mar. 18, 1997 E12773 Dihydrodipicolinic acid reductaseMoriya, M. et al. “Amplification of gene using artificial transposon,”Patent: JP 1997070291-A Mar. 18, 1997 E13655 Glucose-6-phosphatedehydrogenase Hatakeyama, K. et al. “Glucose-6-phosphate dehydrogenaseand DNA capable of coding the same,” Patent: JP 1997224661-A 1 Sep. 02,1997 L01508 IlvA Threonine dehydratase Moeckel, B. et al. “Functionaland structural analysis of the threonine dehydratase of Corynebacteriumglutamicum,” J. Bacteriol., 174: 8065-8072 (1992) L07603 EC 4.2.1.153-deoxy-D-arabinoheptulosonate-7- Chen, C. et al. “The cloning andnucleotide sequence of Corynebacterium phosphate synthase glutamicum3-deoxy-D-arabinoheptulosonate-7-phosphate synthase gene,” FEMSMicrobiol. Lett., 107: 223-230 (1993) L09232 IlvB; ilvN; ilvCAcetohydroxy acid synthase large subunit; Keilhauer, C. et al.“Isoleucine synthesis in Corynebacterium glutamicum: Acetohydroxy acidsynthase small subunit; molecular analysis of the ilvB-ilvN-ilvCoperon,” J. Bacteriol., 175(17): 5595-5603 Acetohydroxy acidisomeroreductase (1993) L18874 PtsM Phosphoenolpyruvate sugar Fouet, Aet al. “Bacillus subtilis sucrose-specific enzyme II of thephosphotransferase phosphotransferase system: expression in Escherichiacoli and homology to enzymes II from enteric bacteria,” PNAS USA,84(24): 8773-8777 (1987); Lee, J. K. et al. “Nucleotide sequence of thegene encoding the Corynebacterium glutamicum mannose enzyme II andanalyses of the deduced protein sequence,” FEMS Microbiol. Lett.,119(1-2): 137-145 (1994) L27123 aceB Malate synthase Lee, H-S. et al.“Molecular characterization of aceB, a gene encoding malate synthase inCorynebacterium glutamicum,” J. Microbiol. Biotechnol., 4(4): 256-263(1994) L27126 Pyruvate kinase Jetten, M. S. et al. “Structural andfunctional analysis of pyruvate kinase from Corynebacterium glutamicum,”Appl. Environ. Microbiol., 60(7): 2501-2507 (1994) L28760 aceAIsocitrate lyase L35906 dtxr Diphtheria toxin repressor Oguiza, J. A. etal. “Molecular cloning, DNA sequence analysis, and characterization ofthe Corynebacterium diphtheriae dtxR from Brevibacteriumlactofermentum,” J. Bacteriol., 177(2): 465-467 (1995) M13774 Prephenatedehydratase Follettie, M. T. et al. “Molecular cloning and nucleotidesequence of the Corynebacterium glutamicum pheA gene,” J. Bacteriol.,167: 695-702 (1986) M16175 5S rRNA Park, Y-H. et al. “Phylogeneticanalysis of the coryneform bacteria by 56 rRNA sequences,” J.Bacteriol., 169: 1801-1806 (1987) M16663 trpE Anthranilate synthase, 5′end Sano, K. et al. “Structure and function of the trp operon controlregions of Brevibacterium lactofermentum, a glutamic-acid-producingbacterium,” Gene, 52: 191-200 (1987) M16664 trpA Tryptophan synthase,3′end Sano, K. et al. “Structure and function of the trp operon controlregions of Brevibacterium lactofermentum, a glutamic-acid-producingbacterium,” Gene, 52: 191-200 (1987) M25819 Phosphoenolpyruvatecarboxylase O'Regan, M. et al. “Cloning and nucleotide sequence of thePhosphoenolpyruvate carboxylase-coding gene of Corynebacteriumglutamicum ATCC13032,” Gene, 77(2): 237-251 (1989) M85106 23S rRNA geneinsertion sequence Roller, C. et al. “Gram-positive bacteria with a highDNA G + C content are characterized by a common insertion within their23S rRNA genes,” J. Gen. Microbiol., 138: 1167-1175 (1992) M85107, 23SrRNA gene insertion sequence Roller, C. et al. “Gram-positive bacteriawith a high DNA G + C content are M85108 characterized by a commoninsertion within their 23S rRNA genes,” J. Gen. Microbiol., 138:1167-1175 (1992) M89931 aecD; brnQ; yhbw Beta C-S lyase; branched-chainamino acid Rossol, I. et al. “The Corynebacterium glutamicum aecD geneencodes a C-S uptake carrier; hypothetical protein yhbw lyase withalpha, beta-elimination activity that degrades aminoethylcysteine,” J.Bacteriol., 174(9): 2968-2977 (1992); Tauch, A. et al. “Isoleucineuptake in Corynebacterium glutamicum ATCC 13032 is directed by the brnQgene product,” Arch. Microbiol., 169(4): 303-312 (1998) S59299 trpLeader gene (promoter) Herry, D. M. et al. “Cloning of the trp genecluster from a tryptophan- hyperproducing strain of Corynebacteriumglutamicum: identification of a mutation in the trp leader sequence,”Appl. Environ. Microbiol., 59(3): 791-799 (1993) U11545 trpDAnthranilate phosphoribosyltransferase O'Gara, J. P. and Dunican, L. K.(1994) Complete nucleotide sequence of the Corynebacterium glutamicumATCC 21850 tpD gene.” Thesis, Microbiology Department, UniversityCollege Galway, Ireland. U13922 cglIM; cglIR; clgIIR Putative type II5-cytosoine Schafer, A. et al. “Cloning and characterization of a DNAregion encoding a methyltransferase; putative type II stress-sensitiverestriction system from Corynebacterium glutamicum ATCC restrictionendonuclease; putative type I or 13032 and analysis of its role inintergeneric conjugation with Escherichia type III restrictionendonuclease coli,” J. Bacteriol., 176(23): 7309-7319 (1994); Schafer,A. et al. “The Corynebacterium glutamicum cglIM gene encoding a5-cytosine in an McrBC- deficient Escherichia coli strain,” Gene,203(2): 95-101 (1997) U14965 recA U31224 ppx Ankri, S. et al. “Mutationsin the Corynebacterium glutamicumproline biosynthetic pathway: A naturalbypass of the proA step,” J. Bacteriol., 178(15): 4412-4419 (1996)U31225 proC L-proline: NADP+ 5-oxidoreductase Ankri, S. et al.“Mutations in the Corynebacterium glutamicumproline biosyntheticpathway: A natural bypass of the proA step,” J. Bacteriol., 178(15):4412-4419 (1996) U31230 obg; proB; unkdh ?; gamma glutamyl kinase;similar to D- Ankri, S. et al. “Mutations in the Corynebacteriumglutamicumproline isomer specific 2-hydroxyacid biosynthetic pathway: Anatural bypass of the proA step,” J. Bacteriol., dehydrogenases 178(15):4412-4419 (1996) U31281 bioB Biotin synthase Serebriiskii, I. G., “Twonew members of the bio B superfamily: Cloning, sequencing and expressionof bio B genes of Methylobacillus flagellatum and Corynebacteriumglutamicum,” Gene, 175: 15-22 (1996) U35023 thtR; accBC Thiosulfatesulfurtransferase; acyl CoA Jager, W. et al. “A Corynebacteriumglutamicum gene encoding a two-domain carboxylase protein similar tobiotin carboxylases and biotin-carboxyl-carrier proteins,” Arch.Microbiol., 166(2); 76-82 (1996) U43535 cmr Multidrug resistance proteinJager, W. et al. “A Corynebacterium glutamicum gene conferring multidrugresistance in the heterologous host Escherichia coli,” J. Bacteriol.,179(7): 2449-2451 (1997) U43536 clpB Heat shock ATP-binding proteinU53587 aphA-3 3′5″-aminoglycoside phosphotransferase U89648Corynebacterium glutamicum unidentified sequence involved in histidinebiosynthesis, partial sequence X04960 trpA; trpB; trpC; trpD; Tryptophanoperon Matsui, K. et al. “Complete nucleotide and deduced amino acidsequences of trpE; trpG; trpL the Brevibacterium lactofermentumtryptophan operon,” Nucleic Acids Res., 14(24): 10113-10114 (1986)X07563 lys A DAP decarboxylase (meso-diaminopimelate Yeh, P. et al.“Nucleic sequence of the lysA gene of Corynebacterium decarboxylase, EC4.1.1.20) glutamicum and possible mechanisms for modulation of itsexpression,” Mol. Gen. Genet., 212(1): 112-119 (1988) X14234 EC 4.1.1.31Phosphoenolpyruvate carboxylase Eikmanns, B. J. et al. “ThePhosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum:Molecular cloning, nucleotide sequence, and expression,” Mol. Gen.Genet., 218(2): 330-339 (1989); Lepiniec, L. et al. “SorghumPhosphoenolpyruvate carboxylase gene family: structure, function andmolecular evolution,” Plant. Mol. Biol., 21 (3): 487-502 (1993) X17313fda Fructose-bisphosphate aldolase Von der Osten, C. H. et al.“Molecular cloning, nucleotide sequence and fine- structural analysis ofthe Corynebacterium glutamicum fda gene: structural comparison of C.glutamicum fructose-1,6-biphosphate aldolase to class I and class IIaldolases,” Mol. Microbiol., X53993 dapA L-2,3-dihydrodipicolinatesynthetase (EC Bonnassie, S. et al. “Nucleic sequence of the dapA genefrom 4.2.1.52) Corynebacterium glutamicum,” Nucleic Acids Res., 18(21):6421 (1990) X54223 AttB-related site Cianciotto, N. et al. “DNA sequencehomology between att B-related sites of Corynebacterium diphtheriae,Corynebacterium ulcerans, Corynebacterium glutamicum, and the attP siteof lambdacorynephage,” FEMS. Microbiol, Lett., 66: 299-302 (1990) X54740argS; lysA Arginyl-tRNA synthetase; Diaminopimelate Marcel, T. et al.“Nucleotide sequence and organization of the upstream regiondecarboxylase of the Corynebacterium glutamicum lysA gene,” Mol.Microbiol., 4(11): 1819-1830 (1990) X55994 trpL; trpE Putative leaderpeptide; anthranilate Heery, D. M. et al. “Nucleotide sequence of theCorynebacterium glutamicum synthase component 1 trpE gene,” NucleicAcids Res., 18(23): 7138 (1990) X56037 thrC Threonine synthase Han, K.S. et al. “The molecular structure of the Corynebacterium glutamicumthreonine synthase gene,” Mol. Microbiol., 4(10): 1693-1702 (1990)X56075 attB-related site Attachment site Cianciotto, N. et al. “DNAsequence homology between att B-related sites of Corynebacteriumdiphtheriae, Corynebacterium ulcerans, Corynebacterium glutamicum, andthe attP site of lambdacorynephage,” FEMS. Microbiol, Lett., 66: 299-302(1990) X57226 lysC-alpha; lysC-beta; Aspartokinase-alpha subunit;Kalinowski, J. et al. “Genetic and biochemical analysis of theAspartokinase asd Aspartokinase-beta subunit; aspartate beta fromCorynebacterium glutamicum,” Mol. Microbiol., 5(5): 1197-1204 (1991);semialdehyde dehydrogenase Kalinowski, J. et al. “Aspartokinase geneslysC alpha and lysC beta overlap and are adjacent to the aspertatebeta-semialdehyde dehydrogenase gene asd in Corynebacterium glutamicum,”Mol. Gen. Genet., 224(3): 317-324 (1990) X59403 gap; pgk; tpiGlyceraldehyde-3-phosphate; Eikmanns, B. J. “Identification, sequenceanalysis, and expression of a phosphoglycerate kinase; triosephosphateCorynebacterium glutamicum gene cluster encoding the three glycolyticisomerase enzymes glyceraldehyde-3-phosphate dehydrogenase,3-phosphoglycerate kinase, and triosephosphate isomeras,” J. Bacteriol.,174(19): 6076-6086 (1992) X59404 gdh Glutamate dehydrogenase Bormann, E.R. et al. “Molecular analysis of the Corynebacterium glutamicum gdh geneencoding glutamate dehydrogenase,” Mol. Microbiol., 6(3): 317-326 (1992)X60312 lysI L-lysine permease Seep-Feldhaus, A. H. et al. “Molecularanalysis of the Corynebacterium glutamicum lysl gene involved in lysineuptake,” Mol. Microbiol., 5(12): 2995-3005 (1991) X66078 cop1 Ps1protein Joliff, G. et al. “Cloning and nucleotide sequence of the csp1gene encoding PS1, one of the two major secreted proteins ofCorynebacterium glutamicum: The deduced N-terminal region of PS1 issimilar to the Mycobacterium antigen 85 complex,” Mol. Microbiol.,6(16): 2349-2362 (1992) X66112 glt Citrate synthase Eikmanns, B. J. etal. “Cloning sequence, expression and transcriptional analysis of theCorynebacterium glutamicum gltA gene encoding citrate synthase,”Microbiol., 140: 1817-1828 (1994) X67737 dapB Dihydrodipicolinatereductase X69103 csp2 Surface layer protein PS2 Peyret, J. L. et al.“Characterization of the cspB gene encoding PS2, an orderedsurface-layer protein in Corynebacterium glutamicum,” Mol. Microbiol.,91: 97-109 (1993) X69104 IS3 related insertion element Bonamy, C. et al.“Identification of IS1206, a Corynebacterium glutamicum IS3-relatedinsertion sequence and phylogenetic analysis,” Mol. Microbiol., 14(3):571-581 (1994) X70959 leuA Isopropylmalate synthase Patek, M. et al.“Leucine synthesis in Corynebacterium glutamicum: enzyme activities,structure of leuA, and effect of leuA inactivation on lysine synthesis,”Appl. Environ. Microbiol., 60(1): 133-140 (1994) X71489 icd Isocitratedehydrogenase (NADP+) Eikmanns, B. J. et al. “Cloning sequence analysis,expression, and inactivation of the Corynebacterium glutamicum icd geneencoding isocitrate dehydrogenase and biochemical characterization ofthe enzyme,” J. Bacteriol., 177(3): 774-782 (1995) X72855 GDHA Glutamatedehydrogenase (NADP+) X75083, mtrA 5-methyltryptophan resistance Heery,D. M. et al. “A sequence from a tryptophan-hyperproducing strain ofX70584 Corynebacterium glutamicum encoding resistance to5-methyltryptophan,” Biochem. Biophys. Res. Commun., 201(3): 1255-1262(1994) X75085 recA Fitzpatrick, R. et al. “Construction andcharacterization of recA mutant strains of Corynebacterium glutamicumand Brevibacterium lactofermentum,” Appl. Microbiol. Biotechnol., 42(4):575-580 (1994) X75504 aceA; thiX Partial Isocitrate lyase; ? Reinscheid,D. J. et al. “Characterization of the isocitrate lyase gene fromCorynebacterium glutamicum and biochemical analysis of the enzyme,” J.Bacteriol., 176(12): 3474-3483 (1994) X76875 ATPase beta-subunit Ludwig,W. et al. “Phylogenetic relationships of bacteria based on comparativesequence analysis of elongation factor Tu and ATP-synthase beta-subunitgenes,” Antonie Van Leeuwenhoek, 64: 285-305 (1993) X77034 tufElongation factor Tu Ludwig, W. et al. “Phylogenetic relationships ofbacteria based on comparative sequence analysis of elongation factor Tuand ATP-synthase beta-subunit genes,” Antonie Van Leeuwenhoek, 64:285-305 (1993) X77384 recA Billman-Jacobe, H. “Nucleotide sequence of arecA gene from Corynebacterium glutamicum,” DNA Seq., 4(6): 403-404(1994) X78491 aceB Malate synthase Reinscheid, D. J. et al. “Malatesynthase from Corynebacterium glutamicum pta-ack operon encodingphosphotransacetylase: sequence analysis,” Microbiology. 140: 3099-3108(1994) X80629 16S rDNA 16S ribosomal RNA Rainey, F. A. et al.“Phylogenetic analysis of the genera Rhodococcus and Norcardia andevidence for the evolutionary origin of the genus Norcardia from withinthe radiation of Rhodococcus species,” Microbiol., 141: 523-528 (1995)X81191 gluA; gluB; gluC; Glutamate uptake system Kronemeyer, W. et al.“Structure of the gluABCD cluster encoding the gluD glutamate uptakesystem of Corynebacterium glutamicum,” J. Bacteriol., 177(5): 1152-1158(1995) X81379 dapE Succinyldiaminopimelate desuccinylase Wehrmann, A. etal. “Analysis of different DNA fragments of Corynebacterium glutamicumcomplementing dapE of Escherichia coli,” Microbiology, 40: 3349-56(1994) X82061 16S rDNA 16S ribosomal RNA Ruimy, R. et al. “Phylogeny ofthe genus Corynebacterium deduced from analyses of small-subunitribosomal DNA sequences,” Int. J. Syst. Bacteriol., 45(4): 740-746(1995) X82928 asd; lysC Aspartate-semialdehyde dehydrogenase; ?Serebrijski, I. et al. “Multicopy suppression by asd gene and osmoticstress- dependent complementation by heterologous proA in proA mutants,”J. Bacteriol., 177(24): 7255-7260 (1995) X82929 proA Gamma-glutamylphosphate reductase Serebrijski, I. et al. “Multicopy suppression by asdgene and osmotic stress- dependent complementation by heterologous proAin proA mutants,” J. Bacteriol., 177(24): 7255-7260 (1995) X84257 16SrDNA 16S ribosomal RNA Pascual, C. et al. “Phylogenetic analysis of thegenus Corynebacterium based on 16S rRNA gene sequences,” Int. J. Syst.Bacteriol., 45(4): 724-728 (1995) X85965 aroP; dapE Aromatic amino acidpermease; ? Wehrmann, A. et al. “Functional analysis of sequencesadjacent to dapE of Corynebacterium glutamicumproline reveals thepresence of aroP, which encodes the aromatic amino acid transporter,” J.Bacteriol., 177(20): 5991-5993 (1995) X86157 argB; argC; argD;Acetylglutamate kinase; N-acetyl-gamma- Sakanyan, V. et al. “Genes andenzymes of the acetyl cycle of arginine argF; argJ glutamyl-phosphatereductase; biosynthesis in Corynebacterium glutamicum: enzyme evolutionin the early acetylornithine aminotransferase; ornithine steps of thearginine pathway,” Microbiology, 142: 99-108 (1996)carbamoyltransferase; glutamate N- acetyltransferase X89084 pta; ackAPhosphate acetyltransferase; acetate kinase Reinscheid, D. J. et al.“Cloning, sequence analysis, expression and inactivation of theCorynebacterium glutamicum pta-ack operon encoding phosphotransacetylaseand acetate kinase,” Microbiology, 145: 503-513 (1999) X89850 attBAttachment site Le Marrec, C. et al. “Genetic characterization ofsite-specific integration functions of phi AAU2 infecting “Arthrobacteraureus C70,” J. Bacteriol., 178(7): 1996-2004 (1996) X90356 Promoterfragment F1 Patek, M. et al. “Promoters from Corynebacterium glutamicum:cloning, molecular analysis and search for a consensus motif,”Microbiology, 142: 1297-1309 (1996) X90357 Promoter fragment F2 Patek,M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecularanalysis and search for a consensus motif,” Microbiology, 142: 1297-1309(1996) X90358 Promoter fragment F10 Patek, M. et al. “Promoters fromCorynebacterium glutamicum: cloning, molecular analysis and search for aconsensus motif,” Microbiology, 142: 1297-1309 (1996) X90359 Promoterfragment F13 Patek, M. et al. “Promoters from Corynebacteriumglutamicum: cloning, molecular analysis and search for a consensusmotif,” Microbiology, 142: 1297-1309 (1996) X90360 Promoter fragment F22Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning,molecular analysis and search for a consensus motif,” Microbiology, 142:1297-1309 (1996) X90361 Promoter fragment F34 Patek, M. et al.“Promoters from Corynebacterium glutamicum: cloning, molecular analysisand search for a consensus motif,” Microbiology, 142: 1297-1309 (1996)X90362 Promoter fragment F37 Patek, M. et al. “Promoters fromCorynebacterium glutamicum: cloning, molecular analysis and search for aconsensus motif,” Microbiology, 142: 1297-1309 (1996) X90363 Promoterfragment F45 Patek, M. et al. “Promoters from Corynebacteriumglutamicum: cloning, molecular analysis and search for a consensusmotif,” Microbiology, 142: 1297-1309 (1996) X90364 Promoter fragment F64Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning,molecular analysis and search for a consensus motif,” Microbiology, 142:1297-1309 (1996) X90365 Promoter fragment F75 Patek, M. et al.“Promoters from Corynebacterium glutamicum: cloning, molecular analysisand search for a consensus motif,” Microbiology, 142: 1297-1309 (1996)X90366 Promoter fragment PF101 Patek, M. et al. “Promoters fromCorynebacterium glutamicum: cloning, molecular analysis and search for aconsensus motif,” Microbiology, 142: 1297-1309 (1996) X90367 Promoterfragment PF104 Patek, M. et al. “Promoters from Corynebacteriumglutamicum: cloning, molecular analysis and search for a consensusmotif,” Microbiology, 142: 1297-1309 (1996) X90368 Promoter fragmentPF109 Patek, M. et al. “Promoters from Corynebacterium glutamicum:cloning, molecular analysis and search for a consensus motif,”Microbiology, 142: 1297-1309 (1996) X93513 amt Ammonium transport systemSiewe, R. M. et al. “Functional and genetic characterization of the(methyl) ammonium uptake carrier of Corynebacterium glutamicum,” J.Biol. Chem., 271(10): 5398-5403 (1996) X93514 betP Glycine betainetransport system Peter, H. et al. “Isolation, characterization, andexpression of the Corynebacterium glutamicum betP gene, encoding thetransport system for the compatible solute glycine betaine,” J.Bacteriol., 178(17): 5229-5234 (1996) X95649 orf4 Patek, M. et al.“Identification and transcriptional analysis of the dapB-ORF2- dapA-ORF4operon of Corynebacterium glutamicum, encoding two enzymes involved inL-lysine synthesis,” Biotechnol. Lett., 19: 1113-1117 (1997) X96471lysE; lysG Lysine exporter protein; Lysine export Vrljic, M. et al. “Anew type of transporter with a new type of cellular regulator proteinfunction: L-lysine export from Corynebacterium glutamicum,” Mol.Microbiol., 22(5): 815-826 (1996) X96580 panB; panC; xylB3-methyl-2-oxobutanoate Sahm, H. et al. “D-pantothenate synthesis inCorynebacterium glutamicum and hydroxymethyltransferase; pantoate-beta-use of panBC and genes encoding L-valine synthesis for D-pantothenatealanine ligase; xylulokinase overproduction,” Appl. Environ. Microbiol.,65(5): 1973-1979 (1999) X96962 Insertion sequence IS1207 and transposaseX99289 Elongation factor P Ramos, A. et al. “Cloning, sequencing andexpression of the gene encoding elongation factor P in the amino-acidproducer Brevibacterium lactofermentum (Corynebacterium glutamicum ATCC13869),” Gene, 198: 217-222 (1997) Y00140 thrB Homoserine kinase Mateos,L. M. et al. “Nucleotide sequence of the homoserine kinase (thrB) geneof the Brevibacterium lactofermentum,” Nucleic Acids Res., 15(9): 3922(1987) Y00151 ddh Meso-diaminopimelate D-dehydrogenase Ishino, S. et al.“Nucleotide sequence of the meso-diammopimelate D- (EC 1.4.1.16)dehydrogenase gene from Corynebacterium glutamicum,” Nucleic Acids Res.,15(9): 3917 (1987) Y00476 thrA Homoserine dehydrogenase Mateos, L. M. etal. “Nucleotide sequence of the homoserine dehydrogenase (thrA) gene ofthe Brevibacterium lactofermentum,” Nucleic Acids Res., 15(24): 10598(1987) Y00546 hom; thrB Homoserine dehydrogenase; homoserine Peoples, O.P. et al. “Nucleotide sequence and fine structural analysis of thekinase Corynebacterium glutamicum hom-thrB operon,” Mol. Microbiol.,2(1): 63-72 (1988) Y08964 murC; ftsQ/divD; ftsZUPD-N-acetylmuramate-alanine ligase; Honrubia, M. P. et al.“Identification, characterization, and chromosomal division initiationprotein or cell division organization of the ftsZ gene fromBrevibacterium lactofermentum,” Mol. Gen. protein; cell division proteinGenet., 259(1): 97-104 (1998) Y09163 putP High affinity prolinetransport system Peter, H. et al. “Isolation of the putP gene ofCorynebacterium glutamicumproline and characterization of a low-affinityuptake system for compatible solutes,” Arch. Microbiol., 168(2): 143-151(1997) Y09548 pyc Pyruvate carboxylase Peters-Wendisch, P. G. et al.“Pyruvate carboxylase from Corynebacterium glutamicum: characterization,expression and inactivation of the pyc gene,” Microbiology, 144: 915-927(1998) Y09578 leuB 3-isopropylmalate dehydrogenase Patek, M. et al.“Analysis of the leuB gene from Corynebacterium glutamicum,” Appl.Microbiol. Biotechnol., 50(1): 42-47 (1998) Y12472 Attachment sitebacteriophage Phi-16 Moreau, S. et al. “Site-specific integration ofcorynephage Phi-16: The construction of an integration vector,”Microbiol., 145: 539-548 (1999) Y12537 proP Proline/ectoine uptakesystem protein Peter, H. et al. “Corynebacterium glutamicum is equippedwith four secondary carriers for compatible solutes: Identification,sequencing, and characterization of the proline/ectoine uptake system,ProP, and the ectoine/proline/glycine betaine carrier, EctP,” J.Bacteriol., 180(22): 6005-6012 (1998) Y13221 glnA Glutamine synthetase IJakoby, M. et al. “Isolation of Corynebacterium glutamicum glnA geneencoding glutamine synthetase I,” FEMS Microbiol. Lett., 154(1): 81-88(1997) Y16642 lpd Dihydrolipoamide dehydrogenase Y18059 Attachment siteCorynephage 304L Moreau, S. et al. “Analysis of the integrationfunctions of &phi; 304L: An integrase module among corynephages,”Virology, 255(1): 150-159 (1999) Z21501 argS; lysA Arginyl-tRNAsynthetase; diaminopimelate Oguiza, J. A. et al. “A gene encodingarginyl-tRNA synthetase is located in the decarboxylase (partial)upstream region of the lysA gene in Brevibacterium lactofermentum:Regulation of argS-lysA cluster expression by arginine,” J. Bacteriol.,175(22): 7356-7362 (1993) Z21502 dapA; dapB Dihydrodipicolinatesynthase; Pisabarro, A. et al. “A cluster of three genes (dapA, orf2,and dapB) of dihydrodipicolinate reductase Brevibacterium lactofermentumencodes dihydrodipicolinate reductase, and a third polypeptide ofunknown function,” J. Bacteriol., 175(9): 2743-2749 1993 Z29563 thrCThreonine synthase Malumbres, M. et al. “Analysis and expression of thethrC gene of the encoded threonine synthase,” Appl. Environ. Microbiol.,60(7)2209-2219 (1994) Z46753 16S rDNA Gene for 16S ribosomal RNA Z49822sigA SigA sigma factor Oguiza, J. A. et al “Multiple sigma factor genesin Brevibacterium lactofermentum: Characterization of sigA and sigB,” J.Bacteriol., 178(2): 550-553 (1996) Z49823 galE; dtxR Catalytic activityUDP-galactose 4- Oguiza, J. A. et al “The galE gene encoding theUDP-galactose 4-epimerase of epimerase; diphtheria toxin regulatoryBrevibacterium lactofermentum is coupled transcriptionally to the dmdRprotein gene,” Gene, 177: 103-107 (1996) Z49824 orfl; sigB ?; SigB sigmafactor Oguiza, J. A. et al “Multiple sigma factor genes inBrevibacterium lactofermentum: Characterization of sigA and sigB,” J.Bacteriol., 178(2): 550-553 (1996) Z66534 Transposase Correia, A. et al.“Cloning and characterization of an IS-like element present in thegenome of Brevibacterium lactofermentum ATCC 13869,” Gene, 170(1): 91-94(1996)¹A sequence for this gene was published in the indicated reference.However, the sequence obtained by the inventors of the presentapplication is significantly longer than the published version. It isbelieved that the published version relied on an incorrect start codon,and thus represents only a fragment of the actual coding region.

TABLE 1 GENES IN THE APPLICATION Nucleic Amino Acid Acid SEQ SEQIdentification ID NO ID NO Code Contig. NT Start NT Stop 1 2 RXN01638VV0005 54646 55545 3 4 F RXA01638 GR00456 825 436 5 6 F RXA01639 GR004561334 897 7 8 RXN01590 VV0015 66740 60294 9 10 F RXA01590 GR00445 1710427 11 12 F RXA01542 GR00429 3 5063 13 14 RXN01539 VV0015 60006 57841 1516 F RXA01539 GR00428 120 2042 17 18 RXN01422 VV0122 17001 16030 19 20 FRXA01422 GR00416 2003 1221 21 22 RXN01403 VV0126 4644 3997 23 24 FRXA01403 GR00409 4410 3997 25 26 RXN01326 VV0102 23923 24288 27 28 FRXA01326 GR00386 45 338 29 30 RXN01301 VV0068 8224 8748 31 32 F RXA01301GR00375 1993 1589 33 34 RXN01276 VV0009 31190 31633 35 36 F RXA01276GR00367 29993 30538 37 38 RXN01231 VV0020 30144 29902 39 40 F RXA01231GR00356 1384 1887 41 42 RXN01210 VV0169 4230 5060 43 44 F RXA01210GR00349 3 695 45 46 RXN01206 VV0268 303 4 47 48 F RXA01206 GR00346 593853 49 50 RXN01121 VV0182 5808 6893 51 52 F RXA01121 GR00310 2479 315653 54 RXN01085 VV0093 16599 15721 55 56 F RXA01085 GR00303 960 4 57 58RXN00022 VV0015 27262 28962 59 60 F RXA00022 GR00002 20563 21297 61 62 FRXA01921 GR00551 943 5 63 64 RXN00027 VV0127 60015 59650 65 66 FRXA00027 GR00003 5142 5507 67 68 RXN00028 VV0127 57099 59045 69 70 FRXA00028 GR00003 8058 6112 71 72 RXN00033 VV0127 51753 53087 73 74RXN00056 VV0044 11980 12729 75 76 F RXA00056 GR00009 1463 714 77 78RXN00067 VV0019 29740 29255 79 80 F RXA00067 GR00011 708 223 81 82RXN00077 VV0154 4222 5583 83 84 F RXA00077 GR00012 4228 5589 85 86RXN00080 VV0154 8446 6917 87 88 F RXA00080 GR00012 7342 6923 89 90RXN00087 VV0048 204 731 91 92 F RXA00087 GR00013 3983 3456 93 94RXN00096 VV0129 22302 22000 95 96 F RXA00096 GR00014 4746 5048 97 98RXN00097 VV0129 21841 20666 99 100 F RXA00097 GR00014 5222 6382 101 102RXN00114 VV0129 5849 6337 103 104 F RXA00114 GR00017 3420 3908 105 106RXN00120 VV0142 2612 3451 107 108 F RXA00120 GR00019 2798 3451 109 110RXN00128 VV0124 7960 9663 111 112 F RXA00128 GR00020 4709 3006 113 114RXN00154 VV0167 3283 4125 115 116 F RXA00154 GR00023 8568 7726 117 118RXN00162 VV0084 9489 9842 119 120 F RXA00162 GR00024 5438 5791 121 122RXN00167 VV0232 4324 4821 123 124 F RXA00167 GR00025 4324 4584 125 126RXN00171 VV0031 5311 5054 127 128 F RXA00171 GR00026 10316 10086 129 130RXN00194 VV0115 4174 4614 131 132 F RXA00194 GR00030 290 6 133 134RXN00197 VV0115 2733 1522 135 136 F RXA00197 GR00030 1731 2741 137 138RXN00216 VV0096 16292 15303 139 140 RXN00222 VV0096 21079 22224 141 142F RXA00222 GR00032 21073 22218 143 144 RXN00232 VV0214 601 92 145 146 FRXA00232 GR00035 527 18 147 148 RXN00236 VV0133 3300 2575 149 150 FRXA00236 GR00036 3300 2575 151 152 RXN00242 VV0133 7031 8308 153 154 FRXA00242 GR00036 7031 8233 155 156 RXN00247 VV0057 35082 34156 157 158 FRXA00247 GR00037 7097 6171 159 160 RXN00256 VV0015 3794 4564 161 162 FRXA00256 GR00039 968 1738 163 164 RXN00264 VV0123 14046 13669 165 166 FRXA00264 GR00040 2459 2836 167 168 RXN00267 VV0123 12366 12683 169 170 FRXA00267 GR00040 4091 3822 171 172 RXN00271 VV0019 4975 3986 173 174 FRXA00271 GR00041 3709 2720 175 176 RXN00272 VV0019 5686 6057 177 178 FRXA00272 GR00041 4420 4791 179 180 RXN00283 VV0127 33097 32066 181 182 FRXA00283 GR00045 142 1269 183 184 RXN00334 VV0197 3581 3246 185 186 FRXA00334 GR00057 16762 17097 187 188 RXN00338 VV0197 26797 25658 189 190F RXA00338 GR00059 1 783 191 192 F RXA00318 GR00055 426 635 193 194RXN00342 VV0049 1576 1148 195 196 F RXA00342 GR00061 73 501 197 198RXN00344 VV0135 42719 43597 199 200 F RXA00344 GR00063 6 584 201 202RXN00353 VV0135 32107 32799 203 204 F RXA00353 GR00068 988 1680 205 206RXN00354 VV0135 33604 32792 207 208 RXN00362 VV0176 33334 34680 209 210F RXA00362 GR00073 2 961 211 212 RXN00373 VV0226 6002 6340 213 214 FRXA00373 GR00079 342 4 215 216 RXN00390 VV0025 9834 9430 217 218 FRXA00390 GR00086 1437 1841 219 220 RXN00399 VV0025 13735 13421 221 222 FRXA00399 GR00087 830 1144 223 224 RXN00416 VV0181 1 225 226 F RXA00416GR00093 1 327 227 228 F RXA00418 GR00094 1 1065 229 230 RXN00422 VV01123820 4713 231 232 F RXA00422 GR00097 428 6 233 234 RXN00447 VV0112 2332522906 235 236 F RXA00447 GR00108 518 817 237 238 RXN00455 VV0076 55234774 239 240 F RXA00455 GR00113 2 619 241 242 RXN00473 VV0086 3149332281 243 244 F RXA00473 GR00119 5799 6563 245 246 RXN00485 VV0086 5120048906 247 248 F RXA00485 GR00119 25230 23188 249 250 RXN00496 VV008617452 18477 251 252 F RXA00496 GR00123 1776 2177 253 254 RXN00503 VV008611688 13409 255 256 RXN00504 VV0086 13486 13905 257 258 F RXA00504GR00125 5007 5252 259 260 RXN00505 VV0086 5810 6304 261 262 F RXA00505GR00126 1 252 263 264 RXN00507 VV0086 4606 3752 265 266 F RXA00507GR00127 1098 244 267 268 RXN00510 VV0086 1924 3432 269 270 F RXA00509GR00128 316 140 271 272 F RXA00510 GR00128 384 914 273 274 RXN00515VV0144 3289 2588 275 276 F RXA00515 GR00131 3 482 277 278 F RXA00520GR00132 599 796 279 280 RXN00527 VV0079 23845 25608 281 282 F RXA00527GR00136 3123 1360 283 284 RXN00547 VV0079 33886 35283 285 286 F RXA00547GR00142 641 1054 287 288 F RXA00546 GR00142 1 690 289 290 RXN00552VV0079 27617 28552 291 292 F RXA00552 GR00145 2 718 293 294 RXN00555VV0079 30437 29499 295 296 F RXA00555 GR00145 2555 1665 297 298 RXN00560VV0103 7606 7980 299 300 F RXA00560 GR00149 256 492 301 302 RXN00574VV0323 16133 15255 303 304 F RXA00574 GR00156 767 1645 305 306 RXN00589VV0323 2680 2231 307 308 F RXA00589 GR00156 14220 14582 309 310 RXN00616VV0054 5670 5326 311 312 F RXA00616 GR00162 3574 3918 313 314 RXN00647VV0109 12861 12229 315 316 F RXA00647 GR00169 641 1273 317 318 RXN00653VV0109 6578 7342 319 320 F RXA00653 GR00169 6924 6160 321 322 RXN00662VV0142 7711 8979 323 324 F RXA00662 GR00172 2671 1403 325 326 RXN00666VV0109 1566 2480 327 328 F RXA00666 GR00175 390 4 329 330 RXN00704VV0005 9240 9866 331 332 F RXA00704 GR00183 2972 3484 333 334 RXN00712VV0005 1195 500 335 336 F RXA00712 GR00187 1048 500 337 338 RXN00720VV0232 4899 5564 339 340 F RXA00720 GR00188 7665 7000 341 342 RXN00722VV0052 2 343 344 F RXA00722 GR00189 1015 512 345 346 RXN00729 VV00243903 2926 347 348 F RXA00729 GR00194 1 642 349 350 F RXA02867 GR10008610 5 351 352 RXN00730 VV0024 2031 2837 353 354 F RXA00730 GR00194 1063731 355 356 RXN00731 VV0133 8314 10809 357 358 F RXA00731 GR00195 2613142 359 360 RXN00738 VV0254 3 361 362 F RXA00738 GR00201 78 365 363 364RXN00750 VV0010 30086 30523 365 366 F RXA00750 GR00202 18937 19374 367368 RXN00762 VV0103 16953 17828 369 370 RXN00768 VV0103 12997 11879 371372 F RXA00768 GR00204 5956 6399 373 374 F RXA00767 GR00204 5280 5993375 376 RXN00769 VV0103 11654 11442 377 378 F RXA00769 GR00204 6624 6836379 380 RXN00771 VV0103 26639 27457 381 382 F RXA00771 GR00205 857 180383 384 RXN00785 VV0321 2 658 385 386 F RXA00785 GR00207 625 5 387 388RXN00795 VV0321 6259 5732 389 390 F RXA00795 GR00211 4228 4755 391 392RXN00831 VV0180 4205 4906 393 394 F RXA00831 GR00224 1662 961 395 396RXN00835 VV0138 12068 13021 397 398 F RXA00835 GR00226 3 692 399 400RXN00836 VV0138 13126 14841 401 402 F RXA00836 GR00226 797 2467 403 404RXN00840 VV0138 6220 6933 405 406 F RXA00840 GR00228 742 1455 407 408RXN00841 VV0138 6944 7480 409 410 F RXA00841 GR00228 1466 2002 411 412RXN00846 VV0138 2367 1498 413 414 F RXA00846 GR00230 391 5 415 416RXN00850 VV0067 4148 3321 417 418 RXN00854 VV0067 371 159 419 420 FRXA00854 GR00231 4708 4920 421 422 RXN00855 VV0255 735 1019 423 424 FRXA00855 GR00232 526 242 425 426 RXN00869 VV0127 5599 4679 427 428 FRXA00869 GR00239 1 792 429 430 RXN00915 VV0238 886 257 431 432 FRXA00915 GR00251 514 5 433 434 RXN00917 VV0238 7202 4524 435 436 FRXA00917 GR00251 5534 4152 437 438 RXN00921 VV0373 1 513 439 440 FRXA00921 GR00252 4750 2852 441 442 RXN00943 VV0116 11376 12287 443 444 FRXA00943 GR00258 3 509 445 446 F RXA02423 GR00706 221 6 447 448 RXN00945VV0107 1876 2847 449 450 RXN00946 VV0107 3034 3807 451 452 F RXA00946GR00259 3034 3807 453 454 RXN00953 VV0260 1834 1082 455 456 RXN00959VV0208 402 857 457 458 F RXA00959 GR00265 402 728 459 460 RXN00963VV0249 1816 2652 461 462 F RXA00963 GR00269 442 5 463 464 RXN00971VV0149 14706 14389 465 466 F RXA00971 GR00273 1421 1149 467 468 RXN00991VV0210 4424 3045 469 470 RXN01004 VV0210 3045 1984 471 472 RXN01016VV0209 14476 15123 473 474 F RXA01016 GR00290 1141 494 475 476 RXN01023VV0143 2343 3320 477 478 F RXA01023 GR00292 1817 867 479 480 RXN01028VV0015 29000 31048 481 482 F RXA01028 GR00295 3 626 483 484 F RXA01812GR00514 3 1232 485 486 RXN01069 VV0030 986 273 487 488 F RXA01069GR00299 606 4 489 490 RXN01071 VV0030 4879 2816 491 492 F RXA02898GR10040 1631 6 493 494 F RXA01071 GR00299 2822 2436 495 496 RXN01075VV0084 42045 41635 497 498 F RXA01075 GR00300 3269 2859 499 500 RXN01128VV0157 2427 3440 501 502 F RXA01128 GR00314 1325 312 503 504 RXN01134VV0077 774 4 505 506 F RXA01134 GR00317 2 460 507 508 RXN01140 VV00771642 710 509 510 F RXA01140 GR00318 3272 4057 511 512 RXN01148 VV01363147 3746 513 514 F RXA01148 GR00323 1452 2051 515 516 RXN01153 VV0265546 4 517 518 F RXA01153 GR00325 546 4 519 520 RXN01154 VV0266 644 6 521522 F RXA01154 GR00326 608 6 523 524 RXN01155 VV0225 252 1721 525 526 FRXA01155 GR00327 1370 6 527 528 RXN01167 VV0117 12777 13172 529 530 FRXA01167 GR00333 3 323 531 532 RXN01169 VV0117 5804 6799 533 534 FRXA01169 GR00334 1 567 535 536 RXN01173 VV0117 11085 10471 537 538 FRXA01173 GR00334 4853 4239 539 540 RXN01174 VV0117 12236 11487 541 542 FRXA01174 GR00334 6004 5255 543 544 RXN01229 VV0020 32482 31205 545 546 FRXA01229 GR00355 2806 3498 547 548 RXN01246 VV0104 2815 3321 549 550 FRXA01246 GR00360 1824 2462 551 552 RXN01249 VV0271 1 553 554 F RXA01249GR00363 303 4 555 556 RXN01251 VV0219 13143 12835 557 558 F RXA01251GR00365 228 536 559 560 RXN01263 VV0009 11816 12727 561 562 F RXA01263GR00367 10720 11631 563 564 RXN01266 VV0009 15553 14519 565 566 FRXA01266 GR00367 14457 13423 567 568 RXN01275 VV0009 29514 30431 569 570F RXA01275 GR00367 28418 29335 571 572 RXN01281 VV0212 4506 5267 573 574F RXA01281 GR00369 3869 4630 575 576 RXN01296 VV0209 10462 9380 577 578F RXA01296 GR00373 5836 4754 579 580 RXN01306 VV0148 8158 7151 581 582 FRXA01306 GR00376 5691 4684 583 584 RXN01324 VV0082 6588 6887 585 586RXN01331 VV0005 39816 42212 587 588 F RXA01331 GR00387 1606 1031 589 590F RXA00668 GR00176 797 6 591 592 F RXA00674 GR00177 755 6 593 594RXN01337 VV0032 1925 3337 595 596 F RXA01337 GR00389 5065 3653 597 598RXN01351 VV0123 2841 3425 599 600 RXN01362 VV0051 27040 23387 601 602 FRXA01362 GR00395 3 1397 603 604 F RXA01364 GR00396 1869 4 605 606RXN01379 VV0091 10518 11459 607 608 F RXA01379 GR00402 926 6 609 610RXN01390 VV0277 6654 7310 611 612 F RXA01390 GR00408 992 336 613 614RXN01391 VV0277 5568 6257 615 616 F RXA01391 GR00408 2078 1389 617 618RXN01400 VV0126 2988 1489 619 620 F RXA01400 GR00409 2988 1489 621 622RXN01409 VV0278 5304 4483 623 624 F RXA01409 GR00410 5296 4481 625 626RXN01434 VV0050 13792 10841 627 628 F RXA01434 GR00417 10228 9863 629630 RXN01448 VV0089 9602 10768 631 632 F RXA01448 GR00418 19796 19017633 634 RXN01459 VV0233 3311 4120 635 636 F RXA01459 GR00420 3311 4120637 638 RXN01460 VV0233 4066 4359 639 640 F RXA01460 GR00420 4066 4359641 642 RXN01471 VV0019 11467 10661 643 644 F RXA01471 GR00422 5243 4437645 646 RXN01479 VV0019 18635 18874 647 648 F RXA01479 GR00422 1242312650 649 650 RXN01484 VV0019 26292 25747 651 652 F RXA01484 GR0042220068 19523 653 654 RXN01485 VV0019 26454 28505 655 656 F RXA01485GR00422 20230 22281 657 658 RXN01492 VV0139 36004 36807 659 660 FRXA01492 GR00423 6133 5330 661 662 RXN01518 VV0008 23238 23711 663 664 FRXA01518 GR00424 23238 23711 665 666 RXN01549 VV0080 46 1704 667 668 FRXA01549 GR00430 8426 7566 669 670 F RXA02011 GR00603 46 363 671 672RXN01557 VV0323 959 1774 673 674 F RXA01557 GR00433 959 1774 675 676RXN01574 VV0009 48980 47946 677 678 F RXA01574 GR00438 6963 5929 679 680RXN01589 VV0227 1216 197 681 682 RXN01592 VV0229 14706 13405 683 684 FRXA01592 GR00447 3 1295 685 686 RXN01597 VV0229 8480 7299 687 688 FRXA01597 GR00447 6220 7401 689 690 RXN01598 VV0229 7286 6324 691 692 FRXA01598 GR00447 7414 8376 693 694 RXN01618 VV0050 23629 23246 695 696 FRXA01618 GR00451 1387 1004 697 698 RXN01634 VV0050 43466 42915 699 700 FRXA01634 GR00454 4988 5539 701 702 RXN01635 VV0050 42879 42139 703 704 FRXA01635 GR00454 5575 6315 705 706 RXN01647 VV0005 43276 44445 707 708 FRXA01647 GR00456 12422 11535 709 710 RXN01658 VV0010 44183 42351 711 712F RXA01658 GR00461 5 1489 713 714 RXN01659 VV0089 5059 5604 715 716 FRXA01659 GR00462 3 488 717 718 RXN01663 VV0089 4271 5128 719 720 FRXA01663 GR00463 438 4 721 722 RXN01669 VV0057 4529 5443 723 724 FRXA01669 GR00465 1002 271 725 726 RXN01672 VV0179 7849 8190 727 728 FRXA01672 GR00467 2 310 729 730 RXN01694 VV0139 13054 13953 731 732 FRXA01694 GR00474 3931 3032 733 734 RXN01696 VV0115 1381 203 735 736 FRXA01696 GR00475 799 203 737 738 RXN01697 VV0139 1581 625 739 740 FRXA01697 GR00476 761 1486 741 742 RXN01701 VV0162 375 4 743 744 FRXA01701 GR00478 196 528 745 746 RXN01703 VV0089 7108 8220 747 748 FRXA01703 GR00479 2118 1648 749 750 RXN01709 VV0022 847 416 751 752 FRXA01709 GR00483 745 416 753 754 RXN01711 VV0191 8153 6996 755 756 FRXA01711 GR00484 2007 850 757 758 RXN01721 VV0036 1026 4 759 760RXN01734 VV0221 1251 1784 761 762 F RXA01734 GR00492 544 1077 763 764RXN01742 VV0233 5246 4743 765 766 F RXA01742 GR00493 7614 8117 767 768RXN01754 VV0127 38790 36850 769 770 F RXA01754 GR00497 4082 2142 771 772RXN01761 VV0010 11968 7505 773 774 F RXA00739 GR00202 819 4 775 776 FRXA01587 GR00442 120 2102 777 778 F RXA01761 GR00499 7001 5484 779 780RXN01765 VV0054 17190 18131 781 782 F RXA01765 GR00500 3144 4085 783 784RXN01767 VV0015 55242 55706 785 786 F RXA01767 GR00501 341 6 787 788RXN01769 VV0015 54296 54736 789 790 F RXA01769 GR00501 1275 847 791 792RXN01771 VV0050 35063 35764 793 794 F RXA01771 GR00502 886 185 795 796RXN01774 VV0015 1794 2519 797 798 F RXA01774 GR00503 634 1416 799 800RXN01787 VV0039 256 948 801 802 F RXA01787 GR00506 2 355 803 804RXN01796 VV0137 2070 2843 805 806 F RXA01796 GR00508 2 484 807 808RXN01803 VV0216 3355 4314 809 810 F RXA01803 GR00509 5671 4712 811 812RXN01809 VV0081 9171 10346 813 814 F RXA01062 GR00297 490 5 815 816 FRXA01809 GR00510 3 638 817 818 RXN01811 VV0146 1243 1923 819 820RXN01813 VV0084 46618 45953 821 822 F RXA01813 GR00515 635 6 823 824RXN01815 VV0084 49277 50068 825 826 F RXA01815 GR00515 3294 4085 827 828RXN01825 VV0083 2847 2578 829 830 F RXA01825 GR00516 2847 2578 831 832RXN01831 VV0083 10874 10413 833 834 F RXA01831 GR00516 10874 10413 835836 RXN01834 VV0143 11244 11945 837 838 F RXA01834 GR00517 2478 1777 839840 RXN01846 VV0010 287 6 841 842 F RXA01846 GR00523 261 4 843 844RXN01847 VV0139 19018 18284 845 846 F RXA01847 GR00524 52 786 847 848RXN01874 VV0248 352 5 849 850 F RXA01874 GR00535 2556 2903 851 852RXN01875 VV0145 2894 2049 853 854 F RXA01875 GR00536 516 1313 855 856 FRXA02734 GR00762 6514 6897 857 858 RXN01877 VV0105 3493 2423 859 860 FRXA01877 GR00537 135 1199 861 862 RXN01879 VV0105 1505 573 863 864 FRXA01879 GR00537 2117 2704 865 866 F RXA01880 GR00537 2641 3048 867 868RXN01896 VV0098 75888 76523 869 870 F RXA01896 GR00544 2 580 871 872RXN01899 VV0098 77817 78602 873 874 F RXA01899 GR00544 1874 2659 875 876RXN01902 VV0098 84095 83037 877 878 F RXA01902 GR00544 7957 7094 879 880RXN01908 VV0187 4030 4875 881 882 F RXA01908 GR00545 4030 4512 883 884RXN01909 VV0218 69 947 885 886 F RXA01909 GR00546 59 937 887 888RXN01910 VV0218 1040 1885 889 890 F RXA01910 GR00546 1030 1875 891 892RXN01911 VV0218 2209 3147 893 894 F RXA01911 GR00546 2199 3044 895 896RXN01930 VV0127 46545 47495 897 898 F RXA01930 GR00555 3817 2867 899 900RXN01944 VV0050 42128 41157 901 902 F RXA01944 GR00558 2 385 903 904 FRXA01636 GR00454 6326 6898 905 906 RXN01945 VV0050 41150 39159 907 908 FRXA01945 GR00558 392 1633 909 910 F RXA01627 GR00453 1 495 911 912RXN01960 VV0200 2259 1942 913 914 F RXA01960 GR00565 187 504 915 916RXN01985 VV0056 1331 282 917 918 RXN01987 VV0149 167 379 919 920 FRXA01987 GR00576 167 379 921 922 RXN01988 VV0149 887 462 923 924 FRXA01988 GR00576 779 462 925 926 RXN01991 VV0230 926 1798 927 928 FRXA01991 GR00581 926 1720 929 930 RXN01996 VV0174 28434 27898 931 932 FRXA01996 GR00585 88 624 933 934 RXN02007 VV0324 855 223 935 936 FRXA02007 GR00598 651 223 937 938 RXN02014 VV0137 8298 8804 939 940 FRXA02014 GR00607 935 540 941 942 RXN02019 VV0129 44705 44205 943 944 FRXA02019 GR00612 597 106 945 946 RXN02023 VV0160 3234 4001 947 948 FRXA02023 GR00613 3234 4001 949 950 RXN02032 VV0117 5181 5750 951 952 FRXA02032 GR00618 4160 4729 953 954 RXN02039 VV0190 1482 643 955 956 FRXA02039 GR00621 3 812 957 958 RXN02044 VV0025 17208 15826 959 960RXN02045 VV0025 15823 15563 961 962 F RXA02045 GR00623 1913 2173 963 964RXN02049 VV0009 35549 36157 965 966 F RXA02049 GR00624 1583 2029 967 968RXN02050 VV0009 36003 36797 969 970 F RXA02050 GR00624 2462 2833 971 972RXN02059 VV0222 10306 10800 973 974 F RXA02059 GR00625 4678 4184 975 976RXN02066 VV0222 6187 6678 977 978 F RXA02066 GR00626 6187 6678 979 980RXN02067 VV0222 6733 7188 981 982 F RXA02067 GR00626 6733 7188 983 984RXN02075 VV0318 12990 13778 985 986 RXN02076 VV0318 13879 14412 987 988F RXA02076 GR00628 6902 7435 989 990 RXN02094 VV0126 18268 18984 991 992F RXA02094 GR00629 13282 13998 993 994 RXN02104 VV0318 7435 6314 995 996F RXA02104 GR00631 5327 4908 997 998 F RXA02071 GR00628 458 6 999 1000RXN02107 VV0123 21585 21244 1001 1002 F RXA02107 GR00632 1536 1877 10031004 RXN02108 VV0123 21217 20609 1005 1006 F RXA02108 GR00632 2077 25111007 1008 RXN02114 VV0180 3 1009 1010 F RXA02114 GR00634 615 130 10111012 RXN02121 VV0102 12833 12129 1013 1014 F RXA02121 GR00636 5813 51091015 1016 RXN02138 VV0300 4409 4750 1017 1018 F RXA02138 GR00639 44094750 1019 1020 RXN02151 VV0300 19913 21100 1021 1022 F RXA02151 GR0063919913 21100 1023 1024 RXN02169 VV0100 3172 4017 1025 1026 F RXA02169GR00641 3172 4017 1027 1028 RXN02180 VV0100 16813 15356 1029 1030 FRXA02180 GR00641 16813 15356 1031 1032 RXN02185 VV0100 20185 20763 10331034 F RXA02185 GR00641 20185 20763 1035 1036 RXN02186 VV0100 2119220995 1037 1038 F RXA02186 GR00641 21213 20995 1039 1040 RXN02207 VV0302802 5 1041 1042 F RXA02207 GR00646 10909 11667 1043 1044 RXN02223 VV03082732 3232 1045 1046 F RXA02223 GR00652 425 6 1047 1048 RXN02226 VV00681059 4 1049 1050 F RXA02226 GR00653 1059 4 1051 1052 RXN02238 VV02041345 1629 1053 1054 F RXA02238 GR00654 5241 5525 1055 1056 RXN02254VV0202 2 1057 1058 F RXA02254 GR00654 21769 22449 1059 1060 RXN02271VV0020 14281 14838 1061 1062 F RXA02271 GR00655 5406 5963 1063 1064RXN02279 VV0020 236 1693 1065 1066 F RXA02279 GR00657 1 1404 1067 1068RXN02296 VV0127 24138 24626 1069 1070 F RXA02296 GR00662 6978 7466 10711072 RXN02300 VV0127 28354 28022 1073 1074 F RXA02300 GR00662 1119410862 1075 1076 RXN02301 VV0127 29070 28354 1077 1078 F RXA02301 GR0066211910 11194 1079 1080 RXN02302 VV0127 29196 30074 1081 1082 F RXA02302GR00662 12036 12800 1083 1084 RXN02303 VV0127 13326 14231 1085 1086 FRXA02303 GR00663 1 720 1087 1088 RXN02307 VV0127 12611 11991 1089 1090 FRXA02307 GR00664 395 6 1091 1092 RXN02314 VV0025 23092 23532 1093 1094 FRXA02314 GR00665 6379 5939 1095 1096 RXN02337 VV0141 4679 3357 1097 1098F RXA02337 GR00672 2893 3816 1099 1100 RXN02339 VV0195 1 1101 1102 FRXA02339 GR00674 1 492 1103 1104 RXN02340 VV0195 1640 576 1105 1106 FRXA02338 GR00673 484 5 1107 1108 F RXA02340 GR00674 1214 576 1109 1110RXN02341 VV0078 4279 4764 1111 1112 F RXA02341 GR00675 415 5 1113 1114RXN02360 VV0051 14638 12206 1115 1116 F RXA02360 GR00685 3644 6076 11171118 RXN02361 VV0051 12122 11472 1119 1120 F RXA02361 GR00685 6160 68101121 1122 RXN02367 VV0102 4639 5247 1123 1124 F RXA02367 GR00687 21621554 1125 1126 RXN02368 VV0102 3883 4557 1127 1128 F RXA02368 GR006872918 2244 1129 1130 RXN02381 VV0213 3765 2743 1131 1132 F RXA02381GR00691 1792 770 1133 1134 RXN02383 VV0213 639 4 1135 1136 F RXA02383GR00692 608 6 1137 1138 RXN02387 VV0176 2729 3490 1139 1140 F RXA02387GR00694 683 6 1141 1142 RXN02398 VV0176 12750 11149 1143 1144 F RXA02398GR00698 2841 4370 1145 1146 RXN02406 VV0084 22016 22564 1147 1148 FRXA02406 GR00701 1322 774 1149 1150 RXN02407 VV0084 21758 21387 11511152 F RXA02407 GR00701 1580 1885 1153 1154 RXN02408 VV0084 20832 199211155 1156 F RXA02408 GR00702 832 5 1157 1158 RXN02409 VV0084 21371 208351159 1160 F RXA02409 GR00702 1248 835 1161 1162 RXN02428 VV0110 45853452 1163 1164 F RXA02428 GR00707 4585 3452 1165 1166 RXN02454 VV01962810 1569 1167 1168 F RXA02454 GR00711 3 815 1169 1170 RXN02457 VV012419193 18084 1171 1172 F RXA02457 GR00712 1295 2404 1173 1174 RXN02460VV0124 14649 15152 1175 1176 F RXA02460 GR00712 5839 5336 1177 1178RXN02464 VV0211 1990 3189 1179 1180 F RXA02464 GR00713 1107 1613 11811182 RXN02465 VV0211 3590 3192 1183 1184 F RXA02465 GR00713 2014 16161185 1186 RXN02466 VV0211 92 6 1187 1188 F RXA02466 GR00714 92 6 11891190 RXN02505 VV0007 23969 24139 1191 1192 F RXA02505 GR00720 1842318593 1193 1194 RXN02510 VV0171 17467 16832 1195 1196 F RXA02510 GR007211983 2618 1197 1198 RXN02519 VV0183 2709 4337 1199 1200 F RXA02519GR00724 1933 128 1201 1202 RXN02520 VV0183 2243 1560 1203 1204 FRXA02520 GR00724 2222 2905 1205 1206 RXN02534 VV0057 11192 11995 12071208 F RXA02534 GR00726 5536 6339 1209 1210 RXN02537 VV0057 14617 150781211 1212 F RXA02537 GR00726 8961 9422 1213 1214 RXN02538 VV0057 1507815749 1215 1216 F RXA02538 GR00726 9422 10093 1217 1218 RXN02555 VV01015340 4738 1219 1220 F RXA02555 GR00731 1757 1155 1221 1222 RXN02564VV0154 10016 9015 1223 1224 F RXA02564 GR00732 2543 3217 1225 1226RXN02568 VV0245 1657 5 1227 1228 F RXA02568 GR00735 1363 5 1229 1230RXN02593 VV0098 11073 11669 1231 1232 F RXA02593 GR00741 18693 184811233 1234 F RXA02594 GR00741 19077 18754 1235 1236 RXN02606 VV0098 3455735927 1237 1238 F RXA02606 GR00742 13514 12144 1239 1240 RXN02610 VV009831620 30694 1241 1242 F RXA02610 GR00742 16452 17378 1243 1244 RXN02624VV0129 29202 30497 1245 1246 F RXA02624 GR00746 5602 4889 1247 1248RXN02626 VV0314 2012 1008 1249 1250 RXN02656 VV0090 15756 14917 12511252 RXN02673 VV0315 14030 13398 1253 1254 F RXA02673 GR00753 1403013398 1255 1256 RXN02680 VV0098 64917 66200 1257 1258 F RXA02680 GR007546392 5109 1259 1260 F RXA02679 GR00754 5268 5693 1261 1262 F RXA02681GR00754 5751 6194 1263 1264 RXN02693 VV0098 74100 75875 1265 1266 FRXA02693 GR00755 1650 4 1267 1268 RXN02696 VV0017 7946 7491 1269 1270 FRXA02696 GR00756 742 287 1271 1272 RXN02697 VV0017 31257 32783 1273 1274F RXA02697 GR00757 1 699 1275 1276 F RXA02719 GR00758 19598 20245 12771278 RXN02720 VV0017 8727 8026 1279 1280 F RXA02720 GR00759 631 5 12811282 RXN02744 VV0074 893 1696 1283 1284 F RXA02744 GR00763 14460 136571285 1286 RXN02770 VV0171 4202 2637 1287 1288 F RXA02770 GR00772 3 13221289 1290 RXN02781 VV0084 14566 13376 1291 1292 F RXA02781 GR00774 1345155 1293 1294 RXN02782 VV0093 7148 8446 1295 1296 F RXA02782 GR00775 204875 1297 1298 RXN02812 VV0210 342 4 1299 1300 F RXA02812 GR00793 2 5681301 1302 RXN02817 VV0346 403 5 1303 1304 F RXA02817 GR00798 403 5 13051306 RXN02818 VV0347 611 6 1307 1308 F RXA02818 GR00799 611 6 1309 1310RXN02825 VV0082 3589 1751 1311 1312 F RXA01322 GR00385 443 6 1313 1314 FRXA02824 GR00805 531 4 1315 1316 F RXA02825 GR00806 565 182 1317 1318RXN02838 VV0161 1 1319 1320 F RXA02838 GR00831 1 462 1321 1322 RXN02840VV0365 488 339 1323 1324 F RXA02840 GR00835 488 339 1325 1326 RXN02841VV0055 11788 12222 1327 1328 F RXA02841 GR00840 283 5 1329 1330 RXN02846VV0127 30861 30112 1331 1332 F RXA02846 GR00845 578 6 1333 1334 RXN02847VV0113 47 1135 1335 1336 F RXA02847 GR00847 598 5 1337 1338 RXN02849VV0237 2 1339 1340 F RXA02849 GR00849 2 283 1341 1342 RXN02911 VV013524643 25101 1343 1344 RXN02914 VV0127 17305 16763 1345 1346 RXN02921VV0213 1871 1401 1347 1348 RXN02924 VV0088 4557 5105 1349 1350 RXN02927VV0082 18836 19303 1351 1352 RXN02928 VV0082 19511 20203 1353 1354RXN02931 VV0090 25420 25644 1355 1356 RXN02932 VV0176 23391 24362 13571358 RXN02934 VV0103 14533 14838 1359 1360 RXN02936 VV0197 24360 245571361 1362 RXN02939 VV0008 33988 32387 1363 1364 F RXA01383 GR00406 11475 1365 1366 RXN02950 VV0224 7629 7306 1367 1368 RXN02951 VV0176 57395131 1369 1370 RXN02957 VV0020 30448 30158 1371 1372 RXN02967 VV03186614 6931 1373 1374 RXN02971 VV0210 951 640 1375 1376 RXN02978 VV00102191 683 1377 1378 RXN02995 VV0069 348 1913 1379 1380 RXN02997 VV00693709 2981 1381 1382 RXN03001 VV0170 422 874 1383 1384 RXN03005 VV02371101 334 1385 1386 RXN03009 VV0238 353 6 1387 1388 RXN03010 VV0238 74357199 1389 1390 RXN03011 VV0098 2984 3184 1391 1392 RXN03012 VV0241 2 5711393 1394 RXN03017 VV0218 5720 7258 1395 1396 F RXA02753 GR00765 2630138 1397 1398 RXN03018 VV0218 7221 8213 1399 1400 RXN03024 VV0003 63157730 1401 1402 RXN03025 VV0003 8668 7796 1403 1404 RXN03027 VV0008 17151 1405 1406 RXN03029 VV0009 95 607 1407 1408 RXN03031 VV0011 1 7891409 1410 RXN03032 VV0012 3652 3936 1411 1412 RXN03034 VV0013 2 661 14131414 F RXA00063 GR00010 1658 1374 1415 1416 RXN03037 VV0015 5364 55491417 1418 RXN03041 VV0018 1770 1273 1419 1420 F RXA02892 GR10035 1171668 1421 1422 RXN03045 VV0019 33044 34039 1423 1424 RXN03046 VV0020 1336 1425 1426 RXN03047 VV0020 25070 26485 1427 1428 F RXA00036 GR000047204 8619 1429 1430 RXN03048 VV0020 27423 26551 1431 1432 F RXA00037GR00004 9557 8685 1433 1434 RXN03050 VV0021 6368 7333 1435 1436 RXN03053VV0026 12 1535 1437 1438 F RXA02885 GR10021 1 1536 1439 1440 RXN03055VV0026 3519 3947 1441 1442 F RXA00261 GR00039 11693 11265 1443 1444 FRXA02888 GR10024 326 754 1445 1446 RXN03059 VV0030 5373 4894 1447 1448 FRXA02899 GR10040 2125 1646 1449 1450 RXN03062 VV0035 525 4 1451 1452RXN03066 VV0038 7298 6636 1453 1454 F RXA02876 GR10016 405 1067 14551456 RXN03067 VV0038 7493 7323 1457 1458 RXN03068 VV0038 7648 7529 14591460 RXN03073 VV0042 1573 944 1461 1462 F RXA02905 GR10044 477 4 14631464 RXN03085 VV0048 4511 4161 1465 1466 RXN03089 VV0053 1183 26 14671468 F RXA00071 GR00011 4013 5464 1469 1470 RXN03098 VV0064 2100 27231471 1472 RXN03099 VV0064 5576 6250 1473 1474 RXN03104 VV0071 401 5771475 1476 RXN03106 VV0074 15930 16121 1477 1478 RXN03107 VV0076 232 4321479 1480 RXN03113 VV0086 6541 8139 1481 1482 F RXA00506 GR00126 4891829 1483 1484 RXN03115 VV0089 148 546 1485 1486 RXN03122 VV0104 33293475 1487 1488 RXN03134 VV0127 65312 65662 1489 1490 RXN03135 VV012766674 67402 1491 1492 F RXA02285 GR00660 1544 2272 1493 1494 RXN03138VV0129 21194 21664 1495 1496 RXN03140 VV0131 4550 4302 1497 1498RXN03141 VV0135 31144 31473 1499 1500 RXN03146 VV0143 25998 26468 15011502 RXN03147 VV0144 2726 2977 1503 1504 RXN03149 VV0146 969 1235 15051506 RXN03152 VV0166 264 536 1507 1508 RXN03153 VV0176 46481 47044 15091510 RXN03154 VV0179 1328 2239 1511 1512 RXN03156 VV0187 4908 5087 15131514 F RXA00176 GR00027 3475 3317 1515 1516 RXN03162 VV0195 909 13041517 1518 RXN03167 VV0327 633 4 1519 1520 F RXA02862 GR10006 1695 23301521 1522 RXN03170 VV0328 457 209 1523 1524 F RXA02856 GR10003 459 2111525 1526 RXN03172 VV0329 1392 367 1527 1528 F RXA02858 GR10004 1392 3671529 1530 RXN03173 VV0330 1340 243 1531 1532 F RXA02874 GR10015 1348 8691533 1534 RXN03174 VV0331 461 6 1535 1536 F RXA02884 GR10020 1695 21561537 1538 RXN03177 VV0333 816 151 1539 1540 F RXA02881 GR10019 94 7591541 1542 RXN03182 VV0339 276 4 1543 1544 RXN03184 VV0374 517 20 15451546 RXN03185 VV0375 311 123 1547 1548 RXA00003 GR00001 2279 3019 15491550 RXA00008 GR00002 606 115 1551 1552 RXA00015 GR00002 5999 6307 15531554 RXA00018 GR00002 12979 14277 1555 1556 RXA00020 GR00002 17142 163631557 1558 RXA00021 GR00002 18766 20538 1559 1560 RXA00025 GR00003 22113647 1561 1562 RXA00031 GR00003 10383 9982 1563 1564 RXA00049 GR000082270 2956 1565 1566 RXA00052 GR00008 7957 7247 1567 1568 RXA00054GR00008 8557 11469 1569 1570 RXA00058 GR00009 7394 6831 1571 1572RXA00059 GR00009 8301 8020 1573 1574 RXA00065 GR00010 4140 4412 15751576 RXA00068 GR00011 1305 724 1577 1578 RXA00079 GR00012 6599 6820 15791580 RXA00082 GR00012 9019 8456 1581 1582 RXA00083 GR00013 771 1070 15831584 RXA00093 GR00014 204 2426 1585 1586 RXA00101 GR00014 10514 101071587 1588 RXA00108 GR00015 546 4 1589 1590 RXA00110 GR00016 364 912 15911592 RXA00117 GR00019 791 201 1593 1594 RXA00118 GR00019 918 1172 15951596 RXA00119 GR00019 1704 2462 1597 1598 RXA00121 GR00019 3473 41831599 1600 RXA00122 GR00019 4220 5842 1601 1602 RXA00127 GR00020 28712416 1603 1604 RXA00134 GR00021 1648 1079 1605 1606 RXA00140 GR000223841 3656 1607 1608 RXA00141 GR00022 4307 3846 1609 1610 RXA00142GR00022 4776 4300 1611 1612 RXA00150 GR00023 4085 4858 1613 1614RXA00151 GR00023 4956 5552 1615 1616 RXA00153 GR00023 7656 7231 16171618 RXA00155 GR00023 8615 9397 1619 1620 RXA00159 GR00024 3868 26871621 1622 RXA00161 GR00024 4893 5354 1623 1624 RXA00169 GR00026 52223150 1625 1626 RXA00170 GR00026 9914 8061 1627 1628 RXA00173 GR000271716 1384 1629 1630 RXA00174 GR00027 2079 1795 1631 1632 RXA00175GR00027 2732 2103 1633 1634 RXA00179 GR00028 1714 1256 1635 1636RXA00180 GR00028 2334 1795 1637 1638 RXA00183 GR00028 7344 8195 16391640 RXA00185 GR00028 9418 12045 1641 1642 RXA00199 GR00031 2172 7541643 1644 RXA00200 GR00031 2837 2535 1645 1646 RXA00207 GR00032 64306747 1647 1648 RXA00211 GR00032 10120 10782 1649 1650 RXA00218 GR0003218104 19243 1651 1652 RXA00220 GR00032 20666 20163 1653 1654 RXA00230GR00034 746 27 1655 1656 RXA00233 GR00036 420 4 1657 1658 RXA00234GR00036 998 459 1659 1660 RXA00237 GR00036 3668 4045 1661 1662 RXA00238GR00036 4186 4554 1663 1664 RXA00239 GR00036 5118 4534 1665 1666RXA00240 GR00036 5342 5133 1667 1668 RXA00244 GR00037 1565 930 1669 1670RXA00245 GR00037 3049 1565 1671 1672 RXA00248 GR00037 7843 7121 16731674 RXA00250 GR00038 6 221 1675 1676 RXA00252 GR00038 485 727 1677 1678RXA00257 GR00039 1760 2215 1679 1680 RXA00258 GR00039 3219 3890 16811682 RXA00260 GR00039 9234 10409 1683 1684 RXA00273 GR00042 185 12971685 1686 RXA00274 GR00042 1556 4165 1687 1688 RXA00275 GR00042 46964238 1689 1690 RXA00276 GR00042 5016 4675 1691 1692 RXA00279 GR000434001 2616 1693 1694 RXA00282 GR00044 793 5 1695 1696 RXA00285 GR00046 3515 1697 1698 RXA00286 GR00046 579 1142 1699 1700 RXA00294 GR00047 27613189 1701 1702 RXA00297 GR00048 2861 3772 1703 1704 RXA00320 GR00057 358537 1705 1706 RXA00321 GR00057 2411 597 1707 1708 RXA00322 GR00057 36582555 1709 1710 RXA00325 GR00057 8594 9238 1711 1712 RXA00326 GR000579378 9857 1713 1714 RXA00336 GR00057 19461 19931 1715 1716 RXA00337GR00058 530 6 1717 1718 RXA00339 GR00059 817 1533 1719 1720 RXA00349GR00066 3 1061 1721 1722 RXA00355 GR00069 635 510 1723 1724 RXA00375GR00080 549 49 1725 1726 RXA00380 GR00082 836 216 1727 1728 RXA00387GR00084 1403 591 1729 1730 RXA00392 GR00086 3890 3027 1731 1732 RXA00394GR00086 5322 4990 1733 1734 RXA00395 GR00086 5417 5716 1735 1736RXA00396 GR00086 6653 6183 1737 1738 RXA00397 GR00086 7206 6667 17391740 RXA00398 GR00087 1 681 1741 1742 RXA00408 GR00091 642 1088 17431744 RXA00409 GR00091 1088 2500 1745 1746 RXA00411 GR00092 1685 10111747 1748 RXA00423 GR00097 909 457 1749 1750 RXA00424 GR00097 1379 9091751 1752 RXA00425 GR00097 1433 1657 1753 1754 RXA00428 GR00098 26572025 1755 1756 RXA00429 GR00098 3063 2662 1757 1758 RXA00430 GR000983473 3063 1759 1760 RXA00433 GR00100 1446 1970 1761 1762 RXA00451GR00110 816 325 1763 1764 RXA00457 GR00114 1451 372 1765 1766 RXA00462GR00116 3023 1644 1767 1768 RXA00463 GR00116 4209 3388 1769 1770RXA00468 GR00118 1282 464 1771 1772 RXA00469 GR00119 1647 472 1773 1774RXA00472 GR00119 5449 4589 1775 1776 RXA00474 GR00119 6575 8152 17771778 RXA00475 GR00119 8822 8163 1779 1780 RXA00476 GR00119 8961 98211781 1782 RXA00481 GR00119 17636 18220 1783 1784 RXA00486 GR00120 1 7021785 1786 RXA00490 GR00121 2676 1774 1787 1788 RXA00491 GR00122 1057 6381789 1790 RXA00493 GR00123 3 326 1791 1792 RXA00519 GR00132 4 516 17931794 RXA00528 GR00136 3562 4650 1795 1796 RXA00529 GR00136 5274 47321797 1798 RXA00530 GR00136 6837 5557 1799 1800 RXA00535 GR00137 51555871 1801 1802 RXA00540 GR00139 2027 2269 1803 1804 RXA00549 GR00143 502897 1805 1806 RXA00550 GR00143 935 1255 1807 1808 RXA00553 GR00145 7421062 1809 1810 RXA00554 GR00145 1606 1136 1811 1812 RXA00563 GR00151 12739 1813 1814 RXA00564 GR00151 3744 4148 1815 1816 RXA00573 GR00156 117767 1817 1818 RXA00576 GR00156 2916 2245 1819 1820 RXA00577 GR00156 29803327 1821 1822 RXA00578 GR00156 4087 3365 1823 1824 RXA00582 GR001569442 8924 1825 1826 RXA00585 GR00156 11894 11577 1827 1828 RXA00586GR00156 12818 11937 1829 1830 RXA00587 GR00156 13008 13490 1831 1832RXA00595 GR00159 3 332 1833 1834 RXA00597 GR00159 797 1066 1835 1836RXA00598 GR00159 1070 1387 1837 1838 RXA00601 GR00159 3459 3749 18391840 RXA00602 GR00159 4907 4155 1841 1842 RXA00604 GR00159 5489 57791843 1844 RXA00610 GR00161 1193 2056 1845 1846 RXA00611 GR00161 36402165 1847 1848 RXA00613 GR00162 1652 1200 1849 1850 RXA00614 GR001621680 2594 1851 1852 RXA00617 GR00162 4002 5084 1853 1854 RXA00628GR00165 1284 877 1855 1856 RXA00631 GR00166 172 1626 1857 1858 RXA00637GR00167 2002 2754 1859 1860 RXA00646 GR00169 446 6 1861 1862 RXA00649GR00169 2823 3278 1863 1864 RXA00652 GR00169 5449 5997 1865 1866RXA00654 GR00169 7213 8478 1867 1868 RXA00656 GR00169 9495 9235 18691870 RXA00657 GR00169 10882 9980 1871 1872 RXA00661 GR00172 664 13531873 1874 RXA00667 GR00175 593 1177 1875 1876 RXA00676 GR00178 647 13931877 1878 RXA00678 GR00179 1037 303 1879 1880 RXA00691 GR00181 2152 12231881 1882 RXA00692 GR00181 3450 2317 1883 1884 RXA00693 GR00181 43033821 1885 1886 RXA00701 GR00182 427 801 1887 1888 RXA00707 GR00185 3771348 1889 1890 RXA00713 GR00188 71 1033 1891 1892 RXA00714 GR00188 18091249 1893 1894 RXA00716 GR00188 3002 3514 1895 1896 RXA00719 GR001885283 6911 1897 1898 RXA00724 GR00191 811 164 1899 1900 RXA00726 GR00192841 701 1901 1902 RXA00740 GR00202 1646 1068 1903 1904 RXA00741 GR002022986 2054 1905 1906 RXA00742 GR00202 5517 3868 1907 1908 RXA00743GR00202 6652 6230 1909 1910 RXA00745 GR00202 13874 13341 1911 1912RXA00746 GR00202 13755 14945 1913 1914 RXA00747 GR00202 15067 15654 19151916 RXA00748 GR00202 15917 16360 1917 1918 RXA00749 GR00202 17240 165421919 1920 RXA00751 GR00202 20245 19418 1921 1922 RXA00752 GR00202 2184721419 1923 1924 RXA00757 GR00203 3119 4372 1925 1926 RXA00763 GR002041384 2166 1927 1928 RXA00765 GR00204 3283 3969 1929 1930 RXA00781GR00206 2682 2395 1931 1932 RXA00788 GR00209 910 686 1933 1934 RXA00804GR00215 438 881 1935 1936 RXA00805 GR00215 2057 2938 1937 1938 RXA00808GR00217 1029 352 1939 1940 RXA00812 GR00219 287 1345 1941 1942 RXA00814GR00219 2463 3236 1943 1944 RXA00815 GR00219 3236 3808 1945 1946RXA00816 GR00219 4382 4678 1947 1948 RXA00826 GR00223 567 37 1949 1950RXA00830 GR00224 266 988 1951 1952 RXA00853 GR00231 3775 3173 1953 1954RXA00861 GR00235 6 431 1955 1956 RXA00862 GR00236 580 17 1957 1958RXA00874 GR00241 758 1846 1959 1960 RXA00876 GR00241 4208 2454 1961 1962RXA00881 GR00242 8057 8434 1963 1964 RXA00882 GR00242 8788 9465 19651966 RXA00883 GR00242 10060 9542 1967 1968 RXA00887 GR00242 13544 142661969 1970 RXA00889 GR00242 15341 15928 1971 1972 RXA00893 GR00244 789193 1973 1974 RXA00895 GR00244 2578 1988 1975 1976 RXA00904 GR00246 1457702 1977 1978 RXA00908 GR00247 1611 2168 1979 1980 RXA00916 GR00251 4108518 1981 1982 RXA00926 GR00253 466 104 1983 1984 RXA00930 GR00253 38413089 1985 1986 RXA00932 GR00253 5068 5541 1987 1988 RXA00933 GR002536047 5586 1989 1990 RXA00940 GR00257 129 524 1991 1992 RXA00949 GR002595400 6047 1993 1994 RXA00969 GR00273 1 147 1995 1996 RXA00973 GR002742272 1670 1997 1998 RXA00978 GR00276 217 831 1999 2000 RXA00986 GR0028060 401 2001 2002 RXA00987 GR00280 875 411 2003 2004 RXA00988 GR002801371 949 2005 2006 RXA01005 GR00286 520 1365 2007 2008 RXA01007 GR002872572 866 2009 2010 RXA01008 GR00287 2719 4659 2011 2012 RXA01011 GR002882089 857 2013 2014 RXA01017 GR00290 2175 1567 2015 2016 RXA01021 GR002911759 2280 2017 2018 RXA01029 GR00295 1338 1826 2019 2020 RXA01031GR00295 3182 3847 2021 2022 RXA01032 GR00295 3974 4348 2023 2024RXA01033 GR00295 4363 4698 2025 2026 RXA01034 GR00295 5177 4824 20272028 RXA01035 GR00295 5818 6423 2029 2030 RXA01036 GR00295 6513 69652031 2032 RXA01037 GR00295 7000 7527 2033 2034 RXA01038 GR00295 75308276 2035 2036 RXA01039 GR00295 9540 8965 2037 2038 RXA01040 GR002959711 10613 2039 2040 RXA01041 GR00295 10780 10932 2041 2042 RXA01042GR00295 11088 12365 2043 2044 RXA01043 GR00295 12774 13346 2045 2046RXA01044 GR00295 14024 15280 2047 2048 RXA01045 GR00295 15407 17230 20492050 RXA01046 GR00295 17441 19219 2051 2052 RXA01047 GR00295 19244 197172053 2054 RXA01058 GR00296 8566 8246 2055 2056 RXA01063 GR00297 828 4992057 2058 RXA01066 GR00298 605 1330 2059 2060 RXA01068 GR00298 2184 32542061 2062 RXA01074 GR00300 2811 2107 2063 2064 RXA01076 GR00300 43743355 2065 2066 RXA01078 GR00300 6043 6876 2067 2068 RXA01083 GR003021777 1502 2069 2070 RXA01088 GR00304 3083 1902 2071 2072 RXA01091GR00305 546 76 2073 2074 RXA01092 GR00305 702 881 2075 2076 RXA01092GR00305 702 881 2077 2078 RXA01096 GR00306 4341 3643 2079 2080 RXA01102GR00306 10018 8774 2081 2082 RXA01103 GR00306 10316 10092 2083 2084RXA01107 GR00306 13612 14811 2085 2086 RXA01108 GR00306 15562 14912 20872088 RXA01109 GR00306 16281 15640 2089 2090 RXA01119 GR00310 1068 1392091 2092 RXA01122 GR00311 557 36 2093 2094 RXA01123 GR00311 1090 6442095 2096 RXA01127 GR00314 2 280 2097 2098 RXA01129 GR00314 1461 33262099 2100 RXA01131 GR00315 445 1311 2101 2102 RXA01137 GR00318 1101 14602103 2104 RXA01156 GR00327 1588 1388 2105 2106 RXA01158 GR00328 25801639 2107 2108 RXA01159 GR00328 3089 2775 2109 2110 RXA01160 GR003284187 3213 2111 2112 RXA01163 GR00331 710 6 2113 2114 RXA01165 GR003322155 1583 2115 2116 RXA01166 GR00332 3005 2523 2117 2118 RXA01170GR00334 638 1120 2119 2120 RXA01171 GR00334 1714 2406 2121 2122 RXA01176GR00335 1980 1477 2123 2124 RXA01177 GR00335 2121 4106 2125 2126RXA01178 GR00335 4106 4555 2127 2128 RXA01184 GR00338 1489 17 2129 2130RXA01186 GR00338 3742 2645 2131 2132 RXA01186 GR00338 3742 2645 21332134 RXA01187 GR00338 3850 4308 2135 2136 RXA01195 GR00343 1413 18592137 2138 RXA01196 GR00343 1889 2578 2139 2140 RXA01197 GR00343 33332881 2141 2142 RXA01198 GR00343 3422 3724 2143 2144 RXA01207 GR00347 126773 2145 2146 RXA01213 GR00351 1508 282 2147 2148 RXA01218 GR00353 10781506 2149 2150 RXA01234 GR00357 633 250 2151 2152 RXA01237 GR00358 27512311 2153 2154 RXA01267 GR00367 16799 15486 2155 2156 RXA01268 GR0036719365 18526 2157 2158 RXA01271 GR00367 23467 21656 2159 2160 RXA01273GR00367 26475 25042 2161 2162 RXA01282 GR00369 5444 4665 2163 2164RXA01294 GR00373 3537 2872 2165 2166 RXA01295 GR00373 3764 4738 21672168 RXA01304 GR00376 1982 2467 2169 2170 RXA01310 GR00380 803 477 21712172 RXA01313 GR00381 1116 172 2173 2174 RXA01315 GR00382 1394 744 21752176 RXA01316 GR00382 1855 1553 2177 2178 RXA01317 GR00382 2296 18772179 2180 RXA01318 GR00382 3616 2315 2181 2182 RXA01330 GR00387 569 10242183 2184 RXA01333 GR00389 1231 227 2185 2186 RXA01336 GR00389 3640 30382187 2188 RXA01342 GR00389 11296 12807 2189 2190 RXA01348 GR00392 261752 2191 2192 RXA01349 GR00392 1531 755 2193 2194 RXA01357 GR00393 43574659 2195 2196 RXA01359 GR00393 6857 8038 2197 2198 RXA01366 GR003971369 980 2199 2200 RXA01367 GR00397 1518 1919 2201 2202 RXA01370 GR003981875 2225 2203 2204 RXA01372 GR00399 1 591 2205 2206 RXA01378 GR004011281 4 2207 2208 RXA01380 GR00403 2 2017 2209 2210 RXA01384 GR00406 32381523 2211 2212 RXA01396 GR00408 6475 6218 2213 2214 RXA01397 GR004086894 6475 2215 2216 RXA01401 GR00409 3193 3453 2217 2218 RXA01402GR00409 3508 3981 2219 2220 RXA01405 GR00410 1844 1389 2221 2222RXA01413 GR00412 854 1453 2223 2224 RXA01414 GR00412 1628 2134 2225 2226RXA01417 GR00414 645 49 2227 2228 RXA01421 GR00416 1215 829 2229 2230RXA01425 GR00417 1701 2585 2231 2232 RXA01429 GR00417 5651 6268 22332234 RXA01439 GR00418 5949 6494 2235 2236 RXA01440 GR00418 7496 64892237 2238 RXA01441 GR00418 8542 7514 2239 2240 RXA01445 GR00418 1508314091 2241 2242 RXA01447 GR00418 17885 18733 2243 2244 RXA01452 GR004192363 2641 2245 2246 RXA01456 GR00420 898 1419 2247 2248 RXA01457 GR004201499 2173 2249 2250 RXA01463 GR00421 2493 1330 2251 2252 RXA01469GR00422 2091 3122 2253 2254 RXA01470 GR00422 4112 3687 2255 2256RXA01472 GR00422 5783 5328 2257 2258 RXA01473 GR00422 6596 5832 22592260 RXA01474 GR00422 6678 7223 2261 2262 RXA01475 GR00422 7651 72262263 2264 RXA01476 GR00422 7847 8188 2265 2266 RXA01488 GR00423 21791349 2267 2268 RXA01494 GR00423 8515 7520 2269 2270 RXA01497 GR00424 2621179 2271 2272 RXA01501 GR00424 8130 7843 2273 2274 RXA01504 GR0042410710 11318 2275 2276 RXA01505 GR00424 11318 11815 2277 2278 RXA01506GR00424 11815 12225 2279 2280 RXA01507 GR00424 12239 12661 2281 2282RXA01519 GR00424 23725 24471 2283 2284 RXA01520 GR00424 24784 25167 22852286 RXA01523 GR00424 27951 28901 2287 2288 RXA01525 GR00424 32301 305802289 2290 RXA01527 GR00425 5126 2616 2291 2292 RXA01536 GR00427 40662825 2293 2294 RXA01540 GR00428 3083 2382 2295 2296 RXA01543 GR004302802 37 2297 2298 RXA01544 GR00430 3496 2897 2299 2300 RXA01545 GR004304838 3588 2301 2302 RXA01546 GR00430 5584 4889 2303 2304 RXA01547GR00430 6371 5709 2305 2306 RXA01548 GR00430 7432 6425 2307 2308RXA01552 GR00431 6122 5145 2309 2310 RXA01554 GR00432 3719 1578 23112312 RXA01560 GR00435 767 438 2313 2314 RXA01575 GR00438 8024 7005 23152316 RXA01577 GR00438 8811 9185 2317 2318 RXA01579 GR00439 671 1054 23192320 RXA01585 GR00441 1226 600 2321 2322 RXA01586 GR00441 1597 1229 23232324 RXA01595 GR00447 3326 4285 2325 2326 RXA01600 GR00447 10460 111282327 2328 RXA01602 GR00447 13591 12062 2329 2330 RXA01605 GR00448 9602474 2331 2332 RXA01610 GR00449 4343 3615 2333 2334 RXA01611 GR004494832 4476 2335 2336 RXA01612 GR00449 5235 4891 2337 2338 RXA01619GR00451 2407 1433 2339 2340 RXA01622 GR00452 1908 2510 2341 2342RXA01623 GR00452 2514 3224 2343 2344 RXA01624 GR00452 3220 3564 23452346 RXA01628 GR00453 866 1879 2347 2348 RXA01630 GR00454 341 1417 23492350 RXA01641 GR00456 5182 6552 2351 2352 RXA01642 GR00456 6557 77982353 2354 RXA01643 GR00456 8374 7949 2355 2356 RXA01645 GR00456 105749969 2357 2358 RXA01646 GR00456 11513 10695 2359 2360 RXA01656 GR004601548 2444 2361 2362 RXA01665 GR00463 2152 1433 2363 2364 RXA01671GR00466 854 1468 2365 2366 RXA01673 GR00467 1807 773 2367 2368 RXA01675GR00467 2824 3234 2369 2370 RXA01676 GR00467 4179 3424 2371 2372RXA01677 GR00467 5043 4300 2373 2374 RXA01681 GR00467 10681 11313 23752376 RXA01685 GR00470 1488 910 2377 2378 RXA01686 GR00470 2026 1586 23792380 RXA01693 GR00474 1553 2974 2381 2382 RXA01714 GR00485 985 371 23832384 RXA01715 GR00485 1267 1962 2385 2386 RXA01729 GR00489 2636 31542387 2388 RXA01731 GR00491 109 807 2389 2390 RXA01738 GR00493 3971 46842391 2392 RXA01741 GR00493 7535 6738 2393 2394 RXA01748 GR00495 36814460 2395 2396 RXA01749 GR00495 4633 6249 2397 2398 RXA01750 GR004961878 3518 2399 2400 RXA01752 GR00497 557 6 2401 2402 RXA01753 GR004972095 557 2403 2404 RXA01760 GR00498 5095 5376 2405 2406 RXA01768 GR00501827 450 2407 2408 RXA01770 GR00501 5134 1370 2409 2410 RXA01773 GR0050334 444 2411 2412 RXA01775 GR00504 178 741 2413 2414 RXA01776 GR00504 8382289 2415 2416 RXA01777 GR00504 2319 2777 2417 2418 RXA01778 GR005042912 4048 2419 2420 RXA01779 GR00504 4246 5664 2421 2422 RXA01780GR00504 5721 6095 2423 2424 RXA01781 GR00504 6052 6312 2425 2426RXA01782 GR00504 6384 6779 2427 2428 RXA01783 GR00504 6842 7078 24292430 RXA01785 GR00505 729 1304 2431 2432 RXA01788 GR00506 361 801 24332434 RXA01789 GR00506 875 1516 2435 2436 RXA01790 GR00506 1672 1731 24372438 RXA01791 GR00506 1885 2247 2439 2440 RXA01792 GR00506 2310 25822441 2442 RXA01793 GR00506 2916 3149 2443 2444 RXA01794 GR00506 31943427 2445 2446 RXA01799 GR00509 377 1570 2447 2448 RXA01800 GR00509 22921573 2449 2450 RXA01804 GR00509 6117 5797 2451 2452 RXA01805 GR005096515 6186 2453 2454 RXA01806 GR00509 6595 7074 2455 2456 RXA01816GR00515 4210 4941 2457 2458 RXA01817 GR00515 4941 5573 2459 2460RXA01820 GR00515 8360 9733 2461 2462 RXA01842 GR00522 1397 480 2463 2464RXA01844 GR00522 1950 1771 2465 2466 RXA01845 GR00522 1919 2326 24672468 RXA01856 GR00527 225 770 2469 2470 RXA01857 GR00527 939 1589 24712472 RXA01858 GR00529 578 6 2473 2474 RXA01870 GR00534 2123 2797 24752476 RXA01871 GR00534 2797 3759 2477 2478 RXA01903 GR00545 3 281 24792480 RXA01904 GR00545 762 340 2481 2482 RXA01905 GR00545 1074 1604 24832484 RXA01906 GR00545 2322 2786 2485 2486 RXA01907 GR00545 3176 37872487 2488 RXA01923 GR00552 1311 1739 2489 2490 RXA01931 GR00555 49135566 2491 2492 RXA01941 GR00557 995 1429 2493 2494 RXA01942 GR00557 35262927 2495 2496 RXA01957 GR00564 389 850 2497 2498 RXA01958 GR00564 9101416 2499 2500 RXA01959 GR00564 1639 2019 2501 2502 RXA01961 GR00565 5211000 2503 2504 RXA01962 GR00565 1022 1591 2505 2506 RXA01963 GR005651757 2440 2507 2508 RXA01964 GR00566 1329 4 2509 2510 RXA01965 GR005661935 1375 2511 2512 RXA01966 GR00567 47 703 2513 2514 RXA01968 GR005673295 2138 2515 2516 RXA01969 GR00567 5689 5216 2517 2518 RXA01973GR00570 2 583 2519 2520 RXA01974 GR00570 658 2109 2521 2522 RXA01976GR00571 3742 2222 2523 2524 RXA01977 GR00571 4547 3972 2525 2526RXA01982 GR00573 3001 1844 2527 2528 RXA01990 GR00581 1 999 2529 2530RXA01992 GR00583 709 260 2531 2532 RXA01999 GR00589 2384 2854 2533 2534RXA02001 GR00590 700 152 2535 2536 RXA02004 GR00594 3 209 2537 2538RXA02006 GR00597 498 4 2539 2540 RXA02009 GR00601 127 5 2541 2542RXA02013 GR00607 553 5 2543 2544 RXA02021 GR00613 2008 1061 2545 2546RXA02036 GR00619 3441 3821 2547 2548 RXA02040 GR00621 1452 925 2549 2550RXA02046 GR00623 2680 2943 2551 2552 RXA02051 GR00624 3186 3683 25532554 RXA02053 GR00624 5484 6062 2555 2556 RXA02057 GR00625 2972 35022557 2558 RXA02058 GR00625 4051 3500 2559 2560 RXA02069 GR00627 11161694 2561 2562 RXA02070 GR00627 1733 2830 2563 2564 RXA02080 GR0062811017 10211 2565 2566 RXA02081 GR00628 12307 13935 2567 2568 RXA02084GR00629 2920 2576 2569 2570 RXA02089 GR00629 8431 8901 2571 2572RXA02090 GR00629 9764 8964 2573 2574 RXA02091 GR00629 10512 9862 25752576 RXA02097 GR00630 184 3555 2577 2578 RXA02102 GR00631 4479 3322 25792580 RXA02103 GR00631 4510 4905 2581 2582 RXA02109 GR00632 3460 25402583 2584 RXA02117 GR00636 1056 1529 2585 2586 RXA02123 GR00636 65587928 2587 2588 RXA02124 GR00636 7956 9911 2589 2590 RXA02125 GR00637 7391539 2591 2592 RXA02129 GR00637 5906 6139 2593 2594 RXA02132 GR00638 7371375 2595 2596 RXA02137 GR00639 4166 3369 2597 2598 RXA02141 GR006398457 8864 2599 2600 RXA02146 GR00639 14742 15368 2601 2602 RXA02152GR00640 237 638 2603 2604 RXA02163 GR00640 10072 10824 2605 2606RXA02164 GR00640 10824 12398 2607 2608 RXA02165 GR00640 12388 12999 26092610 RXA02166 GR00640 13048 13224 2611 2612 RXA02168 GR00641 2894 812613 2614 RXA02170 GR00641 4798 4025 2615 2616 RXA02172 GR00641 69196581 2617 2618 RXA02177 GR00641 12683 13615 2619 2620 RXA02178 GR0064113628 14497 2621 2622 RXA02181 GR00641 17168 17845 2623 2624 RXA02183GR00641 18663 19187 2625 2626 RXA02187 GR00641 21249 23447 2627 2628RXA02199 GR00646 2591 3160 2629 2630 RXA02203 GR00646 7469 7092 26312632 RXA02206 GR00646 9927 10862 2633 2634 RXA02211 GR00648 2537 29892635 2636 RXA02212 GR00649 964 467 2637 2638 RXA02216 GR00651 2 307 26392640 RXA02217 GR00651 968 306 2641 2642 RXA02218 GR00651 1299 1565 26432644 RXA02219 GR00651 1578 2963 2645 2646 RXA02221 GR00651 6720 80812647 2648 RXA02227 GR00653 1236 1853 2649 2650 RXA02230 GR00653 41563620 2651 2652 RXA02231 GR00653 5111 4356 2653 2654 RXA02244 GR0065412058 13590 2655 2656 RXA02255 GR00654 22507 23442 2657 2658 RXA02266GR00655 653 1165 2659 2660 RXA02267 GR00655 2053 1181 2661 2662 RXA02280GR00658 2 754 2663 2664 RXA02286 GR00660 3285 3833 2665 2666 RXA02287GR00660 4071 4622 2667 2668 RXA02294 GR00662 5992 5618 2669 2670RXA02295 GR00662 6842 6063 2671 2672 RXA02297 GR00662 7502 8638 26732674 RXA02298 GR00662 10310 8652 2675 2676 RXA02304 GR00663 1613 7232677 2678 RXA02308 GR00664 939 511 2679 2680 RXA02324 GR00668 1548 26332681 2682 RXA02325 GR00668 4314 3445 2683 2684 RXA02331 GR00671 396 7612685 2686 RXA02336 GR00672 2731 2552 2687 2688 RXA02347 GR00677 509 1892689 2690 RXA02349 GR00678 394 5 2691 2692 RXA02352 GR00681 2 556 26932694 RXA02356 GR00684 761 1756 2695 2696 RXA02358 GR00685 1239 1529 26972698 RXA02362 GR00685 7045 10743 2699 2700 RXA02374 GR00688 1626 22462701 2702 RXA02390 GR00695 1500 832 2703 2704 RXA02393 GR00697 168 4492705 2706 RXA02395 GR00698 2 733 2707 2708 RXA02396 GR00698 1309 10312709 2710 RXA02403 GR00700 896 1660 2711 2712 RXA02412 GR00703 2043 25222713 2714 RXA02417 GR00705 4755 2632 2715 2716 RXA02421 GR00705 72376428 2717 2718 RXA02425 GR00707 1 630 2719 2720 RXA02427 GR00707 34473061 2721 2722 RXA02430 GR00707 7498 7683 2723 2724 RXA02433 GR007082981 3580 2725 2726 RXA02437 GR00709 1661 2470 2727 2728 RXA02443GR00709 6818 7771 2729 2730 RXA02444 GR00709 7836 9113 2731 2732RXA02452 GR00710 5271 5092 2733 2734 RXA02459 GR00712 4341 5075 27352736 RXA02461 GR00712 6252 5845 2737 2738 RXA02467 GR00714 643 419 27392740 RXA02472 GR00715 5435 5725 2741 2742 RXA02473 GR00715 6664 59242743 2744 RXA02475 GR00715 9595 8441 2745 2746 RXA02478 GR00716 1245 102747 2748 RXA02482 GR00718 914 105 2749 2750 RXA02483 GR00718 1813 10012751 2752 RXA02484 GR00718 2317 1817 2753 2754 RXA02486 GR00718 34414076 2755 2756 RXA02488 GR00719 1 369 2757 2758 RXA02489 GR00719 373 9962759 2760 RXA02495 GR00720 9002 6435 2761 2762 RXA02496 GR00720 100259219 2763 2764 RXA02498 GR00720 11016 11819 2765 2766 RXA02500 GR0072013460 13558 2767 2768 RXA02506 GR00720 19484 18603 2769 2770 RXA02514GR00723 1 837 2771 2772 RXA02518 GR00723 3464 3874 2773 2774 RXA02521GR00724 2924 4366 2775 2776 RXA02524 GR00725 2405 3094 2777 2778RXA02525 GR00725 3113 3490 2779 2780 RXA02540 GR00726 12438 12001 27812782 RXA02544 GR00726 16715 18142 2783 2784 RXA02545 GR00726 18749 181922785 2786 RXA02546 GR00726 19927 18824 2787 2788 RXA02549 GR00728 1331 62789 2790 RXA02552 GR00730 924 130 2791 2792 RXA02554 GR00731 1050 4272793 2794 RXA02569 GR00736 82 831 2795 2796 RXA02570 GR00736 837 14782797 2798 RXA02573 GR00739 594 151 2799 2800 RXA02575 GR00739 1907 30642801 2802 RXA02576 GR00740 1569 148 2803 2804 RXA02577 GR00740 2463 15792805 2806 RXA02584 GR00741 8925 8575 2807 2808 RXA02585 GR00741 99178937 2809 2810 RXA02588 GR00741 13037 12354 2811 2812 RXA02591 GR0074115780 17609 2813 2814 RXA02598 GR00742 2576 3166 2815 2816 RXA02600GR00742 5027 3630 2817 2818 RXA02601 GR00742 5258 7246 2819 2820RXA02602 GR00742 7239 7742 2821 2822 RXA02604 GR00742 8800 10875 28232824 RXA02609 GR00742 16197 16445 2825 2826 RXA02617 GR00745 1404 19102827 2828 RXA02619 GR00746 204 1103 2829 2830 RXA02620 GR00746 1192 18452831 2832 RXA02639 GR00749 511 1344 2833 2834 RXA02647 GR00751 4155 46162835 2836 RXA02649 GR00752 1284 283 2837 2838 RXA02652 GR00752 2973 35512839 2840 RXA02655 GR00752 9313 8330 2841 2842 RXA02662 GR00753 14611724 2843 2844 RXA02665 GR00753 6497 6018 2845 2846 RXA02670 GR0075310199 10780 2847 2848 RXA02672 GR00753 12303 13400 2849 2850 RXA02678GR00754 3858 4775 2851 2852 RXA02683 GR00754 7742 7065 2853 2854RXA02685 GR00754 10058 9402 2855 2856 RXA02688 GR00754 12256 12924 28572858 RXA02689 GR00754 13405 13064 2859 2860 RXA02690 GR00754 14502 134052861 2862 RXA02700 GR00757 3507 4742 2863 2864 RXA02701 GR00757 48386145 2865 2866 RXA02712 GR00758 13067 12273 2867 2868 RXA02714 GR0075814754 14326 2869 2870 RXA02715 GR00758 15847 15458 2871 2872 RXA02721GR00759 1373 636 2873 2874 RXA02725 GR00760 1478 867 2875 2876 RXA02727GR00760 6287 5376 2877 2878 RXA02735 GR00763 777 73 2879 2880 RXA02736GR00763 1753 797 2881 2882 RXA02751 GR00764 6393 5920 2883 2884 RXA02756GR00766 3851 2961 2885 2886 RXA02757 GR00766 4475 3930 2887 2888RXA02765 GR00769 3552 2794 2889 2890 RXA02766 GR00770 986 594 2891 2892RXA02774 GR00773 3 473 2893 2894 RXA02775 GR00773 744 968 2895 2896RXA02776 GR00773 1713 1372 2897 2898 RXA02777 GR00773 4626 5732 28992900 RXA02778 GR00773 10095 10319 2901 2902 RXA02779 GR00773 10617 108952903 2904 RXA02780 GR00773 10954 11280 2905 2906 RXA02783 GR00775 8451393 2907 2908 RXA02784 GR00775 1751 1936 2909 2910 RXA02786 GR00777 2808 2911 2912 RXA02789 GR00777 5237 5782 2913 2914 RXA02793 GR00777 93858684 2915 2916 RXA02796 GR00778 1648 1100 2917 2918 RXA02798 GR007782842 4266 2919 2920 RXA02799 GR00780 182 454 2921 2922 RXA02815 GR007963 554 2923 2924 RXA02823 GR00804 275 6 2925 2926 RXA02827 GR00812 428 62927 2928 RXA02842 GR00841 356 15 2929 2930 RXA02845 GR00844 2 616 29312932 RXA02848 GR00848 113 511

1. An isolated nucleic acid molecule selected from the group consistingof a) an isolated nucleic acid molecule comprising the nucleotidesequence of SEQ ID NO:2693, or a complement thereof; b) an isolatednucleic acid molecule which encodes a polypeptide comprising the aminoacid sequence of SEQ ID NO:2694, or a complement thereof; c) an isolatednucleic acid molecule which encodes a naturally occurring allelicvariant of a polypeptide comprising the amino acid sequence of SEQ IDNO:2694, or a complement thereof; d) an isolated nucleic acid moleculecomprising a nucleotide sequence which is at least 50% identical to theentire nucleotide sequence of SEQ ID NO:2693, or a complement thereof;and e) an isolated nucleic acid molecule comprising a fragment of atleast 15 contiguous nucleotides of the nucleotide sequence of SEQ IDNO:2693, or a complement thereof.
 2. An isolated nucleic acid moleculecomprising the nucleic acid molecule of claim 1 and a nucleotidesequence encoding a heterologous polypeptide.
 3. A vector comprising thenucleic acid molecule of claim
 1. 4. The vector of claim 3, which is anexpression vector.
 5. A host cell transfected with the expression vectorof claim
 4. 6. The host cell of claim 5, wherein said cell is amicroorganism.
 7. The host cell of claim 6, wherein said cell belongs tothe genus Corynebacterium or Brevibacterium.
 8. A method of producing apolypeptide comprising culturing the host cell of claim 5 in anappropriate culture medium to, thereby, produce the polypeptide.
 9. Amethod for producing a fine chemical, comprising culturing the cell ofclaim 5 such that the fine chemical is produced.
 10. The method of claim9, wherein said method further comprises the step of recovering the finechemical from said culture.
 11. The method of claim 9, wherein said cellbelongs to the genus Corynebacterium or Brevibacterium.
 12. The methodof claim 9, wherein said cell is selected from the group consisting ofCorynebacterium glutamicum, Corynebacterium herculis, Corynebacterium,lilium, Corynebacterium acetoacidophilum, Corynebacteriumacetoglutamicum, Corynebacterium acetophilum, Corynebacteriumammoniagenes, Corynebacterium fujiokense, Corynebacterium nitrilophilus,Brevibacterium ammoniagenes, Brevibacterium butanicum, Brevibacteriumdivaricatum, Brevibacterium flavum, Brevibacterium healii,Brevibacterium ketoglutamicum, Brevibacterium ketosoreductum,Brevibacterium lactofermentum, Brevibacterium linens, Brevibacteriumparaffinolyticum, and those strains set forth in Table
 3. 13. The methodof claim 9, wherein expression of the nucleic acid molecule from saidvector results in modulation of production of said fine chemical. 14.The method of claim 9, wherein said fine chemical is selected from thegroup consisting of organic acids, proteinogenic and nonproteinogenicamino acids, purine and pyrimidine bases, nucleosides, nucleotides,lipids, saturated and unsaturated fatty acids, diols, carbohydrates,aromatic compounds, vitamins, cofactors, polyketides, and enzymes. 15.The method of claim 9, wherein said fine chemical is an amino acidselected from the group consisting of lysine, glutamate, glutamine,alanine, aspartate, glycine, serine, threonine, methionine, cysteine,valine, leucine, isoleucine, arginine, proline, histidine, tyrosine,phenylalanine, and tryptophan.
 16. An isolated polypeptide selected fromthe group consisting of a) an isolated polypeptide comprising the aminoacid sequence of SEQ ID NO:2694; b) an isolated polypeptide comprising anaturally occurring allelic variant of a polypeptide comprising theamino acid sequence of SEQ ID NO:2694; c) an isolated polypeptide whichis encoded by a nucleic acid molecule comprising the nucleotide sequenceof SEQ ID NO:2693; d) an isolated polypeptide which is encoded by anucleic acid molecule comprising a nucleotide sequence which is at least50% identical to the entire nucleotide sequence of SEQ ID NO:2693; e) anisolated polypeptide comprising an amino acid sequence which is at least50% identical to the entire amino acid sequence of SEQ ID NO:2694; andf) an isolated polypeptide comprising a fragment of a polypeptidecomprising the amino acid sequence of SEQ ID NO:2694, wherein saidpolypeptide fragment maintains a biological activity of the polypeptidecomprising the amino sequence.
 17. The isolated polypeptide of claim 16,further comprising heterologous amino acid sequences.
 18. A method fordiagnosing the presence or activity of Corynebacterium diphtheriae in asubject, comprising detecting the presence of at least one of thenucleic acid molecules of claim 1, thereby diagnosing the presence oractivity of Corynebacterium diphtheriae in the subject.
 19. A method fordiagnosing the presence or activity of Corynebacterium diphtheriae in asubject, comprising detecting the presence of at least one of thepolypeptide molecules of claim 16, thereby diagnosing the presence oractivity of Corynebacterium diphtheriae in the subject.
 20. A host cellcomprising a nucleic acid molecule selected from the group consisting ofa) the nucleic acid molecule of SEQ ID NO:2693, wherein the nucleic acidmolecule is disrupted by at least one technique selected from the groupconsisting of a point mutation, a truncation, an inversion, a deletion,an addition, a substitution and homologous recombination; b) the nucleicacid molecule of SEQ ID NO:2693, wherein the nucleic acid moleculecomprises one or more nucleic acid modifications as compared to thesequence of SEQ ID NO:2693, wherein the modification is selected fromthe group consisting of a point mutation, a truncation, an inversion, adeletion, an addition and a substitution; and c) the nucleic acidmolecule of SEQ ID NO:2693, wherein the regulatory region of the nucleicacid molecule is modified relative to the wild-type regulatory region ofthe molecule by at least one technique selected from the groupconsisting of a point mutation, a truncation, an inversion, a deletion,an addition, a substitution and homologous recombination.